{"id":"https://openalex.org/W3202062402","doi":null,"title":"The Role of Functional Social Isolation in Mediating the Association Between Baseline Depression and Subsequent Executive Function in the Canadian Longitudinal Study on Aging Comprehensive Cohort","display_name":"The Role of Functional Social Isolation in Mediating the Association Between Baseline Depression and Subsequent Executive Function in the Canadian Longitudinal Study on Aging Comprehensive Cohort","publication_year":2021,"publication_date":"2021-09-27","ids":{"openalex":"https://openalex.org/W3202062402","mag":"3202062402"},"language":"en","primary_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/17536","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/17536","pdf_url":"https://uwspace.uwaterloo.ca/bitstreams/92467239-7a27-4ce0-9155-252798a3bf40/download","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uwspace.uwaterloo.ca/bitstreams/92467239-7a27-4ce0-9155-252798a3bf40/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041999261","display_name":"Anita Josephine Iacono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anita Josephine Iacono","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041999261"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.31470000743865967,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12811","display_name":"Aging, Health, and Disability","score":0.19740000367164612,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9190000295639038},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.875},{"id":"https://openalex.org/keywords/mediation","display_name":"mediation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.7440000176429749},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7070000171661377},{"id":"https://openalex.org/keywords/canadian-longitudinal-study-on-aging","display_name":"Canadian Longitudinal Study on Aging","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6902155876159668},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5852717757225037},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5680556893348694},{"id":"https://openalex.org/C2776893239","wikidata":"https://www.wikidata.org/wiki/Q1778765","display_name":"Social isolation","level":2,"score":0.5369759202003479},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.5351935625076294},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5119112730026245},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5104057192802429},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4582492709159851},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.4395171105861664},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.42926231026649475},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4101969003677368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37165963649749756},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3287147879600525},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23307588696479797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1528400182723999},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.12983748316764832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12054622173309326},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.10600537061691284},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06615468859672546},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/17536","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/17536","pdf_url":"https://uwspace.uwaterloo.ca/bitstreams/92467239-7a27-4ce0-9155-252798a3bf40/download","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master Thesis"},{"id":"mag:3202062402","doi":null,"is_oa":false,"landing_page_url":"https://uwspace.uwaterloo.ca/handle/10012/17536","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/17536","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/17536","pdf_url":"https://uwspace.uwaterloo.ca/bitstreams/92467239-7a27-4ce0-9155-252798a3bf40/download","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3202062402.pdf","grobid_xml":"https://content.openalex.org/works/W3202062402.grobid-xml"},"referenced_works_count":210,"referenced_works":["https://openalex.org/W4780062","https://openalex.org/W60601903","https://openalex.org/W601754225","https://openalex.org/W1490964432","https://openalex.org/W1556060490","https://openalex.org/W1692277390","https://openalex.org/W1754685676","https://openalex.org/W1830481607","https://openalex.org/W1849190772","https://openalex.org/W1857587085","https://openalex.org/W1878430514","https://openalex.org/W1937904763","https://openalex.org/W1947997157","https://openalex.org/W1965097904","https://openalex.org/W1968397534","https://openalex.org/W1968632832","https://openalex.org/W1971440513","https://openalex.org/W1971560161","https://openalex.org/W1977496741","https://openalex.org/W1981287173","https://openalex.org/W1981724415","https://openalex.org/W1982273392","https://openalex.org/W1984767015","https://openalex.org/W1987493933","https://openalex.org/W1990523273","https://openalex.org/W1994431376","https://openalex.org/W1995739430","https://openalex.org/W1996209744","https://openalex.org/W2001740486","https://openalex.org/W2002633477","https://openalex.org/W2005089681","https://openalex.org/W2005120755","https://openalex.org/W2005168276","https://openalex.org/W2005689012","https://openalex.org/W2006555526","https://openalex.org/W2011200818","https://openalex.org/W2012240972","https://openalex.org/W2014172961","https://openalex.org/W2014841928","https://openalex.org/W2015037772","https://openalex.org/W2018722928","https://openalex.org/W2022559509","https://openalex.org/W2036744537","https://openalex.org/W2037855378","https://openalex.org/W2043425268","https://openalex.org/W2044580006","https://openalex.org/W2046719635","https://openalex.org/W2047582412","https://openalex.org/W2048512926","https://openalex.org/W2049025142","https://openalex.org/W2055084163","https://openalex.org/W2060854717","https://openalex.org/W2060878195","https://openalex.org/W2067830228","https://openalex.org/W2073006884","https://openalex.org/W2074932610","https://openalex.org/W2076632788","https://openalex.org/W2079185462","https://openalex.org/W2079549043","https://openalex.org/W2080439255","https://openalex.org/W2082541526","https://openalex.org/W2089516197","https://openalex.org/W2090633717","https://openalex.org/W2091687415","https://openalex.org/W2092443377","https://openalex.org/W2092734400","https://openalex.org/W2093220018","https://openalex.org/W2097522066","https://openalex.org/W2098003297","https://openalex.org/W2098516684","https://openalex.org/W2100551304","https://openalex.org/W2100576147","https://openalex.org/W2105143067","https://openalex.org/W2105778736","https://openalex.org/W2106159603","https://openalex.org/W2110356839","https://openalex.org/W2112074475","https://openalex.org/W2112405972","https://openalex.org/W2112778345","https://openalex.org/W2115916424","https://openalex.org/W2116444973","https://openalex.org/W2122122907","https://openalex.org/W2127169747","https://openalex.org/W2127782460","https://openalex.org/W2129203605","https://openalex.org/W2130619528","https://openalex.org/W2131045843","https://openalex.org/W2131334268","https://openalex.org/W2131862642","https://openalex.org/W2134364918","https://openalex.org/W2136080202","https://openalex.org/W2138720796","https://openalex.org/W2140884566","https://openalex.org/W2141279367","https://openalex.org/W2141536496","https://openalex.org/W2144506732","https://openalex.org/W2147068934","https://openalex.org/W2149575392","https://openalex.org/W2150037324","https://openalex.org/W2150230435","https://openalex.org/W2151758923","https://openalex.org/W2157613827","https://openalex.org/W2157984263","https://openalex.org/W2158219051","https://openalex.org/W2158690154","https://openalex.org/W2159030663","https://openalex.org/W2162294947","https://openalex.org/W2165243546","https://openalex.org/W2167354390","https://openalex.org/W2167987787","https://openalex.org/W2169719947","https://openalex.org/W2171293615","https://openalex.org/W2258995012","https://openalex.org/W2265901560","https://openalex.org/W2267093776","https://openalex.org/W2321649157","https://openalex.org/W2341299966","https://openalex.org/W2346048686","https://openalex.org/W2353483402","https://openalex.org/W2395116472","https://openalex.org/W2401519588","https://openalex.org/W2409473085","https://openalex.org/W2418872436","https://openalex.org/W2419087408","https://openalex.org/W2419641359","https://openalex.org/W2466089802","https://openalex.org/W2469970817","https://openalex.org/W2484473026","https://openalex.org/W2510128050","https://openalex.org/W2511013130","https://openalex.org/W2518948616","https://openalex.org/W2520187870","https://openalex.org/W2524657855","https://openalex.org/W2536995545","https://openalex.org/W2548380318","https://openalex.org/W2554654999","https://openalex.org/W2560240165","https://openalex.org/W2583693676","https://openalex.org/W2583762687","https://openalex.org/W2587052381","https://openalex.org/W2589167453","https://openalex.org/W2592310577","https://openalex.org/W2595410546","https://openalex.org/W2601080654","https://openalex.org/W2601251367","https://openalex.org/W2726989147","https://openalex.org/W2736594305","https://openalex.org/W2746201090","https://openalex.org/W2755755460","https://openalex.org/W2758494687","https://openalex.org/W2761559198","https://openalex.org/W2767859606","https://openalex.org/W2777525821","https://openalex.org/W2791321831","https://openalex.org/W2793689244","https://openalex.org/W2796656925","https://openalex.org/W2800752517","https://openalex.org/W2801411947","https://openalex.org/W2803056285","https://openalex.org/W2804839060","https://openalex.org/W2807516012","https://openalex.org/W2810875315","https://openalex.org/W2887898420","https://openalex.org/W2889337733","https://openalex.org/W2892390537","https://openalex.org/W2892508878","https://openalex.org/W2897788276","https://openalex.org/W2898523231","https://openalex.org/W2899152301","https://openalex.org/W2902405936","https://openalex.org/W2904489586","https://openalex.org/W2909376810","https://openalex.org/W2910441929","https://openalex.org/W2911050083","https://openalex.org/W2912682745","https://openalex.org/W2914353810","https://openalex.org/W2914535606","https://openalex.org/W2927454481","https://openalex.org/W2932097920","https://openalex.org/W2941351157","https://openalex.org/W2947755320","https://openalex.org/W2952600397","https://openalex.org/W2961148372","https://openalex.org/W2964643970","https://openalex.org/W2968455027","https://openalex.org/W2972265869","https://openalex.org/W2979986778","https://openalex.org/W2980931757","https://openalex.org/W2981456320","https://openalex.org/W2982106572","https://openalex.org/W2985166481","https://openalex.org/W2991783191","https://openalex.org/W2995367697","https://openalex.org/W2996990963","https://openalex.org/W3004727685","https://openalex.org/W3011247000","https://openalex.org/W3011663503","https://openalex.org/W3011858878","https://openalex.org/W3014379463","https://openalex.org/W3014391114","https://openalex.org/W3014687011","https://openalex.org/W3036966371","https://openalex.org/W3045839399","https://openalex.org/W3080218604","https://openalex.org/W3089091526","https://openalex.org/W3109814052","https://openalex.org/W3126301492","https://openalex.org/W3131360919","https://openalex.org/W3136209728","https://openalex.org/W4294185218"],"related_works":["https://openalex.org/W4381715678","https://openalex.org/W6990321333","https://openalex.org/W7124162795","https://openalex.org/W7160327948","https://openalex.org/W7211967376","https://openalex.org/W4410980316","https://openalex.org/W4407772001","https://openalex.org/W2975177791","https://openalex.org/W4407054337","https://openalex.org/W7125375913"],"abstract_inverted_index":{"Background:":[0],"Depression":[1],"is":[2,20,52],"a":[3,148],"risk":[4],"factor":[5],"for":[6,134,193],"decline":[7],"in":[8,129,211,226,236],"executive":[9,18,48,80,182,209,234],"function.":[10],"One":[11],"mechanism":[12],"that":[13,218],"may":[14,201,232],"link":[15],"depression":[16,46,69,72,170,207,225],"to":[17,26,37,94],"function":[19,49,81,183,210,235],"functional":[21,39,59,221],"social":[22,33,40,60,145,199,222],"isolation,":[23],"which":[24,38],"pertains":[25],"the":[27,43,66,97,152,204],"qualitative":[28],"and":[29,47,79,86,127,138,181,189,208,215,230],"behavioural":[30],"aspects":[31],"of":[32,151],"interactions.":[34],"The":[35],"extent":[36],"isolation":[41,61,146,200,223],"mediates":[42,65],"association":[44,67,153,205],"between":[45,68,154,206],"over":[50,108],"time":[51],"unknown.":[53],"\\n":[54,88,142,196],"\\nObjective:":[55],"To":[56],"determine":[57],"whether":[58],"at":[62,76,82],"follow-up":[63],"(T2)":[64],"(self-reported":[70],"clinical":[71,169],"or":[73,167,224],"depressive":[74,155],"symptoms)":[75],"baseline":[77],"(T1)":[78],"T2":[83],"across":[84,124],"age":[85],"sex.":[87],"\\nMethods:":[89],"Community-dwelling":[90],"adults":[91],"aged":[92,187,213,228],"45":[93],"85":[95],"from":[96],"Canadian":[98],"Longitudinal":[99],"Study":[100],"on":[101],"Aging":[102],"(CLSA)":[103],"Comprehensive":[104],"Cohort":[105],"were":[106,119],"followed":[107],"three":[109],"years":[110],"(complete":[111],"case":[112],"analysis,":[113],"n=14,133).":[114],"Indirect":[115],"(i.e.,":[116],"mediation)":[117],"effects":[118],"assessed":[120],"using":[121],"percentile":[122],"bootstrapping":[123],"moderators":[125],"(age":[126],"sex)":[128],"conditional":[130],"process":[131],"analysis":[132],"controlling":[133,192],"sociodemographic,":[135],"physical":[136],"health":[137,139],"behaviour":[140],"covariates.":[141,195],"\\nResults:":[143],"Functional":[144,198],"was":[147],"significant":[149],"mediator":[150],"symptoms":[156],"(\u03b2":[157,171],"=":[158,165,172,179],"-0.0032,":[159],"95%":[160,174],"CI:":[161,175],"-0.0069,":[162],"-0.0005;":[163],"PM":[164,178],"8.0%)":[166],"self-reported":[168],"-0.0644,":[173],"-0.1282,":[176],"-0.0166;":[177],"17.5%)":[180],"only":[184],"among":[185],"women":[186,212,227],"75":[188,214,229],"older,":[190],"after":[191],"T1":[194],"\\nDiscussion:":[197],"partially":[202],"explain":[203],"older.":[216],"Interventions":[217],"reduce":[219],"either":[220],"older":[231],"promote":[233],"this":[237],"population.":[238]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-11T00:00:00"}
