{"id":"https://openalex.org/W3203089164","doi":"https://doi.org/10.1038/s41467-021-26147-5","title":"Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction","display_name":"Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction","publication_year":2021,"publication_date":"2021-10-07","ids":{"openalex":"https://openalex.org/W3203089164","doi":"https://doi.org/10.1038/s41467-021-26147-5","mag":"3203089164","pmid":"https://pubmed.ncbi.nlm.nih.gov/34620850","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8497513"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-021-26147-5","doi":"https://doi.org/10.1038/s41467-021-26147-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-26147-5","pdf_url":"https://www.nature.com/articles/s41467-021-26147-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-021-26147-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006431042","display_name":"Jorine M. Eeftens","orcid":"https://orcid.org/0000-0001-6784-9955","observed_orcids":["https://orcid.org/0000-0001-6784-9955"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorine M. Eeftens","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA"],"raw_orcid":"https://orcid.org/0000-0001-6784-9955","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040097092","display_name":"Manya Kapoor","orcid":"https://orcid.org/0000-0002-0352-5131","observed_orcids":["https://orcid.org/0000-0002-0352-5131"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manya Kapoor","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA"],"raw_orcid":"https://orcid.org/0000-0002-0352-5131","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066158937","display_name":"Davide Michieletto","orcid":"https://orcid.org/0000-0003-2186-6869","observed_orcids":["https://orcid.org/0000-0003-2186-6869"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Davide Michieletto","raw_affiliation_strings":["MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland","SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I4387154614","https://openalex.org/I98677209"]},{"raw_affiliation_string":"SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, Scotland","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042735526","display_name":"Clifford P. Brangwynne","orcid":"https://orcid.org/0000-0002-1350-9960","observed_orcids":["https://orcid.org/0000-0002-1350-9960"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifford P. Brangwynne","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA. cbrangwy@princeton.edu","The Howard Hughes Medical Institute, Chevy Chase, MD, USA. cbrangwy@princeton.edu","Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA"],"raw_orcid":"https://orcid.org/0000-0002-1350-9960","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA. cbrangwy@princeton.edu","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"The Howard Hughes Medical Institute, Chevy Chase, MD, USA. cbrangwy@princeton.edu","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042735526"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I20089843"],"apc_list":{"value":5560,"currency":"USD","value_usd":5560},"apc_paid":{"value":5560,"currency":"USD","value_usd":5560},"fwci":5.8018,"has_fulltext":true,"cited_by_count":106,"citation_normalized_percentile":{"value":0.98011482,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"5888","last_page":"5888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2996000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycomb-repressive-complex-1","display_name":"PRC1","score":0.7149999737739563},{"id":"https://openalex.org/keywords/phase-separation","display_name":"phase separation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/heterochromatin-formation","display_name":"heterochromatin formation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9539999961853027},{"id":"https://openalex.org/keywords/h2ak119ub","display_name":"H2AK119ub","score":0.9139999747276306},{"id":"https://openalex.org/keywords/epigenetic-memory","display_name":"epigenetic memory","score":0.8140000104904175},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.5809999704360962},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.6399999856948853},{"id":"https://openalex.org/keywords/chromatin-repression","display_name":"chromatin repression","score":0.5040000081062317},{"id":"https://openalex.org/keywords/non-equilibrium-thermodynamics","display_name":"non-equilibrium thermodynamics","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.8732695579528809},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7864993810653687},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.7710213661193848},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6739016771316528},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.6528809666633606},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6355960369110107},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.6215215921401978},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4812302589416504},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.45554038882255554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45073193311691284},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34427034854888916},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.18312695622444153},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16286784410476685},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09699556231498718},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08001893758773804}],"mesh":[{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006570","descriptor_name":"Heterochromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063146","descriptor_name":"Polycomb-Group Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D063146","descriptor_name":"Polycomb-Group Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-021-26147-5","doi":"https://doi.org/10.1038/s41467-021-26147-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-26147-5","pdf_url":"https://www.nature.com/articles/s41467-021-26147-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2020.08.19.254706","doi":"https://doi.org/10.1101/2020.08.19.254706","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.08.19.254706","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/08/19/2020.08.19.254706.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8497513","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8497513","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:34620850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34620850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/0110495d-9174-47f8-819c-7f1ecb435e6d","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11820/0110495d-9174-47f8-819c-7f1ecb435e6d","pdf_url":"https://www.research.ed.ac.uk/files/238769755/s41467_021_26147_5_2.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eeftens, J M, Kapoor, M, Michieletto, D & Brangwynne, C P 2021, 'Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction', Nature, vol. 12, no. 1, 5888, pp. 1-12. https://doi.org/10.1038/s41467-021-26147-5","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26147-5","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-021-26147-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7f452b896dc54166b408650ee691f243","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f452b896dc54166b408650ee691f243","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-021-26147-5","doi":"https://doi.org/10.1038/s41467-021-26147-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-26147-5","pdf_url":"https://www.nature.com/articles/s41467-021-26147-5.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Peace, justice, and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.4300000071525574}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5802930626","display_name":"Optogenetic Droplets:  Using Light to Control Nucleoplasmic Phase Separation","funder_award_id":"U01DA040601","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7147697913","display_name":"Topologically Active Polymers","funder_award_id":"947918","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203089164.pdf","grobid_xml":"https://content.openalex.org/works/W3203089164.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1912455695","https://openalex.org/W1973279069","https://openalex.org/W1976962550","https://openalex.org/W1991125055","https://openalex.org/W2021430400","https://openalex.org/W2025553576","https://openalex.org/W2026914820","https://openalex.org/W2028003321","https://openalex.org/W2038784177","https://openalex.org/W2049780043","https://openalex.org/W2056625030","https://openalex.org/W2067915070","https://openalex.org/W2068363360","https://openalex.org/W2070509435","https://openalex.org/W2077561581","https://openalex.org/W2082319097","https://openalex.org/W2082998819","https://openalex.org/W2095002834","https://openalex.org/W2103324856","https://openalex.org/W2111796925","https://openalex.org/W2113524783","https://openalex.org/W2116235936","https://openalex.org/W2146497742","https://openalex.org/W2150860983","https://openalex.org/W2167343750","https://openalex.org/W2168639701","https://openalex.org/W2170079272","https://openalex.org/W2222857089","https://openalex.org/W2233967916","https://openalex.org/W2255386862","https://openalex.org/W2324890476","https://openalex.org/W2419037911","https://openalex.org/W2554647387","https://openalex.org/W2584394140","https://openalex.org/W2585920126","https://openalex.org/W2595687700","https://openalex.org/W2596561415","https://openalex.org/W2597167505","https://openalex.org/W2610240247","https://openalex.org/W2622030623","https://openalex.org/W2624274298","https://openalex.org/W2694038906","https://openalex.org/W2722642526","https://openalex.org/W2748885774","https://openalex.org/W2765486298","https://openalex.org/W2774218124","https://openalex.org/W2803241699","https://openalex.org/W2810246680","https://openalex.org/W2902026154","https://openalex.org/W2902106157","https://openalex.org/W2902114405","https://openalex.org/W2903264039","https://openalex.org/W2942581560","https://openalex.org/W2953728710","https://openalex.org/W2964273526","https://openalex.org/W2973012083","https://openalex.org/W2973290848","https://openalex.org/W2973602800","https://openalex.org/W2990332438","https://openalex.org/W2999808884","https://openalex.org/W3007432749","https://openalex.org/W3011742814","https://openalex.org/W3017159371","https://openalex.org/W3023602638","https://openalex.org/W3027849952","https://openalex.org/W3093057625","https://openalex.org/W3095917659","https://openalex.org/W3127356623"],"related_works":["https://openalex.org/W4396597684","https://openalex.org/W4389461521","https://openalex.org/W4390742896","https://openalex.org/W4393244694","https://openalex.org/W3095917659","https://openalex.org/W2155975597","https://openalex.org/W4391843275","https://openalex.org/W4390043805","https://openalex.org/W4409997377","https://openalex.org/W2973602800"],"abstract_inverted_index":{"ABSTRACT":[0],"Structural":[1],"organization":[2],"of":[3,25,52,90,97,158,174,197,205],"the":[4,88,159,171,194,201],"genome":[5],"into":[6],"transcriptionally":[7],"active":[8],"euchromatin":[9],"and":[10,27,35,67,129],"silenced":[11],"heterochromatin":[12,48,53,85],"is":[13,20,28,58,79,154,179],"essential":[14],"for":[15,47,71,84,156],"eukaryotic":[16],"cell":[17,110],"function.":[18],"Heterochromatin":[19],"a":[21,45,107,167],"more":[22],"compact":[23],"form":[24,118],"chromatin,":[26],"associated":[29,54],"with":[30,166,200],"characteristic":[31],"post-translational":[32],"histone":[33,184],"modifications":[34],"chromatin":[36,102,149,189],"binding":[37],"proteins.":[38,55],"Phase-separation":[39],"has":[40,93],"recently":[41],"been":[42],"suggested":[43],"as":[44],"mechanism":[46],"formation,":[49,86],"through":[50,121],"condensation":[51],"However,":[56],"it":[57],"unclear":[59],"how":[60],"phase-separated":[61],"condensates":[62,120],"can":[63,147],"contribute":[64],"to":[65,81,101,113,136],"stable":[66],"robust":[68],"repression,":[69],"particularly":[70],"heritable":[72],"epigenetic":[73,206],"changes.":[74],"The":[75],"Polycomb":[76,91,139,144,176],"complex":[77],"PRC1":[78,116],"known":[80],"be":[82],"key":[83],"but":[87,151],"multitude":[89],"proteins":[92,117],"hindered":[94],"our":[95],"understanding":[96],"their":[98],"collective":[99],"contribution":[100],"repression.":[103],"Here,":[104],"we":[105,141],"take":[106],"quantitative":[108],"live":[109],"imaging":[111],"approach":[112],"show":[114,142],"that":[115,143],"multicomponent":[119],"hetero-oligomerization.":[122],"They":[123],"preferentially":[124],"seed":[125],"at":[126],"H3K27me3":[127],"marks,":[128,185],"subsequently":[130,187],"write":[131],"H2AK119Ub":[132],"marks.":[133],"Using":[134],"optogenetics":[135],"nucleate":[137],"local":[138],"condensates,":[140],"phase":[145,152,177,198],"separation":[146,153,178,199],"induce":[148],"compaction,":[150],"dispensable":[155],"maintenance":[157],"compacted":[160],"state.":[161],"Our":[162],"data":[163],"are":[164],"consistent":[165],"model":[168],"in":[169,182],"which":[170,186],"time":[172],"integral":[173],"historical":[175],"progressively":[180],"recorded":[181],"repressive":[183],"drive":[188],"compaction.":[190],"These":[191],"findings":[192],"link":[193],"equilibrium":[195],"thermodynamics":[196],"fundamentally":[202],"non-equilibrium":[203],"concept":[204],"memory.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}
