{"id":"https://openalex.org/W3202253340","doi":null,"title":"Morphological Characterization Cortical Neurons in a mouse model of Rett Syndrome and Design of a Slice Incubation Chamber","display_name":"Morphological Characterization Cortical Neurons in a mouse model of Rett Syndrome and Design of a Slice Incubation Chamber","publication_year":2013,"publication_date":"2013-03-12","ids":{"openalex":"https://openalex.org/W3202253340","mag":"3202253340"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-2719","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2719&context=mqp-all","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2719&context=mqp-all","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2719&context=mqp-all","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089771649","display_name":"Alexandra Clemente","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexandra Clemente","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089771649"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rett-syndrome","display_name":"Rett syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dendritic-morphology","display_name":"dendritic morphology","score":0.7760000228881836},{"id":"https://openalex.org/keywords/dendritic-branching","display_name":"dendritic branching","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.75},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.8870000243186951},{"id":"https://openalex.org/keywords/interneurons","display_name":"interneurons","score":0.996999979019165},{"id":"https://openalex.org/keywords/excitatory-inhibitory-imbalance","display_name":"excitatory-inhibitory imbalance","score":0.949999988079071},{"id":"https://openalex.org/keywords/dendritic-complexity","display_name":"dendritic complexity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.546999990940094},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C2777543196","wikidata":"https://www.wikidata.org/wiki/Q917357","display_name":"Rett syndrome","level":3,"score":0.6112634539604187},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5137213468551636},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.49466606974601746},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3615419864654541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3274303078651428},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3205146789550781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.252294659614563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-2719","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2719&context=mqp-all","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2719&context=mqp-all","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},{"id":"mag:3202253340","doi":null,"is_oa":false,"landing_page_url":"https://digital.wpi.edu/concern/student_works/6d56zz221?locale=fr","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-2719","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2719&context=mqp-all","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2719&context=mqp-all","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3202253340.pdf","grobid_xml":"https://content.openalex.org/works/W3202253340.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1488115555","https://openalex.org/W1536780881","https://openalex.org/W1559742681","https://openalex.org/W1970719523","https://openalex.org/W1984458059","https://openalex.org/W1993341628","https://openalex.org/W1994306864","https://openalex.org/W1994974752","https://openalex.org/W2000313340","https://openalex.org/W2001657520","https://openalex.org/W2010844786","https://openalex.org/W2016279110","https://openalex.org/W2021996855","https://openalex.org/W2025603247","https://openalex.org/W2028600126","https://openalex.org/W2035090622","https://openalex.org/W2035293573","https://openalex.org/W2044246406","https://openalex.org/W2046426203","https://openalex.org/W2055481919","https://openalex.org/W2055667548","https://openalex.org/W2058491837","https://openalex.org/W2059868159","https://openalex.org/W2061311218","https://openalex.org/W2076799937","https://openalex.org/W2082920653","https://openalex.org/W2090051505","https://openalex.org/W2095111987","https://openalex.org/W2096845976","https://openalex.org/W2118489945","https://openalex.org/W2120502497","https://openalex.org/W2125527423","https://openalex.org/W2127311839","https://openalex.org/W2129032286","https://openalex.org/W2135126450","https://openalex.org/W2139411439","https://openalex.org/W2141945292","https://openalex.org/W2143497500","https://openalex.org/W2147204940","https://openalex.org/W2148386452","https://openalex.org/W2152668149","https://openalex.org/W2153900602","https://openalex.org/W2157401166","https://openalex.org/W2159818921","https://openalex.org/W2163719766","https://openalex.org/W2164502083","https://openalex.org/W2188506980"],"related_works":["https://openalex.org/W2042726318","https://openalex.org/W2045042214","https://openalex.org/W7007819382","https://openalex.org/W2792800928","https://openalex.org/W4411605424","https://openalex.org/W2055481919","https://openalex.org/W1977802244","https://openalex.org/W2606140043","https://openalex.org/W2061902674","https://openalex.org/W2002142674"],"abstract_inverted_index":{"Rett":[0],"Syndrome":[1],"(RTT)":[2],"is":[3],"an":[4],"autism-spectrum":[5],"disorder":[6],"caused":[7,32],"by":[8,33,75],"a":[9,29,68,98],"mutation":[10],"in":[11,42,71,85,102],"the":[12,23,43,72,76],"gene":[13],"coding":[14],"for":[15],"methyl-CpG-binding":[16],"protein":[17],"2":[18],"(MeCP2).":[19],"In":[20],"accordance":[21],"with":[22],"theory":[24],"that":[25],"RTT":[26],"arises":[27],"from":[28,56],"excitatory/inhibitory":[30],"imbalance":[31],"dendritic":[34,48,78,82],"alterations,":[35],"we":[36],"hoped":[37],"to":[38,97],"observe":[39],"reduced":[40],"arborization":[41,79],"MeCP2":[44,57,103],"mutant":[45,58],"neurons.":[46],"The":[47],"morphology":[49],"of":[50,91],"pyramidal":[51],"cells":[52],"and":[53,59,64,80,89],"interneurons":[54],"proceeding":[55],"non-mutant":[60],"mice":[61],"were":[62],"reconstructed":[63],"analyzed.":[65],"We":[66],"observed":[67],"possible":[69],"difference":[70],"area":[73],"covered":[74],"basal":[77],"decreased":[81],"complexity":[83],"reflected":[84],"diminished":[86,99],"process":[87],"lengths":[88],"number":[90],"terminal":[92],"segments.":[93],"This":[94],"could":[95],"translate":[96],"integrative":[100],"capacity":[101],"KO":[104],"cells.":[105]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2021-10-11T00:00:00"}
