{"id":"https://openalex.org/W3201619832","doi":"https://doi.org/10.1016/j.bioorg.2021.105343","title":"Design, synthesis and biological evaluation of hybrid of ubenimex-fluorouracil for hepatocellular carcinoma therapy","display_name":"Design, synthesis and biological evaluation of hybrid of ubenimex-fluorouracil for hepatocellular carcinoma therapy","publication_year":2021,"publication_date":"2021-09-11","ids":{"openalex":"https://openalex.org/W3201619832","doi":"https://doi.org/10.1016/j.bioorg.2021.105343","mag":"3201619832","pmid":"https://pubmed.ncbi.nlm.nih.gov/34544027"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioorg.2021.105343","doi":"https://doi.org/10.1016/j.bioorg.2021.105343","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2021.105343","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055668632","display_name":"Kairui Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kairui Yue","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002957222","display_name":"Xiaohan Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohan Hou","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025950940","display_name":"Geng Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Geng Jia","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070112937","display_name":"Liang Zhang","orcid":"https://orcid.org/0000-0002-7888-5043","observed_orcids":["https://orcid.org/0000-0002-7888-5043"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Zhang","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409987","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-6558-791X","observed_orcids":["https://orcid.org/0000-0002-6558-791X"]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["College of Pharmacy, Weifang Medical University, 261053 Wei'fang, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Weifang Medical University, 261053 Wei'fang, Shandong, PR China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006661118","display_name":"Leqiao Tan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leqiao Tan","raw_affiliation_strings":["Weifang Bochuang International Biological Medicinal Institute, Weifang, Shandong 261061, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weifang Bochuang International Biological Medicinal Institute, Weifang, Shandong 261061, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078354156","display_name":"Xuejian Wang","orcid":"https://orcid.org/0009-0001-0561-8032","observed_orcids":["https://orcid.org/0009-0001-0561-8032","https://orcid.org/0000-0003-0389-5674"]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejian Wang","raw_affiliation_strings":["College of Pharmacy, Weifang Medical University, 261053 Wei'fang, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Weifang Medical University, 261053 Wei'fang, Shandong, PR China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101420403","display_name":"Zhaolin Zhang","orcid":"https://orcid.org/0000-0003-1978-8160","observed_orcids":["https://orcid.org/0000-0003-1978-8160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaolin Zhang","raw_affiliation_strings":["Weifang Bochuang International Biological Medicinal Institute, Weifang, Shandong 261061, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weifang Bochuang International Biological Medicinal Institute, Weifang, Shandong 261061, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102932008","display_name":"Peixia Li","orcid":"https://orcid.org/0009-0004-4032-3178","observed_orcids":["https://orcid.org/0009-0004-4032-3178"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peixia Li","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015707550","display_name":"Wenfang Xu","orcid":"https://orcid.org/0009-0000-4909-4667","observed_orcids":["https://orcid.org/0009-0000-4909-4667"]},"institutions":[{"id":"https://openalex.org/I4210145056","display_name":"Marine Biomedical Research Institute of Qingdao","ror":"https://ror.org/03pffnr86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210145056"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenfang Xu","raw_affiliation_strings":["Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong 266071, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong 266071, PR China","institution_ids":["https://openalex.org/I4210145056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606927","display_name":"Xiaoyang Li","orcid":"https://orcid.org/0000-0003-3684-2106","observed_orcids":["https://orcid.org/0000-0003-3684-2106"]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyang Li","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China. Electronic address: lixiaoyang@ouc.edu.cn","Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China. Electronic address: lixiaoyang@ouc.edu.cn","institution_ids":["https://openalex.org/I4210113896","https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China","institution_ids":["https://openalex.org/I4210113896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001594614","display_name":"Yuqi Jiang","orcid":"https://orcid.org/0000-0002-6612-4888","observed_orcids":["https://orcid.org/0000-0002-6612-4888"]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuqi Jiang","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China. Electronic address: jiangyuqi@ouc.edu.cn","Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China. Electronic address: jiangyuqi@ouc.edu.cn","institution_ids":["https://openalex.org/I4210113896","https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China","institution_ids":["https://openalex.org/I4210113896"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001594614","https://openalex.org/A5100606927","https://openalex.org/A5102932008"],"corresponding_institution_ids":["https://openalex.org/I4210113896","https://openalex.org/I59028903"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.2874,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.35220547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"116","issue":null,"first_page":"105343","last_page":"105343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubenimex","display_name":"bestatin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.6880000233650208},{"id":"https://openalex.org/keywords/drug-conjugates","display_name":"drug conjugates","score":0.6200000047683716},{"id":"https://openalex.org/keywords/linker-optimization","display_name":"linker optimization","score":0.722000002861023},{"id":"https://openalex.org/keywords/plasma-stability","display_name":"plasma stability","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.875},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.9919999837875366},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7987411022186279},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7723090648651123},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.7464017868041992},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6516358852386475},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6300384998321533},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5555751323699951},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.521044909954071},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4885734021663666},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.446742445230484},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4202784299850464},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4192522466182709},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39665687084198},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2843795418739319},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22811803221702576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18905219435691833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09900075197219849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bioorg.2021.105343","doi":"https://doi.org/10.1016/j.bioorg.2021.105343","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2021.105343","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:34544027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34544027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1650277643","display_name":null,"funder_award_id":"2018SDKJ0403","funder_id":"https://openalex.org/F4320326721","funder_display_name":"Qingdao National Laboratory for Marine Science and Technology"},{"id":"https://openalex.org/G7390259204","display_name":null,"funder_award_id":"82003584","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G887477577","display_name":null,"funder_award_id":"ZR2020QH343","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320326721","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1509123039","https://openalex.org/W1681044110","https://openalex.org/W1690464810","https://openalex.org/W1983342808","https://openalex.org/W1989280181","https://openalex.org/W2006761645","https://openalex.org/W2028814725","https://openalex.org/W2067849140","https://openalex.org/W2113962165","https://openalex.org/W2128704535","https://openalex.org/W2130200307","https://openalex.org/W2141646543","https://openalex.org/W2169973076","https://openalex.org/W2342794516","https://openalex.org/W2410051200","https://openalex.org/W2767092348","https://openalex.org/W2770258158","https://openalex.org/W2775461490","https://openalex.org/W2797138309","https://openalex.org/W2892255692","https://openalex.org/W2943301710","https://openalex.org/W2963422058","https://openalex.org/W3014722766","https://openalex.org/W3034031765","https://openalex.org/W3034603634","https://openalex.org/W3080912663","https://openalex.org/W3109533492","https://openalex.org/W3161688959","https://openalex.org/W6681069911"],"related_works":["https://openalex.org/W2775461490","https://openalex.org/W2410051200","https://openalex.org/W4409448057","https://openalex.org/W2114902329","https://openalex.org/W2417288661","https://openalex.org/W4407264544","https://openalex.org/W2973251309","https://openalex.org/W1045320441","https://openalex.org/W2048064745","https://openalex.org/W2315233848"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-09-27T00:00:00"}