{"id":"https://openalex.org/W3203066599","doi":"https://doi.org/10.1055/s-0041-1735774","title":"Maternal Plasma Lysophosphatidylcholine Acyltransferase 1 Levels May Allow for Rapid Non-Invasive Assessment of Fetal Lung Maturity","display_name":"Maternal Plasma Lysophosphatidylcholine Acyltransferase 1 Levels May Allow for Rapid Non-Invasive Assessment of Fetal Lung Maturity","publication_year":2021,"publication_date":"2021-09-01","ids":{"openalex":"https://openalex.org/W3203066599","doi":"https://doi.org/10.1055/s-0041-1735774","mag":"3203066599"},"language":"en","primary_location":{"id":"doi:10.1055/s-0041-1735774","doi":"https://doi.org/10.1055/s-0041-1735774","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1735774","pdf_url":null,"source":{"id":"https://openalex.org/S82239980","display_name":"American Journal of Perinatology","issn_l":"0735-1631","issn":["0735-1631","1098-8785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Perinatology","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006440139","display_name":"Courtney Ritchie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I2800326109","display_name":"Detroit Medical Center","ror":"https://ror.org/05gehxw18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800326109"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney Ritchie","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Wayne State University School of Medicine/Detroit Medical Center, Detroit, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine/Detroit Medical Center, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I2800326109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054017099","display_name":"Hanna Ozbeki","orcid":"https://orcid.org/0000-0002-5841-3866","observed_orcids":["https://orcid.org/0000-0002-5841-3866"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanna Ozbeki","raw_affiliation_strings":["The George Washington University Milken Institute of Public Health, Washington DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The George Washington University Milken Institute of Public Health, Washington DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027956887","display_name":"Katherine J. Kramer","orcid":"https://orcid.org/0000-0002-4759-194X","observed_orcids":["https://orcid.org/0000-0002-4759-194X"]},"institutions":[{"id":"https://openalex.org/I4210091615","display_name":"Saint Vincent's Catholic Medical Center","ror":"https://ror.org/00cwrhn79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210091615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine J. Kramer","raw_affiliation_strings":["Department of Obstetrics and Gynecology, St. Vincent's Catholic Medical Centers, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, St. Vincent's Catholic Medical Centers, New York, New York","institution_ids":["https://openalex.org/I4210091615"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015506310","display_name":"Maurice\u2010Andre Recanati","orcid":"https://orcid.org/0000-0003-0974-3962","observed_orcids":["https://orcid.org/0000-0003-0974-3962","https://orcid.org/0000-0001-9813-1954"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurice-Andre Recanati","raw_affiliation_strings":["NIH-Women's Reproductive Health Research Scholar, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH-Women's Reproductive Health Research Scholar, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11586","display_name":"Congenital Diaphragmatic Hernia Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lpcat1","display_name":"LPCAT1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fetal-lung-maturity","display_name":"fetal lung maturity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.8349999785423279},{"id":"https://openalex.org/keywords/maternal-plasma","display_name":"maternal plasma","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cell-free-fetal-rna","display_name":"cell-free fetal RNA","score":0.7580000162124634},{"id":"https://openalex.org/keywords/surfactant-production","display_name":"surfactant production","score":0.753000020980835},{"id":"https://openalex.org/keywords/respiratory-distress-syndrome","display_name":"respiratory distress syndrome","score":0.9419999718666077},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.609000027179718},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2778596009","wikidata":"https://www.wikidata.org/wiki/Q410548","display_name":"Lysophosphatidylcholine","level":5,"score":0.8328061103820801},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.7368921637535095},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6174558401107788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5979465246200562},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.530937910079956},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.47263357043266296},{"id":"https://openalex.org/C2775970874","wikidata":"https://www.wikidata.org/wiki/Q2609152","display_name":"Acyltransferase","level":3,"score":0.43522346019744873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42848631739616394},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.41424429416656494},{"id":"https://openalex.org/C101433766","wikidata":"https://www.wikidata.org/wiki/Q3543263","display_name":"Maturity (psychological)","level":2,"score":0.4103708565235138},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4017331898212433},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35504016280174255},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.28572899103164673},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20526820421218872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18206652998924255},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.14804813265800476},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13207292556762695},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.11018866300582886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05555307865142822},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0041-1735774","doi":"https://doi.org/10.1055/s-0041-1735774","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1735774","pdf_url":null,"source":{"id":"https://openalex.org/S82239980","display_name":"American Journal of Perinatology","issn_l":"0735-1631","issn":["0735-1631","1098-8785"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Perinatology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2944726773","https://openalex.org/W2754019839","https://openalex.org/W4295046182","https://openalex.org/W227679031","https://openalex.org/W4366246039","https://openalex.org/W1601995656","https://openalex.org/W4281733664","https://openalex.org/W2885494584","https://openalex.org/W2419487784","https://openalex.org/W2366482738"],"abstract_inverted_index":{"Objective:":[0],"About":[1],"15":[2],"million":[3],"babies":[4],"are":[5,22],"born":[6],"premature":[7],"and":[8,68,98,135,158],"many":[9],"suffer":[10],"from":[11],"respiratory":[12],"distress":[13],"syndrome":[14],"(RDS).":[15],"RDS":[16],"is":[17,33],"caused":[18],"by":[19,102],"lings":[20],"that":[21],"too":[23],"immature":[24],"to":[25,40,154],"produce":[26],"surfactant.":[27],"Lysophosphatidylcholine":[28],"Acyltransferase":[29],"1":[30],"(":[31],"LPCAT1)":[32],"crucial":[34],"for":[35,73,117,148],"surfactant":[36],"production.":[37],"We":[38],"seek":[39],"determine":[41],"if":[42],"maternal":[43],"plasma":[44],"levels":[45,100,134],"of":[46,55,113,144],"LPCAT1":[47,118,132],"can":[48],"be":[49],"used":[50],"as":[51],"a":[52,145],"non-invasive":[53,146],"marker":[54],"lung":[56,149],"maturity.":[57],"Methods:":[58],"Under":[59],"IRB":[60],"approval,":[61],"women":[62],"with":[63,78,120],"singleton":[64],"pregnancies":[65],"between":[66,131],"28-":[67],"40-weeks\u2019":[69],"gestation":[70],"were":[71,84,87],"invited":[72],"serial":[74],"blood":[75],"draws.":[76],"Those":[77],"anemia,":[79],"medical":[80],"or":[81],"obstetrical":[82],"complications":[83],"excluded.":[85],"Samples":[86],"collected":[88],"in":[89],"EDTA":[90],"tubes,":[91],"RNA":[92],"quantified":[93],"through":[94],"reverse":[95],"transcription":[96],"PCR":[97],"protein":[99,133],"measured":[101],"ELISA.":[103],"Significance":[104],"was":[105,138],"set":[106],"at":[107],"p":[108],"<":[109],"0.05":[110],"Results:":[111],"Levels":[112],"cell-free":[114],"fetal":[115],"mRNA":[116],"correlates":[119],"amniotic":[121],"fluid":[122],"lamellar":[123,136],"bodies":[124,137],"(r":[125],"2":[126],"=0.81).":[127],"A":[128],"linear":[129],"correlation":[130],"also":[139],"found.":[140],"Conclusion:":[141],"The":[142],"development":[143],"biomarker":[147],"maturity":[150],"may":[151],"allow":[152],"obstetricians":[153],"individualize":[155],"clinical":[156],"decisions":[157],"treatment":[159],"plans.":[160],"Publication":[161,163],"History":[162],"Date:":[164],"17":[165],"September":[166],"2021":[167],"(online)":[168],"\u00a9":[169],"2021.":[170],"Thieme.":[171],"All":[172],"rights":[173],"reserved.":[174],"Thieme":[175],"Medical":[176],"Publishers,":[177],"Inc.":[178],"333":[179],"Seventh":[180],"Avenue,":[181],"18th":[182],"Floor,":[183],"New":[184],"York,":[185],"NY":[186],"10001,":[187],"USA":[188]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2021-10-11T00:00:00"}