{"id":"https://openalex.org/W3203093294","doi":"https://doi.org/10.3390/ijms221910695","title":"3-Pyridinylidene Derivatives of Chemically Modified Lupane and Ursane Triterpenes as Promising Anticancer Agents by Targeting Apoptosis","display_name":"3-Pyridinylidene Derivatives of Chemically Modified Lupane and Ursane Triterpenes as Promising Anticancer Agents by Targeting Apoptosis","publication_year":2021,"publication_date":"2021-10-02","ids":{"openalex":"https://openalex.org/W3203093294","doi":"https://doi.org/10.3390/ijms221910695","mag":"3203093294","pmid":"https://pubmed.ncbi.nlm.nih.gov/34639035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8509773"},"language":"en","primary_location":{"id":"doi:10.3390/ijms221910695","doi":"https://doi.org/10.3390/ijms221910695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms221910695","pdf_url":"https://www.mdpi.com/1422-0067/22/19/10695/pdf?version=1633749690","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/19/10695/pdf?version=1633749690","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058390964","display_name":"Oxana B. Kazakova","orcid":"https://orcid.org/0000-0002-5606-1588","observed_orcids":["https://orcid.org/0000-0002-5606-1588","https://orcid.org/0000-0002-8243-9636"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104186","display_name":"Ufa Institute of Chemistry","ror":"https://ror.org/01k8ec266","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104186","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Oxana Kazakova","raw_affiliation_strings":["Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia"],"raw_orcid":"https://orcid.org/0000-0002-5606-1588","affiliations":[{"raw_affiliation_string":"Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112206140","display_name":"Codru\u0163a \u015eoica","orcid":"https://orcid.org/0000-0001-9029-1232","observed_orcids":["https://orcid.org/0000-0001-9029-1232"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Codru\u021ba \u0218oica","raw_affiliation_strings":["Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034402861","display_name":"Marat S. Babaev","orcid":"https://orcid.org/0000-0002-0456-1097","observed_orcids":["https://orcid.org/0000-0002-0456-1097"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104186","display_name":"Ufa Institute of Chemistry","ror":"https://ror.org/01k8ec266","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104186","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Marat Babaev","raw_affiliation_strings":["Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0456-1097","affiliations":[{"raw_affiliation_string":"Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015207156","display_name":"Anastasiya V. Petrova","orcid":"https://orcid.org/0000-0003-2910-6805","observed_orcids":["https://orcid.org/0000-0003-2910-6805"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104186","display_name":"Ufa Institute of Chemistry","ror":"https://ror.org/01k8ec266","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104186","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasiya Petrova","raw_affiliation_strings":["Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia"],"raw_orcid":"https://orcid.org/0000-0003-2910-6805","affiliations":[{"raw_affiliation_string":"Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052056795","display_name":"El'mira F. Khusnutdinova","orcid":"https://orcid.org/0000-0001-6769-6063","observed_orcids":["https://orcid.org/0000-0001-6769-6063"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104186","display_name":"Ufa Institute of Chemistry","ror":"https://ror.org/01k8ec266","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104186","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elmira Khusnutdinova","raw_affiliation_strings":["Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia"],"raw_orcid":"https://orcid.org/0000-0001-6769-6063","affiliations":[{"raw_affiliation_string":"Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008662669","display_name":"Alexander I. Poptsov","orcid":"https://orcid.org/0000-0002-5193-7931","observed_orcids":["https://orcid.org/0000-0002-5193-7931"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104186","display_name":"Ufa Institute of Chemistry","ror":"https://ror.org/01k8ec266","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104186","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Poptsov","raw_affiliation_strings":["Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia"],"raw_orcid":"https://orcid.org/0000-0002-5193-7931","affiliations":[{"raw_affiliation_string":"Ufa Institute of Chemistry UFRC, Russian Academy of Science RAS, pr. Oktyabrya 71, 450054 Ufa, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037899421","display_name":"Ioana Gabriela Macasoi","orcid":"https://orcid.org/0000-0002-9890-2277","observed_orcids":["https://orcid.org/0000-0002-9890-2277"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ioana Maca\u0219oi","raw_affiliation_strings":["Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034636257","display_name":"George Andrei Dr\u0103ghici","orcid":"https://orcid.org/0000-0002-8042-0966","observed_orcids":["https://orcid.org/0000-0002-8042-0966"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"George Dr\u0103ghici","raw_affiliation_strings":["Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania"],"raw_orcid":"https://orcid.org/0000-0002-8042-0966","affiliations":[{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050112685","display_name":"\u0218tefana Avram","orcid":"https://orcid.org/0000-0002-4824-6769","observed_orcids":["https://orcid.org/0000-0002-4824-6769"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"\u0218tefana Avram","raw_affiliation_strings":["Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania"],"raw_orcid":"https://orcid.org/0000-0002-4824-6769","affiliations":[{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104279663","display_name":"Lavinia Lia Vlaia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Lavinia Vlaia","raw_affiliation_strings":["Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","Formulation and Technology of Drugs Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Faculty of Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Faculty of Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069374106","display_name":"Alexandra Mioc","orcid":"https://orcid.org/0000-0001-6459-2074","observed_orcids":["https://orcid.org/0000-0001-6459-2074"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Alexandra Mioc","raw_affiliation_strings":["Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania"],"raw_orcid":"https://orcid.org/0000-0001-6459-2074","affiliations":[{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050827290","display_name":"Marius Mioc","orcid":"https://orcid.org/0000-0002-4033-8060","observed_orcids":["https://orcid.org/0000-0002-4033-8060"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Marius Mioc","raw_affiliation_strings":["Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015552254","display_name":"Cristina Adriana Dehelean","orcid":"https://orcid.org/0000-0002-5482-7092","observed_orcids":["https://orcid.org/0000-0002-5482-7092"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Cristina Dehelean","raw_affiliation_strings":["Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Research Centre Pharmacotoxicol Evaluat, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075362747","display_name":"Adrian Voicu","orcid":"https://orcid.org/0000-0002-9640-3968","observed_orcids":["https://orcid.org/0000-0002-9640-3968"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Adrian Voicu","raw_affiliation_strings":["Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050827290","https://openalex.org/A5058390964"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088791","https://openalex.org/I4210104186"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.3444,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.77444263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"19","first_page":"10695","last_page":"10695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lupane-triterpenoids","display_name":"lupane triterpenoids","score":0.968999981880188},{"id":"https://openalex.org/keywords/ursane-triterpenoids","display_name":"ursane triterpenoids","score":1.0},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.949999988079071},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bcl-xl-inhibition","display_name":"BCL-XL inhibition","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7699999809265137},{"id":"https://openalex.org/keywords/bak","display_name":"Bak","score":0.8870000243186951},{"id":"https://openalex.org/keywords/bad","display_name":"Bad","score":0.984000027179718},{"id":"https://openalex.org/keywords/nci-60-cell-lines","display_name":"NCI-60 cell lines","score":0.8309999704360962},{"id":"https://openalex.org/keywords/antiproliferative-mechanism","display_name":"antiproliferative mechanism","score":0.8429999947547913},{"id":"https://openalex.org/keywords/natural-product-derived-drugs","display_name":"natural product-derived drugs","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2777527632","wikidata":"https://www.wikidata.org/wiki/Q238382","display_name":"DAPI","level":3,"score":0.8521602749824524},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7395752668380737},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5673820972442627},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.5611549019813538},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5199519395828247},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49083811044692993},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4898380935192108},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47072306275367737},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4100194573402405},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3736532926559448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31578975915908813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24432232975959778},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10892215371131897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053978","descriptor_name":"Pentacyclic Triterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms221910695","doi":"https://doi.org/10.3390/ijms221910695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms221910695","pdf_url":"https://www.mdpi.com/1422-0067/22/19/10695/pdf?version=1633749690","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8509773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8509773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:34639035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34639035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3d4a1d7c99ee44b89151b598d2413852","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3d4a1d7c99ee44b89151b598d2413852","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 10695, p 10695 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms221910695","doi":"https://doi.org/10.3390/ijms221910695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms221910695","pdf_url":"https://www.mdpi.com/1422-0067/22/19/10695/pdf?version=1633749690","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2397905016","display_name":null,"funder_award_id":"PN-III-P1-1.1-PD-2019-1078","funder_id":"https://openalex.org/F4320323983","funder_display_name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii"},{"id":"https://openalex.org/G4374009565","display_name":null,"funder_award_id":"19-33-60083","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G4864199281","display_name":null,"funder_award_id":"PN- III -P1-1","funder_id":"https://openalex.org/F4320323983","funder_display_name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii"},{"id":"https://openalex.org/G6058054535","display_name":null,"funder_award_id":"PN-III-P1-1.1","funder_id":"https://openalex.org/F4320323983","funder_display_name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii"},{"id":"https://openalex.org/G6515124215","display_name":null,"funder_award_id":"PN-III-P1","funder_id":"https://openalex.org/F4320323983","funder_display_name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320323983","display_name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","ror":"https://ror.org/01q7jq182"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203093294.pdf","grobid_xml":"https://content.openalex.org/works/W3203093294.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W128094615","https://openalex.org/W1490293412","https://openalex.org/W1966329249","https://openalex.org/W1978668430","https://openalex.org/W1986821597","https://openalex.org/W2008757142","https://openalex.org/W2042493764","https://openalex.org/W2049172807","https://openalex.org/W2055139893","https://openalex.org/W2072037769","https://openalex.org/W2073856059","https://openalex.org/W2074379474","https://openalex.org/W2084682984","https://openalex.org/W2095162782","https://openalex.org/W2107705582","https://openalex.org/W2111170264","https://openalex.org/W2111205112","https://openalex.org/W2130479394","https://openalex.org/W2134967712","https://openalex.org/W2138058222","https://openalex.org/W2155208683","https://openalex.org/W2167395325","https://openalex.org/W2183097477","https://openalex.org/W2184621142","https://openalex.org/W2214273798","https://openalex.org/W2285650663","https://openalex.org/W2315396142","https://openalex.org/W2339919860","https://openalex.org/W2399043568","https://openalex.org/W2515068332","https://openalex.org/W2566148122","https://openalex.org/W2590326505","https://openalex.org/W2601614748","https://openalex.org/W2609186521","https://openalex.org/W2759404824","https://openalex.org/W2766023905","https://openalex.org/W2768529632","https://openalex.org/W2769865513","https://openalex.org/W2775350181","https://openalex.org/W2803554298","https://openalex.org/W2891232912","https://openalex.org/W2901322199","https://openalex.org/W2903326996","https://openalex.org/W2905217593","https://openalex.org/W2910523135","https://openalex.org/W2916911849","https://openalex.org/W2940298401","https://openalex.org/W2950979312","https://openalex.org/W2952012758","https://openalex.org/W2954719006","https://openalex.org/W2965731410","https://openalex.org/W2987574584","https://openalex.org/W3000133356","https://openalex.org/W3008819295","https://openalex.org/W3010773449","https://openalex.org/W3012638502","https://openalex.org/W3013925060","https://openalex.org/W3016273049","https://openalex.org/W3019970601","https://openalex.org/W3025357041","https://openalex.org/W3033669984","https://openalex.org/W3038278491","https://openalex.org/W3041146711","https://openalex.org/W3049342150","https://openalex.org/W3083943391","https://openalex.org/W3089835536","https://openalex.org/W3092738692","https://openalex.org/W3093758706","https://openalex.org/W3094148542","https://openalex.org/W3095225782","https://openalex.org/W3101620107","https://openalex.org/W3106771625","https://openalex.org/W3109785702","https://openalex.org/W3113202492","https://openalex.org/W3119005666","https://openalex.org/W3119787068","https://openalex.org/W3136505420","https://openalex.org/W3155173653","https://openalex.org/W3162819754","https://openalex.org/W6704269504","https://openalex.org/W6734029023","https://openalex.org/W6745088257"],"related_works":["https://openalex.org/W3205395084","https://openalex.org/W2913078570","https://openalex.org/W2012921918","https://openalex.org/W1982580479","https://openalex.org/W2003061036","https://openalex.org/W2038691107","https://openalex.org/W4383058940","https://openalex.org/W4415305038","https://openalex.org/W1977352545","https://openalex.org/W2015334542"],"abstract_inverted_index":{"Cancer":[0],"persists":[1],"as":[2,27,69,172,192],"a":[3,41,102],"global":[4],"challenge":[5],"due":[6],"to":[7,10,51,79,100,174],"the":[8,38,56,175],"extent":[9],"which":[11],"conventional":[12],"anticancer":[13,34],"therapies":[14],"pose":[15],"high":[16,157],"risks":[17],"counterbalanced":[18],"with":[19,72,124],"their":[20],"therapeutic":[21],"benefit.":[22],"Naturally":[23],"occurring":[24],"substances":[25],"stand":[26],"an":[28],"important":[29],"safer":[30],"alternative":[31],"source":[32],"for":[33,159],"drug":[35],"development.":[36],"In":[37],"current":[39],"study,":[40],"series":[42],"of":[43,106,136],"modified":[44],"lupane":[45],"and":[46,64,84,118,139,145],"ursane":[47],"derivatives":[48],"was":[49],"subjected":[50],"in":[52,96,98,167],"vitro":[53],"screening":[54],"on":[55],"NCI-60":[57],"cancer":[58],"cell":[59,120,126,185],"line":[60],"panel.":[61],"Compounds":[62],"6":[63],"7":[65,164],"have":[66],"been":[67],"identified":[68],"highly":[70],"active":[71],"GI50":[73],"values":[74],"ranging":[75],"from":[76],"0.03":[77],"\u00b5M":[78,81,86],"5.9":[80],"(compound":[82,87],"6)":[83],"0.18\u20131.53":[85],"7).":[88],"Thus,":[89],"these":[90],"two":[91],"compounds":[92,114,133,155,181],"were":[93],"further":[94],"assessed":[95],"detail":[97],"order":[99],"identify":[101],"possible":[103],"antiproliferative":[104],"mechanism":[105],"action.":[107],"DAPI":[108],"(4\u2032,6-diamidino-2-phenylindole)":[109],"staining":[110],"revealed":[111,152],"that":[112,131,153,180],"both":[113,132,154],"induced":[115,134],"nuclei":[116],"condensation":[117],"overall":[119],"morphological":[121],"changes":[122],"consistent":[123],"apoptotic":[125,184],"death.":[127],"rtPCR":[128],"analysis":[129,151],"showed":[130,165],"upregulation":[135],"proapoptotic":[137],"Bak":[138],"Bad":[140],"genes":[141],"while":[142,162],"downregulating":[143],"Bcl-XL":[144,160,169],"Bcl-2":[146],"antiapoptotic":[147,189],"genes.":[148],"Molecular":[149],"docking":[150],"exhibited":[156],"scores":[158],"inhibition,":[161,191],"compound":[163],"higher":[166],"silico":[168],"inhibition":[170],"potential":[171],"compared":[173],"native":[176],"inhibitor":[177],"ATB-737,":[178],"suggesting":[179],"may":[182],"induce":[183],"death":[186],"through":[187],"targeted":[188],"protein":[190],"well.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}