{"id":"https://openalex.org/W3201634288","doi":"https://doi.org/10.1039/d1ra05959a","title":"Isostructural cocrystals of metaxalone with improved dissolution characteristics","display_name":"Isostructural cocrystals of metaxalone with improved dissolution characteristics","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3201634288","doi":"https://doi.org/10.1039/d1ra05959a","mag":"3201634288","pmid":"https://pubmed.ncbi.nlm.nih.gov/35479860","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9041148"},"language":"en","primary_location":{"id":"doi:10.1039/d1ra05959a","doi":"https://doi.org/10.1039/d1ra05959a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d1ra05959a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d1ra05959a","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d1ra05959a","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111202829","display_name":"Sunil Kumar Gohel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21675474","display_name":"Lupin Pharmaceuticals (India)","ror":"https://ror.org/04wdr7416","country_code":"IN","type":"company","lineage":["https://openalex.org/I21675474"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sunil Kumar Gohel","raw_affiliation_strings":["Lupin Limited, Lupin Research Park, Pune-412115, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lupin Limited, Lupin Research Park, Pune-412115, Maharashtra, India","institution_ids":["https://openalex.org/I21675474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022552382","display_name":"Vasanthi Palanisamy","orcid":"https://orcid.org/0009-0001-4350-313X","observed_orcids":["https://orcid.org/0009-0001-4350-313X"]},"institutions":[{"id":"https://openalex.org/I145286018","display_name":"SRM Institute of Science and Technology","ror":"https://ror.org/050113w36","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vasanthi Palanisamy","raw_affiliation_strings":["Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, Tamil Nadu 603203, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, Tamil Nadu 603203, India","institution_ids":["https://openalex.org/I145286018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070483959","display_name":"Palash Sanphui","orcid":"https://orcid.org/0000-0001-7854-1964","observed_orcids":["https://orcid.org/0000-0001-7854-1964"]},"institutions":[{"id":"https://openalex.org/I145286018","display_name":"SRM Institute of Science and Technology","ror":"https://ror.org/050113w36","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Palash Sanphui","raw_affiliation_strings":["Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, Tamil Nadu 603203, India"],"raw_orcid":"https://orcid.org/0000-0001-7854-1964","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, Tamil Nadu 603203, India","institution_ids":["https://openalex.org/I145286018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054382077","display_name":"Muthuramalingam Prakash","orcid":"https://orcid.org/0000-0002-1886-7708","observed_orcids":["https://orcid.org/0000-0002-1886-7708"]},"institutions":[{"id":"https://openalex.org/I145286018","display_name":"SRM Institute of Science and Technology","ror":"https://ror.org/050113w36","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Muthuramalingam Prakash","raw_affiliation_strings":["Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, Tamil Nadu 603203, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Chennai, Tamil Nadu 603203, India","institution_ids":["https://openalex.org/I145286018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112444184","display_name":"Girij Pal Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21675474","display_name":"Lupin Pharmaceuticals (India)","ror":"https://ror.org/04wdr7416","country_code":"IN","type":"company","lineage":["https://openalex.org/I21675474"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Girij Pal Singh","raw_affiliation_strings":["Lupin Limited, Lupin Research Park, Pune-412115, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lupin Limited, Lupin Research Park, Pune-412115, Maharashtra, India","institution_ids":["https://openalex.org/I21675474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038619446","display_name":"Vladimir V. Chernyshev","orcid":"https://orcid.org/0000-0001-8514-7471","observed_orcids":["https://orcid.org/0000-0001-8514-7471"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210085913","display_name":"Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences","ror":"https://ror.org/004dzkd51","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210085913","https://openalex.org/I4210145551"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Vladimir Chernyshev","raw_affiliation_strings":["A. N. Frumkin Institute of Physical Chemistry and Electrochemistry RAS, 31 Leninsky Prospect, Moscow 119071, Russian Federation","Department of Chemistry, M. V. Lomonosov Moscow State University, 1-3 Leninskie Gory, Moscow 119991, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. N. Frumkin Institute of Physical Chemistry and Electrochemistry RAS, 31 Leninsky Prospect, Moscow 119071, Russian Federation","institution_ids":["https://openalex.org/I4210085913"]},{"raw_affiliation_string":"Department of Chemistry, M. V. Lomonosov Moscow State University, 1-3 Leninskie Gory, Moscow 119991, Russian Federation","institution_ids":["https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038619446","https://openalex.org/A5070483959"],"corresponding_institution_ids":["https://openalex.org/I145286018","https://openalex.org/I19880235","https://openalex.org/I4210085913"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":1.1784,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.72342847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":"49","first_page":"30689","last_page":"30700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.13169999420642853,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metaxalone","display_name":"metaxalone","score":1.0},{"id":"https://openalex.org/keywords/cocrystals","display_name":"cocrystals","score":0.8190000057220459},{"id":"https://openalex.org/keywords/nicotinamide","display_name":"nicotinamide","score":0.9309999942779541},{"id":"https://openalex.org/keywords/salicylamide","display_name":"salicylamide","score":1.0},{"id":"https://openalex.org/keywords/p-hydroxybenzoic-acid","display_name":"p-hydroxybenzoic acid","score":1.0},{"id":"https://openalex.org/keywords/water-solubility-enhancement","display_name":"aqueous solubility enhancement","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.699999988079071},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6359999775886536},{"id":"https://openalex.org/keywords/muscle-relaxants","display_name":"muscle relaxants","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C205188671","wikidata":"https://www.wikidata.org/wiki/Q3803316","display_name":"Isostructural","level":3,"score":0.9874011874198914},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.7027302980422974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3782729506492615},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35536473989486694},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3538399934768677},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.13534331321716309},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.10242578387260437}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d1ra05959a","doi":"https://doi.org/10.1039/d1ra05959a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d1ra05959a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d1ra05959a","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmid:35479860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35479860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9041148","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9041148/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1039/d1ra05959a","doi":"https://doi.org/10.1039/d1ra05959a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d1ra05959a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d1ra05959a","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G581384771","display_name":null,"funder_award_id":"SR/FST/CST266/2015","funder_id":"https://openalex.org/F4320317486","funder_display_name":"SRM Institute of Science and Technology"},{"id":"https://openalex.org/G5840838886","display_name":null,"funder_award_id":"SR/FST/CST266/2015","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320317486","display_name":"SRM Institute of Science and Technology","ror":"https://ror.org/037skf023"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3201634288.pdf","grobid_xml":"https://content.openalex.org/works/W3201634288.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W774493609","https://openalex.org/W1541838239","https://openalex.org/W1951885505","https://openalex.org/W1969360633","https://openalex.org/W1973034440","https://openalex.org/W1993187261","https://openalex.org/W2005351388","https://openalex.org/W2013103299","https://openalex.org/W2023271753","https://openalex.org/W2030136979","https://openalex.org/W2049014538","https://openalex.org/W2059205366","https://openalex.org/W2067129640","https://openalex.org/W2067777829","https://openalex.org/W2078447254","https://openalex.org/W2086945873","https://openalex.org/W2092157292","https://openalex.org/W2113859472","https://openalex.org/W2131350133","https://openalex.org/W2145538332","https://openalex.org/W2148941593","https://openalex.org/W2166000509","https://openalex.org/W2270927172","https://openalex.org/W2275090351","https://openalex.org/W2314544068","https://openalex.org/W2318047941","https://openalex.org/W2320260186","https://openalex.org/W2325717405","https://openalex.org/W2328901473","https://openalex.org/W2334267072","https://openalex.org/W2335434301","https://openalex.org/W2344282129","https://openalex.org/W2356915594","https://openalex.org/W2489555118","https://openalex.org/W2526222923","https://openalex.org/W2570192058","https://openalex.org/W2793337835","https://openalex.org/W2885151378","https://openalex.org/W2886419664","https://openalex.org/W2897966245","https://openalex.org/W2898072064","https://openalex.org/W2902359770","https://openalex.org/W2960992988","https://openalex.org/W2972805691","https://openalex.org/W3000039142","https://openalex.org/W3016236767","https://openalex.org/W3041775778","https://openalex.org/W3092034382","https://openalex.org/W3097843392","https://openalex.org/W3127381280"],"related_works":["https://openalex.org/W3127381280","https://openalex.org/W7133722857","https://openalex.org/W2897966245","https://openalex.org/W4317932441","https://openalex.org/W7135219036","https://openalex.org/W6968154257","https://openalex.org/W4404193229","https://openalex.org/W7154284018","https://openalex.org/W3168359740","https://openalex.org/W7034157979"],"abstract_inverted_index":{"Muscle":[0],"relaxant":[1],"and":[2,20,29,78,92,100,192,199,237],"pain":[3],"reliever":[4],"metaxalone":[5],"(MET)":[6],"is":[7,111],"a":[8,112,238],"biopharmaceutical":[9],"classification":[10],"systems":[11],"(BCS)":[12],"class":[13],"II":[14],"drug":[15,55,181],"with":[16,73,98,107,241],"poor":[17],"aqueous":[18,40],"solubility":[19,176,202,213],"high":[21,49,201],"permeability.":[22],"The":[23,144,185,218],"presence":[24],"of":[25,53,71,146,187,203,214],"an":[26,138],"aromatic":[27],"skeleton":[28],"cyclic":[30],"carboxamate":[31],"moiety":[32],"are":[33,206],"the":[34,38,54,62,109,122,127,135,142,147,171,174,179,193,200,204,207,211,215,222,227],"probable":[35,208],"reasons":[36,209],"for":[37,137,210],"decreased":[39],"solubility,":[41],"which":[42,232],"impacts":[43],"on":[44,61,156],"its":[45],"low":[46],"bioavailability.":[47],"A":[48],"dose":[50,240],"(800":[51],"mg)":[52],"often":[56],"creates":[57],"adverse":[58],"side":[59,243],"effects":[60],"central":[63],"nervous":[64],"system":[65],"that":[66,86,170],"needs":[67],"urgent":[68],"remedy.":[69],"Cocrystallization":[70],"MET":[72,129,191],"nicotinamide":[74],"(NAM),":[75],"salicylamide":[76],"(SAM),":[77],"4-hydroxybenzoic":[79],"acid":[80],"(HBA)":[81],"resulted":[82],"in":[83,141,164],"multicomponent":[84],"solids":[85],"were":[87],"characterized":[88],"by":[89,182],"PXRD,":[90],"DSC":[91],"single":[93],"crystal":[94],"X-ray":[95],"diffraction.":[96],"Cocrystals":[97],"SAM":[99],"NAM":[101],"form":[102],"2D":[103],"isostructural":[104],"cocrystals,":[105,130],"whereas":[106],"HBA":[108],"result":[110],"differently":[113],"packed":[114],"cocrystal":[115,220],"hydrate":[116],"(or":[117],"anisole":[118],"hemisolvate)":[119],"depending":[120],"upon":[121],"crystallization":[123],"medium.":[124],"Similar":[125],"to":[126,178],"reported":[128],"these":[131],"cocrystals":[132,172],"also":[133],"confirm":[134],"preference":[136],"imide\u22efimide":[139],"homosynthon":[140],"drug.":[143],"dominance":[145],"drug-drug":[148],"homodimer":[149],"over":[150],"drug-coformer":[151],"heterodimers":[152],"was":[153],"demonstrated":[154],"based":[155],"binding":[157],"energy":[158],"calculations.":[159],"Further,":[160],"powder":[161],"dissolution":[162],"experiments":[163],"pH":[165],"6.8":[166],"phosphate":[167],"buffer":[168],"indicate":[169],"improved":[173,235],"apparent":[175],"compared":[177],"native":[180],"3-9":[183],"fold.":[184],"absence":[186],"stronger":[188],"heterosynthons":[189],"between":[190],"coformers,":[194],"their":[195],"lower":[196,239],"melting":[197],"points":[198],"coformers":[205],"enhanced":[212],"bioactive":[216],"component.":[217],"MET-NAM":[219],"exhibited":[221],"highest":[223],"solubility/dissolution":[224],"rate":[225],"among":[226],"three":[228],"binary":[229],"solid":[230],"forms,":[231],"may":[233],"offer":[234],"bioavailability":[236],"minimal":[242],"effects.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-09-27T00:00:00"}