{"id":"https://openalex.org/W3202018474","doi":null,"title":"FORMULASI DAN UJI AKTIVITAS IMUNOMODULATOR NANOPARTIKEL POLIMERIK EKSTRAK ETANOLIK HERBA MENIRAN (Phyllanthus niruri L.)","display_name":"FORMULASI DAN UJI AKTIVITAS IMUNOMODULATOR NANOPARTIKEL POLIMERIK EKSTRAK ETANOLIK HERBA MENIRAN (Phyllanthus niruri L.)","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3202018474","mag":"3202018474"},"language":"id","primary_location":{"id":"mag:3202018474","doi":null,"is_oa":false,"landing_page_url":"http://etd.repository.ugm.ac.id/penelitian/detail/162816","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074183663","display_name":"Galih Pratiwi","orcid":"https://orcid.org/0000-0002-1057-4441","observed_orcids":["https://orcid.org/0000-0002-1057-4441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galih Pratiwi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1057-4441","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068544874","display_name":"M.Si. rer. nat. Ronny Martien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.Si. Dr.rer.nat. Ronny Martien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027334238","display_name":"M.P. drh. Retno Murwanti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.P. drh. Retno Murwanti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.37209999561309814,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.3140000104904175,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.14749999344348907,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phyllanthus-niruri","display_name":"Phyllanthus niruri","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.6259999871253967},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.7099999785423279},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.7390000224113464},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tripolyphosphate","display_name":"tripolyphosphate","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ionic-gelation","display_name":"ionic gelation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nanoparticle-formulation","display_name":"nanoparticle formulation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/phagocytosis-index","display_name":"phagocytosis index","score":0.875},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.5979999899864197},{"id":"https://openalex.org/keywords/herbal-medicine-formulation","display_name":"herbal medicine formulation","score":0.492000013589859},{"id":"https://openalex.org/keywords/simplex-lattice-design","display_name":"simplex lattice design","score":0.7730000019073486},{"id":"https://openalex.org/keywords/design-optimization","display_name":"design optimization","score":0.5680000185966492},{"id":"https://openalex.org/keywords/immune-enhancement","display_name":"immune enhancement","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.8315156698226929},{"id":"https://openalex.org/C2776718122","wikidata":"https://www.wikidata.org/wiki/Q310927","display_name":"Phyllanthus","level":2,"score":0.8110452890396118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4162037968635559}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3202018474","doi":null,"is_oa":false,"landing_page_url":"http://etd.repository.ugm.ac.id/penelitian/detail/162816","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2994768865","https://openalex.org/W2989272279","https://openalex.org/W2974948264","https://openalex.org/W3196120904","https://openalex.org/W7217243946","https://openalex.org/W2707934777","https://openalex.org/W7216021393","https://openalex.org/W4386321459","https://openalex.org/W3000423392","https://openalex.org/W2337847196"],"abstract_inverted_index":{"Meniran":[0],"atau":[1],"Phyllanthus":[2,194],"niruri":[3,195],"L.":[4,196],"merupakan":[5],"herbal":[6,298,378],"yang":[7,24,30,57,63,76,129,177,189],"dapat":[8,69],"digunakan":[9],"untuk":[10,36],"meningkatkan":[11,70],"daya":[12],"tahan":[13],"tubuh.":[14],"Penggunaan":[15],"ekstrak":[16,38,52,74,82,102,148,158,188],"meniran":[17,40,54,83,160,176,211,236,266,299,363],"pada":[18,144],"sediaan":[19,42],"oral":[20,214],"terbatas":[21],"karena":[22],"kelarutan":[23],"rendah":[25],"dalam":[26,55,179],"air":[27],"dan":[28,66,91,134,150,164],"bioavailabilitasnya":[29],"kurang":[31],"baik.":[32],"Penelitian":[33],"ini":[34,46],"bertujuan":[35],"memformulasikan":[37],"herba":[39,53,103,159,175],"menjadi":[41],"nanopartikel":[43,81,101,181],"polimerik.":[44],"Formula":[45,138],"diharapkan":[47,68],"mampu":[48],"menjerap":[49],"senyawa":[50],"aktif":[51,62],"jumlah":[56],"lebih":[58,64],"banyak.":[59],"Senyawa":[61],"banyak":[65],"stabil":[67],"aktivitas":[71,135,165],"imunomodulator":[72,123],"dibandingkan":[73,169,186],"bebas":[75],"tidak":[77,190],"diformulasi.":[78],"Sediaan":[80],"dibuat":[84],"dengan":[85,117,153,170,187],"metode":[86,118,125],"gelasi":[87],"ionik":[88],"menggunakan":[89,107,112,124],"kitosan":[90,146],"tripolifosfat.":[92],"Orientasi":[93],"formula":[94,243,282,337],"diperoleh":[95,143],"rentang":[96],"kadar":[97],"masing-masing":[98],"komponen":[99],"penyusun":[100],"meniran.":[104],"Optimasi":[105],"dikerjakan":[106],"pendekatan":[108],"design":[109,307,317],"of":[110,210,235,263,265,280,288,290,293,297,308,338,357,362],"experiment":[111,309],"bantuan":[113],"piranti":[114],"lunak":[115],"design-expert":[116,312],"simplex":[119,315],"lattice":[120,316],"design.":[121],"Uji":[122],"biolatex":[126,322],"assay.":[127],"Parameter":[128],"diuji":[130],"meliputi":[131],"indeks":[132,162],"fagositosis":[133,136,163,166],"makrofag.\r":[137],"optimum":[139,336],"dari":[140],"proses":[141],"optimasi":[142],"komposisi":[145],"0,270%,":[147],"0,626%":[149],"tripolifosfat":[151],"0,074%":[152],"nilai":[154],"desirabilitas":[155],"0,841.":[156],"Nanopartikel":[157],"memiliki":[161],"makrofag":[167],"tertinggi":[168],"kelompok":[171],"perlakuan":[172],"lain.":[173],"Ekstrak":[174],"diformulasikan":[178],"bentuk":[180],"polimerik":[182],"berbeda":[183],"bermakna":[184],"(p<0,05)":[185],"diformulasi.\r":[191],"\n\nMeniran":[192],"or":[193],"is":[197,216,244,268,283,303],"an":[198],"herb":[199],"that":[200],"can":[201],"be":[202],"used":[203],"to":[204,219,230,246,258,366],"increase":[205,367],"immune":[206],"system.":[207],"The":[208,242,261,278,301,325,335,359],"use":[209],"extract":[212,234,267,349],"on":[213],"preparations":[215],"limited":[217],"due":[218],"low":[220],"solubility":[221],"in":[222],"water":[223],"and":[224,276,331,350,371],"poor":[225],"bioavailability.":[226],"This":[227],"study":[228],"aims":[229],"formulate":[231],"the":[232,253,281,286,294,306,339],"ethanolic":[233],"into":[237],"a":[238,354],"polymeric":[239,360],"nanoparticle":[240,295],"preparation.":[241],"expected":[245],"absorb":[247],"more":[248],"extracts":[249,364],"so":[250],"it":[251],"affects":[252],"increased":[254],"immunomodulator":[255],"activity":[256,374],"compared":[257,375],"un-formulated":[259],"extract.\r":[260],"preparation":[262],"nanoparticles":[264,361],"prepared":[269],"by":[270,285],"ionic":[271],"gelation":[272],"method":[273],"using":[274,305,311,321],"chitosan":[275,346],"tripolyphosphate.":[277],"orientation":[279],"obtained":[284,343],"range":[287],"levels":[289],"each":[291],"component":[292],"compound":[296],"extract.":[300],"optimization":[302,340],"done":[304],"approach":[310],"software":[313],"with":[314,353,376],"method.":[318,324],"Immunomodulatory":[319],"test":[320],"assay":[323],"parameters":[326],"tested":[327],"included":[328],"phagocytosis":[329,333,369,373],"index":[330,370],"macrophage":[332,372],"activity.\r":[334],"process":[341],"was":[342],"at":[344],"0.270%":[345],"composition,":[347],"0.626%":[348],"0.074%":[351],"tripolyphosphate":[352],"desirability":[355],"value":[356],"0.841.":[358],"tend":[365],"(p<0.05)":[368],"unformulated":[377],"extracts.":[379]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2021-10-11T00:00:00"}