{"id":"https://openalex.org/W3203057313","doi":"https://doi.org/10.4014/jmb.2109.09002","title":"Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/\u03b2-Catenin Pathway","display_name":"Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/\u03b2-Catenin Pathway","publication_year":2021,"publication_date":"2021-09-29","ids":{"openalex":"https://openalex.org/W3203057313","doi":"https://doi.org/10.4014/jmb.2109.09002","mag":"3203057313","pmid":"https://pubmed.ncbi.nlm.nih.gov/34584036","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9706038"},"language":"en","primary_location":{"id":"doi:10.4014/jmb.2109.09002","doi":"https://doi.org/10.4014/jmb.2109.09002","is_oa":true,"landing_page_url":"https://doi.org/10.4014/jmb.2109.09002","pdf_url":"https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.2109.09002","source":{"id":"https://openalex.org/S70307536","display_name":"Journal of Microbiology and Biotechnology","issn_l":"1017-7825","issn":["1017-7825","1738-8872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microbiology and Biotechnology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3203057313"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.2109.09002","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081387156","display_name":"Geu Rim Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110273157","display_name":"Kookmin University","ror":"https://ror.org/0049erg63","country_code":"KR","type":"education","lineage":["https://openalex.org/I110273157"]},{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Geu Rim Song","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea","Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea","Department of Interdisciplinary Program for Bio-Health Convergence, Kookmin University, Seoul 02707, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]},{"raw_affiliation_string":"Department of Interdisciplinary Program for Bio-Health Convergence, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010213016","display_name":"Yoon Jung Choi","orcid":"https://orcid.org/0000-0003-2328-1493","observed_orcids":["https://orcid.org/0000-0003-2328-1493"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon Jung Choi","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447413","display_name":"Soo Jin Park","orcid":"https://orcid.org/0000-0002-7382-230X","observed_orcids":["https://orcid.org/0000-0002-7382-230X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo Jin Park","raw_affiliation_strings":["Department of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute for Agricultural and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute for Agricultural and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019227761","display_name":"Subeen Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110273157","display_name":"Kookmin University","ror":"https://ror.org/0049erg63","country_code":"KR","type":"education","lineage":["https://openalex.org/I110273157"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Subeen Shin","raw_affiliation_strings":["Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea","Department of Interdisciplinary Program for Bio-Health Convergence, Kookmin University, Seoul 02707, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]},{"raw_affiliation_string":"Department of Interdisciplinary Program for Bio-Health Convergence, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006518333","display_name":"Giseong Lee","orcid":"https://orcid.org/0000-0001-7480-4173","observed_orcids":["https://orcid.org/0000-0001-7480-4173"]},"institutions":[{"id":"https://openalex.org/I110273157","display_name":"Kookmin University","ror":"https://ror.org/0049erg63","country_code":"KR","type":"education","lineage":["https://openalex.org/I110273157"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Giseong Lee","raw_affiliation_strings":["College of General Education, Kookmin University, Seoul 02707, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of General Education, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070879400","display_name":"Hui Ji Choi","orcid":"https://orcid.org/0000-0002-0455-4022","observed_orcids":["https://orcid.org/0000-0002-0455-4022"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hui Ji Choi","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443293","display_name":"Do Yup Lee","orcid":"https://orcid.org/0000-0002-3273-1313","observed_orcids":["https://orcid.org/0000-0002-3273-1313"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Do Yup Lee","raw_affiliation_strings":["Department of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute for Agricultural and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute for Agricultural and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017124239","display_name":"Gyu\u2010Yong Song","orcid":"https://orcid.org/0000-0001-6058-5790","observed_orcids":["https://orcid.org/0000-0001-6058-5790"]},"institutions":[{"id":"https://openalex.org/I110273157","display_name":"Kookmin University","ror":"https://ror.org/0049erg63","country_code":"KR","type":"education","lineage":["https://openalex.org/I110273157"]},{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Gyu-Yong Song","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea","Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea","Department of Interdisciplinary Program for Bio-Health Convergence, Kookmin University, Seoul 02707, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]},{"raw_affiliation_string":"Department of Interdisciplinary Program for Bio-Health Convergence, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071746355","display_name":"Sangtaek Oh","orcid":"https://orcid.org/0000-0003-3241-0488","observed_orcids":["https://orcid.org/0000-0003-3241-0488"]},"institutions":[{"id":"https://openalex.org/I110273157","display_name":"Kookmin University","ror":"https://ror.org/0049erg63","country_code":"KR","type":"education","lineage":["https://openalex.org/I110273157"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sangtaek Oh","raw_affiliation_strings":["Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea","Department of Interdisciplinary Program for Bio-Health Convergence, Kookmin University, Seoul 02707, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]},{"raw_affiliation_string":"Department of Interdisciplinary Program for Bio-Health Convergence, Kookmin University, Seoul 02707, Republic of Korea","institution_ids":["https://openalex.org/I110273157"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017124239","https://openalex.org/A5071746355"],"corresponding_institution_ids":["https://openalex.org/I110273157","https://openalex.org/I196345858"],"apc_list":null,"apc_paid":null,"fwci":0.958,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.6624679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"11","first_page":"1559","last_page":"1567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.13779999315738678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morus-alba","display_name":"Morus alba","score":0.9599999785423279},{"id":"https://openalex.org/keywords/root-bark","display_name":"root bark","score":0.6740000247955322},{"id":"https://openalex.org/keywords/ursolic-acid","display_name":"ursolic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.996999979019165},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/beta-catenin-degradation","display_name":"\u03b2-catenin degradation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9570000171661377},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rpmi-8226-cells","display_name":"RPMI 8226 cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.6408026814460754},{"id":"https://openalex.org/C2779513101","wikidata":"https://www.wikidata.org/wiki/Q416260","display_name":"Ursolic acid","level":2,"score":0.6310251355171204},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5842271447181702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4532531201839447},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.44778570532798767},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4216497540473938},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.41503220796585083},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41195547580718994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3783074617385864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33456504344940186},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.1949133276939392},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14924320578575134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06438139081001282},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097245","descriptor_name":"Ursolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024301","descriptor_name":"Plant Bark","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031625","descriptor_name":"Morus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4014/jmb.2109.09002","doi":"https://doi.org/10.4014/jmb.2109.09002","is_oa":true,"landing_page_url":"https://doi.org/10.4014/jmb.2109.09002","pdf_url":"https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.2109.09002","source":{"id":"https://openalex.org/S70307536","display_name":"Journal of Microbiology and Biotechnology","issn_l":"1017-7825","issn":["1017-7825","1738-8872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microbiology and Biotechnology","raw_type":"journal-article"},{"id":"pmid:34584036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34584036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microbiology and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9706038","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9706038/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Microbiol Biotechnol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4014/jmb.2109.09002","doi":"https://doi.org/10.4014/jmb.2109.09002","is_oa":true,"landing_page_url":"https://doi.org/10.4014/jmb.2109.09002","pdf_url":"https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.2109.09002","source":{"id":"https://openalex.org/S70307536","display_name":"Journal of Microbiology and Biotechnology","issn_l":"1017-7825","issn":["1017-7825","1738-8872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microbiology and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321204","display_name":"Chungnam National University","ror":"https://ror.org/0227as991"},{"id":"https://openalex.org/F4320322007","display_name":"Ministry of Environment","ror":"https://ror.org/04xmt0833"},{"id":"https://openalex.org/F4320334877","display_name":"Korea Environmental Industry and Technology Institute","ror":"https://ror.org/022r1q746"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203057313.pdf","grobid_xml":"https://content.openalex.org/works/W3203057313.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W121708982","https://openalex.org/W1554815317","https://openalex.org/W1927911671","https://openalex.org/W1979201752","https://openalex.org/W1983755269","https://openalex.org/W1989703280","https://openalex.org/W1993243592","https://openalex.org/W1994901323","https://openalex.org/W2002404925","https://openalex.org/W2010808726","https://openalex.org/W2019230169","https://openalex.org/W2040942754","https://openalex.org/W2048161189","https://openalex.org/W2051788298","https://openalex.org/W2052881865","https://openalex.org/W2066141091","https://openalex.org/W2068692736","https://openalex.org/W2069125586","https://openalex.org/W2069561137","https://openalex.org/W2075011718","https://openalex.org/W2081985759","https://openalex.org/W2088681495","https://openalex.org/W2092261702","https://openalex.org/W2101035019","https://openalex.org/W2111113377","https://openalex.org/W2125347681","https://openalex.org/W2148001945","https://openalex.org/W2164807675","https://openalex.org/W2165061154","https://openalex.org/W2181115948","https://openalex.org/W2267602551","https://openalex.org/W2523695964","https://openalex.org/W2806376838","https://openalex.org/W2894589681","https://openalex.org/W2931969628","https://openalex.org/W2943989414","https://openalex.org/W2948293131","https://openalex.org/W3109992463","https://openalex.org/W3207138734","https://openalex.org/W4248066024"],"related_works":["https://openalex.org/W2068692736","https://openalex.org/W4205623232","https://openalex.org/W4210575020","https://openalex.org/W4401033666","https://openalex.org/W1985907155","https://openalex.org/W2254138106","https://openalex.org/W4387103239","https://openalex.org/W4254635095","https://openalex.org/W2590974846","https://openalex.org/W7171319210"],"abstract_inverted_index":{"The":[0],"root":[1,34],"bark":[2,35],"of":[3,13,54,61,75,94,127,154],"Morus":[4],"alba":[5,32],"L.":[6,33],"has":[7],"cytotoxic":[8],"activity":[9,149],"against":[10,162],"several":[11],"types":[12],"cancer":[14],"cells.However,":[15],"little":[16],"is":[17,44],"known":[18],"about":[19],"its":[20,142],"chemopreventive":[21,160],"mechanisms":[22],"and":[23,68,98,110,119,135,141,156],"bioactive":[24],"metabolites.In":[25],"this":[26],"study,":[27],"we":[28],"showed":[29],"that":[30,112,139],"M.":[31],"extracts":[36],"(MRBE)":[37],"suppressed":[38,124],"\u03b2-catenin":[39,155],"response":[40],"transcription":[41],"(CRT),":[42],"which":[43],"aberrantly":[45],"activated":[46],"in":[47,83,91,104],"various":[48],"cancers,":[49],"by":[50,88,130,150],"promoting":[51,151],"the":[52,59,62,73,89,92,125,152],"degradation":[53,153],"\u03b2-catenin.In":[55],"addition,":[56],"MRBE":[57,105,140],"repressed":[58],"expression":[60],"\u03b2-catenin/T-cell":[63],"factor":[64],"(TCF)-dependent":[65],"genes,":[66],"cmyc":[67],"cyclin":[69,120],"D1,":[70],"thus":[71],"inhibiting":[72],"proliferation":[74,126],"RPMI-8226":[76,128],"multiple":[77],"myeloma":[78],"(MM)":[79],"cells.MRBE":[80],"induced":[81],"apoptosis":[82],"MM":[84],"cells,":[85],"as":[86],"evidenced":[87],"increase":[90],"population":[93],"annexin":[95],"V-FITC-positive":[96],"cells":[97,129],"caspase-3/7":[99],"activity.We":[100],"identified":[101],"ursolic":[102,145],"acid":[103],"through":[106],"LC/mass":[107],"spectrum":[108],"(MS)":[109],"observed":[111],"it":[113,123],"also":[114],"decreased":[115],"intracellular":[116],"\u03b2-catenin,":[117],"c-myc,":[118],"D1":[121],"levels.Furthermore,":[122],"stimulating":[131],"cell":[132],"cycle":[133],"arrest":[134],"apoptosis.These":[136],"findings":[137],"suggest":[138],"active":[143],"ingredient,":[144],"acid,":[146],"exert":[147],"antiproliferative":[148],"may":[157],"have":[158],"significant":[159],"potential":[161],"MM.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}
