{"id":"https://openalex.org/W3203558137","doi":"https://doi.org/10.1080/08820538.2021.1987482","title":"Macular microcirculation characteristics in Parkinson\u2019s disease evaluated by OCT-Angiography: a literature review","display_name":"Macular microcirculation characteristics in Parkinson\u2019s disease evaluated by OCT-Angiography: a literature review","publication_year":2021,"publication_date":"2021-10-06","ids":{"openalex":"https://openalex.org/W3203558137","doi":"https://doi.org/10.1080/08820538.2021.1987482","mag":"3203558137","pmid":"https://pubmed.ncbi.nlm.nih.gov/34612157"},"language":"en","primary_location":{"id":"doi:10.1080/08820538.2021.1987482","doi":"https://doi.org/10.1080/08820538.2021.1987482","is_oa":false,"landing_page_url":"https://doi.org/10.1080/08820538.2021.1987482","pdf_url":null,"source":{"id":"https://openalex.org/S118649763","display_name":"Seminars in Ophthalmology","issn_l":"0882-0538","issn":["0882-0538","1744-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063936193","display_name":"Evita Evangelia Christou","orcid":"https://orcid.org/0000-0002-7959-4854","observed_orcids":["https://orcid.org/0000-0002-7959-4854"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Evita Evangelia Christou","raw_affiliation_strings":["University Hospital of Ioannina","Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":"https://orcid.org/0000-0002-7959-4854","affiliations":[{"raw_affiliation_string":"University Hospital of Ioannina","institution_ids":["https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607","https://openalex.org/I4210141877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035755127","display_name":"Ioannis Asproudis","orcid":"https://orcid.org/0000-0002-4286-2720","observed_orcids":["https://orcid.org/0000-0002-4286-2720"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Asproudis","raw_affiliation_strings":["University Hospital of Ioannina","Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Ioannina","institution_ids":["https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607","https://openalex.org/I4210141877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054014630","display_name":"Christoforos Asproudis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christoforos Asproudis","raw_affiliation_strings":["University Hospital of Ioannina","Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Ioannina","institution_ids":["https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607","https://openalex.org/I4210141877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064862796","display_name":"Alexandros Giannakis","orcid":"https://orcid.org/0000-0002-7787-9979","observed_orcids":["https://orcid.org/0000-0002-7787-9979"]},"institutions":[{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alexandros Giannakis","raw_affiliation_strings":["University Hospital of Ioannina","Faculty of Medicine, Department of Neurology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Ioannina","institution_ids":["https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Neurology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I4210141877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113468363","display_name":"Maria I. Stefaniotou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Stefaniotou","raw_affiliation_strings":["University Hospital of Ioannina","Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Ioannina","institution_ids":["https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607","https://openalex.org/I4210141877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034121897","display_name":"Spyridon Konitsiotis","orcid":"https://orcid.org/0000-0002-5217-1317","observed_orcids":["https://orcid.org/0000-0002-5217-1317"]},"institutions":[{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Spiridon Konitsiotis","raw_affiliation_strings":["University Hospital of Ioannina","Faculty of Medicine, Department of Neurology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Ioannina","institution_ids":["https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Neurology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I4210141877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063936193"],"corresponding_institution_ids":["https://openalex.org/I194019607","https://openalex.org/I4210141877"],"apc_list":null,"apc_paid":null,"fwci":0.3205,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.26555387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"37","issue":"3","first_page":"399","last_page":"407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.6820999979972839,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.6820999979972839,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.20149999856948853,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/macular-microcirculation","display_name":"macular microcirculation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/retinal-biomarkers","display_name":"retinal biomarkers","score":0.7960000038146973},{"id":"https://openalex.org/keywords/optical-coherence-tomography-angiography","display_name":"optical coherence tomography angiography","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cerebral-microvasculature","display_name":"cerebral microvasculature","score":0.9240000247955322},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6949999928474426},{"id":"https://openalex.org/keywords/retinal-imaging","display_name":"retinal imaging","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8715869188308716},{"id":"https://openalex.org/C2779988585","wikidata":"https://www.wikidata.org/wiki/Q7204920","display_name":"Plexus","level":2,"score":0.6543669104576111},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.6540052890777588},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.5782893300056458},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.48570212721824646},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4853600561618805},{"id":"https://openalex.org/C2985858981","wikidata":"https://www.wikidata.org/wiki/Q60760969","display_name":"Optical coherence tomography angiography","level":3,"score":0.47641217708587646},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.43545860052108765},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4205786883831024},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.4163277745246887},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3754459023475647},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.35098493099212646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27595484256744385},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2058185636997223},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1960521638393402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000792","descriptor_name":"Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/08820538.2021.1987482","doi":"https://doi.org/10.1080/08820538.2021.1987482","is_oa":false,"landing_page_url":"https://doi.org/10.1080/08820538.2021.1987482","pdf_url":null,"source":{"id":"https://openalex.org/S118649763","display_name":"Seminars in Ophthalmology","issn_l":"0882-0538","issn":["0882-0538","1744-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Ophthalmology","raw_type":"journal-article"},{"id":"pmid:34612157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34612157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in ophthalmology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W175818139","https://openalex.org/W323326881","https://openalex.org/W1513065729","https://openalex.org/W1539268972","https://openalex.org/W1621325175","https://openalex.org/W1920030402","https://openalex.org/W1972653353","https://openalex.org/W1978043326","https://openalex.org/W1995237298","https://openalex.org/W1997343243","https://openalex.org/W2008560062","https://openalex.org/W2009534627","https://openalex.org/W2040621412","https://openalex.org/W2053339890","https://openalex.org/W2060996843","https://openalex.org/W2065195353","https://openalex.org/W2066777502","https://openalex.org/W2070486213","https://openalex.org/W2076149753","https://openalex.org/W2080678410","https://openalex.org/W2082718353","https://openalex.org/W2112455323","https://openalex.org/W2124181868","https://openalex.org/W2134886133","https://openalex.org/W2141483618","https://openalex.org/W2154761807","https://openalex.org/W2156411508","https://openalex.org/W2259564000","https://openalex.org/W2317002432","https://openalex.org/W2462081900","https://openalex.org/W2466278438","https://openalex.org/W2737861152","https://openalex.org/W2775636951","https://openalex.org/W2799826073","https://openalex.org/W2806838419","https://openalex.org/W2887140563","https://openalex.org/W2887173236","https://openalex.org/W2889558476","https://openalex.org/W2913470461","https://openalex.org/W2915473219","https://openalex.org/W2921093995","https://openalex.org/W2942886053","https://openalex.org/W2948657684","https://openalex.org/W2972071731","https://openalex.org/W2993359737","https://openalex.org/W3033144628","https://openalex.org/W3040814542","https://openalex.org/W3042083569","https://openalex.org/W3082283702","https://openalex.org/W3092320695","https://openalex.org/W3114692318","https://openalex.org/W3116180543","https://openalex.org/W3134138288","https://openalex.org/W3141938374","https://openalex.org/W3161128890","https://openalex.org/W3168676105","https://openalex.org/W4256324391"],"related_works":["https://openalex.org/W2887140563","https://openalex.org/W4323050324","https://openalex.org/W7135049881","https://openalex.org/W4328048254","https://openalex.org/W4414166999","https://openalex.org/W4412463786","https://openalex.org/W4405171484","https://openalex.org/W4390206487","https://openalex.org/W4224084936","https://openalex.org/W3178509793"],"abstract_inverted_index":{"PURPOSE:":[0],"Given":[1],"the":[2,11,46,74,79,88,103,106,123,134,140,151,164,170,174,195,198,201,212],"fact":[3],"that":[4,36,119],"retina":[5],"may":[6,44,129],"provide":[7],"a":[8,70],"window":[9],"into":[10],"central":[12],"nervous":[13],"system,":[14],"there":[15],"has":[16,34,59],"been":[17],"interest":[18],"in":[19,29,40,63,92,110,137,157,182,208],"identifying":[20],"retinal":[21],"biomarkers":[22,132,207],"as":[23,66,154,178],"predicting":[24,155],"factors":[25,156],"of":[26,48,53,73,76,87,105,122,163,173,191,200,205],"pathological":[27],"processes":[28],"neurodegenerative":[30],"disorders.":[31],"Emerging":[32],"evidence":[33,142],"suggested":[35],"macular":[37,80,107,124,175],"microcirculation":[38],"changes":[39,77,172],"Parkinson":[41],"disease":[42],"(PD)":[43],"indicate":[45],"alterations":[47,104,121],"cerebral":[49,135],"microvasculature.":[50],"The":[51,185],"use":[52],"Optical":[54],"Coherence":[55],"Tomography":[56],"Angiography":[57],"(OCT-A)":[58],"attracted":[60],"significant":[61],"attention":[62],"recent":[64],"years":[65],"this":[67],"technique":[68],"offers":[69],"detailed":[71,85],"analysis":[72],"existence":[75],"at":[78],"capillary":[81,108,125,176],"plexus.":[82],"METHODS:":[83],"A":[84,115,161],"review":[86,162],"literature":[89,166],"was":[90],"performed":[91],"PubMed":[93],"until":[94],"June":[95],"2021.":[96],"We":[97],"identified":[98],"all":[99],"papers":[100],"referring":[101],"to":[102,149],"plexus":[109,126,177],"PD":[111,183,209],"using":[112],"OCT-A.":[113],"RESULTS:":[114],"comprehensive":[116],"update":[117],"indicates":[118],"microvasculature":[120,171],"utilizing":[127],"OCT-A":[128,152,181,206],"comprise":[130],"useful":[131],"regarding":[133],"vasculature":[136],"PD.":[138],"Since":[139],"available":[141],"is":[143],"limited,":[144],"additional":[145],"studies":[146],"are":[147],"warranted":[148],"establish":[150],"parameters":[153],"clinical":[158],"practice.":[159],"CONCLUSIONS:":[160],"existing":[165],"sheds":[167],"light":[168],"on":[169,180,194],"seen":[179],"patients.":[184],"current":[186],"article":[187],"discusses":[188],"notable":[189],"aspects":[190],"key":[192],"publications":[193],"topic,":[196],"highlights":[197],"importance":[199],"potential":[202],"long-term":[203],"effectiveness":[204],"and":[210],"proposes":[211],"need":[213],"for":[214],"further":[215],"future":[216],"research.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-11T00:00:00"}