{"id":"https://openalex.org/W3201812440","doi":"https://doi.org/10.3389/fcimb.2021.702628","title":"Surgical Menopause and Estrogen Therapy Modulate the Gut Microbiota, Obesity Markers, and Spatial Memory in Rats","display_name":"Surgical Menopause and Estrogen Therapy Modulate the Gut Microbiota, Obesity Markers, and Spatial Memory in Rats","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3201812440","doi":"https://doi.org/10.3389/fcimb.2021.702628","mag":"3201812440","pmid":"https://pubmed.ncbi.nlm.nih.gov/34660336","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8515187"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2021.702628","doi":"https://doi.org/10.3389/fcimb.2021.702628","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2021.702628","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcimb.2021.702628","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001724514","display_name":"Lydia Zeibich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lydia Zeibich","raw_affiliation_strings":["Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081636446","display_name":"Stephanie V. Koebele","orcid":"https://orcid.org/0000-0001-5502-2790","observed_orcids":["https://orcid.org/0000-0001-5502-2790"]},"institutions":[{"id":"https://openalex.org/I4387154484","display_name":"Arizona Alzheimer\u2019s Consortium","ror":"https://ror.org/00cvnc278","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154484"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie V. Koebele","raw_affiliation_strings":["Arizona Alzheimer's Consortium, Phoenix, AZ, United States","Department of Psychology, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Alzheimer's Consortium, Phoenix, AZ, United States","institution_ids":["https://openalex.org/I4387154484"]},{"raw_affiliation_string":"Department of Psychology, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070808404","display_name":"Victoria E. Bernaud","orcid":"https://orcid.org/0000-0003-3398-8193","observed_orcids":["https://orcid.org/0000-0003-3398-8193"]},"institutions":[{"id":"https://openalex.org/I4387154484","display_name":"Arizona Alzheimer\u2019s Consortium","ror":"https://ror.org/00cvnc278","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154484"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria E. Bernaud","raw_affiliation_strings":["Arizona Alzheimer's Consortium, Phoenix, AZ, United States","Department of Psychology, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Alzheimer's Consortium, Phoenix, AZ, United States","institution_ids":["https://openalex.org/I4387154484"]},{"raw_affiliation_string":"Department of Psychology, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042003740","display_name":"Zehra Esra Ilhan","orcid":"https://orcid.org/0000-0002-3387-9424","observed_orcids":["https://orcid.org/0000-0002-3387-9424"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zehra Esra Ilhan","raw_affiliation_strings":["Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046411515","display_name":"Blake Dirks","orcid":"https://orcid.org/0000-0003-4060-5306","observed_orcids":["https://orcid.org/0000-0003-4060-5306"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake Dirks","raw_affiliation_strings":["Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023567952","display_name":"Steven N. Northup-Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154484","display_name":"Arizona Alzheimer\u2019s Consortium","ror":"https://ror.org/00cvnc278","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154484"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven N. Northup-Smith","raw_affiliation_strings":["Arizona Alzheimer's Consortium, Phoenix, AZ, United States","Department of Psychology, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Alzheimer's Consortium, Phoenix, AZ, United States","institution_ids":["https://openalex.org/I4387154484"]},{"raw_affiliation_string":"Department of Psychology, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080532854","display_name":"Rachel Neeley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154484","display_name":"Arizona Alzheimer\u2019s Consortium","ror":"https://ror.org/00cvnc278","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154484"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Neeley","raw_affiliation_strings":["Arizona Alzheimer's Consortium, Phoenix, AZ, United States","Department of Psychology, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Alzheimer's Consortium, Phoenix, AZ, United States","institution_ids":["https://openalex.org/I4387154484"]},{"raw_affiliation_string":"Department of Psychology, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031445197","display_name":"Juan Maldonado","orcid":"https://orcid.org/0000-0002-2322-9620","observed_orcids":["https://orcid.org/0000-0002-2322-9620"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Maldonado","raw_affiliation_strings":["Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States","Genomics Core, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Genomics Core, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036871867","display_name":"Khemlal Nirmalkar","orcid":"https://orcid.org/0000-0001-6732-9175","observed_orcids":["https://orcid.org/0000-0001-6732-9175"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khemlal Nirmalkar","raw_affiliation_strings":["Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035358839","display_name":"Julia A. Files","orcid":"https://orcid.org/0000-0002-6571-9687","observed_orcids":["https://orcid.org/0000-0002-6571-9687"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia A. Files","raw_affiliation_strings":["Division of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ, United States","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103179189","display_name":"Anita P. Mayer","orcid":"https://orcid.org/0000-0002-4557-680X","observed_orcids":["https://orcid.org/0000-0002-4557-680X"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita P. Mayer","raw_affiliation_strings":["Division of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ, United States","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006414984","display_name":"Heather A. Bimonte\u2010Nelson","orcid":"https://orcid.org/0000-0001-7297-7978","observed_orcids":["https://orcid.org/0000-0001-7297-7978"]},"institutions":[{"id":"https://openalex.org/I4387154484","display_name":"Arizona Alzheimer\u2019s Consortium","ror":"https://ror.org/00cvnc278","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154484"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heather A. Bimonte-Nelson","raw_affiliation_strings":["Arizona Alzheimer's Consortium, Phoenix, AZ, United States","Department of Psychology, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Alzheimer's Consortium, Phoenix, AZ, United States","institution_ids":["https://openalex.org/I4387154484"]},{"raw_affiliation_string":"Department of Psychology, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035488966","display_name":"Rosa Krajmalnik\u2010Brown","orcid":"https://orcid.org/0000-0001-6064-3524","observed_orcids":["https://orcid.org/0000-0001-6064-3524"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rosa Krajmalnik-Brown","raw_affiliation_strings":["Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006414984","https://openalex.org/A5035488966"],"corresponding_institution_ids":["https://openalex.org/I4387154484","https://openalex.org/I55732556"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.5104,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.91793118,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"11","issue":null,"first_page":"702628","last_page":"702628"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surgical-menopause","display_name":"surgical menopause","score":0.996999979019165},{"id":"https://openalex.org/keywords/estrogen-therapy","display_name":"estrogen therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.902999997138977},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.953000009059906},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.968999981880188},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.875},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.7549999952316284},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9549999833106995},{"id":"https://openalex.org/keywords/isobutyrate","display_name":"isobutyrate","score":0.9079999923706055},{"id":"https://openalex.org/keywords/bifidobacteriaceae","display_name":"Bifidobacteriaceae","score":0.9390000104904175},{"id":"https://openalex.org/keywords/porphyromonadaceae","display_name":"Porphyromonadaceae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.7499852180480957},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6419150829315186},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6110458970069885},{"id":"https://openalex.org/C2910557164","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Surgical Menopause","level":3,"score":0.5706545114517212},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5312879681587219},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5089337825775146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46314001083374023},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.452719509601593},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43128734827041626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3863636255264282},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3572665750980377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35446470975875854},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30373242497444153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18441984057426453}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065852","descriptor_name":"Spatial Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fcimb.2021.702628","doi":"https://doi.org/10.3389/fcimb.2021.702628","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2021.702628","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8515187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8515187","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:34660336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34660336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04334077v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04334077","pdf_url":"https://hal.science/hal-04334077/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, 2021, 11, ⟨10.3389/fcimb.2021.702628⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3dba91dbd0d5426085f03ae107c1d73d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3dba91dbd0d5426085f03ae107c1d73d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2021.702628","doi":"https://doi.org/10.3389/fcimb.2021.702628","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2021.702628","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G12773222","display_name":"Variations in Hormones During Menopause: Effects on Cognitive and Brain Aging","funder_award_id":"R01AG028084","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2429393223","display_name":"Integrating quantitative energetics determines the microbiome's contribution to energy balance","funder_award_id":"R01DK105829","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G320719514","display_name":null,"funder_award_id":"ADHS 14-052688","funder_id":"https://openalex.org/F4320309677","funder_display_name":"Arizona Department of Health Services"},{"id":"https://openalex.org/G4800959754","display_name":null,"funder_award_id":"ADHS14-052688","funder_id":"https://openalex.org/F4320309835","funder_display_name":"Arizona State University"},{"id":"https://openalex.org/G704822541","display_name":"Arizona Alzheimer's Disease Core Center","funder_award_id":"P30AG019610","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8652363577","display_name":null,"funder_award_id":"AG028084","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000893714","display_name":"Arizona Alzheimer's Disease Research Center","funder_award_id":"P30AG072980","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320309677","display_name":"Arizona Department of Health Services","ror":"https://ror.org/01smpj292"},{"id":"https://openalex.org/F4320309835","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":186,"referenced_works":["https://openalex.org/W61385001","https://openalex.org/W317238995","https://openalex.org/W750398379","https://openalex.org/W801877057","https://openalex.org/W1529983368","https://openalex.org/W1564280579","https://openalex.org/W1716352502","https://openalex.org/W1834687907","https://openalex.org/W1924557697","https://openalex.org/W1943204001","https://openalex.org/W1964560480","https://openalex.org/W1966135823","https://openalex.org/W1968470615","https://openalex.org/W1970693713","https://openalex.org/W1971415551","https://openalex.org/W1976171855","https://openalex.org/W1977078171","https://openalex.org/W1978404627","https://openalex.org/W1979525833","https://openalex.org/W1982057972","https://openalex.org/W1982595964","https://openalex.org/W1984829519","https://openalex.org/W1985061586","https://openalex.org/W1989576853","https://openalex.org/W1989643757","https://openalex.org/W1989868932","https://openalex.org/W1990382521","https://openalex.org/W1997751808","https://openalex.org/W2005856400","https://openalex.org/W2006091607","https://openalex.org/W2010166612","https://openalex.org/W2010351278","https://openalex.org/W2014025849","https://openalex.org/W2014190906","https://openalex.org/W2014409017","https://openalex.org/W2022318388","https://openalex.org/W2023667812","https://openalex.org/W2024630005","https://openalex.org/W2025399737","https://openalex.org/W2025994995","https://openalex.org/W2031117980","https://openalex.org/W2031848890","https://openalex.org/W2033068288","https://openalex.org/W2035512890","https://openalex.org/W2035956425","https://openalex.org/W2038256929","https://openalex.org/W2048690065","https://openalex.org/W2051026082","https://openalex.org/W2056745382","https://openalex.org/W2057688664","https://openalex.org/W2057742222","https://openalex.org/W2058056109","https://openalex.org/W2058543084","https://openalex.org/W2061310823","https://openalex.org/W2062176149","https://openalex.org/W2063165012","https://openalex.org/W2063566800","https://openalex.org/W2064200220","https://openalex.org/W2064671008","https://openalex.org/W2065014046","https://openalex.org/W2065871117","https://openalex.org/W2068851561","https://openalex.org/W2070752385","https://openalex.org/W2074949233","https://openalex.org/W2075945132","https://openalex.org/W2078599166","https://openalex.org/W2080979269","https://openalex.org/W2085143128","https://openalex.org/W2088955068","https://openalex.org/W2089919592","https://openalex.org/W2090316207","https://openalex.org/W2091577778","https://openalex.org/W2092725930","https://openalex.org/W2093495190","https://openalex.org/W2104047392","https://openalex.org/W2104231345","https://openalex.org/W2105551601","https://openalex.org/W2108576543","https://openalex.org/W2110300022","https://openalex.org/W2117890073","https://openalex.org/W2119691301","https://openalex.org/W2120814367","https://openalex.org/W2122494133","https://openalex.org/W2125678015","https://openalex.org/W2127303481","https://openalex.org/W2127790258","https://openalex.org/W2130632811","https://openalex.org/W2132733483","https://openalex.org/W2133856765","https://openalex.org/W2137007429","https://openalex.org/W2137096265","https://openalex.org/W2139629203","https://openalex.org/W2140445777","https://openalex.org/W2140703378","https://openalex.org/W2142472354","https://openalex.org/W2148103005","https://openalex.org/W2148386446","https://openalex.org/W2154026962","https://openalex.org/W2154747636","https://openalex.org/W2158723294","https://openalex.org/W2165065263","https://openalex.org/W2166655850","https://openalex.org/W2167062509","https://openalex.org/W2170988125","https://openalex.org/W2172273404","https://openalex.org/W2179828787","https://openalex.org/W2193546234","https://openalex.org/W2205349065","https://openalex.org/W2259558034","https://openalex.org/W2264369089","https://openalex.org/W2272134694","https://openalex.org/W2274315004","https://openalex.org/W2292048640","https://openalex.org/W2320146093","https://openalex.org/W2323490146","https://openalex.org/W2327790265","https://openalex.org/W2333702587","https://openalex.org/W2335786001","https://openalex.org/W2341191157","https://openalex.org/W2395064609","https://openalex.org/W2401404581","https://openalex.org/W2467383487","https://openalex.org/W2523444109","https://openalex.org/W2545892218","https://openalex.org/W2548933161","https://openalex.org/W2580792129","https://openalex.org/W2581406049","https://openalex.org/W2605240544","https://openalex.org/W2614434814","https://openalex.org/W2618161090","https://openalex.org/W2619424771","https://openalex.org/W2624151437","https://openalex.org/W2640475594","https://openalex.org/W2761210275","https://openalex.org/W2761865284","https://openalex.org/W2762815147","https://openalex.org/W2765104503","https://openalex.org/W2769787189","https://openalex.org/W2770170730","https://openalex.org/W2771119295","https://openalex.org/W2786608785","https://openalex.org/W2789341033","https://openalex.org/W2790194570","https://openalex.org/W2801009528","https://openalex.org/W2802800736","https://openalex.org/W2885720444","https://openalex.org/W2886425960","https://openalex.org/W2888904023","https://openalex.org/W2893322268","https://openalex.org/W2898087716","https://openalex.org/W2900494132","https://openalex.org/W2902029737","https://openalex.org/W2903833977","https://openalex.org/W2904266452","https://openalex.org/W2905300225","https://openalex.org/W2917177127","https://openalex.org/W2925159351","https://openalex.org/W2944599852","https://openalex.org/W2945512770","https://openalex.org/W2952437732","https://openalex.org/W2954124338","https://openalex.org/W2963276645","https://openalex.org/W2965191969","https://openalex.org/W2966500580","https://openalex.org/W2980532544","https://openalex.org/W2982254388","https://openalex.org/W2983964235","https://openalex.org/W2989281288","https://openalex.org/W2992318817","https://openalex.org/W2994087481","https://openalex.org/W2996018541","https://openalex.org/W2997216738","https://openalex.org/W2998556742","https://openalex.org/W3005482948","https://openalex.org/W3005585888","https://openalex.org/W3006595334","https://openalex.org/W3008005014","https://openalex.org/W3010928772","https://openalex.org/W3011341999","https://openalex.org/W3030441098","https://openalex.org/W3031973342","https://openalex.org/W3087031822","https://openalex.org/W3126471658","https://openalex.org/W3178503617","https://openalex.org/W4230919389","https://openalex.org/W4237865950"],"related_works":["https://openalex.org/W2137096265","https://openalex.org/W6958684542","https://openalex.org/W2889663667","https://openalex.org/W2944233070","https://openalex.org/W2607367756","https://openalex.org/W4389023050","https://openalex.org/W4207052692","https://openalex.org/W4412640516","https://openalex.org/W2529341781","https://openalex.org/W4398167811"],"abstract_inverted_index":{"Menopause":[0],"in":[1,42,79,191,218],"human":[2],"females":[3],"and":[4,27,50,73,82,94,103,124,140,157,166,183,186,215,231,236],"subsequent":[5,74],"ovarian":[6,100],"hormone":[7,51,101],"deficiency,":[8],"particularly":[9],"concerning":[10],"17\u03b2-estradiol":[11],"(E2),":[12],"increase":[13],"the":[14,43,54,83,115,128,160,192,219,226,229],"risk":[15,227],"for":[16,228],"metabolic":[17,80],"dysfunctions":[18],"associated":[19,38,180],"with":[20,39,92,181],"obesity,":[21],"diabetes":[22],"type":[23],"2,":[24],"cardiovascular":[25],"diseases,":[26],"dementia.":[28],"Several":[29],"studies":[30],"indicate":[31],"that":[32,98,176,187,223],"these":[33],"disorders":[34],"are":[35],"also":[36],"strongly":[37],"compositional":[40,189],"changes":[41,78,190],"intestinal":[44,119,153,193],"microbiota;":[45],"however,":[46],"how":[47,70],"E2":[48,75,104,167],"deficiency":[49,102],"therapy":[52],"affect":[53],"gut":[55,84],"microbial":[56,85,131],"community":[57],"is":[58,179],"not":[59],"well":[60,88],"understood.":[61],"Using":[62],"a":[63],"rat":[64],"model,":[65],"we":[66],"aimed":[67],"to":[68,197],"evaluate":[69],"ovariectomy":[71],"(OVX)":[72],"administration":[76,168],"drive":[77],"health":[81,203],"community,":[86],"as":[87,89],"potential":[90],"associations":[91],"learning":[93],"memory.":[95],"Findings":[96],"indicated":[97],"OVX-induced":[99],"treatment":[105],"had":[106],"significant":[107],"impacts":[108],"on":[109,169],"several":[110],"health-affecting":[111],"parameters,":[112],"including":[113],"(a)":[114],"abundance":[116,129],"of":[117,130,163,199,233],"some":[118,198],"bacterial":[120],"taxa":[121],"(e.g.,":[122,136],"Bifidobacteriaceae":[123],"Porphyromonadaceae":[125],"),":[126],"(b)":[127],"short-chain":[132],"fatty":[133],"acids":[134],"(SCFAs)":[135],"isobutyrate),":[137],"(c)":[138],"weight/BMI,":[139],"(d)":[141],"high-demand":[142],"spatial":[143],"working":[144],"memory":[145],"following":[146],"surgical":[147,164,177],"menopause.":[148],"Furthermore,":[149],"exploratory":[150],"correlations":[151],"among":[152,213],"bacteria":[154],"abundance,":[155],"cognition,":[156],"BMI":[158],"underscored":[159],"putative":[161],"influence":[162],"menopause":[165,178],"gut-brain":[170],"interactions.":[171],"Collectively,":[172],"this":[173,206],"study":[174,207],"showed":[175],"physiological":[182],"behavioral":[184],"changes,":[185],"E2-linked":[188],"microbiota":[194],"might":[195],"contribute":[196],"its":[200],"related":[201],"negative":[202],"consequences.":[204],"Overall,":[205],"provides":[208],"novel":[209],"insights":[210],"into":[211],"interactions":[212],"endocrine":[214],"gastrointestinal":[216],"systems":[217],"post-menopausal":[220],"life":[221],"stage":[222],"collectively":[224],"alter":[225],"development":[230],"progression":[232],"cardiovascular,":[234],"metabolic,":[235],"dementia-related":[237],"diseases.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}