{"id":"https://openalex.org/W3202019417","doi":"https://doi.org/10.1039/d1ra04890b","title":"Biomedical nanobubbles and opportunities for microfluidics","display_name":"Biomedical nanobubbles and opportunities for microfluidics","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3202019417","doi":"https://doi.org/10.1039/d1ra04890b","mag":"3202019417","pmid":"https://pubmed.ncbi.nlm.nih.gov/35493576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9042222"},"language":"en","primary_location":{"id":"doi:10.1039/d1ra04890b","doi":"https://doi.org/10.1039/d1ra04890b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d1ra04890b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d1ra04890b","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d1ra04890b","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ali A. Paknahad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4399598460","display_name":"Unity Health Toronto","ror":"https://ror.org/012x5xb44","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4405285845","display_name":"Keenan Research Centre for Biomedical Science","ror":"https://ror.org/00f7km543","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]},{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ali A. Paknahad","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I530967"]},{"raw_affiliation_string":"Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada","institution_ids":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074743146","display_name":"Liam Kerr","orcid":"https://orcid.org/0000-0003-2795-5600","observed_orcids":["https://orcid.org/0000-0003-2795-5600"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4399598460","display_name":"Unity Health Toronto","ror":"https://ror.org/012x5xb44","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4405285845","display_name":"Keenan Research Centre for Biomedical Science","ror":"https://ror.org/00f7km543","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]},{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Liam Kerr","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I530967"]},{"raw_affiliation_string":"Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada","institution_ids":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049558807","display_name":"Daniel A. Wong","orcid":"https://orcid.org/0000-0002-5539-6490","observed_orcids":["https://orcid.org/0000-0002-5539-6490"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4399598460","display_name":"Unity Health Toronto","ror":"https://ror.org/012x5xb44","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4405285845","display_name":"Keenan Research Centre for Biomedical Science","ror":"https://ror.org/00f7km543","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]},{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Daniel A. Wong","raw_affiliation_strings":["Department of Electrical, Computer, and Biomedical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5539-6490","affiliations":[{"raw_affiliation_string":"Department of Electrical, Computer, and Biomedical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I530967"]},{"raw_affiliation_string":"Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada","institution_ids":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027024186","display_name":"Michael C. Kolios","orcid":"https://orcid.org/0000-0002-9994-8293","observed_orcids":["https://orcid.org/0000-0002-9994-8293"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4399598460","display_name":"Unity Health Toronto","ror":"https://ror.org/012x5xb44","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4405285845","display_name":"Keenan Research Centre for Biomedical Science","ror":"https://ror.org/00f7km543","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]},{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael C. Kolios","raw_affiliation_strings":["Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3, Canada","Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9994-8293","affiliations":[{"raw_affiliation_string":"Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3, Canada","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I530967"]},{"raw_affiliation_string":"Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada","institution_ids":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088356878","display_name":"Scott S. H. Tsai","orcid":"https://orcid.org/0000-0001-6607-8191","observed_orcids":["https://orcid.org/0000-0001-6607-8191"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4399598460","display_name":"Unity Health Toronto","ror":"https://ror.org/012x5xb44","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I4405285845","display_name":"Keenan Research Centre for Biomedical Science","ror":"https://ror.org/00f7km543","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]},{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Scott S. H. Tsai","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","Graduate Program in Biomedical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6607-8191","affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"Graduate Program in Biomedical Engineering, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario M5B 1T8, Canada","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I530967"]},{"raw_affiliation_string":"Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada","institution_ids":["https://openalex.org/I4399598460","https://openalex.org/I4405285845"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088356878"],"corresponding_institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I4399598460","https://openalex.org/I4405285845","https://openalex.org/I530967"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.4128,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.32666667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"52","first_page":"32750","last_page":"32774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11401","display_name":"Minerals Flotation and Separation Techniques","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11401","display_name":"Minerals Flotation and Separation Techniques","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.20909999310970306,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bulk-nanobubbles","display_name":"bulk nanobubbles","score":0.8830000162124634},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nanobubble-generation","display_name":"nanobubble generation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ultrasound-contrast-enhancement","display_name":"ultrasound contrast enhancement","score":0.8799999952316284},{"id":"https://openalex.org/keywords/malaria-diagnosis","display_name":"malaria diagnosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"organ-on-a-chip","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7708369493484497},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.7031986713409424},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3342653214931488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32355040311813354},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29729199409484863},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.17517757415771484}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1039/d1ra04890b","doi":"https://doi.org/10.1039/d1ra04890b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d1ra04890b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d1ra04890b","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"doi:10.32920/24026673","doi":"https://doi.org/10.32920/24026673","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32920/24026673","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},{"id":"doi:10.32920/27912714.v1","doi":"https://doi.org/10.32920/27912714.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32920/27912714.v1","pdf_url":null,"source":null,"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9042222","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9042222","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmid:35493576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35493576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/27912714","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Biomedical_nanobubbles_and_opportunities_for_microfluidics/27912714","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1039/d1ra04890b","doi":"https://doi.org/10.1039/d1ra04890b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d1ra04890b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d1ra04890b","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1097593322","display_name":null,"funder_award_id":"CPG 146484","funder_id":"https://openalex.org/F4320319952","funder_display_name":"Canada Foundation for Innovation"},{"id":"https://openalex.org/G1944040268","display_name":null,"funder_award_id":"CPG 146484","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G279537525","display_name":null,"funder_award_id":"RGPIN 2017 ?","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G3750655874","display_name":null,"funder_award_id":"36687","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G3978669723","display_name":null,"funder_award_id":"RGPIN-2019-04618","funder_id":"https://openalex.org/F4320319952","funder_display_name":"Canada Foundation for Innovation"},{"id":"https://openalex.org/G459041169","display_name":null,"funder_award_id":"36442","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G4822697544","display_name":null,"funder_award_id":"RGPIN-2017-06496","funder_id":"https://openalex.org/F4320319952","funder_display_name":"Canada Foundation for Innovation"},{"id":"https://openalex.org/G6138338407","display_name":"Fundamental studies in the temporal changes of light and sound scattering and absorption to generate new forms of biological and biomaterial contrast","funder_award_id":"rgpin-2017-06496","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7032691593","display_name":null,"funder_award_id":"30994","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8130000942","display_name":"All-aqueous water-in-water droplet microfluidics","funder_award_id":"rgpin-2019-04618","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G832689143","display_name":null,"funder_award_id":"RGPIN-2019","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320319952","display_name":"Canada Foundation for Innovation","ror":"https://ror.org/000az4664"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3202019417.pdf","grobid_xml":"https://content.openalex.org/works/W3202019417.grobid-xml"},"referenced_works_count":177,"referenced_works":["https://openalex.org/W54782832","https://openalex.org/W139532289","https://openalex.org/W159877510","https://openalex.org/W1665098425","https://openalex.org/W1670069093","https://openalex.org/W1673579099","https://openalex.org/W1727492847","https://openalex.org/W1744726727","https://openalex.org/W1747469260","https://openalex.org/W1857111139","https://openalex.org/W1951979505","https://openalex.org/W1962400655","https://openalex.org/W1966626984","https://openalex.org/W1969793936","https://openalex.org/W1972442039","https://openalex.org/W1972861065","https://openalex.org/W1973914215","https://openalex.org/W1979801398","https://openalex.org/W1983570934","https://openalex.org/W1990938811","https://openalex.org/W1995369048","https://openalex.org/W1996681886","https://openalex.org/W2004591922","https://openalex.org/W2005623320","https://openalex.org/W2006252514","https://openalex.org/W2007037818","https://openalex.org/W2007347895","https://openalex.org/W2012099137","https://openalex.org/W2012747342","https://openalex.org/W2015279811","https://openalex.org/W2017473180","https://openalex.org/W2019982556","https://openalex.org/W2020087502","https://openalex.org/W2023074414","https://openalex.org/W2023091227","https://openalex.org/W2027137358","https://openalex.org/W2028136963","https://openalex.org/W2031419583","https://openalex.org/W2031565553","https://openalex.org/W2031937820","https://openalex.org/W2037333675","https://openalex.org/W2037795122","https://openalex.org/W2038804240","https://openalex.org/W2039535868","https://openalex.org/W2042144858","https://openalex.org/W2042338436","https://openalex.org/W2043300744","https://openalex.org/W2044610013","https://openalex.org/W2044638539","https://openalex.org/W2049682101","https://openalex.org/W2050714394","https://openalex.org/W2050771782","https://openalex.org/W2054924910","https://openalex.org/W2058150095","https://openalex.org/W2058222938","https://openalex.org/W2063112494","https://openalex.org/W2063703688","https://openalex.org/W2065711499","https://openalex.org/W2065999058","https://openalex.org/W2068637594","https://openalex.org/W2071319032","https://openalex.org/W2072308542","https://openalex.org/W2072895181","https://openalex.org/W2074138119","https://openalex.org/W2074353166","https://openalex.org/W2074369961","https://openalex.org/W2075311306","https://openalex.org/W2078224390","https://openalex.org/W2080202676","https://openalex.org/W2087580430","https://openalex.org/W2088642020","https://openalex.org/W2089080726","https://openalex.org/W2092605209","https://openalex.org/W2096033494","https://openalex.org/W2101397512","https://openalex.org/W2102828744","https://openalex.org/W2107941718","https://openalex.org/W2119778962","https://openalex.org/W2120065201","https://openalex.org/W2127929689","https://openalex.org/W2131083445","https://openalex.org/W2131883639","https://openalex.org/W2136446623","https://openalex.org/W2147585883","https://openalex.org/W2149562261","https://openalex.org/W2152160351","https://openalex.org/W2157048271","https://openalex.org/W2157387668","https://openalex.org/W2209851710","https://openalex.org/W2214252443","https://openalex.org/W2280918202","https://openalex.org/W2314806056","https://openalex.org/W2324905769","https://openalex.org/W2341878157","https://openalex.org/W2342045650","https://openalex.org/W2379615365","https://openalex.org/W2401262504","https://openalex.org/W2462217047","https://openalex.org/W2469629034","https://openalex.org/W2508430161","https://openalex.org/W2508608097","https://openalex.org/W2524993827","https://openalex.org/W2528451823","https://openalex.org/W2580767461","https://openalex.org/W2591792436","https://openalex.org/W2604830385","https://openalex.org/W2694050140","https://openalex.org/W2731570319","https://openalex.org/W2756324167","https://openalex.org/W2763263478","https://openalex.org/W2767424529","https://openalex.org/W2773366532","https://openalex.org/W2780012931","https://openalex.org/W2782711509","https://openalex.org/W2789419963","https://openalex.org/W2789966157","https://openalex.org/W2791935253","https://openalex.org/W2804817826","https://openalex.org/W2806774512","https://openalex.org/W2890988943","https://openalex.org/W2892851850","https://openalex.org/W2893940793","https://openalex.org/W2894918092","https://openalex.org/W2898998542","https://openalex.org/W2900496893","https://openalex.org/W2900667983","https://openalex.org/W2900789066","https://openalex.org/W2905757330","https://openalex.org/W2907643426","https://openalex.org/W2909240409","https://openalex.org/W2909272945","https://openalex.org/W2911336091","https://openalex.org/W2918951092","https://openalex.org/W2919210400","https://openalex.org/W2923196085","https://openalex.org/W2928125163","https://openalex.org/W2939601796","https://openalex.org/W2946139765","https://openalex.org/W2946666505","https://openalex.org/W2951681746","https://openalex.org/W2956180571","https://openalex.org/W2964903749","https://openalex.org/W2969015422","https://openalex.org/W2991371752","https://openalex.org/W2996696635","https://openalex.org/W2997998095","https://openalex.org/W3000048870","https://openalex.org/W3000222383","https://openalex.org/W3006534931","https://openalex.org/W3007349550","https://openalex.org/W3008347668","https://openalex.org/W3009176187","https://openalex.org/W3014306876","https://openalex.org/W3014719573","https://openalex.org/W3019353188","https://openalex.org/W3020503202","https://openalex.org/W3022461256","https://openalex.org/W3034660618","https://openalex.org/W3044242368","https://openalex.org/W3045302278","https://openalex.org/W3084168244","https://openalex.org/W3103540983","https://openalex.org/W3128511975","https://openalex.org/W3146146685","https://openalex.org/W3148600717","https://openalex.org/W3149852802","https://openalex.org/W3158419016","https://openalex.org/W3159034163","https://openalex.org/W4242845573","https://openalex.org/W4252621551","https://openalex.org/W6600804061","https://openalex.org/W6602169078","https://openalex.org/W6603036350","https://openalex.org/W6605040138","https://openalex.org/W6608782863","https://openalex.org/W6737719158","https://openalex.org/W6804761195"],"related_works":["https://openalex.org/W4386583550","https://openalex.org/W4409889718","https://openalex.org/W4313368163","https://openalex.org/W2892220297","https://openalex.org/W3149852802","https://openalex.org/W3208725882","https://openalex.org/W3137219943","https://openalex.org/W4280512502","https://openalex.org/W4386223812","https://openalex.org/W4212766834"],"abstract_inverted_index":{"The":[0],"use":[1,66],"of":[2,18,43,51,64,72,83,92,107,115,159,165,172,186],"bulk":[3,26,52,93,121,166],"nanobubbles":[4,53,94,106],"in":[5,9,95],"biomedicine":[6],"is":[7,13],"increasing":[8],"recent":[10],"years,":[11],"which":[12,116],"attributable":[14],"to":[15,37,61,104,181,189],"the":[16,41,48,62,70,84,140,151,163,183],"array":[17],"therapeutic":[19],"and":[20,33,40,56,78,89,110,143,169],"diagnostic":[21],"tools":[22],"promised":[23],"by":[24,147],"developing":[25],"nanobubble":[27,122,167],"technologies.":[28],"From":[29],"cancer":[30],"drug":[31],"delivery":[32],"ultrasound":[34],"contrast":[35],"enhancement":[36],"malaria":[38],"detection":[39],"diagnosis":[42],"acute":[44],"donor":[45],"tissue":[46],"rejection,":[47],"potential":[49],"applications":[50],"are":[54,101,117],"broad":[55],"diverse.":[57],"Developing":[58],"these":[59],"technologies":[60],"point":[63],"clinical":[65],"may":[67,149],"significantly":[68],"impact":[69],"quality":[71,164],"patient":[73],"care.":[74],"This":[75],"review":[76],"compiles":[77],"summarizes":[79],"a":[80,133],"representative":[81],"collection":[82],"current":[85],"applications,":[86],"fabrication":[87],"techniques,":[88],"characterization":[90],"methods":[91,100],"biomedicine.":[96],"Current":[97],"state-of-the-art":[98],"generation":[99],"not":[102,128],"designed":[103],"create":[105],"high":[108],"concentration":[109],"low":[111],"polydispersity,":[112],"both":[113],"characteristics":[114],"important":[118],"for":[119,135,161],"several":[120],"applications.":[123],"To":[124],"date,":[125],"microfluidics":[126,148,160],"has":[127],"been":[129],"widely":[130],"considered":[131],"as":[132,178],"tool":[134],"generating":[136],"nanobubbles,":[137],"even":[138],"though":[139],"small-scale":[141],"precision":[142],"real-time":[144],"control":[145],"offered":[146],"overcome":[150],"challenges":[152],"mentioned":[153],"above.":[154],"We":[155],"suggest":[156],"possible":[157],"uses":[158],"improving":[162],"populations":[168],"propose":[170],"ways":[171],"leveraging":[173],"existing":[174],"microfluidic":[175],"technologies,":[176],"such":[177],"organ-on-a-chip":[179],"platforms,":[180],"expand":[182],"experimental":[184],"toolbox":[185],"researchers":[187],"working":[188],"develop":[190],"biomedical":[191],"nanobubbles.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-11T00:00:00"}