{"id":"https://openalex.org/W3201611552","doi":"https://doi.org/10.1021/acs.molpharmaceut.1c00520","title":"Improved Liver Delivery of Primaquine by Phospholipid-Free Small Unilamellar Vesicles with Reduced Hemolytic Toxicity","display_name":"Improved Liver Delivery of Primaquine by Phospholipid-Free Small Unilamellar Vesicles with Reduced Hemolytic Toxicity","publication_year":2021,"publication_date":"2021-09-21","ids":{"openalex":"https://openalex.org/W3201611552","doi":"https://doi.org/10.1021/acs.molpharmaceut.1c00520","mag":"3201611552","pmid":"https://pubmed.ncbi.nlm.nih.gov/34546758"},"language":"en","primary_location":{"id":"doi:10.1021/acs.molpharmaceut.1c00520","doi":"https://doi.org/10.1021/acs.molpharmaceut.1c00520","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.1c00520","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078026282","display_name":"Nojoud AL Fayez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nojoud AL Fayez","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024157972","display_name":"Roland B\u00f6ttger","orcid":"https://orcid.org/0000-0002-5764-6844","observed_orcids":["https://orcid.org/0000-0002-5764-6844"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Roland B\u00f6ttger","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109071042","display_name":"Elham Rouhollahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Elham Rouhollahi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050350074","display_name":"Pieter R. Cullis","orcid":"https://orcid.org/0000-0001-9586-2508","observed_orcids":["https://orcid.org/0000-0001-9586-2508"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210127544","display_name":"NanoMedicines Innovation Network","ror":"https://ror.org/038rwe723","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210127544"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pieter R. Cullis","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","NanoMedicines Innovation Network (NMIN), University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":"https://orcid.org/0000-0001-9586-2508","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"NanoMedicines Innovation Network (NMIN), University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210127544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055119291","display_name":"Dominik Witzigmann","orcid":"https://orcid.org/0000-0002-8197-8558","observed_orcids":["https://orcid.org/0000-0002-8197-8558"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210127544","display_name":"NanoMedicines Innovation Network","ror":"https://ror.org/038rwe723","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210127544"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dominik Witzigmann","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","NanoMedicines Innovation Network (NMIN), University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"NanoMedicines Innovation Network (NMIN), University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210127544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036686531","display_name":"Shyh\u2010Dar Li","orcid":"https://orcid.org/0000-0002-1763-2667","observed_orcids":["https://orcid.org/0000-0002-1763-2667"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210127544","display_name":"NanoMedicines Innovation Network","ror":"https://ror.org/038rwe723","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210127544"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Shyh-Dar Li","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","NanoMedicines Innovation Network (NMIN), University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":"https://orcid.org/0000-0002-1763-2667","affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"NanoMedicines Innovation Network (NMIN), University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210127544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036686531"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210127544"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.2378,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.29842013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"19","issue":"6","first_page":"1778","last_page":"1785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primaquine","display_name":"primaquine","score":1.0},{"id":"https://openalex.org/keywords/hemolytic-toxicity","display_name":"hemolytic toxicity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/liver-stage-malaria","display_name":"liver-stage malaria","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hepatocyte-targeting","display_name":"hepatocyte targeting","score":0.671999990940094},{"id":"https://openalex.org/keywords/red-blood-cell-uptake","display_name":"red blood cell uptake","score":0.746999979019165},{"id":"https://openalex.org/keywords/tween-80","display_name":"Tween 80","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.8769999742507935},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.5860000252723694},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/hepatic-uptake","display_name":"hepatic uptake","score":0.7580000162124634},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.36800000071525574},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7328583002090454},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6983195543289185},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6729112863540649},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6691452860832214},{"id":"https://openalex.org/C2776793103","wikidata":"https://www.wikidata.org/wiki/Q419834","display_name":"Primaquine","level":4,"score":0.6492487788200378},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.6375818848609924},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5825814604759216},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5387417078018188},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5182392597198486},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.48509085178375244},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.4820209741592407},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.47154951095581055},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4538730978965759},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.43476641178131104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3638457655906677},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.33665597438812256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14745670557022095},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13128390908241272},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12711632251739502},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011319","descriptor_name":"Primaquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.molpharmaceut.1c00520","doi":"https://doi.org/10.1021/acs.molpharmaceut.1c00520","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.1c00520","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:34546758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34546758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4076141860","display_name":null,"funder_award_id":"35816","funder_id":"https://openalex.org/F4320319952","funder_display_name":"Canada Foundation for Innovation"},{"id":"https://openalex.org/G6561637601","display_name":null,"funder_award_id":"183923","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6629208816","display_name":null,"funder_award_id":"PJT148610","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6795405498","display_name":"Entwicklung eines stabilen LeuEnkephalinDerivats mit verbesserter antinozizeptiver Wirkung","funder_award_id":"423802991","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8275932967","display_name":"Validation and commercialization of an innovative analgesic for chronic pain","funder_award_id":"168861_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G931230598","display_name":"Development of active loading technologies for encapsulating highly charged molecules into liposomes","funder_award_id":"rgpin-2017-03787","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320319952","display_name":"Canada Foundation for Innovation","ror":"https://ror.org/000az4664"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322997","display_name":"King Abdulaziz City for Science and Technology","ror":"https://ror.org/05tdz6m39"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1558435203","https://openalex.org/W2037912215","https://openalex.org/W2070129920","https://openalex.org/W2088888368","https://openalex.org/W2098424855","https://openalex.org/W2107918320","https://openalex.org/W2114462172","https://openalex.org/W2158149195","https://openalex.org/W2936139108","https://openalex.org/W2957858641","https://openalex.org/W2971457390","https://openalex.org/W2978347369","https://openalex.org/W3136294879"],"related_works":["https://openalex.org/W6923533699","https://openalex.org/W3202197765","https://openalex.org/W2747458291","https://openalex.org/W1697313311","https://openalex.org/W4393097043","https://openalex.org/W2054958558","https://openalex.org/W2071905391","https://openalex.org/W2765626335","https://openalex.org/W1529740929","https://openalex.org/W2003088232"],"abstract_inverted_index":{"Hemolytic":[0],"toxicity":[1,218],"caused":[2],"by":[3,74,103,110,150,197],"primaquine":[4],"(PQ)":[5],"is":[6],"a":[7,59,122,159,180],"high-risk":[8],"condition":[9],"that":[10,24],"hampers":[11],"the":[12,41,47,97,131,134,145,192,205,210,226,246],"wide":[13],"use":[14],"of":[15,31,62,80,125,136,248],"PQ":[16,39,105,120,142,162,224,249],"to":[17,40,46,93,152,155,225,233,237],"treat":[18],"liver-stage":[19,252],"malaria.":[20,253],"This":[21],"study":[22],"demonstrated":[23],"phospholipid-free":[25],"small":[26],"unilamellar":[27],"vesicles":[28],"(PFSUVs)":[29],"composed":[30],"Tween80":[32],"and":[33,37,55,77,87,106,128,189,199,228],"cholesterol":[34],"could":[35],"encapsulate":[36],"deliver":[38],"hepatocytes":[42],"with":[43,58,140,212],"reduced":[44,149,229,238],"exposure":[45],"red":[48],"blood":[49,215],"cells":[50],"(RBCs).":[51],"Nonionic":[52],"surfactant":[53],"(Tween80)":[54],"cholesterol-forming":[56],"SUVs":[57],"mean":[60],"diameter":[61],"50":[63],"nm":[64],"were":[65,82],"fabricated":[66],"for":[67,119,250],"delivering":[68],"PQ.":[69,157],"Drug":[70],"release/retention,":[71],"drug":[72,132],"uptake":[73,79,143,194,231],"RBCs,":[75,141],"pharmacokinetics,":[76],"liver":[78,193,217,227],"PFSUVs-PQ":[81,107,169,178],"evaluated":[83,109],"in":[84,85,88,91,133,144,202,219,244],"vitro":[86],"vivo":[89],"models":[90],"comparison":[92],"free":[94,104,156,161,185,234],"drugs.":[95],"Additionally,":[96],"stress":[98],"effect":[99],"on":[100],"RBCs":[101],"induced":[102,163],"was":[108,148,195],"examining":[111],"RBC":[112,165,230,239],"morphology.":[113],"PFSUVs":[114,146,207,221,241],"provided":[115],">95%":[116],"encapsulation":[117],"efficiency":[118],"at":[121],"drug-to-lipid":[123],"ratio":[124],"1:20":[126],"(w/w)":[127],"stably":[129],"retained":[130],"presence":[135],"serum.":[137],"When":[138],"incubated":[139],"group":[147],"4-":[151],"8-folds":[153],"compared":[154,232],"As":[158],"result,":[160],"significant":[164,214],"morphology":[166],"changes,":[167],"while":[168,191],"showed":[170],"no":[171,213],"such":[172],"adverse":[173],"effect.":[174],"Intravenously":[175],"(i.v.)":[176],"delivered":[177],"produced":[179],"comparable":[181],"plasma":[182],"profile":[183],"as":[184],"PQ,":[186,235],"given":[187],"i.v.":[188],"orally,":[190],"increased":[196],"4.8":[198],"1.6-folds,":[200],"respectively,":[201],"mice.":[203,220],"Within":[204],"liver,":[206],"selectively":[208],"targeted":[209,223],"hepatocytes,":[211],"or":[216],"effectively":[222],"leading":[236],"toxicity.":[240],"exhibited":[242],"potential":[243],"improving":[245],"efficacy":[247],"treating":[251]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-09-27T00:00:00"}
