{"id":"https://openalex.org/W3203519640","doi":"https://doi.org/10.1016/j.isci.2021.103193","title":"Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease","display_name":"Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease","publication_year":2021,"publication_date":"2021-09-29","ids":{"openalex":"https://openalex.org/W3203519640","doi":"https://doi.org/10.1016/j.isci.2021.103193","mag":"3203519640","pmid":"https://pubmed.ncbi.nlm.nih.gov/34703992","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8524153"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2021.103193","doi":"https://doi.org/10.1016/j.isci.2021.103193","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2021.103193","pdf_url":"http://www.cell.com/article/S2589004221011615/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2589004221011615/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103254124","display_name":"Cuiyan Xin","orcid":"https://orcid.org/0000-0002-5343-8554","observed_orcids":["https://orcid.org/0000-0002-5343-8554"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cuiyan Xin","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5343-8554","affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiahui Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jiahui Lei","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China","Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100391039","display_name":"Qian Wang","orcid":"https://orcid.org/0000-0002-1904-7787","observed_orcids":["https://orcid.org/0000-0002-1904-7787"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Qian Wang","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","The Second Department of General Geriatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"The Second Department of General Geriatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077607026","display_name":"Yixia Yin","orcid":"https://orcid.org/0000-0002-0326-1658","observed_orcids":["https://orcid.org/0000-0002-0326-1658","https://orcid.org/0000-0001-8183-918X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I196699116","display_name":"Wuhan University of Technology","ror":"https://ror.org/03fe7t173","country_code":"CN","type":"education","lineage":["https://openalex.org/I196699116"]},{"id":"https://openalex.org/I4391767798","display_name":"State Key Laboratory of Advanced Technology For Materials Synthesis and Processing","ror":"https://ror.org/05njhbf68","country_code":"CN","type":"facility","lineage":["https://openalex.org/I196699116","https://openalex.org/I4391767798"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yixia Yin","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China","institution_ids":["https://openalex.org/I196699116","https://openalex.org/I4391767798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091877690","display_name":"Xiaoqian Yang","orcid":"https://orcid.org/0000-0001-8956-4694","observed_orcids":["https://orcid.org/0000-0001-8956-4694"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqian Yang","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018406135","display_name":"Jose A. Moran-Guerrero","orcid":"https://orcid.org/0009-0004-7851-7808","observed_orcids":["https://orcid.org/0009-0004-7851-7808"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Alberto Moran Guerrero","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051178808","display_name":"Venkata S. Sabbisetti","orcid":"https://orcid.org/0000-0001-8696-2726","observed_orcids":["https://orcid.org/0000-0001-8696-2726"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkata Sabbisetti","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoming Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoming Sun","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005111771","display_name":"Vishal S. Vaidya","orcid":"https://orcid.org/0000-0003-0553-9825","observed_orcids":["https://orcid.org/0000-0003-0553-9825"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vishal S. Vaidya","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0553-9825","affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089781525","display_name":"Joseph Vincent Bonventre","orcid":"https://orcid.org/0000-0001-7144-386X","observed_orcids":["https://orcid.org/0000-0001-7144-386X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph V. Bonventre","raw_affiliation_strings":["Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5005111771","https://openalex.org/A5089781525","https://openalex.org/A5103254124"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.1685,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75808076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"24","issue":"10","first_page":"103193","last_page":"103193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smoc2","display_name":"SMOC2","score":0.972000002861023},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7300000190734863},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8259999752044678},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.8870000243186951},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6336082220077515},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6008827090263367},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5909417271614075},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5881757736206055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5258225202560425},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.49999237060546875},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4960809648036957},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.48140430450439453},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.449799507856369},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3934858441352844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3007275462150574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22973480820655823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2126064896583557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1925867795944214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06590238213539124},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.isci.2021.103193","doi":"https://doi.org/10.1016/j.isci.2021.103193","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2021.103193","pdf_url":"http://www.cell.com/article/S2589004221011615/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7430898","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8524153","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34703992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34703992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8524153","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8524153/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0191900a45db43debe2d94491ac0a6ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0191900a45db43debe2d94491ac0a6ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 24, Iss 10, Pp 103193- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2021.103193","doi":"https://doi.org/10.1016/j.isci.2021.103193","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2021.103193","pdf_url":"http://www.cell.com/article/S2589004221011615/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G204946639","display_name":"Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model Disease","funder_award_id":"UH3TR002155","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4287377736","display_name":null,"funder_award_id":"UH3 TR002155","funder_id":"https://openalex.org/F4320308347","funder_display_name":"Brigham and Women's Hospital"},{"id":"https://openalex.org/G8688097438","display_name":"Role of SMOC2 in Kidney Fibrosis","funder_award_id":"R01ES017543","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000861971","display_name":"Kidney Injury Molecule-1 in Epithelial Repair","funder_award_id":"R01DK072381","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308347","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94"},{"id":"https://openalex.org/F4320310091","display_name":"Partners Healthcare","ror":"https://ror.org/04py2rh25"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203519640.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W19843932","https://openalex.org/W1541081371","https://openalex.org/W1966980951","https://openalex.org/W1975574047","https://openalex.org/W1982066003","https://openalex.org/W1987239717","https://openalex.org/W2016671423","https://openalex.org/W2026027152","https://openalex.org/W2033056573","https://openalex.org/W2045214716","https://openalex.org/W2068627412","https://openalex.org/W2083544543","https://openalex.org/W2114869511","https://openalex.org/W2141297458","https://openalex.org/W2156935689","https://openalex.org/W2165246427","https://openalex.org/W2330117733","https://openalex.org/W2342598090","https://openalex.org/W2405183840","https://openalex.org/W2425862687","https://openalex.org/W2607490199","https://openalex.org/W2608333216","https://openalex.org/W2776995867","https://openalex.org/W2804087081","https://openalex.org/W2809302144","https://openalex.org/W2896613080","https://openalex.org/W2906658161","https://openalex.org/W2911770040","https://openalex.org/W4211127568"],"related_works":["https://openalex.org/W2607490199","https://openalex.org/W4403831888","https://openalex.org/W7202250445","https://openalex.org/W2078504272","https://openalex.org/W4387340274","https://openalex.org/W3113228844","https://openalex.org/W2323645949","https://openalex.org/W7160672243","https://openalex.org/W6977658309","https://openalex.org/W7128473213"],"abstract_inverted_index":{"Chronic":[0],"kidney":[1,66],"disease":[2,59],"(CKD)":[3],"is":[4],"associated":[5,30],"with":[6,20,53],"substantial":[7],"morbidity":[8],"and":[9,29,65,89,102],"mortality.":[10],"We":[11],"developed":[12],"a":[13],"mouse":[14],"model":[15],"that":[16,43,72],"mimics":[17],"human":[18],"CKD":[19,103],"inflammation,":[21,63],"extracellular":[22],"matrix":[23],"deposition,":[24],"tubulointerstitial":[25],"fibrosis,":[26,64],"increased":[27],"proteinuria,":[28],"reduction":[31],"in":[32],"glomerular":[33],"filtration":[34],"rate":[35],"over":[36],"time.":[37],"Using":[38],"this":[39],"model,":[40],"we":[41,70],"show":[42],"genetic":[44],"deficiency":[45],"of":[46,51,81],"SMOC2":[47,52,73,93],"or":[48],"therapeutic":[49],"silencing":[50],"small":[54],"interfering":[55],"RNAs":[56],"(siRNAs)":[57],"after":[58,104],"onset":[60],"significantly":[61],"ameliorates":[62],"function":[67],"loss.":[68],"Mechanistically,":[69],"found":[71],"promotes":[74],"fibroblast":[75],"to":[76,98],"myofibroblast":[77],"differentiation":[78],"by":[79],"activation":[80],"diverse":[82],"cellular":[83],"signaling":[84],"pathways":[85],"including":[86],"MAPKs,":[87],"Smad,":[88],"Akt.":[90],"Thus,":[91],"targeting":[92],"therapeutically":[94],"offers":[95],"an":[96],"approach":[97],"prevent":[99],"fibrosis":[100],"progression":[101],"injury.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}
