{"id":"https://openalex.org/W3202213536","doi":"https://doi.org/10.1093/femsyr/foab053","title":"Efficient production of shinorine, a natural sunscreen material, from glucose and xylose by deleting HXK2 encoding hexokinase in Saccharomyces cerevisiae","display_name":"Efficient production of shinorine, a natural sunscreen material, from glucose and xylose by deleting HXK2 encoding hexokinase in Saccharomyces cerevisiae","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3202213536","doi":"https://doi.org/10.1093/femsyr/foab053","mag":"3202213536","pmid":"https://pubmed.ncbi.nlm.nih.gov/34612490"},"language":"en","primary_location":{"id":"doi:10.1093/femsyr/foab053","doi":"https://doi.org/10.1093/femsyr/foab053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/femsyr/foab053","pdf_url":"https://academic.oup.com/femsyr/article-pdf/21/7/foab053/41772683/foab053.pdf","source":{"id":"https://openalex.org/S58380981","display_name":"FEMS Yeast Research","issn_l":"1567-1356","issn":["1567-1356","1567-1364"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Yeast Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/femsyr/article-pdf/21/7/foab053/41772683/foab053.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047288760","display_name":"Chaeyeon Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chaeyeon Jin","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102833547","display_name":"Sojeong Kim","orcid":"https://orcid.org/0000-0002-1662-6855","observed_orcids":["https://orcid.org/0000-0002-1662-6855"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sojeong Kim","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Seokjun Moon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seokjun Moon","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039202908","display_name":"Hyunbin Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunbin Jin","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023801774","display_name":"Ji\u2010Sook Hahn","orcid":"https://orcid.org/0000-0002-3710-3674","observed_orcids":["https://orcid.org/0000-0002-3710-3674","https://orcid.org/0000-0002-5738-4039"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ji-Sook Hahn","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3710-3674","affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023801774"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":2687,"currency":"GBP","value_usd":4030},"apc_paid":null,"fwci":1.0486,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.73451327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.03869999945163727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shinorine","display_name":"shinorine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mycosporine-like-amino-acids","display_name":"mycosporine-like amino acids","score":0.9959999918937683},{"id":"https://openalex.org/keywords/natural-sunscreen","display_name":"natural sunscreen","score":0.6759999990463257},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sedoheptulose-7-phosphate","display_name":"sedoheptulose-7-phosphate","score":0.9549999833106995},{"id":"https://openalex.org/keywords/glucose-catabolism","display_name":"glucose catabolism","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nostoc-punctiforme","display_name":"Nostoc punctiforme","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anabaena-variabilis","display_name":"Anabaena variabilis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/heterologous-biosynthesis","display_name":"heterologous biosynthesis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/uva-absorption","display_name":"UVA absorption","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7163693904876709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6337361335754395},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.5813705921173096},{"id":"https://openalex.org/C2780294150","wikidata":"https://www.wikidata.org/wiki/Q66589603","display_name":"Xylose","level":3,"score":0.5809611082077026},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5332472324371338},{"id":"https://openalex.org/C2779490540","wikidata":"https://www.wikidata.org/wiki/Q10723443","display_name":"Yarrowia","level":3,"score":0.4795265197753906},{"id":"https://openalex.org/C2780261296","wikidata":"https://www.wikidata.org/wiki/Q205654","display_name":"Pentose","level":3,"score":0.4291527271270752},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.41526538133621216},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3807378113269806},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.37700092792510986},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.28544896841049194}],"mesh":[{"descriptor_ui":"D003514","descriptor_name":"Cyclohexylamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006593","descriptor_name":"Hexokinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013473","descriptor_name":"Sunscreening Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014994","descriptor_name":"Xylose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/femsyr/foab053","doi":"https://doi.org/10.1093/femsyr/foab053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/femsyr/foab053","pdf_url":"https://academic.oup.com/femsyr/article-pdf/21/7/foab053/41772683/foab053.pdf","source":{"id":"https://openalex.org/S58380981","display_name":"FEMS Yeast Research","issn_l":"1567-1356","issn":["1567-1356","1567-1364"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Yeast Research","raw_type":"journal-article"},{"id":"pmid:34612490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34612490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS yeast research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/femsyr/foab053","doi":"https://doi.org/10.1093/femsyr/foab053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/femsyr/foab053","pdf_url":"https://academic.oup.com/femsyr/article-pdf/21/7/foab053/41772683/foab053.pdf","source":{"id":"https://openalex.org/S58380981","display_name":"FEMS Yeast Research","issn_l":"1567-1356","issn":["1567-1356","1567-1364"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Yeast Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5857068180","display_name":null,"funder_award_id":"2021R1A2C2003595","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3202213536.pdf","grobid_xml":"https://content.openalex.org/works/W3202213536.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1667784456","https://openalex.org/W1862509991","https://openalex.org/W1983022446","https://openalex.org/W1985191630","https://openalex.org/W1987890761","https://openalex.org/W2013163129","https://openalex.org/W2013894933","https://openalex.org/W2031348086","https://openalex.org/W2064711347","https://openalex.org/W2095021805","https://openalex.org/W2097666362","https://openalex.org/W2101762601","https://openalex.org/W2115420193","https://openalex.org/W2135914993","https://openalex.org/W2142356607","https://openalex.org/W2153381264","https://openalex.org/W2166015109","https://openalex.org/W2169333620","https://openalex.org/W2177691638","https://openalex.org/W2220204085","https://openalex.org/W2337294995","https://openalex.org/W2460972051","https://openalex.org/W2512542445","https://openalex.org/W2561554297","https://openalex.org/W2766289964","https://openalex.org/W2781510265","https://openalex.org/W2792109576","https://openalex.org/W2800172473","https://openalex.org/W2886850841","https://openalex.org/W2906429371","https://openalex.org/W2984966015","https://openalex.org/W3089860792","https://openalex.org/W3091327715","https://openalex.org/W3096220778","https://openalex.org/W3115377984","https://openalex.org/W3149493595","https://openalex.org/W4248351578"],"related_works":["https://openalex.org/W2906429371","https://openalex.org/W4396764793","https://openalex.org/W4310942836","https://openalex.org/W6958533850","https://openalex.org/W4378674979","https://openalex.org/W2781510265","https://openalex.org/W4411505300","https://openalex.org/W7160145024","https://openalex.org/W4403182533","https://openalex.org/W7049033192"],"abstract_inverted_index":{"Mycosporine-like":[0],"amino":[1],"acids":[2],"(MAAs),":[3],"microbial":[4],"secondary":[5],"metabolites":[6],"with":[7,42,207],"ultraviolet":[8],"(UV)":[9],"absorption":[10,45],"properties,":[11],"are":[12],"promising":[13],"natural":[14,26],"sunscreen":[15],"materials.":[16],"Due":[17],"to":[18,98,113,139,152],"the":[19,75,93,104,134,140,148,208],"low":[20],"efficiency":[21],"of":[22,103,157,172,186],"extracting":[23],"MAAs":[24],"from":[25,61,68,137,174],"producers,":[27],"production":[28,80,124],"in":[29,74,164,190],"heterologous":[30],"hosts":[31],"has":[32],"recently":[33],"received":[34],"attention.":[35],"Shinorine":[36,65,79],"is":[37,66],"a":[38,88,99,111,178,203],"well":[39],"characterized":[40],"MAA":[41],"strong":[43],"UV-A":[44],"property.":[46],"Previous,":[47],"we":[48,120,150],"developed":[49],"Saccharomyces":[50],"cerevisiae":[51],"strain":[52],"producing":[53],"shinorine":[54,58,123,145,166,187],"by":[55,84,125,169],"introducing":[56],"four":[57],"biosynthetic":[59],"genes":[60],"cyanobacterium":[62],"Nostoc":[63],"punctiforme.":[64],"produced":[67,189],"sedoheptulose":[69],"7-phosphate":[70],"(S7P),":[71],"an":[72,191],"intermediate":[73],"pentose":[76,141],"phosphate":[77,142],"pathway.":[78],"was":[81,108,161,188],"greatly":[82],"improved":[83,122],"using":[85],"xylose":[86],"as":[87,110],"co-substrate,":[89],"which":[90,131],"can":[91,132],"increase":[92,205],"S7P":[94],"pool.":[95],"However,":[96],"due":[97],"limited":[100],"xylose-utilizing":[101],"capacity":[102],"engineered":[105],"strain,":[106],"glucose":[107,127,138,197],"used":[109],"co-substrate":[112],"support":[114],"cell":[115],"growth.":[116],"In":[117],"this":[118],"study,":[119],"further":[121],"attenuating":[126],"catabolism":[128],"via":[129],"glycolysis,":[130],"redirect":[133],"carbon":[135],"flux":[136],"pathway":[143],"favoring":[144],"production.":[146,167],"Of":[147],"strategies":[149],"examined":[151],"reduce":[153],"glycolytic":[154],"flux,":[155],"deletion":[156],"HXK2,":[158],"encoding":[159,177],"hexokinase,":[160],"most":[162],"effective":[163],"increasing":[165],"Furthermore,":[168],"additional":[170],"expression":[171],"Ava3858":[173],"Anabaena":[175],"variabilis,":[176],"rate-limiting":[179],"enzyme":[180],"2-demethyl":[181],"4-deoxygadusol":[182],"synthase,":[183],"68.4":[184],"mg/L":[185],"optimized":[192],"medium":[193],"containing":[194],"14":[195],"g/L":[196,200],"and":[198],"6":[199],"xylose,":[201],"achieving":[202],"2.2-fold":[204],"compared":[206],"previous":[209],"strain.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-10-11T00:00:00"}
