{"id":"https://openalex.org/W3203484820","doi":"https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","title":"Experimental substantiation of the use of hydroxyapatite \u2014 tricalcium phosphate bioceramics for replacing bone defects after tumor removal","display_name":"Experimental substantiation of the use of hydroxyapatite \u2014 tricalcium phosphate bioceramics for replacing bone defects after tumor removal","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3203484820","doi":"https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","mag":"3203484820","pmid":"https://pubmed.ncbi.nlm.nih.gov/34591421"},"language":"en","primary_location":{"id":"doi:10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","doi":"https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","is_oa":true,"landing_page_url":"https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","pdf_url":"https://exp-oncology.com.ua/index.php/Exp/article/download/2021-3-16/2021-3-16","source":{"id":"https://openalex.org/S22800154","display_name":"Experimental Oncology","issn_l":"0204-3564","issn":["0204-3564","1812-9269","2312-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://exp-oncology.com.ua/index.php/Exp/article/download/2021-3-16/2021-3-16","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037512462","display_name":"Volodymyr F. Konovalenko","orcid":"https://orcid.org/0000-0001-7486-3835","observed_orcids":["https://orcid.org/0000-0001-7486-3835"]},"institutions":[{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"V.F. Konovalenko","raw_affiliation_strings":["R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kyiv 03022, Ukraine","R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kyiv 03022, Ukraine","institution_ids":["https://openalex.org/I4210113428"]},{"raw_affiliation_string":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076889084","display_name":"N.K. Ternovyy","orcid":"https://orcid.org/0000-0001-8769-0451","observed_orcids":["https://orcid.org/0000-0001-8769-0451"]},"institutions":[{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"N.K. Ternovyi","raw_affiliation_strings":["R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kyiv 03022, Ukraine","R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kyiv 03022, Ukraine","institution_ids":["https://openalex.org/I4210113428"]},{"raw_affiliation_string":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067041208","display_name":"E.V. Tuz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"E.V. Tuz","raw_affiliation_strings":["R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kyiv 03022, Ukraine","R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kyiv 03022, Ukraine","institution_ids":["https://openalex.org/I4210113428"]},{"raw_affiliation_string":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033275439","display_name":"Volodymyr V. Protsenko","orcid":"https://orcid.org/0000-0001-8896-8371","observed_orcids":["https://orcid.org/0000-0001-8896-8371"]},"institutions":[{"id":"https://openalex.org/I4405283749","display_name":"State Institution \u201cNational Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine\u201d","ror":"https://ror.org/026y64y79","country_code":"UA","type":"healthcare","lineage":["https://openalex.org/I4210144782","https://openalex.org/I4405283749"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"V.V. Protsenko","raw_affiliation_strings":["SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine","institution_ids":["https://openalex.org/I4405283749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022534449","display_name":"Yevgen O. Solonitsyn","orcid":"https://orcid.org/0000-0001-7057-1405","observed_orcids":["https://orcid.org/0000-0001-7057-1405"]},"institutions":[{"id":"https://openalex.org/I4405283749","display_name":"State Institution \u201cNational Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine\u201d","ror":"https://ror.org/026y64y79","country_code":"UA","type":"healthcare","lineage":["https://openalex.org/I4210144782","https://openalex.org/I4405283749"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"E.O. Solonitsyn","raw_affiliation_strings":["SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine","institution_ids":["https://openalex.org/I4405283749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046100132","display_name":"Audai Helmi Abudayeh","orcid":"https://orcid.org/0009-0006-5499-0152","observed_orcids":["https://orcid.org/0009-0006-5499-0152"]},"institutions":[{"id":"https://openalex.org/I4405283749","display_name":"State Institution \u201cNational Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine\u201d","ror":"https://ror.org/026y64y79","country_code":"UA","type":"healthcare","lineage":["https://openalex.org/I4210144782","https://openalex.org/I4405283749"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"A. Audai","raw_affiliation_strings":["SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine","institution_ids":["https://openalex.org/I4405283749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073612587","display_name":"O.V. Drobotun","orcid":"https://orcid.org/0000-0002-5404-141X","observed_orcids":["https://orcid.org/0000-0002-5404-141X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O.V. Drobotun","raw_affiliation_strings":["Kyiv City Clinical Hospital No.3, Kyiv 02125, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyiv City Clinical Hospital No.3, Kyiv 02125, Ukraine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080843509","display_name":"Nataliia. V. Ulianchych","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098675","display_name":"Frantsevich Institute for Problems in Materials Science","ror":"https://ror.org/010jn4k46","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210098675"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"N.V. Ulianchych","raw_affiliation_strings":["I.M. Frantsevich Institute for Problems of Material Science of the NAS of Ukraine, Kyiv 03142, Ukraine","Frantsevich Institute for Problems in Materials Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.M. Frantsevich Institute for Problems of Material Science of the NAS of Ukraine, Kyiv 03142, Ukraine","institution_ids":["https://openalex.org/I4210098675"]},{"raw_affiliation_string":"Frantsevich Institute for Problems in Materials Science","institution_ids":["https://openalex.org/I4210098675"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2725,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.39799689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"43","issue":"3","first_page":"237","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tricalcium-phosphate","display_name":"tricalcium phosphate","score":1.0},{"id":"https://openalex.org/keywords/bioceramic-implants","display_name":"bioceramic implants","score":0.7170000076293945},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.7250000238418579},{"id":"https://openalex.org/keywords/osteoinduction","display_name":"osteoinduction","score":0.8560000061988831},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.847000002861023},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.5860000252723694},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.622998833656311},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.5995103120803833},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.535112202167511},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5216265320777893},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5162853598594666},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.4848536252975464},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.4792099893093109},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4733300805091858},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.4375470280647278},{"id":"https://openalex.org/C183586093","wikidata":"https://www.wikidata.org/wiki/Q610457","display_name":"Biomineralization","level":2,"score":0.41559192538261414},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4142683744430542},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.37955108284950256},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17313537001609802},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12470826506614685},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.08923676609992981},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06695455312728882},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.061430931091308594},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001847","descriptor_name":"Bone Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001847","descriptor_name":"Bone Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001847","descriptor_name":"Bone Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002130","descriptor_name":"Calcium Phosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002516","descriptor_name":"Ceramics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002516","descriptor_name":"Ceramics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","doi":"https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","is_oa":true,"landing_page_url":"https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","pdf_url":"https://exp-oncology.com.ua/index.php/Exp/article/download/2021-3-16/2021-3-16","source":{"id":"https://openalex.org/S22800154","display_name":"Experimental Oncology","issn_l":"0204-3564","issn":["0204-3564","1812-9269","2312-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Oncology","raw_type":"journal-article"},{"id":"pmid:34591421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34591421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","doi":"https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","is_oa":true,"landing_page_url":"https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584","pdf_url":"https://exp-oncology.com.ua/index.php/Exp/article/download/2021-3-16/2021-3-16","source":{"id":"https://openalex.org/S22800154","display_name":"Experimental Oncology","issn_l":"0204-3564","issn":["0204-3564","1812-9269","2312-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203484820.pdf","grobid_xml":"https://content.openalex.org/works/W3203484820.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1806687088","https://openalex.org/W1915531950","https://openalex.org/W2065765779","https://openalex.org/W2081965734","https://openalex.org/W2320398522","https://openalex.org/W2767584283","https://openalex.org/W2807241802","https://openalex.org/W2996951767","https://openalex.org/W3011049081","https://openalex.org/W3016574373","https://openalex.org/W3020119366","https://openalex.org/W3100190476","https://openalex.org/W3108932994"],"related_works":["https://openalex.org/W2778935916","https://openalex.org/W2056302230","https://openalex.org/W2283224192","https://openalex.org/W2738298379","https://openalex.org/W7160447190","https://openalex.org/W2321852827","https://openalex.org/W2318146056","https://openalex.org/W2427844891","https://openalex.org/W3189311262","https://openalex.org/W2128009893"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recently,":[1],"bioactive":[2],"ceramics":[3],"based":[4],"on":[5,44,84],"hydroxyapatite":[6],"(HAP)":[7],"and":[8,62,74,82,115,118,120,142],"tricalcium":[9],"phosphate":[10],"(TCP)":[11],"have":[12],"been":[13],"preferred":[14],"as":[15],"implants":[16],"in":[17],"bone":[18,23,97,125,134],"engineering.":[19],"AIM:":[20],"To":[21],"study":[22],"regeneration":[24],"under":[25],"conditions":[26],"of":[27,69,80,87,104,106,110,113,123,132,139,145,156],"filling":[28],"metaphyseal":[29],"defects":[30,135],"with":[31,96],"the":[32,47,67,85,100,102,121,137,140],"original":[33],"HAP-TCP":[34,88,146],"composition.":[35],"MATERIALS":[36],"AND":[37],"METHODS:":[38],"The":[39],"experiment":[40],"was":[41,50,89],"carried":[42,58],"out":[43,59],"inbred":[45],"rats,":[46],"observation":[48,70],"period":[49],"2,":[51,72],"4,":[52],"8":[53,75],"weeks.":[54],"Morphological":[55],"studies":[56,131],"were":[57,127],"using":[60],"light":[61],"electron":[63],"microscopy.":[64],"RESULTS:":[65],"In":[66],"dynamics":[68],"at":[71],"4":[73],"weeks,":[76],"a":[77,151],"gradual":[78],"arrangement":[79],"osteoclasts":[81],"osteoblasts":[83],"surface":[86],"recorded,":[90],"which":[91,148],"indicates":[92],"its":[93],"high":[94],"biocompatibility":[95],"tissue.":[98],"During":[99],"experiment,":[101],"processes":[103],"resorption":[105],"implants,":[107],"mineralization,":[108],"proliferation":[109],"cellular":[111],"elements":[112],"collagen":[114],"osteogenesis":[116],"(osteoblasts":[117],"osteoclasts)":[119],"formation":[122],"mature":[124],"tissue":[126],"recorded.":[128],"CONCLUSIONS:":[129],"Experimental":[130],"plastic":[133],"proved":[136],"presence":[138],"osteoinductive":[141],"osteointegrative":[143],"effect":[144],"composition,":[147],"contributes":[149],"to":[150],"more":[152],"dynamic":[153],"uncomplicated":[154],"course":[155],"reparative":[157],"osteogenesis.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}