{"id":"https://openalex.org/W3202017675","doi":"https://doi.org/10.1002/cpt.2431","title":"Pharmacokinetics, Pharmacodynamics, and Therapeutic Drug Monitoring of Valganciclovir and Ganciclovir in Transplantation","display_name":"Pharmacokinetics, Pharmacodynamics, and Therapeutic Drug Monitoring of Valganciclovir and Ganciclovir in Transplantation","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3202017675","doi":"https://doi.org/10.1002/cpt.2431","mag":"3202017675","pmid":"https://pubmed.ncbi.nlm.nih.gov/34596243"},"language":"en","primary_location":{"id":"doi:10.1002/cpt.2431","doi":"https://doi.org/10.1002/cpt.2431","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt.2431","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089237846","display_name":"B\u00e9n\u00e9dicte Franck","orcid":"https://orcid.org/0000-0001-8150-3467","observed_orcids":["https://orcid.org/0000-0001-8150-3467"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4405284615","display_name":"Ciblage individuel et pr\u00e9vention des risques de traitements immunosupresseurs et de la transplantation","ror":"https://ror.org/03wbncc78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I4405284615","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B\u00e9n\u00e9dicte Franck","raw_affiliation_strings":["Individual Profiling and Prevention of Risks With Immunosuppressive Therapies and Transplantations Unit\u00e9 Mixte de Recherche 1248 Universit\u00e9 de Limoges Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Limoges France","Service de Pharmacologie, Toxicologie et Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France"],"raw_orcid":"https://orcid.org/0000-0001-8150-3467","affiliations":[{"raw_affiliation_string":"Individual Profiling and Prevention of Risks With Immunosuppressive Therapies and Transplantations Unit\u00e9 Mixte de Recherche 1248 Universit\u00e9 de Limoges Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405284615","https://openalex.org/I65806277"]},{"raw_affiliation_string":"Service de Pharmacologie, Toxicologie et Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065567983","display_name":"Julie Autmizguine","orcid":"https://orcid.org/0000-0001-8975-5052","observed_orcids":["https://orcid.org/0000-0001-8975-5052"]},"institutions":[{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405268511","display_name":"CHU Sainte-Justine Research Center","ror":"https://ror.org/016e4fa89","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405268511"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julie Autmizguine","raw_affiliation_strings":["Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada","Department of Pharmacology and Physiology Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada","Research Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada"],"raw_orcid":"https://orcid.org/0000-0001-8975-5052","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2802351361"]},{"raw_affiliation_string":"Department of Pharmacology and Physiology Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Research Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2802351361","https://openalex.org/I4405268511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003712720","display_name":"Pierre Marquet","orcid":"https://orcid.org/0000-0001-7698-0760","observed_orcids":["https://orcid.org/0000-0001-7698-0760"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4405284615","display_name":"Ciblage individuel et pr\u00e9vention des risques de traitements immunosupresseurs et de la transplantation","ror":"https://ror.org/03wbncc78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I4405284615","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Marquet","raw_affiliation_strings":["Individual Profiling and Prevention of Risks With Immunosuppressive Therapies and Transplantations Unit\u00e9 Mixte de Recherche 1248 Universit\u00e9 de Limoges Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Limoges France","Service de Pharmacologie, Toxicologie et Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France"],"raw_orcid":"https://orcid.org/0000-0001-7698-0760","affiliations":[{"raw_affiliation_string":"Individual Profiling and Prevention of Risks With Immunosuppressive Therapies and Transplantations Unit\u00e9 Mixte de Recherche 1248 Universit\u00e9 de Limoges Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405284615","https://openalex.org/I65806277"]},{"raw_affiliation_string":"Service de Pharmacologie, Toxicologie et Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031574844","display_name":"Philippe Ovetchkine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Philippe Ovetchkine","raw_affiliation_strings":["Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2802351361"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010899888","display_name":"Jean\u2010Baptiste Woillard","orcid":"https://orcid.org/0000-0003-1695-0695","observed_orcids":["https://orcid.org/0000-0003-1695-0695"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4405284615","display_name":"Ciblage individuel et pr\u00e9vention des risques de traitements immunosupresseurs et de la transplantation","ror":"https://ror.org/03wbncc78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I4405284615","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean\u2010Baptiste Woillard","raw_affiliation_strings":["Individual Profiling and Prevention of Risks With Immunosuppressive Therapies and Transplantations Unit\u00e9 Mixte de Recherche 1248 Universit\u00e9 de Limoges Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Limoges France","Service de Pharmacologie, Toxicologie et Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France"],"raw_orcid":"https://orcid.org/0000-0003-1695-0695","affiliations":[{"raw_affiliation_string":"Individual Profiling and Prevention of Risks With Immunosuppressive Therapies and Transplantations Unit\u00e9 Mixte de Recherche 1248 Universit\u00e9 de Limoges Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405284615","https://openalex.org/I65806277"]},{"raw_affiliation_string":"Service de Pharmacologie, Toxicologie et Pharmacovigilance Centre Hospitalier Universitaire de Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5010899888"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4405284615","https://openalex.org/I65806277"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":1.0646,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.71154791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"112","issue":"2","first_page":"233","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.06430000066757202,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valganciclovir","display_name":"valganciclovir","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ganciclovir","display_name":"ganciclovir","score":1.0},{"id":"https://openalex.org/keywords/cytomegalovirus-infection","display_name":"cytomegalovirus infection","score":0.8500000238418579},{"id":"https://openalex.org/keywords/transplant-recipients","display_name":"transplant recipients","score":0.7200000286102295},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":1.0},{"id":"https://openalex.org/keywords/exposure-efficacy-relationship","display_name":"exposure-efficacy relationship","score":0.7680000066757202},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7429999709129333},{"id":"https://openalex.org/keywords/area-under-the-concentration-time-curve","display_name":"area under the concentration-time curve","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bayesian-estimation","display_name":"Bayesian estimation","score":0.5040000081062317},{"id":"https://openalex.org/keywords/limited-sampling-strategy","display_name":"limited sampling strategy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6660000085830688},{"id":"https://openalex.org/keywords/pediatric-transplantation","display_name":"pediatric transplantation","score":0.4909999966621399},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/solid-organ-transplantation","display_name":"solid organ transplantation","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C2776317777","wikidata":"https://www.wikidata.org/wiki/Q423384","display_name":"Valganciclovir","level":5,"score":0.9745290279388428},{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.9190465211868286},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7782305479049683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6955367922782898},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6174033880233765},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.6096013188362122},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.46217411756515503},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4235362708568573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3813095688819885},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3246597647666931},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.19276630878448486},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1303192675113678},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077562","descriptor_name":"Valganciclovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D016377","descriptor_name":"Organ Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cpt.2431","doi":"https://doi.org/10.1002/cpt.2431","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt.2431","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:34596243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34596243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1519512970","https://openalex.org/W1564804328","https://openalex.org/W1599285274","https://openalex.org/W1722485249","https://openalex.org/W1847510258","https://openalex.org/W1973646541","https://openalex.org/W1974796184","https://openalex.org/W1977695988","https://openalex.org/W1979621114","https://openalex.org/W1981693925","https://openalex.org/W1982731972","https://openalex.org/W1982816315","https://openalex.org/W1982960418","https://openalex.org/W1997456241","https://openalex.org/W2001016226","https://openalex.org/W2008730109","https://openalex.org/W2010223774","https://openalex.org/W2014540155","https://openalex.org/W2027684643","https://openalex.org/W2034752116","https://openalex.org/W2039735164","https://openalex.org/W2042403790","https://openalex.org/W2043265202","https://openalex.org/W2047636084","https://openalex.org/W2049690813","https://openalex.org/W2059471557","https://openalex.org/W2059738555","https://openalex.org/W2061974719","https://openalex.org/W2063622588","https://openalex.org/W2064282949","https://openalex.org/W2064445868","https://openalex.org/W2067826528","https://openalex.org/W2071991687","https://openalex.org/W2075855379","https://openalex.org/W2076542978","https://openalex.org/W2092091932","https://openalex.org/W2093351121","https://openalex.org/W2100882163","https://openalex.org/W2105162357","https://openalex.org/W2117767253","https://openalex.org/W2127763131","https://openalex.org/W2133714268","https://openalex.org/W2137333397","https://openalex.org/W2147622609","https://openalex.org/W2151812098","https://openalex.org/W2157039730","https://openalex.org/W2163700512","https://openalex.org/W2234744238","https://openalex.org/W2286127041","https://openalex.org/W2291085969","https://openalex.org/W2293007045","https://openalex.org/W2293035635","https://openalex.org/W2304107253","https://openalex.org/W2317079950","https://openalex.org/W2503666777","https://openalex.org/W2510513174","https://openalex.org/W2511843294","https://openalex.org/W2519655828","https://openalex.org/W2604280559","https://openalex.org/W2793284319","https://openalex.org/W2794366919","https://openalex.org/W2898483126","https://openalex.org/W2907734794","https://openalex.org/W2910689449","https://openalex.org/W2914296645","https://openalex.org/W2967633286","https://openalex.org/W2989649849","https://openalex.org/W3022678747","https://openalex.org/W3036975907","https://openalex.org/W3086498253","https://openalex.org/W3117926950","https://openalex.org/W3118828602","https://openalex.org/W3122058072","https://openalex.org/W3164015288","https://openalex.org/W3187055207","https://openalex.org/W4293380371"],"related_works":["https://openalex.org/W4386880961","https://openalex.org/W3036975907","https://openalex.org/W2981811888","https://openalex.org/W4323348209","https://openalex.org/W2980726512","https://openalex.org/W2133714268","https://openalex.org/W2001016226","https://openalex.org/W3100420829","https://openalex.org/W4416635566","https://openalex.org/W3121295008"],"abstract_inverted_index":{"Ganciclovir":[0],"and":[1,10,15,20,32,39,49,83,85,91,96,104,111,113,132,155,177,197,212],"valganciclovir":[2,40,90,105],"are":[3,51],"first":[4],"choice":[5],"drugs":[6],"for":[7,60,89,204],"the":[8,30,55,72,76,86,123,141,150,205],"prevention":[9],"treatment":[11],"of":[12,37,71,81,102,153,159,180,210],"cytomegalovirus":[13],"infection":[14],"disease":[16],"in":[17,41,79,94,109,130,134,163,170,201],"solid":[18],"organ":[19],"stem":[21],"cell":[22],"transplant":[23,42,98],"recipients.":[24,99],"Only":[25],"a":[26,114],"few":[27],"studies":[28],"on":[29,187],"pharmacokinetics":[31,74,101],"exposure/efficacy":[33],"or":[34],"exposure/safety":[35],"relationships":[36,78],"ganciclovir":[38,92,103,211],"recipients":[43],"have":[44,191],"been":[45,127,192],"published":[46],"so":[47],"far,":[48],"there":[50],"still":[52],"controversies":[53],"about":[54],"exposure":[56],"parameter":[57],"to":[58,148,173],"use":[59],"therapeutic":[61],"drug":[62,124],"monitoring":[63],"(TDM).":[64],"We":[65],"performed":[66],"an":[67],"extensive":[68],"literature":[69],"review":[70],"clinical":[73,202],"data,":[75],"exposure/effect":[77],"terms":[80],"efficacy":[82,154],"safety,":[84],"available":[87],"tools":[88],"TDM":[93,160],"adults":[95,110,131],"pediatrics":[97],"The":[100,136,157],"is":[106,118],"well":[107],"described":[108,129],"children,":[112],"high":[115],"interindividual":[116,175],"variability":[117,176],"commonly":[119],"observed.":[120],"In":[121],"contrast,":[122],"pharmacodynamics":[125],"has":[126],"poorly":[128],"barely":[133],"children.":[135],"average":[137],"24\u2010hour":[138],"area":[139],"under":[140],"concentration\u2010time":[142],"curve":[143],"(AUC":[144],"0\u201324h":[145],")":[146],"seems":[147],"be":[149,168,199],"best":[151],"predictor":[152],"toxicity.":[156],"benefit":[158],"remains":[161],"controversial":[162],"adult":[164],"patients":[165],"but":[166],"should":[167],"considered":[169],"children":[171],"due":[172],"higher":[174],"lower":[178],"probability":[179],"target":[181],"attainment.":[182],"Several":[183],"bayesian":[184],"estimators":[185],"based":[186],"limited":[188],"sampling":[189],"strategies":[190],"developed":[193],"with":[194],"this":[195],"aim":[196],"may":[198],"used":[200],"practice":[203],"AUC\u2010based":[206],"individual":[207],"dose":[208],"adjustment":[209],"valganciclovir.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}