{"id":"https://openalex.org/W3203447802","doi":"https://doi.org/10.1111/jre.12939","title":"Association of different antidepressant classes with clinical attachment level and alveolar bone loss in patients with periodontitis: A retrospective study","display_name":"Association of different antidepressant classes with clinical attachment level and alveolar bone loss in patients with periodontitis: A retrospective study","publication_year":2021,"publication_date":"2021-10-08","ids":{"openalex":"https://openalex.org/W3203447802","doi":"https://doi.org/10.1111/jre.12939","mag":"3203447802","pmid":"https://pubmed.ncbi.nlm.nih.gov/34622954"},"language":"en","primary_location":{"id":"doi:10.1111/jre.12939","doi":"https://doi.org/10.1111/jre.12939","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jre.12939","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052816698","display_name":"Abeer Essam Hakam","orcid":"https://orcid.org/0000-0002-4704-6060","observed_orcids":["https://orcid.org/0000-0002-4704-6060"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abeer Essam Hakam","raw_affiliation_strings":["Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000792685","display_name":"Poliana Mendes Duarte","orcid":"https://orcid.org/0000-0001-8872-5943","observed_orcids":["https://orcid.org/0000-0001-8872-5943"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Poliana Mendes Duarte","raw_affiliation_strings":["Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0001-8872-5943","affiliations":[{"raw_affiliation_string":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082053778","display_name":"Marcia Phemba Mbadu","orcid":"https://orcid.org/0009-0002-4929-9392","observed_orcids":["https://orcid.org/0009-0002-4929-9392"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcia Phemba Mbadu","raw_affiliation_strings":["Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035118556","display_name":"Ikramuddin Aukhil","orcid":"https://orcid.org/0000-0002-7127-3693","observed_orcids":["https://orcid.org/0000-0002-7127-3693","https://orcid.org/0009-0007-7623-9893"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ikramuddin Aukhil","raw_affiliation_strings":["Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078686447","display_name":"H\u00e9lio Doyle Pereira da Silva","orcid":"https://orcid.org/0000-0002-7954-2771","observed_orcids":["https://orcid.org/0000-0002-7954-2771"]},"institutions":[{"id":"https://openalex.org/I4210106491","display_name":"Guarulhos University","ror":"https://ror.org/01rx63s97","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210106491"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"H\u00e9lio Doyle Pereira da Silva","raw_affiliation_strings":["Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, Brazil","institution_ids":["https://openalex.org/I4210106491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101434416","display_name":"Jia Chang","orcid":"https://orcid.org/0000-0003-0592-5750","observed_orcids":["https://orcid.org/0000-0003-0592-5750"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jia Chang","raw_affiliation_strings":["Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0003-0592-5750","affiliations":[{"raw_affiliation_string":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101434416"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":1.2446,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.74365371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"57","issue":"1","first_page":"75","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.9160000085830688},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/clinical-attachment-loss","display_name":"clinical attachment loss","score":0.9160000085830688},{"id":"https://openalex.org/keywords/alveolar-bone-level","display_name":"alveolar bone level","score":0.8889999985694885},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/serotonin-norepinephrine-reuptake-inhibitors","display_name":"serotonin-norepinephrine reuptake inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9890000224113464},{"id":"https://openalex.org/keywords/atypical-antidepressants","display_name":"atypical antidepressants","score":0.9079999923706055},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibitors","display_name":"monoamine oxidase inhibitors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/combination-antidepressant-therapy","display_name":"antidepressant combination therapy","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cementoenamel-junction","display_name":"cementoenamel junction","score":0.6460000276565552},{"id":"https://openalex.org/keywords/alveolar-crest","display_name":"alveolar crest","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.7837357521057129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6838715672492981},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.6447538733482361},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5621541738510132},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5064328908920288},{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.5014791488647461},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.4457316994667053},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.42650890350341797},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.33409491181373596},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jre.12939","doi":"https://doi.org/10.1111/jre.12939","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jre.12939","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},{"id":"pmid:34622954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34622954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontal research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1505298137","https://openalex.org/W1783775059","https://openalex.org/W1800567007","https://openalex.org/W1919000277","https://openalex.org/W1964765023","https://openalex.org/W1966206956","https://openalex.org/W1977961748","https://openalex.org/W1983649358","https://openalex.org/W1987785379","https://openalex.org/W1996454121","https://openalex.org/W2010183151","https://openalex.org/W2014970377","https://openalex.org/W2026813394","https://openalex.org/W2027778520","https://openalex.org/W2041055523","https://openalex.org/W2049297817","https://openalex.org/W2051342023","https://openalex.org/W2060040409","https://openalex.org/W2071880486","https://openalex.org/W2092672238","https://openalex.org/W2103397712","https://openalex.org/W2116354035","https://openalex.org/W2116571291","https://openalex.org/W2134977774","https://openalex.org/W2135221903","https://openalex.org/W2147851499","https://openalex.org/W2150017343","https://openalex.org/W2153729000","https://openalex.org/W2154901939","https://openalex.org/W2169171309","https://openalex.org/W2553123944","https://openalex.org/W2561017480","https://openalex.org/W2579967741","https://openalex.org/W2589713121","https://openalex.org/W2752372999","https://openalex.org/W2791379434","https://openalex.org/W2793845846","https://openalex.org/W2828995963","https://openalex.org/W2888853364","https://openalex.org/W2890446865","https://openalex.org/W2896672491","https://openalex.org/W2909775712","https://openalex.org/W2980070432","https://openalex.org/W2982479957","https://openalex.org/W2996067376","https://openalex.org/W3003710034","https://openalex.org/W3008730712","https://openalex.org/W3010457767","https://openalex.org/W3015650266","https://openalex.org/W3046126038","https://openalex.org/W4230662466","https://openalex.org/W6638419899","https://openalex.org/W6729883194","https://openalex.org/W6771647956"],"related_works":["https://openalex.org/W4409255564","https://openalex.org/W3008730712","https://openalex.org/W4401249948","https://openalex.org/W3018792150","https://openalex.org/W4415673419","https://openalex.org/W7120418248","https://openalex.org/W4412856390","https://openalex.org/W7118006770","https://openalex.org/W2752372999","https://openalex.org/W7166472037"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Our":[1],"study":[2,65,85],"aimed":[3],"to":[4,111,263],"determine":[5],"the":[6,16,44,67,105,167,211,230,307,316,321],"relationship":[7],"of":[8,18,22,26,46,69,92,107,122,180,229,233,310],"antidepressant":[9,23,47,71,123,185,209,258],"medicine":[10],"use":[11],"with":[12,24,38,73,99,196,271,292,304],"periodontal":[13,50,327],"diseases,":[14,151,253],"exploring":[15],"association":[17,68],"different":[19,70,231,308],"pharmacological":[20,127],"classes":[21,56,72,128,232,309],"observations":[25],"clinical":[27,74,299],"attachment":[28,75,300],"loss":[29,76,274,301],"(CAL)":[30,77],"and":[31,58,78,125,140,153,157,174,193,218,239,254,268,279,297,320],"alveolar":[32,79,158,294],"bone":[33,80,159,273,295],"level":[34,81,296],"(BL)":[35],"in":[36,89,166,302],"patients":[37,93,177,303],"periodontitis.":[39,305],"BACKGROUND:":[40],"Existing":[41],"evidence":[42],"on":[43,49,54],"impact":[45],"medication":[48],"tissues":[51],"has":[52],"focused":[53],"some":[55],"only":[57,315],"is":[59],"still":[60],"unclear.":[61],"Therefore,":[62],"this":[63],"retrospective":[64],"evaluated":[66],"(BL).":[82],"METHODS:":[83],"This":[84],"was":[86],"carried":[87],"out":[88],"a":[90],"population":[91],"aged":[94],"\u2265":[95],"30":[96],"years":[97],"old":[98],"periodontitis":[100,176],"who":[101],"sought":[102],"treatment":[103],"at":[104],"University":[106],"Florida":[108],"from":[109,118],"2014":[110],"2018.":[112],"The":[113],"following":[114],"variables":[115,247],"were":[116,178,184,260,290,312],"obtained":[117],"patients'":[119],"records;":[120],"usage":[121],"medications":[124,289],"their":[126],"(selective":[129],"serotonin":[130],"reuptake":[131,135],"inhibitors":[132,136,143],"[SSRI],":[133],"serotonin-norepinephrine":[134],"[SNRI],":[137],"tricyclic,":[138],"atypical,":[139],"monoamine":[141],"oxidase":[142],"[MAO]),":[144],"age,":[145,251],"gender,":[146,250],"smoking":[147],"habit,":[148],"mild":[149],"systemic":[150,252],"CAL,":[152],"cement-enamel":[154],"junction":[155],"(CEJ)":[156],"crest":[160],"(BC)":[161],"distance,":[162],"defined":[163],"as":[164,249],"BL,":[165],"Ramfjord":[168],"index":[169],"teeth.":[170],"RESULTS:":[171],"Five":[172],"hundred":[173],"eighty-two":[175],"evaluated,":[179],"which":[181],"113":[182],"(19.4%)":[183],"users.":[186],"Antidepressant":[187,288],"users":[188,213,259,319,323],"exhibited":[189],"significantly":[190,215,325],"lower":[191,219,265],"BL":[192,220,240,267,276],"fewer":[194,269],"sites":[195,270],"severe":[197,272],"CAL":[198,217,238],"(\u22655":[199],"mm),":[200],"than":[201,221,241,282,329],"non-users":[202,222,283],"(p":[203,223,284],"<":[204,224,285],".05).":[205,225,286],"Among":[206],"all":[207],"single-class":[208],"users,":[210],"SSRI":[212,317],"showed":[214,236,324],"less":[216,298,326],"Patients":[226],"taking":[227],"combinations":[228],"antidepressants":[234,311],"also":[235],"better":[237],"non-users.":[242,330],"Generalized":[243],"linear":[244],"models,":[245],"including":[246],"such":[248],"smoking,":[255],"demonstrated":[256],"that":[257],"more":[261],"likely":[262],"have":[264],"mean":[266],"(i.e.":[275],">":[277],"3":[278],">5":[280],"mm)":[281],"CONCLUSIONS:":[287],"associated":[291],"higher":[293],"When":[306],"analyzed":[313],"individually,":[314],"class":[318],"multiple-class":[322],"breakdown":[328]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}
