{"id":"https://openalex.org/W3203395331","doi":null,"title":"A preclinical study of tamoxifen in combination with bevacizumab (Avastin) for the treatment of ER-positive breast cancer","display_name":"A preclinical study of tamoxifen in combination with bevacizumab (Avastin) for the treatment of ER-positive breast cancer","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W3203395331","mag":"3203395331"},"language":"en","primary_location":{"id":"mag:3203395331","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/65/9_Supplement/254.3","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Anshu Mittal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anshu Mittal","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021533593","display_name":"Yulia Y. Maxuitenko","orcid":"https://orcid.org/0000-0001-5518-4941","observed_orcids":["https://orcid.org/0000-0001-5518-4941"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yulia Maxuitenko","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":"https://orcid.org/0000-0001-5518-4941","affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110187618","display_name":"John J. Rinehart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Rinehart","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113498025","display_name":"William R. Waud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Waud","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046252186","display_name":"Jaideep V. Thottassery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaideep V. Thottassery","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111951219","display_name":"Andra R. Frost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andra R. Frost","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Grizzle","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":"https://orcid.org/0000-0001-9245-0401","affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000514275","display_name":"Rongbao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rongbao Li","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002938075","display_name":"Zhican Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhican Qu","raw_affiliation_strings":["Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, AL and University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.3314535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"65","issue":null,"first_page":"254","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.984000027179718},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tamoxifen-resistance","display_name":"tamoxifen resistance","score":0.9399999976158142},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.8959885835647583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8240160942077637},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.7727137804031372},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7104382514953613},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5804282426834106},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5794429183006287},{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.5321563482284546},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5221619606018066},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5030147433280945},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47056910395622253},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4685301184654236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45603665709495544},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.4256989657878876},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42269593477249146},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2788003087043762},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.07628163695335388}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3203395331","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/65/9_Supplement/254.3","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966392018","https://openalex.org/W2967275531","https://openalex.org/W780140235","https://openalex.org/W7099162859","https://openalex.org/W3088830723","https://openalex.org/W2536118765","https://openalex.org/W7217743307","https://openalex.org/W2418508848","https://openalex.org/W2142957794","https://openalex.org/W2075369275"],"abstract_inverted_index":{"1091":[0],"Clinical":[2],"studies":[3],"have":[4,69],"shown":[5],"that":[6,35,104,126],"elevated":[7],"levels":[8],"of":[9,75,117,128,166,176,185,194],"VEGF":[10,38,82,93,118],"are":[11],"associated":[12],"with":[13,173],"poor":[14],"response":[15],"to":[16,54,62,148],"tamoxifen":[17,64,120,153],"treatment":[18,232,237],"for":[19,141,179,228],"estrogen":[20],"receptor":[21],"(ER)-positive":[22],"breast":[23,60,78,142,196],"cancer.":[24,143,197],"Our":[25],"previous":[26],"study":[27,112,145],"provided":[28],"the":[29,97,167,186,189,199,205,230,234],"first":[30],"direct":[31],"in":[32,80,89,96,107,119,217],"vivo":[33],"evidence":[34],"tumor":[36,48,61,98,133,224],"cytosolic":[37],"expression":[39,83],"at":[40],"a":[41,71,102,114,138,157],"clinically":[42],"relevant":[43],"level":[44,94],"not":[45],"only":[46],"increases":[47],"angiogenesis,":[49],"but":[50],"also":[51],"is":[52,84,100,105],"sufficient":[53],"promote":[55],"ER-positive,":[56],"tamoxifen-responsive,":[57],"and":[58,66,122,124,131,154,181,207,233],"non-metastatic":[59],"become":[63],"resistant":[65],"metastatic.":[67],"We":[68],"developed":[70,191],"xenograft":[72],"mouse":[73],"model":[74,193],"ER-positive":[76,195],"human":[77],"cancer,":[79],"which":[81],"tightly":[85],"controlled":[86],"by":[87],"doxycycline":[88],"drinking":[90],"water.":[91],"The":[92,164],"detected":[95],"sample":[99],"within":[101],"range":[103],"found":[106],"patient":[108],"biopsy":[109],"samples.":[110],"This":[111,144],"suggested":[113],"new":[115],"function":[116],"resistance":[121],"metastasis":[123],"indicated":[125],"inhibition":[127],"both":[129,229],"ER-dependent":[130],"VEGF-induced":[132],"cell":[134],"growth":[135,225],"would":[136],"be":[137],"potential":[139],"therapy":[140,170],"was":[146,171,226],"designed":[147,178],"test":[149],"this":[150],"hypothesis":[151],"using":[152,188],"bevacizumab":[155],"(Avastin\u2122),":[156],"recombinant":[158],"humanized":[159],"monoclonal":[160],"antibody":[161],"against":[162],"VEGF.":[163],"efficacy":[165],"tamoxifen-Avastin":[168],"combined":[169,206,231],"evaluated":[172],"two":[174],"arms":[175],"mice":[177,203],"early":[180,200],"late":[182],"stage":[183,201],"settings":[184],"disease":[187],"newly":[190],"animal":[192],"For":[198],"setting,":[202],"received":[204],"mono":[208,236],"treatments":[209],"when":[210],"their":[211],"tumors":[212],"reached":[213],"about":[214],"100":[215],"mm3":[216],"size.":[218],"Significant":[219],"inhibitory":[220],"effect":[221],"on":[222],"primary":[223],"observed":[227],"Avastin":[235],"(P":[238]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-10-11T00:00:00"}