{"id":"https://openalex.org/W3202019255","doi":"https://doi.org/10.3390/pharmaceutics13101558","title":"Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Patients with Chronic Graft-versus-Host Disease: A First-in-Human Study","display_name":"Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Patients with Chronic Graft-versus-Host Disease: A First-in-Human Study","publication_year":2021,"publication_date":"2021-09-26","ids":{"openalex":"https://openalex.org/W3202019255","doi":"https://doi.org/10.3390/pharmaceutics13101558","mag":"3202019255","pmid":"https://pubmed.ncbi.nlm.nih.gov/34683851","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8538664"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics13101558","doi":"https://doi.org/10.3390/pharmaceutics13101558","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13101558","pdf_url":"https://www.mdpi.com/1999-4923/13/10/1558/pdf?version=1632897991","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/13/10/1558/pdf?version=1632897991","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089064745","display_name":"Eidi Christensen","orcid":"https://orcid.org/0000-0002-6848-9290","observed_orcids":["https://orcid.org/0000-0002-6848-9290"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Eidi Christensen","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway","Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway","Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0002-6848-9290","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I4210104358"]},{"raw_affiliation_string":"Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022820687","display_name":"Olav Andreas Foss","orcid":"https://orcid.org/0000-0001-8232-4356","observed_orcids":["https://orcid.org/0000-0001-8232-4356"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Olav A. Foss","raw_affiliation_strings":["Department of Neuroscience and Movement Science, Norwegian University of Science and Technology, 7030 Trondheim, Norway","Department of Orthopaedic Surgery, Clinic of Orthopaedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway"],"raw_orcid":"https://orcid.org/0000-0001-8232-4356","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Movement Science, Norwegian University of Science and Technology, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Clinic of Orthopaedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I4210104358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103161374","display_name":"Petter Quist\u2010Paulsen","orcid":"https://orcid.org/0009-0003-6201-8548","observed_orcids":["https://orcid.org/0009-0003-6201-8548","https://orcid.org/0000-0002-8164-016X"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Petter Quist-Paulsen","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway","Department of Haematology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"Department of Haematology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I4210104358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059497329","display_name":"Ingrid Staur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ingrid Staur","raw_affiliation_strings":["Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I4210104358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056262301","display_name":"Frode Pettersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Frode Pettersen","raw_affiliation_strings":["Department of Nephrology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I4210104358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049608650","display_name":"Toril Holien","orcid":"https://orcid.org/0000-0002-2051-5824","observed_orcids":["https://orcid.org/0000-0002-2051-5824"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Toril Holien","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway","Department of Haematology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway","Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"Department of Haematology, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway","institution_ids":["https://openalex.org/I4210104358"]},{"raw_affiliation_string":"Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089578099","display_name":"Petras Juzenas","orcid":"https://orcid.org/0000-0002-0114-903X","observed_orcids":["https://orcid.org/0000-0002-0114-903X"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Petras Juzenas","raw_affiliation_strings":["Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0002-0114-903X","affiliations":[{"raw_affiliation_string":"Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024811171","display_name":"Qian Peng","orcid":"https://orcid.org/0000-0003-3261-3330","observed_orcids":["https://orcid.org/0000-0003-3261-3330"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN","NO"],"is_corresponding":false,"raw_author_name":"Qian Peng","raw_affiliation_strings":["Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, Shanghai 200433, China","Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0003-3261-3330","affiliations":[{"raw_affiliation_string":"Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089064745"],"corresponding_institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I204778367","https://openalex.org/I4210104358"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":0.6878,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.60402992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"13","issue":"10","first_page":"1558","last_page":"1558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.1509000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.7480000257492065},{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extracorporeal-photopheresis","display_name":"extracorporeal photopheresis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/8-methoxypsoralen","display_name":"8-methoxypsoralen","score":0.9710000157356262},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.8889999985694885},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7279999852180481},{"id":"https://openalex.org/keywords/first-in-human-study","display_name":"first-in-human study","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2909962264","wikidata":"https://www.wikidata.org/wiki/Q774032","display_name":"Extracorporeal Photopheresis","level":4,"score":0.879233181476593},{"id":"https://openalex.org/C2781468836","wikidata":"https://www.wikidata.org/wiki/Q774032","display_name":"Photopheresis","level":3,"score":0.8584388494491577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8351069688796997},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7605330944061279},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7430160045623779},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.5795716643333435},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5632765889167786},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4479838013648987},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4251541793346405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40572649240493774},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3876194953918457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38165318965911865},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3657214641571045},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33513516187667847},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.23599499464035034},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/pharmaceutics13101558","doi":"https://doi.org/10.3390/pharmaceutics13101558","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13101558","pdf_url":"https://www.mdpi.com/1999-4923/13/10/1558/pdf?version=1632897991","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8538664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8538664","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:34683851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34683851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:507c3c3c3a2e465b98cd1525f38a5ead","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/507c3c3c3a2e465b98cd1525f38a5ead","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 13, Iss 10, p 1558 (2021)","raw_type":"article"},{"id":"pmh:oai:ntnuopen.ntnu.no:11250/2825254","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11250/2825254","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1-13","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics13101558","doi":"https://doi.org/10.3390/pharmaceutics13101558","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13101558","pdf_url":"https://www.mdpi.com/1999-4923/13/10/1558/pdf?version=1632897991","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1944422820","display_name":null,"funder_award_id":"190397","funder_id":"https://openalex.org/F4320310758","funder_display_name":"Kreftforeningen"},{"id":"https://openalex.org/G3419111948","display_name":null,"funder_award_id":"2020069","funder_id":"https://openalex.org/F4320335102","funder_display_name":"Helse S\u00f8r-\u00d8st RHF"},{"id":"https://openalex.org/G4152283517","display_name":null,"funder_award_id":"2016092","funder_id":"https://openalex.org/F4320335102","funder_display_name":"Helse S\u00f8r-\u00d8st RHF"},{"id":"https://openalex.org/G6262076514","display_name":null,"funder_award_id":"2015075","funder_id":"https://openalex.org/F4320335102","funder_display_name":"Helse S\u00f8r-\u00d8st RHF"},{"id":"https://openalex.org/G7116634579","display_name":null,"funder_award_id":"2015075,2016092, 2017058,2020069","funder_id":"https://openalex.org/F4320335102","funder_display_name":"Helse S\u00f8r-\u00d8st RHF"},{"id":"https://openalex.org/G8841062102","display_name":null,"funder_award_id":"2017058","funder_id":"https://openalex.org/F4320335102","funder_display_name":"Helse S\u00f8r-\u00d8st RHF"}],"funders":[{"id":"https://openalex.org/F4320310758","display_name":"Kreftforeningen","ror":"https://ror.org/01925vb10"},{"id":"https://openalex.org/F4320335102","display_name":"Helse S\u00f8r-\u00d8st RHF","ror":"https://ror.org/02qx2s478"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3202019255.pdf","grobid_xml":"https://content.openalex.org/works/W3202019255.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1964219512","https://openalex.org/W1965378211","https://openalex.org/W1976916629","https://openalex.org/W1983489694","https://openalex.org/W2011637304","https://openalex.org/W2012434943","https://openalex.org/W2013894560","https://openalex.org/W2018351351","https://openalex.org/W2021051988","https://openalex.org/W2021957372","https://openalex.org/W2032660269","https://openalex.org/W2034152630","https://openalex.org/W2044096564","https://openalex.org/W2044158364","https://openalex.org/W2063197182","https://openalex.org/W2080081628","https://openalex.org/W2086092185","https://openalex.org/W2101212185","https://openalex.org/W2107464754","https://openalex.org/W2125372543","https://openalex.org/W2131969113","https://openalex.org/W2137164598","https://openalex.org/W2138730271","https://openalex.org/W2144998822","https://openalex.org/W2155817714","https://openalex.org/W2278220001","https://openalex.org/W2337557724","https://openalex.org/W2379365975","https://openalex.org/W2618073389","https://openalex.org/W2789629534","https://openalex.org/W2971137587","https://openalex.org/W2999456544","https://openalex.org/W3004705260","https://openalex.org/W3091855120","https://openalex.org/W3092554446","https://openalex.org/W6655791763"],"related_works":["https://openalex.org/W4399729994","https://openalex.org/W4402926801","https://openalex.org/W2898611810","https://openalex.org/W2401125732","https://openalex.org/W1153605306","https://openalex.org/W2394562640","https://openalex.org/W2299856539","https://openalex.org/W2789629534","https://openalex.org/W4405875506","https://openalex.org/W2899883127"],"abstract_inverted_index":{"Extracorporeal":[0],"photopheresis":[1],"(ECP),":[2],"an":[3,68],"immunomodulatory":[4],"therapy":[5],"for":[6],"the":[7,28,101,124,127,163,168,180],"treatment":[8],"of":[9,30,57,93,105,126,162],"chronic":[10],"graft-versus-host":[11],"disease":[12],"(cGvHD),":[13],"exposes":[14],"isolated":[15],"white":[16],"blood":[17],"cells":[18,44],"to":[19,26,34,99,123,175,179],"photoactivatable":[20],"8-methoxypsoralen":[21],"(8-MOP)":[22],"and":[23,42,48,61,84,103,156,190],"UVA":[24],"light":[25,62],"induce":[27],"apoptosis":[29],"T-cells":[31,78],"and,":[32],"hence,":[33],"modulate":[35],"immune":[36],"responses.":[37],"However,":[38],"8-MOP-ECP":[39],"kills":[40,77],"diseased":[41],"healthy":[43],"with":[45,89],"no":[46],"selectivity":[47],"has":[49],"limited":[50],"efficacy":[51],"in":[52,107,115,134],"many":[53],"cases.":[54],"The":[55,91,110,183],"use":[56],"5-aminolevulinic":[58],"acid":[59],"(ALA)":[60],"(ALA-based":[63],"photodynamic":[64],"therapy)":[65],"may":[66],"be":[67,176],"alternative,":[69],"as":[70],"ex":[71],"vivo":[72],"investigations":[73],"show":[74],"that":[75,186],"ALA-ECP":[76,106,187],"from":[79],"cGvHD":[80,108,196],"patients":[81],"more":[82],"selectively":[83],"efficiently":[85],"than":[86],"those":[87],"treated":[88],"8-MOP-ECP.":[90],"purpose":[92],"this":[94],"phase":[95],"I-(II)":[96],"study":[97,111,181],"was":[98,120],"evaluate":[100],"safety":[102,170],"tolerability":[104],"patients.":[109,117,197],"included":[112],"82":[113],"treatments":[114],"five":[116],"One":[118],"patient":[119],"discharged":[121],"due":[122],"progression":[125],"haematological":[128],"disease.":[129],"No":[130],"significant":[131],"persistent":[132],"changes":[133],"vital":[135],"signs":[136],"or":[137],"laboratory":[138],"values":[139],"were":[140,147,151,154,158,173],"detected.":[141],"In":[142],"total,":[143],"62":[144],"adverse":[145,164],"events":[146,150,165],"reported.":[148],"Two":[149],"severe,":[152],"17":[153],"moderate,":[155],"43":[157],"mild":[159],"symptoms.":[160],"None":[161],"evaluated":[166],"by":[167,195],"internal":[169],"review":[171],"committee":[172],"considered":[174],"likely":[177],"related":[178],"medication.":[182],"results":[184],"indicate":[185],"is":[188,191],"safe":[189],"mainly":[192],"tolerated":[193],"well":[194]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-10-11T00:00:00"}
