{"id":"https://openalex.org/W3203083241","doi":"https://doi.org/10.1016/j.annonc.2021.08.1486","title":"1377P Preliminary efficacy and safety results of KN026 (a HER2-targeted bispecific antibody) in combination with KN046 (an anti-PD-L1/CTLA-4 bispecific antibody) in patients (pts) with HER2-positive gastrointestinal tumors","display_name":"1377P Preliminary efficacy and safety results of KN026 (a HER2-targeted bispecific antibody) in combination with KN046 (an anti-PD-L1/CTLA-4 bispecific antibody) in patients (pts) with HER2-positive gastrointestinal tumors","publication_year":2021,"publication_date":"2021-09-01","ids":{"openalex":"https://openalex.org/W3203083241","doi":"https://doi.org/10.1016/j.annonc.2021.08.1486","mag":"3203083241"},"language":"en","primary_location":{"id":"doi:10.1016/j.annonc.2021.08.1486","doi":"https://doi.org/10.1016/j.annonc.2021.08.1486","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2021.08.1486","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.annonc.2021.08.1486","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056912160","display_name":"Jiuyu Gong","orcid":"https://orcid.org/0000-0003-1532-9637","observed_orcids":["https://orcid.org/0000-0003-1532-9637"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Gong","raw_affiliation_strings":["Department of GI Oncology, Peking University Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of GI Oncology, Peking University Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015779745","display_name":"Lan Shen","orcid":"https://orcid.org/0000-0002-1579-4013","observed_orcids":["https://orcid.org/0000-0002-1579-4013"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. Shen","raw_affiliation_strings":["Department of GI Oncology, Peking University Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of GI Oncology, Peking University Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. Luo","raw_affiliation_strings":["Department of Medical Oncology, Henan Cancer Hospital, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Henan Cancer Hospital, Zhengzhou, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Z. Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z. Dong","raw_affiliation_strings":["GI Oncology, Beijing Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Oncology, Beijing Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054815654","display_name":"Dongrui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"D. Liu","raw_affiliation_strings":["GI Oncology, Beijing Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Oncology, Beijing Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. An","raw_affiliation_strings":["Department of Medical Oncology, Henan Cancer Hospital, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Henan Cancer Hospital, Zhengzhou, China","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042095527","display_name":"Jie Xu","orcid":"https://orcid.org/0000-0001-8307-6091","observed_orcids":["https://orcid.org/0000-0001-8307-6091","https://orcid.org/0009-0006-2299-9734"]},"institutions":[{"id":"https://openalex.org/I4405266976","display_name":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (China)","ror":"https://ror.org/00jp0wa87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405266976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Xu","raw_affiliation_strings":["Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China","institution_ids":["https://openalex.org/I4405266976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I4405266976","display_name":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (China)","ror":"https://ror.org/00jp0wa87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405266976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Yang","raw_affiliation_strings":["Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China","institution_ids":["https://openalex.org/I4405266976"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266976","display_name":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (China)","ror":"https://ror.org/00jp0wa87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405266976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Qi","raw_affiliation_strings":["Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China","institution_ids":["https://openalex.org/I4405266976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031178472","display_name":"Jing-Sheng Men","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266976","display_name":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (China)","ror":"https://ror.org/00jp0wa87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405266976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Men","raw_affiliation_strings":["Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China","institution_ids":["https://openalex.org/I4405266976"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266976","display_name":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (China)","ror":"https://ror.org/00jp0wa87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405266976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. Kong","raw_affiliation_strings":["Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China","institution_ids":["https://openalex.org/I4405266976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056516932","display_name":"Ying Yang","orcid":"https://orcid.org/0000-0001-9252-5071","observed_orcids":["https://orcid.org/0000-0001-9252-5071","https://orcid.org/0009-0006-0925-2177"]},"institutions":[{"id":"https://openalex.org/I4405266976","display_name":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (China)","ror":"https://ror.org/00jp0wa87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405266976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Yang","raw_affiliation_strings":["Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Jiangsu Alphamab Biopharmaceuticals Co.,Ltd., Shanghai, China","institution_ids":["https://openalex.org/I4405266976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101954436","display_name":"Ting Xu","orcid":"https://orcid.org/0000-0003-1764-9036","observed_orcids":["https://orcid.org/0000-0003-1764-9036"]},"institutions":[{"id":"https://openalex.org/I4405266976","display_name":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (China)","ror":"https://ror.org/00jp0wa87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405266976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"T. Xu","raw_affiliation_strings":["Jiangsu Alphamab Biopharmaceuticals Co., Ltd., Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd., Suzhou, China","institution_ids":["https://openalex.org/I4405266976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.6414,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70594732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"32","issue":null,"first_page":"S1042","last_page":"S1042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/efficacy","display_name":"efficacy","score":0.39899998903274536},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.8220000267028809},{"id":"https://openalex.org/keywords/expansion-phase","display_name":"expansion phase","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9355392456054688},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.8965176939964294},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5658730268478394},{"id":"https://openalex.org/C21705690","wikidata":"https://www.wikidata.org/wiki/Q2907609","display_name":"CTLA-4","level":4,"score":0.47537294030189514},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4177328050136566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38476699590682983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29324477910995483},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17917361855506897},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.16375994682312012},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1599830985069275}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.annonc.2021.08.1486","doi":"https://doi.org/10.1016/j.annonc.2021.08.1486","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2021.08.1486","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.annonc.2021.08.1486","doi":"https://doi.org/10.1016/j.annonc.2021.08.1486","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2021.08.1486","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8899999856948853,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4295828339","https://openalex.org/W4379282390","https://openalex.org/W3111248036","https://openalex.org/W4285275831","https://openalex.org/W3099291860","https://openalex.org/W6920433640","https://openalex.org/W4408588786","https://openalex.org/W4282969316","https://openalex.org/W4306810797","https://openalex.org/W4402560479"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-10-11T00:00:00"}
