{"id":"https://openalex.org/W3203042291","doi":null,"title":"Human Bronchial Epithelial Cells Display Alterations in Chromatin Accessibility and Gene Expression According to Oxygen Availability","display_name":"Human Bronchial Epithelial Cells Display Alterations in Chromatin Accessibility and Gene Expression According to Oxygen Availability","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3203042291","mag":"3203042291"},"language":"en","primary_location":{"id":"pmh:oai:ntlrepository.blob.core.windows.net:82191","doi":null,"is_oa":false,"landing_page_url":"http://ntlsearch.bts.gov/ntl/md.do?id=82191","pdf_url":null,"source":{"id":"https://openalex.org/S7407051159","display_name":"ROSA P","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066161846","display_name":"Scott J. Nicholson","orcid":"https://orcid.org/0000-0002-2201-744X","observed_orcids":["https://orcid.org/0000-0002-2201-744X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott J. Nicholson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David Hutchings","orcid":"https://orcid.org/0000-0002-5402-8565","observed_orcids":["https://orcid.org/0000-0002-5402-8565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Hutchings","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5402-8565","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030911572","display_name":"Jordan Patrick Metcalf","orcid":"https://orcid.org/0000-0003-4359-5270","observed_orcids":["https://orcid.org/0000-0003-4359-5270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan P. Metcalf","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4359-5270","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09843467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.13570000231266022,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.8069999814033508},{"id":"https://openalex.org/keywords/human-bronchial-epithelial-cells","display_name":"human bronchial epithelial cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7260000109672546},{"id":"https://openalex.org/keywords/high-altitude-adaptation","display_name":"high-altitude adaptation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/histone-genes","display_name":"histone genes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/angptl4","display_name":"ANGPTL4","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nucleosome-organization","display_name":"nucleosome organization","score":0.3970000147819519},{"id":"https://openalex.org/keywords/transcriptional-response","display_name":"transcriptional response","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6912095546722412},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5492786765098572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5075875520706177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47036975622177124},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4518432915210724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44460010528564453},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3732866644859314},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21346092224121094},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ntlrepository.blob.core.windows.net:82191","doi":null,"is_oa":false,"landing_page_url":"http://ntlsearch.bts.gov/ntl/md.do?id=82191","pdf_url":null,"source":{"id":"https://openalex.org/S7407051159","display_name":"ROSA P","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:3203042291","doi":null,"is_oa":false,"landing_page_url":"https://rosap.ntl.bts.gov/view/dot/57505","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1790297113","https://openalex.org/W1986500735","https://openalex.org/W1992589664","https://openalex.org/W2022451432","https://openalex.org/W2035991083","https://openalex.org/W2045972828","https://openalex.org/W2071361463","https://openalex.org/W2073535977","https://openalex.org/W2087145462","https://openalex.org/W2094856548","https://openalex.org/W2110085982","https://openalex.org/W2110278793","https://openalex.org/W2117131162","https://openalex.org/W2119451273","https://openalex.org/W2142712902","https://openalex.org/W2146512944","https://openalex.org/W2148310630","https://openalex.org/W2149426879","https://openalex.org/W2153584576","https://openalex.org/W2280335874","https://openalex.org/W2305594222","https://openalex.org/W2494734173","https://openalex.org/W2542576093","https://openalex.org/W2576208023","https://openalex.org/W2767950681","https://openalex.org/W2773689951","https://openalex.org/W2803078965","https://openalex.org/W2807271945"],"related_works":["https://openalex.org/W7100356716","https://openalex.org/W2320964622","https://openalex.org/W7117918019","https://openalex.org/W7097733961","https://openalex.org/W4367608160","https://openalex.org/W1964661882","https://openalex.org/W3203232114","https://openalex.org/W2334886016","https://openalex.org/W2915633769","https://openalex.org/W7095792626"],"abstract_inverted_index":{"Aircraft":[0],"passengers":[1],"and":[2,20,30,44,52,56,71,88,107,119,132,137,155,216],"crew":[3],"experience":[4],"mild":[5,45],"hypoxia":[6,224],"during":[7],"flight":[8],"equivalent":[9,102],"to":[10,17,26,75,150,159,206,221],"an":[11,164],"8,000-ft":[12],"elevation.":[13],"Hypoxia":[14,60],"is":[15],"known":[16],"induce":[18],"physiological":[19,39],"transcriptional":[21,48,215],"changes":[22,63,115,147],"that":[23,219],"function":[24,32],"together":[25],"permit":[27],"normal":[28],"cellular":[29],"tissue":[31,112],"at":[33,98,124,168,173,189],"reduced":[34],"oxygen":[35],"(O2)":[36],"levels.":[37],"Short-term":[38],"responses":[40,49],"include":[41],"increased":[42,167],"respiration":[43],"tachycardia;":[46],"short-term":[47],"promote":[50,76],"glycolysis":[51],"initiate":[53],"angiogenesis,":[54],"hematopoiesis,":[55],"other":[57],"mitigating":[58],"adaptations.":[59],"also":[61],"induces":[62],"in":[64,91,116,135,148],"nuclear":[65],"chromatin":[66,72,86,117,139],"structure,":[67],"altering":[68],"histone":[69,130],"methylation":[70],"accessibility":[73,87,118],"profiles":[74],"or":[77],"inhibit":[78],"the":[79,151,160,179,183,194,198],"transcription":[80],"of":[81,103,111,129,178,182,197],"specific":[82],"genes.":[83],"We":[84],"assayed":[85],"gene":[89,120],"expression":[90,121,195],"human":[92],"bronchial":[93],"epithelial":[94],"cells":[95],"(HBECs)":[96],"treated":[97],"21%,":[99],"15%":[100,125,174,190,207],"(the":[101],"aircraft":[104],"cabin":[105],"pressurization),":[106],"2%":[108,142,169],"O2":[109,143,153,170,191,208],"(typical":[110],"hypoxia).":[113],"Large-scale":[114],"were":[122,156],"observed":[123],"O2,":[126],"including":[127],"upregulation":[128],"genes":[131,199],"a":[133,213,229],"reduction":[134],"intergenic":[136],"intronic":[138],"accessibility.":[140],"The":[141],"treatment":[144,154],"exhibited":[145],"fewer":[146],"relation":[149],"21%":[152],"mainly":[157],"limited":[158],"hypoxic":[161,184],"response.":[162],"ANGPTL4,":[163],"angiogenic":[165],"regulator,":[166],"but":[171],"decreased":[172],"O2.":[175],"Further,":[176],"downregulation":[177],"master":[180],"regulator":[181],"response,":[185],"HIF1\u03b1,":[186],"was":[187],"predicted":[188],"based":[192],"on":[193],"status":[196],"it":[200],"regulates.":[201],"In":[202],"summary,":[203],"HBECs":[204],"exposed":[205],"for":[209],"16":[210],"hours":[211],"exhibit":[212],"large-scale":[214],"nucleosomal":[217],"response":[218,230],"appears":[220],"exclude":[222],"most":[223],"regulators":[225],"and,":[226],"instead,":[227],"triggers":[228],"possibly":[231],"promoting":[232],"altitude":[233],"acclimatization.\\n":[234]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-10-11T00:00:00"}
