{"id":"https://openalex.org/W3203604872","doi":"https://doi.org/10.30799/jpmr.055.21060103","title":"Targeting Brain-Derived Neurotrophic Factor (BDNF) - An Important Strategy to Alzheimer's Disease","display_name":"Targeting Brain-Derived Neurotrophic Factor (BDNF) - An Important Strategy to Alzheimer's Disease","publication_year":2021,"publication_date":"2021-09-28","ids":{"openalex":"https://openalex.org/W3203604872","doi":"https://doi.org/10.30799/jpmr.055.21060103","mag":"3203604872"},"language":"en","primary_location":{"id":"doi:10.30799/jpmr.055.21060103","doi":"https://doi.org/10.30799/jpmr.055.21060103","is_oa":true,"landing_page_url":"https://doi.org/10.30799/jpmr.055.21060103","pdf_url":"http://jacsdirectory.com/journal-of-pharmaceutical-and-medicinal-research/admin/issues/20210928063524_6-1-03_JPMR21055_Targeting_brain-derived_neurotrophic_factor_alzheimers_disease.pdf","source":{"id":"https://openalex.org/S4210232711","display_name":"Journal of Pharmaceutical and Medicinal Research","issn_l":"2455-0280","issn":["2455-0280"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Medicinal Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://jacsdirectory.com/journal-of-pharmaceutical-and-medicinal-research/admin/issues/20210928063524_6-1-03_JPMR21055_Targeting_brain-derived_neurotrophic_factor_alzheimers_disease.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S. Kanhere Hemant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S. Kanhere Hemant","raw_affiliation_strings":["Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur \u2013 441 002, MS, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur \u2013 441 002, MS, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038544569","display_name":"C. Bansinge Pallavi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Bansinge Pallavi","raw_affiliation_strings":["Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur \u2013 441 002, MS, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur \u2013 441 002, MS, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030886441","display_name":"Jeyarajan Helen Ratna Monica","orcid":"https://orcid.org/0000-0003-1385-9511","observed_orcids":["https://orcid.org/0000-0003-1385-9511"]},"institutions":[{"id":"https://openalex.org/I2800849556","display_name":"American College, Madurai","ror":"https://ror.org/01b1fn946","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800849556"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J. Helen Ratna Monica","raw_affiliation_strings":["Post Graduate and Research Department of Chemistry, The American College, Madurai - 625 002, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Post Graduate and Research Department of Chemistry, The American College, Madurai - 625 002, Tamilnadu, India","institution_ids":["https://openalex.org/I2800849556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086972631","display_name":"K. Rathod Sawan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Rathod Sawan","raw_affiliation_strings":["Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur \u2013 441 002, MS, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur \u2013 441 002, MS, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":"121","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8870000243186951},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6959999799728394},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.7630000114440918},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9710000157356262},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/riluzole","display_name":"riluzole","score":0.9629999995231628},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7039999961853027},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cognitive-enhancement","display_name":"cognitive enhancement","score":0.5210000276565552},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.7213402390480042},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6441763639450073},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6273472309112549},{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.576103687286377},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5015974044799805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44189339876174927},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39695316553115845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2226557433605194},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1314397156238556}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.30799/jpmr.055.21060103","doi":"https://doi.org/10.30799/jpmr.055.21060103","is_oa":true,"landing_page_url":"https://doi.org/10.30799/jpmr.055.21060103","pdf_url":"http://jacsdirectory.com/journal-of-pharmaceutical-and-medicinal-research/admin/issues/20210928063524_6-1-03_JPMR21055_Targeting_brain-derived_neurotrophic_factor_alzheimers_disease.pdf","source":{"id":"https://openalex.org/S4210232711","display_name":"Journal of Pharmaceutical and Medicinal Research","issn_l":"2455-0280","issn":["2455-0280"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Medicinal Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.30799/jpmr.055.21060103","doi":"https://doi.org/10.30799/jpmr.055.21060103","is_oa":true,"landing_page_url":"https://doi.org/10.30799/jpmr.055.21060103","pdf_url":"http://jacsdirectory.com/journal-of-pharmaceutical-and-medicinal-research/admin/issues/20210928063524_6-1-03_JPMR21055_Targeting_brain-derived_neurotrophic_factor_alzheimers_disease.pdf","source":{"id":"https://openalex.org/S4210232711","display_name":"Journal of Pharmaceutical and Medicinal Research","issn_l":"2455-0280","issn":["2455-0280"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Medicinal Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203604872.pdf","grobid_xml":"https://content.openalex.org/works/W3203604872.grobid-xml"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W1486548283","https://openalex.org/W1498746154","https://openalex.org/W1543871129","https://openalex.org/W1565095682","https://openalex.org/W1578708051","https://openalex.org/W1603180106","https://openalex.org/W1702230308","https://openalex.org/W1759135250","https://openalex.org/W1777314638","https://openalex.org/W1783235797","https://openalex.org/W1917653939","https://openalex.org/W1933828059","https://openalex.org/W1963500709","https://openalex.org/W1964049915","https://openalex.org/W1965318694","https://openalex.org/W1966435491","https://openalex.org/W1966607391","https://openalex.org/W1967649090","https://openalex.org/W1971402768","https://openalex.org/W1972371732","https://openalex.org/W1972869003","https://openalex.org/W1973276415","https://openalex.org/W1976915575","https://openalex.org/W1979017394","https://openalex.org/W1979702721","https://openalex.org/W1980750700","https://openalex.org/W1981250359","https://openalex.org/W1981782246","https://openalex.org/W1990064667","https://openalex.org/W1990752558","https://openalex.org/W1991988242","https://openalex.org/W1993247547","https://openalex.org/W1993784825","https://openalex.org/W1993850918","https://openalex.org/W1998751550","https://openalex.org/W1999108861","https://openalex.org/W2000613539","https://openalex.org/W2003601855","https://openalex.org/W2005170723","https://openalex.org/W2005306977","https://openalex.org/W2006733352","https://openalex.org/W2008180577","https://openalex.org/W2008499928","https://openalex.org/W2009582310","https://openalex.org/W2012133068","https://openalex.org/W2019297242","https://openalex.org/W2021056295","https://openalex.org/W2021104084","https://openalex.org/W2022579786","https://openalex.org/W2023536393","https://openalex.org/W2024489974","https://openalex.org/W2025563134","https://openalex.org/W2026329107","https://openalex.org/W2026538105","https://openalex.org/W2027189256","https://openalex.org/W2034497459","https://openalex.org/W2036234078","https://openalex.org/W2038003980","https://openalex.org/W2044715983","https://openalex.org/W2051229117","https://openalex.org/W2051616244","https://openalex.org/W2051935955","https://openalex.org/W2053896250","https://openalex.org/W2058096955","https://openalex.org/W2059304365","https://openalex.org/W2059554404","https://openalex.org/W2064629987","https://openalex.org/W2069488251","https://openalex.org/W2070757879","https://openalex.org/W2071610467","https://openalex.org/W2073639952","https://openalex.org/W2073644964","https://openalex.org/W2076406171","https://openalex.org/W2081619938","https://openalex.org/W2084188625","https://openalex.org/W2084207599","https://openalex.org/W2086835104","https://openalex.org/W2087465947","https://openalex.org/W2087672059","https://openalex.org/W2090359564","https://openalex.org/W2092006791","https://openalex.org/W2094570848","https://openalex.org/W2094958540","https://openalex.org/W2095147724","https://openalex.org/W2100464372","https://openalex.org/W2100775280","https://openalex.org/W2103119955","https://openalex.org/W2104009593","https://openalex.org/W2109221379","https://openalex.org/W2109480636","https://openalex.org/W2112473391","https://openalex.org/W2116424646","https://openalex.org/W2119757776","https://openalex.org/W2120819751","https://openalex.org/W2122804887","https://openalex.org/W2128883244","https://openalex.org/W2132297564","https://openalex.org/W2134613265","https://openalex.org/W2136873160","https://openalex.org/W2138023910","https://openalex.org/W2145356761","https://openalex.org/W2145976523","https://openalex.org/W2146787134","https://openalex.org/W2151986987","https://openalex.org/W2158994354","https://openalex.org/W2168694025","https://openalex.org/W2169152986","https://openalex.org/W2199496451","https://openalex.org/W2201801060","https://openalex.org/W2270188886","https://openalex.org/W2270702517","https://openalex.org/W2343404379","https://openalex.org/W2490633794","https://openalex.org/W2510233326","https://openalex.org/W2514934551","https://openalex.org/W2515246204","https://openalex.org/W2518195265","https://openalex.org/W2529170838","https://openalex.org/W2537167978","https://openalex.org/W2544486419","https://openalex.org/W2595402501","https://openalex.org/W2766099104","https://openalex.org/W2767022115","https://openalex.org/W2793296647","https://openalex.org/W2885514874","https://openalex.org/W2885745400","https://openalex.org/W2947634966","https://openalex.org/W2963936193","https://openalex.org/W2974868658","https://openalex.org/W2976163884","https://openalex.org/W3014251530","https://openalex.org/W3035185761","https://openalex.org/W3094053673","https://openalex.org/W4211028926","https://openalex.org/W4240168071","https://openalex.org/W4243693606","https://openalex.org/W6600660881"],"related_works":["https://openalex.org/W2058996741","https://openalex.org/W2087672059","https://openalex.org/W2375640311","https://openalex.org/W4404487831","https://openalex.org/W1826284293","https://openalex.org/W3006430273","https://openalex.org/W2348040835","https://openalex.org/W2977097361","https://openalex.org/W3196192112","https://openalex.org/W3120299062"],"abstract_inverted_index":{"Many":[0],"theories":[1],"have":[2,100,123,151,185,266],"been":[3,124,152,186],"proposed":[4],"to":[5,113,126,154,188,226,262],"explain":[6],"why":[7],"candidate":[8],"disease-modifying":[9],"drugs":[10],"(DMTs)":[11],"for":[12,83],"Alzheimer's":[13,62,90,258,264],"disease":[14,265],"(AD)":[15],"failed.":[16],"Late":[17],"initiation":[18],"of":[19,29,37,41,50,61,86,108,130,175,192,206,257,270,285,299],"treatments":[20],"during":[21],"AD":[22,42],"development,":[23],"inappropriate":[24],"drug":[25,150],"dosages,":[26],"incorrect":[27],"selection":[28],"main":[30],"therapeutic":[31,176],"targets,":[32],"and":[33,71,75,96,132,147,160,183],"primarily":[34],"inadequate":[35],"understanding":[36],"the":[38,44,59,84,87,92,101,190,210,221,255,267,280,297],"complex":[39],"pathophysiology":[40],"are":[43,167],"most":[45,102],"prominent":[46],"ones.":[47],"Reduced":[48],"expression":[49],"Brain":[51],"Derived":[52],"Neurotrophic":[53],"Factor":[54],"(BDNF)":[55],"is":[56,224],"essential":[57,168],"in":[58,68,135,209,220,254,274,279,291],"pathogenesis":[60,256],"disease.":[63,88,259],"BDNF":[64,104,109,121,136,148,164,218,244,249,272,290],"plays":[65,251],"important":[66],"functions":[67,208],"cell":[69],"survival":[70],"differentiation,":[72],"neuronal":[73,114],"outgrowth":[74],"plasticity.":[76],"It":[77],"can":[78,110,162],"be":[79,111],"a":[80,127,172,195,204,233,252],"novel":[81],"target":[82],"treatment":[85],"In":[89,232],"disease,":[91],"hippocampus,":[93],"parietal,":[94],"entorhinal,":[95],"frontal":[97],"cortex":[98],"all":[99],"extreme":[103],"deficits.":[105],"Lower":[106],"levels":[107,122,137,273],"linked":[112],"death,":[115],"masking":[116],"any":[117],"gene-related":[118],"effects.":[119],"High":[120],"attributed":[125],"lower":[128],"risk":[129],"dementia":[131],"Alzheimer's.":[133],"Improvements":[134],"imparted":[138],"by":[139],"exercise,":[140],"plant":[141,169],"based":[142],"drugs,":[143],"trkB":[144],"receptor":[145],"agonist":[146],"enhancer":[149],"proved":[153],"enhance":[155],"cognitive":[156],"performance.":[157],"Plant-based":[158],"products":[159],"nutraceuticals":[161],"boost":[163],"levels.":[165,245],"Polyphenols":[166],"compounds":[170],"with":[171,236],"wide":[173],"range":[174],"potentials.":[177],"Flavonoids":[178],"like":[179],"calycosin,":[180],"genistein,":[181],"isorhamnetin,":[182],"luteolin":[184],"shown":[187],"affect":[189],"level":[191,219],"BDNF.":[193],"Curcumin,":[194],"compound":[196],"derived":[197],"from":[198],"spice":[199],"turmeric":[200],"(curcuma":[201],"longa),":[202],"has":[203],"variety":[205],"biological":[207],"brain,":[211],"including":[212],"antidepressant":[213],"properties":[214],"which":[215],"also":[216,241],"increase":[217,296],"hippocampus.":[222],"Riluzole":[223],"used":[225,261],"treat":[227,263],"amyotrophic":[228],"lateral":[229],"sclerosis":[230],"(ALS).":[231],"depression":[234],"model":[235],"chronic":[237],"corticosteroid":[238],"intake,":[239],"riluzole":[240],"restores":[242],"hippocampal":[243],"Evidence":[246],"indicates":[247],"that":[248,287],"deficiency":[250],"role":[253],"Drugs":[260],"unintended":[268],"property":[269],"modulating":[271],"brain":[275],"regions":[276],"specifically":[277],"involved":[278],"disease's":[281],"pathophysiology.":[282],"The":[283],"discovery":[284],"molecules":[286],"precisely":[288],"control":[289],"particular":[292],"cellular":[293],"phenotypes":[294],"could":[295],"effectiveness":[298],"therapy":[300],"against":[301],"AD.":[302]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-11T00:00:00"}
