{"id":"https://openalex.org/W3202006133","doi":"https://doi.org/10.1016/j.biopha.2021.112253","title":"Intraperitoneal supplementation of iron alleviates dextran sodium sulfate-induced colitis by enhancing intestinal barrier function","display_name":"Intraperitoneal supplementation of iron alleviates dextran sodium sulfate-induced colitis by enhancing intestinal barrier function","publication_year":2021,"publication_date":"2021-10-02","ids":{"openalex":"https://openalex.org/W3202006133","doi":"https://doi.org/10.1016/j.biopha.2021.112253","mag":"3202006133","pmid":"https://pubmed.ncbi.nlm.nih.gov/34607106"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2021.112253","doi":"https://doi.org/10.1016/j.biopha.2021.112253","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.112253","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2021.112253","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101397539","display_name":"Liang Li","orcid":"https://orcid.org/0000-0002-6168-6574","observed_orcids":["https://orcid.org/0000-0002-6168-6574"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Liang","raw_affiliation_strings":["Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qingqing Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqing Xiong","raw_affiliation_strings":["Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086623944","display_name":"Jingxia Kong","orcid":"https://orcid.org/0000-0002-8385-4081","observed_orcids":["https://orcid.org/0000-0002-8385-4081"]},"institutions":[{"id":"https://openalex.org/I4210090985","display_name":"Zhejiang Financial College","ror":"https://ror.org/00deghz86","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210090985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingxia Kong","raw_affiliation_strings":["Department of Investment and Insurance, Zhejiang Financial College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Investment and Insurance, Zhejiang Financial College, Hangzhou, China","institution_ids":["https://openalex.org/I4210090985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085518552","display_name":"Chenying Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenying Tian","raw_affiliation_strings":["Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Linfeng Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linfeng Miao","raw_affiliation_strings":["Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108101181","display_name":"Xiaofeng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126939","display_name":"ZheJiang Academy of Agricultural Sciences","ror":"https://ror.org/02qbc3192","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210126939"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofeng Zhang","raw_affiliation_strings":["Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China","institution_ids":["https://openalex.org/I4210126939"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055661262","display_name":"Huahua Du","orcid":"https://orcid.org/0000-0002-9603-8366","observed_orcids":["https://orcid.org/0000-0002-9603-8366"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huahua Du","raw_affiliation_strings":["Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China. Electronic address: huahuadu@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou, China. Electronic address: huahuadu@zju.edu.cn","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055661262"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":2660,"currency":"USD","value_usd":2660},"apc_paid":{"value":2660,"currency":"USD","value_usd":2660},"fwci":2.1455,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.88184694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"144","issue":null,"first_page":"112253","last_page":"112253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-repletion","display_name":"iron repletion","score":0.703000009059906},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intestinal-barrier-function","display_name":"intestinal barrier function","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.9750000238418579},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8199999928474426},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6060000061988831},{"id":"https://openalex.org/keywords/bacteroidetes","display_name":"Bacteroidetes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.8119999766349792},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8009999990463257},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7327153086662292},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6515148878097534},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.6224884390830994},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6151309609413147},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.5873240232467651},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5135986804962158},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47749611735343933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47488921880722046},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.43698686361312866},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.43433523178100586},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30208641290664673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1662009358406067},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12399697303771973},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007505","descriptor_name":"Iron-Dextran Complex","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007505","descriptor_name":"Iron-Dextran Complex","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007505","descriptor_name":"Iron-Dextran Complex","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007505","descriptor_name":"Iron-Dextran Complex","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062725","descriptor_name":"Tight Junction Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062725","descriptor_name":"Tight Junction Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062725","descriptor_name":"Tight Junction Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062725","descriptor_name":"Tight Junction Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biopha.2021.112253","doi":"https://doi.org/10.1016/j.biopha.2021.112253","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.112253","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:34607106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34607106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:93e3fb2e471a41af9d7fad5eb33a0332","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/93e3fb2e471a41af9d7fad5eb33a0332","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112253- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2021.112253","doi":"https://doi.org/10.1016/j.biopha.2021.112253","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.112253","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2790923303","display_name":null,"funder_award_id":"LZ20C170004","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G4542147563","display_name":null,"funder_award_id":"31872363","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W58189747","https://openalex.org/W1855226200","https://openalex.org/W2012680181","https://openalex.org/W2014723793","https://openalex.org/W2015908777","https://openalex.org/W2031967942","https://openalex.org/W2110302416","https://openalex.org/W2113517130","https://openalex.org/W2137337213","https://openalex.org/W2142613038","https://openalex.org/W2144656212","https://openalex.org/W2148251643","https://openalex.org/W2166171121","https://openalex.org/W2268544397","https://openalex.org/W2319166398","https://openalex.org/W2581853302","https://openalex.org/W2588576443","https://openalex.org/W2590830829","https://openalex.org/W2600893054","https://openalex.org/W2623427319","https://openalex.org/W2769466337","https://openalex.org/W2778416039","https://openalex.org/W2783641539","https://openalex.org/W2885877348","https://openalex.org/W2896706054","https://openalex.org/W2906727442","https://openalex.org/W2906992606","https://openalex.org/W3012543904","https://openalex.org/W3112846417","https://openalex.org/W3119299567"],"related_works":["https://openalex.org/W1509080832","https://openalex.org/W2750722062","https://openalex.org/W2361940148","https://openalex.org/W2373669175","https://openalex.org/W3172027973","https://openalex.org/W1981178506","https://openalex.org/W2349787864","https://openalex.org/W2376204027","https://openalex.org/W1214479236","https://openalex.org/W2490132574"],"abstract_inverted_index":{"Iron":[0,93],"supplementation":[1,23,94,117],"is":[2],"necessary":[3],"for":[4,212],"the":[5,11,38,50,58,126,154,169,178,190,213],"treatment":[6,214],"of":[7,10,28,40,44,60,82,106,112,118,129,150,158,172,181,193,200,215],"anemia,":[8],"one":[9],"most":[12],"frequent":[13],"complications":[14],"in":[15,37,63,153,177],"inflammatory":[16],"bowel":[17],"disease":[18],"(IBD).":[19],"However,":[20],"oral":[21],"iron":[22,119,165,195,201,218],"leads":[24],"to":[25,48],"an":[26],"exacerbation":[27],"intestinal":[29,55,61,121,134,203],"inflammation.":[30],"Gut":[31],"barrier":[32,56,122,204],"plays":[33],"a":[34,64,209],"key":[35],"role":[36],"pathogenesis":[39],"IBD.":[41],"The":[42,206],"aim":[43],"this":[45],"study":[46],"was":[47,175],"characterize":[49],"interrelationship":[51],"between":[52],"systemic":[53,98,194],"iron,":[54],"and":[57,97,109,142,146],"development":[59],"inflammation":[62,81,99],"dextran":[65],"sulfate":[66],"sodium":[67],"(DSS)":[68],"induced":[69],"experimental":[70],"colitis":[71,183],"mice":[72,78],"model.":[73],"We":[74],"found":[75],"that":[76,164],"DSS-treated":[77],"developed":[79],"severe":[80],"colon,":[83],"but":[84],"became":[85],"much":[86],"healthy":[87],"when":[88],"intraperitoneal":[89,116,198],"injection":[90,166,199,219],"with":[91,217],"iron.":[92],"alleviated":[95],"colonic":[96,107,127],"by":[100,124,137,197],"lower":[101],"histological":[102],"scores,":[103],"restorative":[104],"morphology":[105],"villi,":[108],"reduced":[110],"expression":[111],"pro-inflammatory":[113],"cytokines.":[114],"Moreover,":[115],"enhanced":[120],"function":[123],"upregulating":[125],"expressions":[128],"tight":[130],"junction":[131],"proteins,":[132],"restoring":[133],"immune":[135,139],"homeostasis":[136],"regulating":[138],"cell":[140],"infiltration":[141],"T":[143],"lymphocyte":[144],"subsets,":[145],"increasing":[147],"mucous":[148],"secretion":[149],"goblet":[151],"cells":[152],"colon.":[155],"High-throughput":[156],"sequencing":[157],"fecal":[159],"16":[160],"S":[161],"rRNA":[162],"showed":[163],"significantly":[167],"increased":[168],"relative":[170],"abundance":[171],"Bacteroidetes,":[173],"which":[174],"suppressed":[176],"gut":[179],"microbiota":[180],"DSS-induced":[182],"mice.":[184],"These":[185],"results":[186],"provided":[187],"evidences":[188],"supporting":[189],"protective":[191],"effects":[192],"repletion":[196],"on":[202],"functions.":[205],"finding":[207],"highlights":[208],"novel":[210],"approach":[211],"IBD":[216],"therapy.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
