{"id":"https://openalex.org/W3201765320","doi":"https://doi.org/10.3390/ph14100971","title":"Assessing a Novel 3D Assay System for Drug Screening against OS Metastasis","display_name":"Assessing a Novel 3D Assay System for Drug Screening against OS Metastasis","publication_year":2021,"publication_date":"2021-09-25","ids":{"openalex":"https://openalex.org/W3201765320","doi":"https://doi.org/10.3390/ph14100971","mag":"3201765320","pmid":"https://pubmed.ncbi.nlm.nih.gov/34681195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8540451"},"language":"en","primary_location":{"id":"doi:10.3390/ph14100971","doi":"https://doi.org/10.3390/ph14100971","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14100971","pdf_url":"https://www.mdpi.com/1424-8247/14/10/971/pdf?version=1632560130","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/14/10/971/pdf?version=1632560130","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Natalie Koons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Natalie Koons","raw_affiliation_strings":["Surgery Department, Massachusetts Veterinary Referral Hospital, Woburn, MA 01801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Department, Massachusetts Veterinary Referral Hospital, Woburn, MA 01801, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nicole Amato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Amato","raw_affiliation_strings":["Surgery Department, Massachusetts Veterinary Referral Hospital, Woburn, MA 01801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Department, Massachusetts Veterinary Referral Hospital, Woburn, MA 01801, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021237206","display_name":"Scott J. Sauer","orcid":"https://orcid.org/0000-0001-6677-5827","observed_orcids":["https://orcid.org/0000-0001-6677-5827"]},"institutions":[{"id":"https://openalex.org/I4405264103","display_name":"Namics Corporation (Japan)","ror":"https://ror.org/00zd3ey68","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Scott Sauer","raw_affiliation_strings":["Vuja De Sciences, Inc., Natick, MA 01760, USA"],"raw_orcid":"https://orcid.org/0000-0001-6677-5827","affiliations":[{"raw_affiliation_string":"Vuja De Sciences, Inc., Natick, MA 01760, USA","institution_ids":["https://openalex.org/I4405264103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080015943","display_name":"David Warshawsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264103","display_name":"Namics Corporation (Japan)","ror":"https://ror.org/00zd3ey68","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"David Warshawsky","raw_affiliation_strings":["Vuja De Sciences, Inc., Natick, MA 01760, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vuja De Sciences, Inc., Natick, MA 01760, USA","institution_ids":["https://openalex.org/I4405264103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110459960","display_name":"Dalit Barkan","orcid":"https://orcid.org/0000-0003-4714-0580","observed_orcids":["https://orcid.org/0000-0003-4714-0580"]},"institutions":[{"id":"https://openalex.org/I91203450","display_name":"University of Haifa","ror":"https://ror.org/02f009v59","country_code":"IL","type":"education","lineage":["https://openalex.org/I91203450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dalit Barkan","raw_affiliation_strings":["Department of Human Biology and Medical Sciences, University of Haifa, Haifa 3498838, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology and Medical Sciences, University of Haifa, Haifa 3498838, Israel","institution_ids":["https://openalex.org/I91203450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112077722","display_name":"Chand Khanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chand Khanna","raw_affiliation_strings":["Ethos Discovery, Woburn, MA 01801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ethos Discovery, Woburn, MA 01801, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021237206"],"corresponding_institution_ids":["https://openalex.org/I4405264103"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1944},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1944},"fwci":0.4554,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64123524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"10","first_page":"971","last_page":"971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.03929999843239784,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/phenotypic-screening","display_name":"phenotypic screening","score":0.8619999885559082},{"id":"https://openalex.org/keywords/metastatic-dormancy","display_name":"metastatic dormancy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/metastatic-outgrowth","display_name":"metastatic outgrowth","score":0.9649999737739563},{"id":"https://openalex.org/keywords/oclacitinib","display_name":"oclacitinib","score":0.9229999780654907},{"id":"https://openalex.org/keywords/janus-kinase-1-inhibitor","display_name":"Janus kinase 1 inhibitor","score":0.8169999718666077},{"id":"https://openalex.org/keywords/regorafenib","display_name":"regorafenib","score":0.9409999847412109},{"id":"https://openalex.org/keywords/saracatinib","display_name":"saracatinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/canine-osteosarcoma","display_name":"canine osteosarcoma","score":0.7490000128746033},{"id":"https://openalex.org/keywords/translational-drug-discovery","display_name":"translational drug discovery","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8168414831161499},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.5084730386734009},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5030106902122498},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46344852447509766},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46207714080810547},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4613044857978821},{"id":"https://openalex.org/C2776248978","wikidata":"https://www.wikidata.org/wiki/Q3891664","display_name":"Regorafenib","level":4,"score":0.45012593269348145},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44782155752182007},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.4322829246520996},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39921748638153076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3604978322982788},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3238376975059509},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.305103600025177},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.29003894329071045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12879419326782227}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ph14100971","doi":"https://doi.org/10.3390/ph14100971","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14100971","pdf_url":"https://www.mdpi.com/1424-8247/14/10/971/pdf?version=1632560130","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8540451","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8540451","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmid:34681195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34681195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5ab316e93ced435f8efe43144842109e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5ab316e93ced435f8efe43144842109e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 14, Iss 10, p 971 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph14100971","doi":"https://doi.org/10.3390/ph14100971","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14100971","pdf_url":"https://www.mdpi.com/1424-8247/14/10/971/pdf?version=1632560130","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3201765320.pdf","grobid_xml":"https://content.openalex.org/works/W3201765320.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1908149944","https://openalex.org/W1968209756","https://openalex.org/W1975868501","https://openalex.org/W1992891544","https://openalex.org/W2002586415","https://openalex.org/W2019402966","https://openalex.org/W2076679216","https://openalex.org/W2088225866","https://openalex.org/W2101335366","https://openalex.org/W2128188903","https://openalex.org/W2133627716","https://openalex.org/W2163821296","https://openalex.org/W2167514745","https://openalex.org/W2316206479","https://openalex.org/W2416943754","https://openalex.org/W2592028643","https://openalex.org/W2592338101","https://openalex.org/W2611412318","https://openalex.org/W2754016505","https://openalex.org/W2899358621","https://openalex.org/W2900713299","https://openalex.org/W2901259053","https://openalex.org/W2921722535","https://openalex.org/W2982376008","https://openalex.org/W3005326482","https://openalex.org/W3022054967","https://openalex.org/W3082201370","https://openalex.org/W3159530350"],"related_works":["https://openalex.org/W2807414933","https://openalex.org/W4408936934","https://openalex.org/W2746019479","https://openalex.org/W2901291633","https://openalex.org/W7214141339","https://openalex.org/W7221846370","https://openalex.org/W7221777738","https://openalex.org/W4386725622","https://openalex.org/W4414199713","https://openalex.org/W4410707812"],"abstract_inverted_index":{"Osteosarcoma":[0],"(OS)":[1],"is":[2,26,29,74],"an":[3,165,213],"aggressive":[4],"mesenchymal":[5],"cell":[6],"tumor":[7,20,55,101],"that":[8,50],"carries":[9],"a":[10,45,88,130,176,226],"poor":[11],"long-term":[12],"prognosis.":[13],"Despite":[14,198],"definitive":[15],"surgery":[16],"for":[17,38,48,67,100,233],"the":[18,30,85,121,127,184,199,208],"primary":[19,31],"and":[21,28,43,58,103,112,146,157,192],"adjuvant":[22],"chemotherapy,":[23],"pulmonary":[24],"metastasis":[25],"common":[27],"cause":[32],"of":[33,87,110,120,129,138,171,183,187,210],"morbidity.":[34],"To":[35],"improve":[36],"outcomes":[37],"patients,":[39],"we":[40,151,202],"have":[41],"developed":[42],"optimized":[44],"phenotypic":[46],"screen":[47],"drugs":[49,232],"may":[51],"target":[52],"OS":[53,115,142,188,237],"disseminated":[54],"cells":[56],"(DTCs)":[57],"inhibit":[59],"their":[60],"metastatic":[61,104,114],"outbreak":[62],"rather":[63],"than":[64],"merely":[65],"screening":[66],"cytotoxic":[68],"activity":[69,128,139,234],"against":[70],"proliferating":[71],"cells,":[72],"as":[73,175,212,225],"commonly":[75],"conducted":[76],"in":[77,132,140,189,216,235],"conventional":[78],"drug":[79,131,178],"discovery":[80],"approaches.":[81],"We":[82,162],"report":[83],"on":[84],"validation":[86,119],"previously":[89],"described":[90],"3D":[91,222],"reconstituted":[92],"basement":[93],"membrane":[94],"extract":[95],"(3D":[96],"BME)":[97],"model":[98],"system":[99],"dormancy":[102],"outgrowth":[105],"adapted":[106],"to":[107,180,196,206,230],"clonal":[108],"pairs":[109],"high":[111,185],"low":[113],"cells.":[116],"A":[117],"post-hoc":[118],"assay":[122,134,156,224],"was":[123],"possible":[124],"by":[125],"comparing":[126],"our":[133,155,221],"with":[135],"early":[136],"evidence":[137,205],"human":[141,158],"clinical":[143,159],"trials":[144],"(regorafenib":[145],"saracatinib).":[147],"In":[148],"this":[149],"validation,":[150],"found":[152,203],"concordance":[153],"between":[154],"trial":[160],"experience":[161],"then":[163],"explored":[164],"approved":[166],"veterinary":[167],"small":[168],"molecule":[169],"inhibitor":[170],"Janus":[172],"kinase-1":[173],"(oclacitinib)":[174],"potential":[177],"candidate":[179],"take":[181],"advantage":[182],"prevalence":[186],"pet":[190],"dogs":[191],"its":[193],"translational":[194],"value":[195],"humans.":[197],"biological":[200],"rationale,":[201],"no":[204],"support":[207,220],"use":[209],"oclacitinib":[211],"antimetastatic":[214],"agent":[215],"OS.":[217],"The":[218],"findings":[219],"BME":[223],"highly":[227],"efficient":[228],"method":[229],"examine":[231],"targeting":[236],"DTCs.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-10-11T00:00:00"}
