{"id":"https://openalex.org/W3202569578","doi":"https://doi.org/10.46889/josr.2021.2302","title":"Non Metastatic Rhabdomyosarcoma in Children and Adolescents: Prognostic Factors and Survival","display_name":"Non Metastatic Rhabdomyosarcoma in Children and Adolescents: Prognostic Factors and Survival","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3202569578","doi":"https://doi.org/10.46889/josr.2021.2302","mag":"3202569578"},"language":"en","primary_location":{"id":"doi:10.46889/josr.2021.2302","doi":"https://doi.org/10.46889/josr.2021.2302","is_oa":true,"landing_page_url":"https://doi.org/10.46889/josr.2021.2302","pdf_url":"https://doi.org/10.46889/josr.2021.2302","source":{"id":"https://openalex.org/S5407055779","display_name":"Journal of Orthopaedic Science and Research","issn_l":"3068-3726","issn":["3068-3726"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Science and Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.46889/josr.2021.2302","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112950715","display_name":"Feryel Letaief-Ksontini","orcid":"https://orcid.org/0000-0002-5351-5740","observed_orcids":["https://orcid.org/0000-0002-5351-5740"]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Feryel Letaief-Ksontini","raw_affiliation_strings":["Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210090597","https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000972382","display_name":"Mouna Ayadi","orcid":"https://orcid.org/0000-0002-8649-9054","observed_orcids":["https://orcid.org/0000-0002-8649-9054"]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Mouna Ayadi","raw_affiliation_strings":["Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210090597","https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110575714","display_name":"Azza Gabsi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Azza Gabsi","raw_affiliation_strings":["Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210090597","https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067125772","display_name":"Safia Yahiaoui","orcid":"https://orcid.org/0000-0002-3285-6298","observed_orcids":["https://orcid.org/0000-0002-3285-6298"]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Safia Yahiaoui","raw_affiliation_strings":["Associate Professor, Radiotherapy Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Radiotherapy Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210090597","https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110935737","display_name":"Houcine Magherbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Houcine Magherbi","raw_affiliation_strings":["Associate Professor, Surgery Department, Faculty of Medicine of Tunis, La Rabta Hospital, El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Surgery Department, Faculty of Medicine of Tunis, La Rabta Hospital, El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112830449","display_name":"Amina Mokrani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Amina Mokrani","raw_affiliation_strings":["Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia","University of Tunis el Manar Faculty of Medicine of Tunis , Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210090597","https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"raw_affiliation_string":"University of Tunis el Manar Faculty of Medicine of Tunis , Tunisia","institution_ids":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036270827","display_name":"Khedija Meddeb","orcid":"https://orcid.org/0000-0002-3418-1749","observed_orcids":["https://orcid.org/0000-0002-3418-1749"]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Khedija Meddeb","raw_affiliation_strings":["Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Medical Oncology Department, Faculty of Medicine of Tunis, Salah Azaiez Institute, El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210090597","https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"02","issue":"03","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pediatric-soft-tissue-sarcoma","display_name":"pediatric soft tissue sarcoma","score":0.8339999914169312},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.984000027179718},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9290000200271606},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9869999885559082},{"id":"https://openalex.org/keywords/embryonal-rhabdomyosarcoma","display_name":"embryonal rhabdomyosarcoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/alveolar-rhabdomyosarcoma","display_name":"alveolar rhabdomyosarcoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.6129999756813049},{"id":"https://openalex.org/keywords/urological-cancer","display_name":"genitourinary cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.753000020980835},{"id":"https://openalex.org/keywords/postoperative-radiotherapy","display_name":"postoperative radiotherapy","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tunisian-children","display_name":"Tunisian children","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.8477938175201416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5818145871162415},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5669176578521729},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.4779908061027527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42374932765960693},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1645890772342682},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.13293495774269104}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.46889/josr.2021.2302","doi":"https://doi.org/10.46889/josr.2021.2302","is_oa":true,"landing_page_url":"https://doi.org/10.46889/josr.2021.2302","pdf_url":"https://doi.org/10.46889/josr.2021.2302","source":{"id":"https://openalex.org/S5407055779","display_name":"Journal of Orthopaedic Science and Research","issn_l":"3068-3726","issn":["3068-3726"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Science and Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.46889/josr.2021.2302","doi":"https://doi.org/10.46889/josr.2021.2302","is_oa":true,"landing_page_url":"https://doi.org/10.46889/josr.2021.2302","pdf_url":"https://doi.org/10.46889/josr.2021.2302","source":{"id":"https://openalex.org/S5407055779","display_name":"Journal of Orthopaedic Science and Research","issn_l":"3068-3726","issn":["3068-3726"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Science and Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3202569578.pdf","grobid_xml":"https://content.openalex.org/works/W3202569578.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1504229479","https://openalex.org/W1693048258","https://openalex.org/W1926287352","https://openalex.org/W2017374699","https://openalex.org/W2056863931","https://openalex.org/W2103690933","https://openalex.org/W2146188663","https://openalex.org/W2155578635","https://openalex.org/W2156822604","https://openalex.org/W2239229810","https://openalex.org/W4251338298"],"related_works":["https://openalex.org/W3217342822","https://openalex.org/W3089196473","https://openalex.org/W2230158152","https://openalex.org/W2415329802","https://openalex.org/W2433859898","https://openalex.org/W7163570489","https://openalex.org/W4292359909","https://openalex.org/W2390976160","https://openalex.org/W4294607205","https://openalex.org/W4399446025"],"abstract_inverted_index":{"Background:":[0],"Rhabdomyosarcoma":[1],"(RMS)":[2],"is":[3],"the":[4,14,68],"most":[5,69,81],"common":[6,70],"softttissue":[7],"tumor":[8],"in":[9,20,39,123],"childhood.We":[10],"aimed":[11],"to":[12,107],"study":[13],"prognostic":[15],"factors":[16,50],"of":[17,27],"non-metastatic":[18,45],"RMS":[19,37,46,66],"Tunisian":[21],"paediatric":[22,28],"patients.Methods:":[23],"We":[24],"reviewed":[25],"data":[26,55],"patients":[29,58],"(aged":[30],"<":[31],"18":[32],"years),":[33],"with":[34,114],"histologically":[35],"confirmed":[36],"treated":[38],"Salah":[40],"Azaiez":[41],"Institute":[42],"for":[43],"a":[44],"during":[47],"20":[48],"years.Prognostic":[49],"were":[51,59,85,96],"studied":[52],"and":[53,63,78,87,90,94,98,111,117],"survival":[54],"analysed.Results:":[56],"75":[57],"included":[60],"(42":[61],"males":[62],"33":[64],"females).Embryonal":[65],"was":[67,104,121],"histologic":[71],"type":[72],"(72%)":[73],"followed":[74],"by":[75],"alveolar":[76],"(21%)":[77],"pleomorphic":[79],"(1%).The":[80],"frequently":[82],"affected":[83],"sites":[84],"head":[86],"neck":[88],"(43%)":[89],"genito-urinary":[91],"(28%).5-year":[92],"OS":[93],"DFS":[95,103],"50%":[97],"26%,":[99],"respectively.By":[100],"univariate":[101,126],"analysis,":[102,127],"significantly":[105],"correlated":[106],"chemotherapy,":[108],"Radiotherapy":[109],"(RT)":[110],"post-surgical":[112],"RT":[113],"p=0.02,":[115],"0.003":[116],"0.01,":[118],"respectively.No":[119],"factor":[120],"significant":[122],"multivariate":[124],"analysis.By":[125],"5-year":[128]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-10-11T00:00:00"}