{"id":"https://openalex.org/W3201615547","doi":"https://doi.org/10.1111/cts.13150","title":"A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults","display_name":"A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults","publication_year":2021,"publication_date":"2021-09-15","ids":{"openalex":"https://openalex.org/W3201615547","doi":"https://doi.org/10.1111/cts.13150","mag":"3201615547","pmid":"https://pubmed.ncbi.nlm.nih.gov/34523814","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8841454"},"language":"en","primary_location":{"id":"doi:10.1111/cts.13150","doi":"https://doi.org/10.1111/cts.13150","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.13150","pdf_url":null,"source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/cts.13150","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101549764","display_name":"Ji\u2010Hyun Jung","orcid":"https://orcid.org/0000-0002-8904-3212","observed_orcids":["https://orcid.org/0000-0002-8904-3212"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihyun Jung","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-8904-3212","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017969197","display_name":"Ki Young Huh","orcid":"https://orcid.org/0000-0002-1872-9954","observed_orcids":["https://orcid.org/0000-0002-1872-9954"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki Young Huh","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-1872-9954","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085428014","display_name":"Xuanyou Jin","orcid":"https://orcid.org/0000-0003-0559-3039","observed_orcids":["https://orcid.org/0000-0003-0559-3039"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Xuanyou Jin","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-0559-3039","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041387187","display_name":"Ahnul Ha","orcid":"https://orcid.org/0000-0003-4211-7971","observed_orcids":["https://orcid.org/0000-0003-4211-7971"]},"institutions":[{"id":"https://openalex.org/I4210165782","display_name":"Jeju National University Hospital","ror":"https://ror.org/05p64mb74","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210165782","https://openalex.org/I83202590"]},{"id":"https://openalex.org/I83202590","display_name":"Jeju National University","ror":"https://ror.org/05hnb4n85","country_code":"KR","type":"education","lineage":["https://openalex.org/I83202590"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ahnul Ha","raw_affiliation_strings":["Department of Ophthalmology, Jeju National University Hospital, Jeju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Jeju National University Hospital, Jeju, Korea","institution_ids":["https://openalex.org/I4210165782","https://openalex.org/I83202590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725708","display_name":"Ki Ho Park","orcid":"https://orcid.org/0000-0002-8137-8843","observed_orcids":["https://orcid.org/0000-0002-8137-8843"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki Ho Park","raw_affiliation_strings":["Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea","Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089202732","display_name":"Jun\u2010Sang Park","orcid":"https://orcid.org/0000-0002-3416-8130","observed_orcids":["https://orcid.org/0000-0002-3416-8130"]},"institutions":[{"id":"https://openalex.org/I4210109750","display_name":"GL PharmTech (South Korea)","ror":"https://ror.org/01ejgx395","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210109750"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun Sang Park","raw_affiliation_strings":["GL PharmTech Corporation, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GL PharmTech Corporation, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I4210109750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462684","display_name":"Eun-Jung Kim","orcid":"https://orcid.org/0000-0003-4982-9517","observed_orcids":["https://orcid.org/0000-0003-4982-9517","https://orcid.org/0009-0006-5842-8116","https://orcid.org/0000-0001-6802-2028"]},"institutions":[{"id":"https://openalex.org/I4210109750","display_name":"GL PharmTech (South Korea)","ror":"https://ror.org/01ejgx395","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210109750"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunjung Kim","raw_affiliation_strings":["GL PharmTech Corporation, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GL PharmTech Corporation, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I4210109750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060525186","display_name":"Jaehwi Lee","orcid":"https://orcid.org/0000-0003-3696-2626","observed_orcids":["https://orcid.org/0000-0003-3696-2626"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaehwi Lee","raw_affiliation_strings":["College of Pharmacy, Chung-Ang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chung-Ang University, Seoul, Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064370332","display_name":"In\u2010Jin Jang","orcid":"https://orcid.org/0000-0002-8384-3139","observed_orcids":["https://orcid.org/0000-0002-8384-3139"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In\u2010Jin Jang","raw_affiliation_strings":["Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061392624","display_name":"Howard Lee","orcid":"https://orcid.org/0000-0001-6713-5418","observed_orcids":["https://orcid.org/0000-0001-6713-5418"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210120602","display_name":"Advanced Institute of Convergence Technology","ror":"https://ror.org/01w62yz22","country_code":"KR","type":"facility","lineage":["https://openalex.org/I139264467","https://openalex.org/I4210120602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Howard Lee","raw_affiliation_strings":["Advanced Institute of Convergence Technology, Gyeonggi-do, Korea","Center for Convergence Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea","Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6713-5418","affiliations":[{"raw_affiliation_string":"Advanced Institute of Convergence Technology, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I4210120602"]},{"raw_affiliation_string":"Center for Convergence Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5061392624"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210120602"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":0.6364,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.60671199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"2","first_page":"343","last_page":"352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.7250000238418579},{"id":"https://openalex.org/keywords/topical-ocular-administration","display_name":"topical ocular administration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.9079999923706055},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.7910000085830688},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.9120380878448486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8933652639389038},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7411421537399292},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7211365699768066},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7014049291610718},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6574262976646423},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6184521317481995},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.41541844606399536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34204530715942383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07819211483001709},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/cts.13150","doi":"https://doi.org/10.1111/cts.13150","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.13150","pdf_url":null,"source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8841454","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8841454/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8841454/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Sci","raw_type":"Text"},{"id":"pmid:34523814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34523814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational science","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:doaj.org/article:81566b0542084efaa9843d231a18e8af","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/81566b0542084efaa9843d231a18e8af","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Science, Vol 15, Iss 2, Pp 343-352 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/cts.13150","doi":"https://doi.org/10.1111/cts.13150","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.13150","pdf_url":null,"source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3201615547.pdf","grobid_xml":"https://content.openalex.org/works/W3201615547.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1979172709","https://openalex.org/W1981284335","https://openalex.org/W2003345406","https://openalex.org/W2004313583","https://openalex.org/W2008868250","https://openalex.org/W2022003523","https://openalex.org/W2027025191","https://openalex.org/W2027422235","https://openalex.org/W2042211250","https://openalex.org/W2045018440","https://openalex.org/W2062047918","https://openalex.org/W2083980783","https://openalex.org/W2088344821","https://openalex.org/W2124196104","https://openalex.org/W2150408174","https://openalex.org/W2164796071","https://openalex.org/W2175015138","https://openalex.org/W2289478614","https://openalex.org/W2333779236","https://openalex.org/W2517440157","https://openalex.org/W2539812081","https://openalex.org/W2556885080","https://openalex.org/W2560124981","https://openalex.org/W2738160893","https://openalex.org/W2738794130","https://openalex.org/W2739359388","https://openalex.org/W2765861461","https://openalex.org/W2766784631","https://openalex.org/W2771007065","https://openalex.org/W2795279419","https://openalex.org/W2799529947","https://openalex.org/W2891690527","https://openalex.org/W2907764593","https://openalex.org/W2909487578","https://openalex.org/W2947656127","https://openalex.org/W2972904630","https://openalex.org/W3106908696"],"related_works":["https://openalex.org/W4255422558","https://openalex.org/W3092150685","https://openalex.org/W4281686111","https://openalex.org/W2326687208","https://openalex.org/W2607232866","https://openalex.org/W2993896537","https://openalex.org/W2023455569","https://openalex.org/W995941616","https://openalex.org/W4405356693","https://openalex.org/W4307262096"],"abstract_inverted_index":{"Abstract":[0],"GLH8NDE,":[1],"a":[2,17,52,60],"derivative":[3],"of":[4,32,45,65,97,105,114,162,168,177],"eupatilin,":[5],"is":[6],"currently":[7],"under":[8,156],"development":[9],"to":[10,25,165],"treat":[11],"dry":[12],"eye":[13,128],"disease.":[14],"We":[15],"conducted":[16],"randomized,":[18],"double\u2010masked,":[19],"placebo\u2010controlled,":[20],"single\u2010":[21,207],"and":[22,30,74,120,194,199,208],"multiple\u2010day":[23,209],"study":[24,79],"evaluate":[26],"safety,":[27],"tolerability,":[28],"pharmacodynamics,":[29],"pharmacokinetics":[31],"ocular":[33,43],"GLH8NDE":[34,46,137,191],"in":[35,83,118,127,184,187,196],"healthy":[36,197],"male":[37,201],"adults.":[38],"Subjects":[39],"randomly":[40],"received":[41],"topical":[42],"dosing":[44],"or":[47,91],"its":[48],"matching":[49],"placebo":[50],"for":[51,55],"day,":[53],"then":[54],"7":[56],"consecutive":[57],"days":[58],"with":[59,89],"62\u2010h":[61],"washout":[62],"at":[63,203],"one":[64],"the":[66,101,142,157,166,169,178],"following":[67],"daily":[68],"doses:":[69],"9,":[70],"18,":[71],"36":[72,75],"(Koreans),":[73],"mg":[76],"(Whites).":[77],"The":[78,149],"drug":[80],"was":[81,138,181,192],"administered":[82],"divided":[84],"doses":[85],"over":[86],"10":[87],"h":[88,147],"2\u2010":[90],"5\u2010h":[92],"intervals.":[93],"Thirty\u2010nine":[94],"(97.5%)":[95],"out":[96],"40":[98],"subjects":[99,107],"completed":[100],"study.":[102],"A":[103],"total":[104],"17":[106],"experienced":[108],"31":[109],"treatment\u2010emergent":[110],"adverse":[111],"events,":[112],"all":[113],"which":[115],"were":[116,135],"mild":[117],"severity":[119],"recovered":[121],"without":[122],"sequelae.":[123],"Neither":[124],"pathological":[125],"changes":[126],"compartments":[129],"nor":[130],"clinically":[131],"significant":[132],"systemic":[133,150],"effects":[134],"observed.":[136],"rapidly":[139],"absorbed":[140],"reaching":[141],"peak":[143],"concentration":[144,172],"within":[145],"0.25\u20130.75":[146],"postdose.":[148],"exposure":[151],"as":[152],"measured":[153],"by":[154],"area":[155],"concentration\u2010time":[158],"curve":[159],"from":[160],"time":[161,167],"administration":[163,176],"up":[164],"last":[170],"quantifiable":[171],"(AUClast)":[173],"after":[174,206],"single\u2010day":[175],"same":[179],"dose":[180],"109%":[182],"higher":[183],"Koreans":[185],"than":[186],"Whites.":[188],"In":[189],"conclusion,":[190],"safe":[193],"well\u2010tolerated":[195],"Korean":[198],"White":[200],"adults":[202],"9\u201336":[204],"mg/day":[205],"administrations.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-09-27T00:00:00"}