{"id":"https://openalex.org/W3203608032","doi":"https://doi.org/10.22487/j24428744.2021.v7.i2.15578","title":"Development of Nanocapsules Containing Cytotoxic Agents- A Review: Kajian Literatur Pengembangan Sediaan Nanokapsul Mengandung Agen Sitotoksik","display_name":"Development of Nanocapsules Containing Cytotoxic Agents- A Review: Kajian Literatur Pengembangan Sediaan Nanokapsul Mengandung Agen Sitotoksik","publication_year":2021,"publication_date":"2021-10-04","ids":{"openalex":"https://openalex.org/W3203608032","doi":"https://doi.org/10.22487/j24428744.2021.v7.i2.15578","mag":"3203608032"},"language":"en","primary_location":{"id":"doi:10.22487/j24428744.2021.v7.i2.15578","doi":"https://doi.org/10.22487/j24428744.2021.v7.i2.15578","is_oa":true,"landing_page_url":"https://doi.org/10.22487/j24428744.2021.v7.i2.15578","pdf_url":"https://bestjournal.untad.ac.id/index.php/Galenika/article/download/15578/11557","source":{"id":"https://openalex.org/S4210176192","display_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","issn_l":"2442-7284","issn":["2442-7284","2442-8744"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314972","host_organization_name":"Tadulako University","host_organization_lineage":["https://openalex.org/P4310314972"],"host_organization_lineage_names":["Tadulako University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bestjournal.untad.ac.id/index.php/Galenika/article/download/15578/11557","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080187441","display_name":"Sani Ega Priani","orcid":"https://orcid.org/0000-0001-6544-5463","observed_orcids":["https://orcid.org/0000-0001-6544-5463"]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sani Ega Priani","raw_affiliation_strings":["Universitas Islam Bandung, Bandung, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Islam Bandung, Bandung, Indonesia","institution_ids":["https://openalex.org/I4210150439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030694593","display_name":"Tia Nur Setianty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Tia Nur Setianty","raw_affiliation_strings":["Universitas Islam Bandung (UNISBA), Bandung, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Islam Bandung (UNISBA), Bandung, Indonesia","institution_ids":["https://openalex.org/I4210150439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087003916","display_name":"Ratih Aryani","orcid":"https://orcid.org/0000-0003-1956-030X","observed_orcids":["https://orcid.org/0000-0003-1956-030X"]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ratih Aryani","raw_affiliation_strings":["Universitas Islam Bandung, Bandung, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Islam Bandung, Bandung, Indonesia","institution_ids":["https://openalex.org/I4210150439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076812077","display_name":"Sri Peni Fitrianingsih","orcid":"https://orcid.org/0000-0003-2038-8754","observed_orcids":["https://orcid.org/0000-0003-2038-8754"]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sri Peni Fitrianingsih","raw_affiliation_strings":["Universitas Islam Bandung, Bandung, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Islam Bandung, Bandung, Indonesia","institution_ids":["https://openalex.org/I4210150439"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030264687","display_name":"Livia Syafnir","orcid":"https://orcid.org/0000-0001-7097-9566","observed_orcids":["https://orcid.org/0000-0001-7097-9566","https://orcid.org/0000-0001-6399-600X"]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Livia Syafnir","raw_affiliation_strings":["Universitas Islam Bandung, Bandung, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Islam Bandung, Bandung, Indonesia","institution_ids":["https://openalex.org/I4210150439"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210150439"],"apc_list":{"value":500000,"currency":"IDR","value_usd":32},"apc_paid":{"value":500000,"currency":"IDR","value_usd":32},"fwci":0.1784,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.26038619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"2","first_page":"151","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoencapsulation","display_name":"nanoencapsulation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nanocapsules","display_name":"nanocapsules","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cytotoxic-drugs","display_name":"cytotoxic drugs","score":0.9639999866485596},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7929999828338623},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.8529999852180481},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.8019999861717224},{"id":"https://openalex.org/keywords/plga","display_name":"PLGA","score":0.9229999780654907},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":0.9879999756813049},{"id":"https://openalex.org/keywords/poly-methyl-methacrylate","display_name":"poly(methyl methacrylate)","score":0.9760000109672546},{"id":"https://openalex.org/keywords/in-vitro-cytotoxicity","display_name":"in vitro cytotoxicity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/particle-size-reduction","display_name":"particle size reduction","score":0.7799999713897705},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C204399865","wikidata":"https://www.wikidata.org/wiki/Q17157402","display_name":"Nanocapsules","level":3,"score":0.6664798259735107},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.6637992262840271},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.6282345652580261},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5703970193862915},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5345956683158875},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.48701339960098267},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4693965017795563},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4570562541484833},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4397922158241272},{"id":"https://openalex.org/C2778551929","wikidata":"https://www.wikidata.org/wiki/Q146339","display_name":"Polyvinyl alcohol","level":2,"score":0.42976170778274536},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.41646310687065125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36885982751846313},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3272862434387207},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23302489519119263},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2083258032798767},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1723335087299347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0879574716091156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0816081166267395}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22487/j24428744.2021.v7.i2.15578","doi":"https://doi.org/10.22487/j24428744.2021.v7.i2.15578","is_oa":true,"landing_page_url":"https://doi.org/10.22487/j24428744.2021.v7.i2.15578","pdf_url":"https://bestjournal.untad.ac.id/index.php/Galenika/article/download/15578/11557","source":{"id":"https://openalex.org/S4210176192","display_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","issn_l":"2442-7284","issn":["2442-7284","2442-8744"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314972","host_organization_name":"Tadulako University","host_organization_lineage":["https://openalex.org/P4310314972"],"host_organization_lineage_names":["Tadulako University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22487/j24428744.2021.v7.i2.15578","doi":"https://doi.org/10.22487/j24428744.2021.v7.i2.15578","is_oa":true,"landing_page_url":"https://doi.org/10.22487/j24428744.2021.v7.i2.15578","pdf_url":"https://bestjournal.untad.ac.id/index.php/Galenika/article/download/15578/11557","source":{"id":"https://openalex.org/S4210176192","display_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","issn_l":"2442-7284","issn":["2442-7284","2442-8744"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310314972","host_organization_name":"Tadulako University","host_organization_lineage":["https://openalex.org/P4310314972"],"host_organization_lineage_names":["Tadulako University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320330147","display_name":"Universitas Islam Bandung","ror":"https://ror.org/04tp6pr14"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203608032.pdf","grobid_xml":"https://content.openalex.org/works/W3203608032.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1851997713","https://openalex.org/W1934632378","https://openalex.org/W1969666381","https://openalex.org/W1974241574","https://openalex.org/W1981238513","https://openalex.org/W1982546793","https://openalex.org/W1989359894","https://openalex.org/W1991697331","https://openalex.org/W2015041010","https://openalex.org/W2040625016","https://openalex.org/W2068164877","https://openalex.org/W2079078103","https://openalex.org/W2087032263","https://openalex.org/W2125493976","https://openalex.org/W2203320477","https://openalex.org/W2577300750","https://openalex.org/W2734754609","https://openalex.org/W2771155547","https://openalex.org/W2783680910","https://openalex.org/W2898712541","https://openalex.org/W2910779515","https://openalex.org/W2939822974","https://openalex.org/W2942202823","https://openalex.org/W2978901485","https://openalex.org/W2991153670","https://openalex.org/W3004456788","https://openalex.org/W3047476760","https://openalex.org/W3048788804","https://openalex.org/W3082386395","https://openalex.org/W3093854213","https://openalex.org/W3128646645","https://openalex.org/W3132675971"],"related_works":["https://openalex.org/W1991843607","https://openalex.org/W3187585346","https://openalex.org/W2804388864","https://openalex.org/W2978901485","https://openalex.org/W3213817034","https://openalex.org/W7126454431","https://openalex.org/W2907507390","https://openalex.org/W2160053712","https://openalex.org/W2066651265","https://openalex.org/W3118547665"],"abstract_inverted_index":{"Background:":[0],"The":[1,69,91,115,163,190],"incidence":[2],"and":[3,25,58,87,112,140,157,206],"mortality":[4],"of":[5,27,32,51,55,62,178,202,208],"cancer":[6],"are":[7,146],"rapidly":[8],"growing":[9],"worldwide.":[10],"Modification":[11],"on":[12,17,64,165],"drug":[13,209],"delivery":[14],"systems":[15,103],"based":[16],"nanotechnology":[18],"was":[19,34,45,71,118],"applied":[20,220],"to":[21,47,105,152,187,224],"improve":[22],"the":[23,49,60,65,85,159,170,176,182,229],"effectiveness":[24],"safety":[26],"treatment.":[28],"Nanoencapsulation,":[29],"a":[30],"part":[31],"nanotechnology,":[33],"known":[35],"can":[36,213,218],"be":[37,195,214,219],"involved":[38],"in":[39,101,171,181,192],"cytotoxic":[40,56,66,96,166,222],"agents.":[41],"Objective:":[42],"This":[43],"research":[44],"conducted":[46],"determine":[48],"type":[50],"polymers":[52,125,145],"for":[53,149,221],"nanoencapsulation":[54,63,116,150,164,217],"agents":[57,97,167,223],"analyze":[59],"effect":[61],"activity.":[67],"Methods:":[68],"study":[70],"performed":[72],"by":[73,175,197],"systematic":[74],"literature":[75],"review":[76],"using":[77,121,228],"selected":[78],"articles":[79],"from":[80],"reputable":[81],"databases":[82],"that":[83,94,216],"meet":[84],"inclusion":[86],"exclusion":[88],"criteria.":[89],"Results:":[90],"results":[92],"show":[93],"many":[95],"have":[98],"been":[99],"developed":[100],"nanocapsules":[102],"due":[104],"their":[106,153,226],"low":[107,113],"water":[108],"solubility,":[109],"chemical":[110],"instability,":[111],"bioavailability.":[114],"process":[117],"carried":[119],"out":[120],"synthetic":[122],"or":[123],"natural":[124],"such":[126],"as":[127],"polylactic-co-glycolic":[128],"acid":[129],"(PLGA),":[130],"PEGylated":[131],"PLGA,":[132],"polycaprolactone":[133],"(PCL),":[134],"chitosan-sodium":[135,137],"tripolyphosphate,":[136],"alginate,":[138],"heparin-poly(l-lysine),":[139],"polymethyl":[141],"methacrylate":[142],"(PMMA).":[143],"Those":[144],"widely":[147],"used":[148],"related":[151],"biocompatible,":[154],"biodegradable,":[155],"non-toxic,":[156],"providing":[158],"desired":[160],"coating":[161,231],"properties.":[162],"significantly":[168],"increases":[169],"vitro":[172],"cytotoxicity,":[173],"marked":[174],"decrease":[177],"IC50":[179],"value":[180],"range":[183],"1.4-15.4":[184],"folds":[185],"compared":[186],"pure":[188],"drugs.":[189],"increase":[191,225],"cytotoxicity":[193],"could":[194],"caused":[196],"particle":[198,203],"size":[199],"reduction,":[200],"modification":[201],"surface":[204],"properties,":[205],"enhancement":[207],"stability.":[210],"Conclusion:":[211],"It":[212],"concluded":[215],"activity":[227],"appropriate":[230],"polymer.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-10-11T00:00:00"}
