{"id":"https://openalex.org/W3202782004","doi":"https://doi.org/10.21010/ajidv15i2s.5","title":"INCIDENCE OF HIGH GRADE QTCF PROLONGATION AND ITS MANAGEMENT AMONG PATIENTS UNDERGOING TREATMENT FOR DRUG RESISTANT TUBERCULOSIS (DR-TB): CASE SERIES.","display_name":"INCIDENCE OF HIGH GRADE QTCF PROLONGATION AND ITS MANAGEMENT AMONG PATIENTS UNDERGOING TREATMENT FOR DRUG RESISTANT TUBERCULOSIS (DR-TB): CASE SERIES.","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3202782004","doi":"https://doi.org/10.21010/ajidv15i2s.5","mag":"3202782004","pmid":"https://pubmed.ncbi.nlm.nih.gov/34595385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8457348"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:7369745","doi":"https://doi.org/10.21010/ajidv15i2s.5","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8457348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC8457348","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065862531","display_name":"Marye Asfaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129364015","display_name":"Partners In Health","ror":"https://ror.org/05tsvnv68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129364015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meseret T Asfaw","raw_affiliation_strings":["Partners in Health, Maseru, Lesotho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners in Health, Maseru, Lesotho","institution_ids":["https://openalex.org/I129364015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072629040","display_name":"David L. Holtzman","orcid":"https://orcid.org/0000-0001-9214-5685","observed_orcids":["https://orcid.org/0000-0001-9214-5685"]},"institutions":[{"id":"https://openalex.org/I129364015","display_name":"Partners In Health","ror":"https://ror.org/05tsvnv68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129364015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L Holtzman","raw_affiliation_strings":["Partners in Health, Maseru, Lesotho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners in Health, Maseru, Lesotho","institution_ids":["https://openalex.org/I129364015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005970027","display_name":"Gene F. Kwan","orcid":"https://orcid.org/0000-0002-0929-6800","observed_orcids":["https://orcid.org/0000-0002-0929-6800"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I129364015","display_name":"Partners In Health","ror":"https://ror.org/05tsvnv68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129364015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gene F Kwan","raw_affiliation_strings":["Partners in Health, Boston, MA, USA","Boston University School of Medicine, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners in Health, Boston, MA, USA","institution_ids":["https://openalex.org/I129364015"]},{"raw_affiliation_string":"Boston University School of Medicine, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042559210","display_name":"Lawrence Oyewusi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129364015","display_name":"Partners In Health","ror":"https://ror.org/05tsvnv68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129364015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence T Oyewusi","raw_affiliation_strings":["Partners in Health, Maseru, Lesotho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners in Health, Maseru, Lesotho","institution_ids":["https://openalex.org/I129364015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052396258","display_name":"Carole Diane Mitnick","orcid":"https://orcid.org/0000-0002-3455-658X","observed_orcids":["https://orcid.org/0000-0002-3455-658X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carole D Mitnick","raw_affiliation_strings":["Harvard Medical School, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113012179","display_name":"Kwonjune J. Seung","orcid":"https://orcid.org/0000-0003-0417-4625","observed_orcids":["https://orcid.org/0000-0003-0417-4625"]},"institutions":[{"id":"https://openalex.org/I129364015","display_name":"Partners In Health","ror":"https://ror.org/05tsvnv68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129364015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwonjune J Seung","raw_affiliation_strings":["Partners in Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners in Health, Boston, MA, USA","institution_ids":["https://openalex.org/I129364015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2375,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58557642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"15","issue":"2 Suppl","first_page":"38","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/bedaquiline","display_name":"bedaquiline","score":0.8360000252723694},{"id":"https://openalex.org/keywords/delamanid","display_name":"delamanid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.5989999771118164},{"id":"https://openalex.org/keywords/ecg-monitoring","display_name":"ECG monitoring","score":0.7720000147819519},{"id":"https://openalex.org/keywords/adverse-drug-reaction-management","display_name":"adverse drug reaction management","score":0.6690000295639038},{"id":"https://openalex.org/keywords/lesotho","display_name":"Lesotho","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9476774334907532},{"id":"https://openalex.org/C2780544761","wikidata":"https://www.wikidata.org/wiki/Q1257318","display_name":"Bedaquiline","level":4,"score":0.8655081987380981},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.8250699043273926},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.669732391834259},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5662370920181274},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5183271169662476},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5129720568656921},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4895575940608978},{"id":"https://openalex.org/C2777672339","wikidata":"https://www.wikidata.org/wiki/Q7249641","display_name":"Prolongation","level":2,"score":0.4675375819206238},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3469359874725342},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05908095836639404},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:7369745","doi":"https://doi.org/10.21010/ajidv15i2s.5","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8457348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8457348","doi":"https://doi.org/10.21010/ajidv15i2s.5","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8457348","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Afr J Infect Dis","raw_type":"Text"},{"id":"pmid:34595385","doi":"https://doi.org/10.21010/ajidv15i2s.5","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34595385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African journal of infectious diseases","raw_type":"Journal Article"},{"id":"mag:3202782004","doi":"https://doi.org/10.21010/ajidv15i2s.5","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34595385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7369745","doi":"https://doi.org/10.21010/ajidv15i2s.5","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8457348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2276165593","https://openalex.org/W2322372189","https://openalex.org/W2769462175","https://openalex.org/W2789501684","https://openalex.org/W2969691822"],"related_works":["https://openalex.org/W4256071179","https://openalex.org/W7163373523","https://openalex.org/W4405219434","https://openalex.org/W4301396118","https://openalex.org/W4385382777","https://openalex.org/W7125634366","https://openalex.org/W3175881525","https://openalex.org/W4311674987","https://openalex.org/W4396608075","https://openalex.org/W4396569569"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,158],"World":[2],"Health":[3],"Organization":[4],"(WHO)":[5],"has":[6],"approved":[7],"the":[8,29,33,51,63,67,103,118,200],"use":[9,34],"of":[10,22,28,35,69,77,91,105,123,132,154,160,192,196],"two":[11],"new":[12],"drugs,":[13],"namely":[14],"Bedaquiline":[15,138],"(Bdq)":[16],"and":[17,46,53,65,98,113,121,170,190],"Delamanid":[18,140],"(Dlm),":[19],"for":[20],"treatment":[21],"Drug":[23],"Resistant":[24],"Tuberculosis":[25],"(DR-TB).":[26],"One":[27],"concerns":[30],"raised":[31],"with":[32,89,184],"these":[36,83],"drugs":[37,207],"was":[38],"QT-interval":[39,72,197],"prolongation.":[40,146],"This":[41,59],"condition":[42],"could":[43],"be":[44,182],"serious":[45],"life":[47],"threatening.":[48],"Hence,":[49],"knowing":[50],"magnitude":[52],"its":[54],"management":[55,68,122,191],"is":[56,115,175],"very":[57],"important.":[58],"case":[60],"series":[61],"identifies":[62],"incidence":[64],"discusses":[66],"clinically":[70,161],"significant":[71,162],"prolongation":[73,95,164,198],"amongst":[74],"a":[75],"cohort":[76,104],"patients":[78,107,135,167],"who":[79],"have":[80,141],"been":[81],"on":[82,109,117,137],"medicines.":[84],"MATERIALS":[85],"AND":[86],"METHODS:":[87],"Patients":[88],"reports":[90],"high":[92,143],"grade":[93,144],"QT-Interval":[94,145],"(i.e.":[96],"Grade-3":[97],"Grade-4)":[99],"were":[100],"identified":[101],"from":[102],"265":[106,134],"enrolled":[108,136],"bedaquiline":[110,169],"and/or":[111,139],"delamanid":[112,172],"discussion":[114],"made":[116],"pattern,":[119],"severity":[120],"each":[124],"cases":[125,180],"identified.":[126],"RESULTS:":[127],"Only":[128],"4":[129],"(1.5%)":[130],"out":[131],"all":[133,148,179],"developed":[142],"And":[147,177],"are":[149],"managed":[150,183],"without":[151,199],"permanent":[152],"discontinuation":[153],"both":[155,206],"drugs.":[156],"CONCLUSION:":[157],"Incidence":[159],"QTcF-interval":[163],"among":[165],"DR-TB":[166],"taking":[168],"/or":[171],"in":[173],"Lesotho":[174],"low.":[176],"almost":[178],"can":[181],"more":[185],"frequent":[186],"Electrocardiogram":[187],"(ECG)":[188],"monitoring":[189],"other":[193],"possible":[194],"causes":[195],"need":[201],"to":[202],"stop":[203],"one":[204],"or":[205],"permanently.":[208]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-10-11T00:00:00"}
