{"id":"https://openalex.org/W3202731102","doi":"https://doi.org/10.1016/j.cub.2021.09.027","title":"Spatial organization of transcribing loci during early genome activation in Drosophila","display_name":"Spatial organization of transcribing loci during early genome activation in Drosophila","publication_year":2021,"publication_date":"2021-10-05","ids":{"openalex":"https://openalex.org/W3202731102","doi":"https://doi.org/10.1016/j.cub.2021.09.027","mag":"3202731102","pmid":"https://pubmed.ncbi.nlm.nih.gov/34614388","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8612988"},"language":"en","primary_location":{"id":"doi:10.1016/j.cub.2021.09.027","doi":"https://doi.org/10.1016/j.cub.2021.09.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2021.09.027","pdf_url":null,"source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.cub.2021.09.027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028383052","display_name":"Shao-Kuei Huang","orcid":"https://orcid.org/0000-0002-4715-9612","observed_orcids":["https://orcid.org/0000-0002-4715-9612"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shao-Kuei Huang","raw_affiliation_strings":["Department of Biology, New York University, New York, NY 10003, USA"],"raw_orcid":"https://orcid.org/0000-0002-4715-9612","affiliations":[{"raw_affiliation_string":"Department of Biology, New York University, New York, NY 10003, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077734565","display_name":"Peter H. Whitney","orcid":"https://orcid.org/0009-0009-5276-0232","observed_orcids":["https://orcid.org/0009-0009-5276-0232"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H. Whitney","raw_affiliation_strings":["Department of Biology, New York University, New York, NY 10003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, New York University, New York, NY 10003, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028511480","display_name":"Sayantan Dutta","orcid":"https://orcid.org/0000-0002-3366-735X","observed_orcids":["https://orcid.org/0000-0002-3366-735X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayantan Dutta","raw_affiliation_strings":["The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA"],"raw_orcid":"https://orcid.org/0000-0002-3366-735X","affiliations":[{"raw_affiliation_string":"The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012005058","display_name":"Stanislav Y. Shvartsman","orcid":"https://orcid.org/0000-0002-9152-9334","observed_orcids":["https://orcid.org/0000-0002-9152-9334"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislav Y. Shvartsman","raw_affiliation_strings":["The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA; Center for Computational Biology, Flatiron Research Institute, New York, NY 10010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA; Center for Computational Biology, Flatiron Research Institute, New York, NY 10010, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004571265","display_name":"Christine\u00a0A. Rushlow","orcid":"https://orcid.org/0000-0001-6762-2005","observed_orcids":["https://orcid.org/0000-0001-6762-2005"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christine A. Rushlow","raw_affiliation_strings":["Department of Biology, New York University, New York, NY 10003, USA. Electronic address: chris.rushlow@nyu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, New York University, New York, NY 10003, USA. Electronic address: chris.rushlow@nyu.edu","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004571265"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":{"value":6700,"currency":"USD","value_usd":6700},"apc_paid":null,"fwci":1.4015,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81828552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"31","issue":"22","first_page":"5102","last_page":"5110.e5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.675000011920929},{"id":"https://openalex.org/keywords/drosophila-embryo","display_name":"Drosophila embryo","score":0.9279999732971191},{"id":"https://openalex.org/keywords/zelda","display_name":"Zelda","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pioneer-factors","display_name":"pioneer factors","score":0.7149999737739563},{"id":"https://openalex.org/keywords/topologically-associated-domains","display_name":"topologically associating domains","score":0.7879999876022339},{"id":"https://openalex.org/keywords/gene-clustering","display_name":"gene clustering","score":0.41600000858306885},{"id":"https://openalex.org/keywords/co-regulation","display_name":"co-regulation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/nuclear-organization","display_name":"nuclear organization","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8969315886497498},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6750302910804749},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6463865041732788},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6165160536766052},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5474035739898682},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5187123417854309},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.516216516494751},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4352342486381531},{"id":"https://openalex.org/C172407341","wikidata":"https://www.wikidata.org/wiki/Q7833931","display_name":"Transcription factories","level":5,"score":0.43313175439834595},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.43283721804618835},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.3189200162887573},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2441091537475586},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.2166820466518402},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.cub.2021.09.027","doi":"https://doi.org/10.1016/j.cub.2021.09.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2021.09.027","pdf_url":null,"source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2021.01.08.425929","doi":"https://doi.org/10.1101/2021.01.08.425929","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.01.08.425929","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/03/04/2021.01.08.425929.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:34614388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34614388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8612988","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8612988","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.cub.2021.09.027","doi":"https://doi.org/10.1016/j.cub.2021.09.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2021.09.027","pdf_url":null,"source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1287817103","display_name":"TRAINING PROGRAM IN DEVELOPMENTAL GENETICS","funder_award_id":"T32HD007520","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G187715334","display_name":"Harnessing optogenetics to diagnose and therapeutically rewire cancer cell signaling","funder_award_id":"1dp2eb024247-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3960619836","display_name":"Regulation of zygotic genome activation by Zelda","funder_award_id":"R01GM063024","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4893908262","display_name":null,"funder_award_id":"RO1HD0858870","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7944573268","display_name":"Optogenetic control of spatio-temporal patterning in early embryogenesis","funder_award_id":"F32GM119297","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000912569","display_name":"Collective dynamics in cell clusters","funder_award_id":"R01GM134204","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3202731102.pdf","grobid_xml":"https://content.openalex.org/works/W3202731102.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W11162155","https://openalex.org/W1529048149","https://openalex.org/W1882164115","https://openalex.org/W1976595861","https://openalex.org/W1978252332","https://openalex.org/W1979315404","https://openalex.org/W1989618744","https://openalex.org/W1991149014","https://openalex.org/W1993062465","https://openalex.org/W1995251947","https://openalex.org/W2002673451","https://openalex.org/W2004533772","https://openalex.org/W2010079162","https://openalex.org/W2022755414","https://openalex.org/W2039270292","https://openalex.org/W2041611886","https://openalex.org/W2047755766","https://openalex.org/W2050234082","https://openalex.org/W2054220127","https://openalex.org/W2056482755","https://openalex.org/W2063276354","https://openalex.org/W2073761355","https://openalex.org/W2090461046","https://openalex.org/W2099034339","https://openalex.org/W2107271890","https://openalex.org/W2111868960","https://openalex.org/W2113146724","https://openalex.org/W2119588819","https://openalex.org/W2126282428","https://openalex.org/W2136805808","https://openalex.org/W2145074167","https://openalex.org/W2145645515","https://openalex.org/W2146404878","https://openalex.org/W2152464785","https://openalex.org/W2154675388","https://openalex.org/W2160130765","https://openalex.org/W2164240145","https://openalex.org/W2171338385","https://openalex.org/W2171675401","https://openalex.org/W2334656801","https://openalex.org/W2570943423","https://openalex.org/W2603000633","https://openalex.org/W2604200375","https://openalex.org/W2625007641","https://openalex.org/W2808847099","https://openalex.org/W2809265915","https://openalex.org/W2884101170","https://openalex.org/W2887741043","https://openalex.org/W2888425844","https://openalex.org/W2890893954","https://openalex.org/W2902773595","https://openalex.org/W2920852097","https://openalex.org/W2937151182","https://openalex.org/W2947039670","https://openalex.org/W2949107687","https://openalex.org/W2950942545","https://openalex.org/W2951271895","https://openalex.org/W2961406494","https://openalex.org/W3035906587","https://openalex.org/W3112048517","https://openalex.org/W3144036649","https://openalex.org/W3145419749","https://openalex.org/W4232942257","https://openalex.org/W4300102919"],"related_works":["https://openalex.org/W3118777902","https://openalex.org/W4405285842","https://openalex.org/W1968065062","https://openalex.org/W2073761355","https://openalex.org/W2951271895","https://openalex.org/W2954834803","https://openalex.org/W2917779347","https://openalex.org/W4300102919","https://openalex.org/W2004533772","https://openalex.org/W2073612080"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2021-10-11T00:00:00"}