{"id":"https://openalex.org/W3202904073","doi":"https://doi.org/10.1093/braincomms/fcab223","title":"Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy","display_name":"Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy","publication_year":2021,"publication_date":"2021-09-23","ids":{"openalex":"https://openalex.org/W3202904073","doi":"https://doi.org/10.1093/braincomms/fcab223","mag":"3202904073","pmid":"https://pubmed.ncbi.nlm.nih.gov/34632384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8495137"},"language":"en","primary_location":{"id":"doi:10.1093/braincomms/fcab223","doi":"https://doi.org/10.1093/braincomms/fcab223","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcab223","pdf_url":"https://academic.oup.com/braincomms/article-pdf/3/4/fcab223/40516262/fcab223.pdf","source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/braincomms/article-pdf/3/4/fcab223/40516262/fcab223.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025037879","display_name":"Nguyen\u2010Vi Mohamed","orcid":"https://orcid.org/0000-0002-3593-2444","observed_orcids":["https://orcid.org/0000-0002-3593-2444"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nguyen-Vi Mohamed","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":"https://orcid.org/0000-0002-3593-2444","affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044052439","display_name":"Julien Sirois","orcid":"https://orcid.org/0000-0001-6606-4961","observed_orcids":["https://orcid.org/0000-0001-6606-4961"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julien Sirois","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058039708","display_name":"Janani Ramamurthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Janani Ramamurthy","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074791646","display_name":"Meghna Mathur","orcid":"https://orcid.org/0000-0001-9561-1493","observed_orcids":["https://orcid.org/0000-0001-9561-1493"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Meghna Mathur","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015300040","display_name":"Paula L\u00e9pine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paula L\u00e9pine","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015676124","display_name":"\u00c9ric Deneault","orcid":"https://orcid.org/0000-0002-6875-0380","observed_orcids":["https://orcid.org/0000-0002-6875-0380"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eric Deneault","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017363465","display_name":"Gilles Maussion","orcid":"https://orcid.org/0000-0001-5785-6238","observed_orcids":["https://orcid.org/0000-0001-5785-6238"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gilles Maussion","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035497813","display_name":"Micha\u00ebl Nicouleau","orcid":"https://orcid.org/0000-0001-9319-3355","observed_orcids":["https://orcid.org/0000-0001-9319-3355"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Nicouleau","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025179711","display_name":"Carol X.\u2010Q. Chen","orcid":"https://orcid.org/0000-0001-6167-8083","observed_orcids":["https://orcid.org/0000-0001-6167-8083"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carol X -Q Chen","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081365733","display_name":"Narges Abdian","orcid":"https://orcid.org/0000-0003-0858-1391","observed_orcids":["https://orcid.org/0000-0003-0858-1391"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Narges Abdian","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026377589","display_name":"Vincent Soubannier","orcid":"https://orcid.org/0000-0002-0347-1364","observed_orcids":["https://orcid.org/0000-0002-0347-1364"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vincent Soubannier","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086287818","display_name":"Eddie Cai","orcid":"https://orcid.org/0000-0002-3341-9671","observed_orcids":["https://orcid.org/0000-0002-3341-9671"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eddie Cai","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070067005","display_name":"Harris Nami","orcid":"https://orcid.org/0000-0002-4464-4209","observed_orcids":["https://orcid.org/0000-0002-4464-4209"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Harris Nami","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032318601","display_name":"Rhalena A. Thomas","orcid":"https://orcid.org/0000-0002-5396-7587","observed_orcids":["https://orcid.org/0000-0002-5396-7587"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rhalena A Thomas","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007285324","display_name":"Dingke Wen","orcid":"https://orcid.org/0000-0002-5564-5995","observed_orcids":["https://orcid.org/0000-0002-5564-5995"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingke Wen","raw_affiliation_strings":["Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610063, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610063, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065683268","display_name":"Mahdieh Tabatabaei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mahdieh Tabatabaei","raw_affiliation_strings":["C-BIG Biorepository (C-BIG), Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C-BIG Biorepository (C-BIG), Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011601675","display_name":"Lenore K. Beitel","orcid":"https://orcid.org/0000-0002-2836-5568","observed_orcids":["https://orcid.org/0000-0002-2836-5568"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lenore K Beitel","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058019569","display_name":"Karamjit Singh Dolt","orcid":"https://orcid.org/0000-0002-0584-7505","observed_orcids":["https://orcid.org/0000-0002-0584-7505"]},"institutions":[{"id":"https://openalex.org/I4210108209","display_name":"MRC Centre for Regenerative Medicine","ror":"https://ror.org/01x802g65","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210108209","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karamjit Singh Dolt","raw_affiliation_strings":["Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK"],"raw_orcid":"https://orcid.org/0000-0002-0584-7505","affiliations":[{"raw_affiliation_string":"Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK","institution_ids":["https://openalex.org/I4210108209","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002890512","display_name":"Jason Karamchandani","orcid":"https://orcid.org/0000-0002-3906-5616","observed_orcids":["https://orcid.org/0000-0002-3906-5616"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jason Karamchandani","raw_affiliation_strings":["C-BIG Biorepository (C-BIG), Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C-BIG Biorepository (C-BIG), Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074478086","display_name":"Jo Anne Stratton","orcid":"https://orcid.org/0000-0002-1205-1353","observed_orcids":["https://orcid.org/0000-0002-1205-1353"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jo Anne Stratton","raw_affiliation_strings":["Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057119874","display_name":"Tilo Kunath","orcid":"https://orcid.org/0000-0002-8805-7356","observed_orcids":["https://orcid.org/0000-0002-8805-7356"]},"institutions":[{"id":"https://openalex.org/I4210108209","display_name":"MRC Centre for Regenerative Medicine","ror":"https://ror.org/01x802g65","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210108209","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tilo Kunath","raw_affiliation_strings":["Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK"],"raw_orcid":"https://orcid.org/0000-0002-8805-7356","affiliations":[{"raw_affiliation_string":"Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK","institution_ids":["https://openalex.org/I4210108209","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032473070","display_name":"Edward A. Fon","orcid":"https://orcid.org/0000-0002-5520-6239","observed_orcids":["https://orcid.org/0000-0002-5520-6239","https://orcid.org/0000-0001-9496-2216"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Edward A Fon","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5520-6239","affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014873628","display_name":"Thomas M. Durcan","orcid":"https://orcid.org/0000-0003-3942-1956","observed_orcids":["https://orcid.org/0000-0003-3942-1956","https://orcid.org/0000-0003-0077-8333","https://orcid.org/0000-0002-2836-5568"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Thomas M Durcan","raw_affiliation_strings":["Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5014873628","https://openalex.org/A5032473070"],"corresponding_institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"],"apc_list":{"value":2500,"currency":"GBP","value_usd":3400},"apc_paid":{"value":2500,"currency":"GBP","value_usd":3400},"fwci":6.5052,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.97957172,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"3","issue":"4","first_page":"fcab223","last_page":"fcab223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8389999866485596},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.8640000224113464},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.7950000166893005},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.9309999942779541},{"id":"https://openalex.org/keywords/midbrain-organoids","display_name":"midbrain organoids","score":0.9649999737739563},{"id":"https://openalex.org/keywords/human-induced-pluripotent-stem-cells","display_name":"human induced pluripotent stem cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/alpha-synuclein-phosphorylation","display_name":"alpha-synuclein phosphorylation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.8519999980926514},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.9405947923660278},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8654356598854065},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.6575191020965576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6145344972610474},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5652884244918823},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5334895849227905},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5083605647087097},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5059191584587097},{"id":"https://openalex.org/C2777916540","wikidata":"https://www.wikidata.org/wiki/Q24767155","display_name":"Synuclein","level":5,"score":0.4759654402732849},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.4400598704814911},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4263542592525482},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3258194327354431},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26473522186279297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2441062033176422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21541747450828552},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.15070420503616333},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14351677894592285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1322307288646698},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0632927417755127}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1093/braincomms/fcab223","doi":"https://doi.org/10.1093/braincomms/fcab223","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcab223","pdf_url":"https://academic.oup.com/braincomms/article-pdf/3/4/fcab223/40516262/fcab223.pdf","source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2021.04.12.439480","doi":"https://doi.org/10.1101/2021.04.12.439480","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.04.12.439480","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/04/12/2021.04.12.439480.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:7388398","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8495137","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34632384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34632384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8495137","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8495137/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Commun","raw_type":"Text"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/258243a7-6efb-4c6e-a8c0-0d80a2f6c4dc","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/files/249446080/fcab223.pdf","pdf_url":"https://www.research.ed.ac.uk/files/249446080/fcab223.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mohamed, N-V, Sirois, J, Ramamurthy, J, Mathur, M, L\u00e9pine, P, Deneault, E, Maussion, G, Nicouleau, M, Chen, C X -Q, Abdian, N, Soubannier, V, Cai, E, Nami, H, Thomas, R A, Wen, D, Tabatabaei, M, Beitel, L K, Singh Dolt, K, Karamchandani, J, Stratton, J A, Kunath, T, Fon, E A & Durcan, T M 2021, 'Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy', Brain Communications, vol. 3, no. 4, fcab223. https://doi.org/10.1093/braincomms/fcab223","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:escholarship.mcgill.ca:3r0751867","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.mcgill.ca/concern/articles/3r0751867","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1093/braincomms/fcab223","raw_type":"Article"},{"id":"pmh:oai:mcgill.scholaris.ca:20.500.14905/74552","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcab223","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"https://vocabularies.coar-repositories.org/resource_types/c_6501/"}],"best_oa_location":{"id":"doi:10.1093/braincomms/fcab223","doi":"https://doi.org/10.1093/braincomms/fcab223","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcab223","pdf_url":"https://academic.oup.com/braincomms/article-pdf/3/4/fcab223/40516262/fcab223.pdf","source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G199863978","display_name":"The role of ciprofloxacin in prolonging polyethylene biliary stent patency","funder_award_id":"15430_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G2521954626","display_name":"Investigation of alpha-synuclein pathogenic mechanisms with human stem cells and neurons","funder_award_id":"MR/J012831/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2668716943","display_name":null,"funder_award_id":"FDN - 154301","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4442932687","display_name":"Differentiation of GMP-grade human embryonic stem cells to midbrain dopaminergic neurons for transplantation","funder_award_id":"MR/K017276/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7176773705","display_name":null,"funder_award_id":"PJT - 169095","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320315912","display_name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","ror":"https://ror.org/029c4ct76"},{"id":"https://openalex.org/F4320316039","display_name":"Qu\u00e9bec Consortium for Drug Discovery","ror":"https://ror.org/03hhwkj37"},{"id":"https://openalex.org/F4320325689","display_name":"Parkinson Canada","ror":null},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3202904073.pdf","grobid_xml":"https://content.openalex.org/works/W3202904073.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1815242288","https://openalex.org/W1965778124","https://openalex.org/W1974282501","https://openalex.org/W1979527613","https://openalex.org/W1979591162","https://openalex.org/W2010612415","https://openalex.org/W2014413787","https://openalex.org/W2022348337","https://openalex.org/W2025260963","https://openalex.org/W2030725090","https://openalex.org/W2052011437","https://openalex.org/W2066972199","https://openalex.org/W2070953412","https://openalex.org/W2072509284","https://openalex.org/W2073760242","https://openalex.org/W2081644238","https://openalex.org/W2091265794","https://openalex.org/W2102678193","https://openalex.org/W2108802551","https://openalex.org/W2108865709","https://openalex.org/W2111191613","https://openalex.org/W2114570899","https://openalex.org/W2119998182","https://openalex.org/W2123403456","https://openalex.org/W2123431154","https://openalex.org/W2127508962","https://openalex.org/W2130128490","https://openalex.org/W2134964344","https://openalex.org/W2149756019","https://openalex.org/W2150656456","https://openalex.org/W2151199043","https://openalex.org/W2154737306","https://openalex.org/W2201901179","https://openalex.org/W2293547289","https://openalex.org/W2310305711","https://openalex.org/W2417670847","https://openalex.org/W2490424988","https://openalex.org/W2507172980","https://openalex.org/W2528543174","https://openalex.org/W2536179678","https://openalex.org/W2552351585","https://openalex.org/W2607293416","https://openalex.org/W2608500349","https://openalex.org/W2616733389","https://openalex.org/W2734548565","https://openalex.org/W2745164635","https://openalex.org/W2799836148","https://openalex.org/W2804405581","https://openalex.org/W2806989085","https://openalex.org/W2898567653","https://openalex.org/W2898613835","https://openalex.org/W2900489664","https://openalex.org/W2904938386","https://openalex.org/W2907514116","https://openalex.org/W2909365621","https://openalex.org/W2910235035","https://openalex.org/W2912391906","https://openalex.org/W2912581779","https://openalex.org/W2917272302","https://openalex.org/W2930303216","https://openalex.org/W2933400096","https://openalex.org/W2942984797","https://openalex.org/W2952602120","https://openalex.org/W2954385672","https://openalex.org/W2955588013","https://openalex.org/W3004512212","https://openalex.org/W3014185549","https://openalex.org/W3018835152","https://openalex.org/W3023626818","https://openalex.org/W3030239116","https://openalex.org/W3046634271","https://openalex.org/W3080632072","https://openalex.org/W3114016256","https://openalex.org/W3164692211","https://openalex.org/W3186824561"],"related_works":["https://openalex.org/W7005982066","https://openalex.org/W3178881132","https://openalex.org/W4409764776","https://openalex.org/W4320919285","https://openalex.org/W3184564931","https://openalex.org/W7212237953","https://openalex.org/W4402451148","https://openalex.org/W4411990427","https://openalex.org/W1985010554","https://openalex.org/W4414065885"],"abstract_inverted_index":{"Abstract":[0],"SNCA,":[1],"the":[2,10,13,30,35,55,72,81,106,128,159,220],"first":[3],"gene":[4,108,202],"associated":[5],"with":[6,39,51,132,186],"Parkinson\u2019s":[7,40,211],"disease,":[8,41],"encodes":[9],"\u03b1-synuclein":[11,58,124,148,155,171],"protein,":[12],"predominant":[14],"component":[15],"within":[16],"pathological":[17,208],"inclusions":[18],"termed":[19],"Lewy":[20,25,43],"bodies.":[21],"The":[22],"presence":[23,160],"of":[24,29,37,57,105,123,130,147,161,167,210,222],"bodies":[26,44],"is":[27],"one":[28],"classical":[31],"hallmarks":[32],"found":[33,79,174],"in":[34,49,60,80,127,154,175,190],"brain":[36],"patients":[38,50,101,131,199],"and":[42,75,109,149,164,178,181,213],"have":[45],"also":[46],"been":[47],"observed":[48,126],"other":[52],"synucleinopathies.":[53,133,223],"However,":[54],"study":[56,219],"pathology":[59,125],"cells":[61,98,180],"has":[62],"relied":[63],"largely":[64],"on":[65],"two-dimensional":[66],"culture":[67],"models,":[68],"which":[69],"typically":[70],"lack":[71],"cellular":[73],"diversity":[74],"complex":[76],"spatial":[77],"environment":[78],"brain.":[82],"Here,":[83],"to":[84,218],"address":[85],"this":[86],"gap,":[87],"we":[88,136],"use":[89],"three-dimensional":[90],"midbrain":[91,118,142,196],"organoids,":[92],"differentiated":[93],"from":[94,100,110,198],"human-induced":[95],"pluripotent":[96],"stem":[97],"derived":[99],"carrying":[102,200],"a":[103,187,215],"triplication":[104,140],"SNCA":[107,139,201],"CRISPR/Cas9":[111],"corrected":[112],"isogenic":[113],"control":[114],"iPSCs.":[115],"These":[116,169],"human":[117,141,195],"organoids":[119,143,197],"recapitulate":[120],"key":[121,207],"features":[122,209],"brains":[129],"In":[134],"particular,":[135],"find":[137],"that":[138],"express":[144],"elevated":[145],"levels":[146],"exhibit":[150],"an":[151],"age-dependent":[152],"increase":[153],"aggregation,":[156],"manifested":[157],"by":[158],"both":[162,176],"oligomeric":[163],"phosphorylated":[165,170],"forms":[166],"\u03b1-synuclein.":[168],"aggregates":[172],"were":[173],"neurons":[177],"glial":[179],"their":[182],"time-dependent":[183],"accumulation":[184],"correlated":[185],"selective":[188],"reduction":[189],"dopaminergic":[191],"neuron":[192],"numbers.":[193],"Thus,":[194],"multiplication":[203],"can":[204],"reliably":[205],"model":[206],"disease":[212],"provide":[214],"powerful":[216],"system":[217],"pathogenesis":[221]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}
