{"id":"https://openalex.org/W3201464801","doi":"https://doi.org/10.1016/j.nephro.2021.07.238","title":"Atteinte r\u00e9nale de l\u2019amylose \u00e0 transthyr\u00e9tine mut\u00e9e : cohorte r\u00e9trospective marseillaise et n\u00eemoise","display_name":"Atteinte r\u00e9nale de l\u2019amylose \u00e0 transthyr\u00e9tine mut\u00e9e : cohorte r\u00e9trospective marseillaise et n\u00eemoise","publication_year":2021,"publication_date":"2021-09-01","ids":{"openalex":"https://openalex.org/W3201464801","doi":"https://doi.org/10.1016/j.nephro.2021.07.238","mag":"3201464801"},"language":"fr","primary_location":{"id":"doi:10.1016/j.nephro.2021.07.238","doi":"https://doi.org/10.1016/j.nephro.2021.07.238","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nephro.2021.07.238","pdf_url":null,"source":{"id":"https://openalex.org/S149374293","display_name":"N\u00e9phrologie & Th\u00e9rapeutique","issn_l":"1769-7255","issn":["1769-7255","1872-9177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"N\u00e9phrologie &amp; Th\u00e9rapeutique","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058429227","display_name":"Justine Solignac","orcid":"https://orcid.org/0000-0002-3621-3329","observed_orcids":["https://orcid.org/0000-0002-3621-3329"]},"institutions":[{"id":"https://openalex.org/I4210087487","display_name":"Assistance Publique H\u00f4pitaux de Marseille","ror":"https://ror.org/002cp4060","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J. Solignac","raw_affiliation_strings":["APHM, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APHM, Marseille, France","institution_ids":["https://openalex.org/I4210087487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059243583","display_name":"\u00c9milien Delmont","orcid":"https://orcid.org/0000-0002-5591-2774","observed_orcids":["https://orcid.org/0000-0002-5591-2774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Delmont","raw_affiliation_strings":["APHM, Nimes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APHM, Nimes, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050970375","display_name":"Ioana Maria Ion","orcid":"https://orcid.org/0000-0002-8864-6775","observed_orcids":["https://orcid.org/0000-0002-8864-6775"]},"institutions":[{"id":"https://openalex.org/I4210104607","display_name":"Centre Hospitalier Universitaire de N\u00eemes","ror":"https://ror.org/0275ye937","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210104607"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Ion","raw_affiliation_strings":["CHU Nimes, Nimes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Nimes, Nimes, France","institution_ids":["https://openalex.org/I4210104607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085515155","display_name":"J.E. Rici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104607","display_name":"Centre Hospitalier Universitaire de N\u00eemes","ror":"https://ror.org/0275ye937","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210104607"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.E. Rici","raw_affiliation_strings":["CHU Nimes, Nimes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Nimes, Nimes, France","institution_ids":["https://openalex.org/I4210104607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018471206","display_name":"Thomas Robert","orcid":"https://orcid.org/0000-0002-7580-0913","observed_orcids":["https://orcid.org/0000-0002-7580-0913"]},"institutions":[{"id":"https://openalex.org/I4210087487","display_name":"Assistance Publique H\u00f4pitaux de Marseille","ror":"https://ror.org/002cp4060","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T. Robert","raw_affiliation_strings":["APHM, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APHM, Marseille, France","institution_ids":["https://openalex.org/I4210087487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083828441","display_name":"Gilbert Habib","orcid":"https://orcid.org/0000-0003-3899-9983","observed_orcids":["https://orcid.org/0000-0003-3899-9983","https://orcid.org/0000-0003-1544-2322"]},"institutions":[{"id":"https://openalex.org/I4210087487","display_name":"Assistance Publique H\u00f4pitaux de Marseille","ror":"https://ror.org/002cp4060","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Habib","raw_affiliation_strings":["APHM, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APHM, Marseille, France","institution_ids":["https://openalex.org/I4210087487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087896662","display_name":"Olivier P. Moranne","orcid":"https://orcid.org/0000-0002-3127-1415","observed_orcids":["https://orcid.org/0000-0002-3127-1415"]},"institutions":[{"id":"https://openalex.org/I4210104607","display_name":"Centre Hospitalier Universitaire de N\u00eemes","ror":"https://ror.org/0275ye937","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210104607"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O. Moranne","raw_affiliation_strings":["CHU Nimes, Nimes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Nimes, Nimes, France","institution_ids":["https://openalex.org/I4210104607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018755487","display_name":"No\u00e9mie Jourde\u2010Chiche","orcid":"https://orcid.org/0000-0001-9315-1577","observed_orcids":["https://orcid.org/0000-0001-9315-1577"]},"institutions":[{"id":"https://openalex.org/I4210087487","display_name":"Assistance Publique H\u00f4pitaux de Marseille","ror":"https://ror.org/002cp4060","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Jourde Chiche","raw_affiliation_strings":["APHM, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APHM, Marseille, France","institution_ids":["https://openalex.org/I4210087487"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058429227"],"corresponding_institution_ids":["https://openalex.org/I4210087487"],"apc_list":{"value":1400,"currency":"USD","value_usd":1400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"341","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transthyretin-amyloidosis","display_name":"transthyretin amyloidosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/renal-amyloidosis","display_name":"renal amyloidosis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/transthyretin-mutations","display_name":"transthyretin mutations","score":0.777999997138977},{"id":"https://openalex.org/keywords/v30m-mutation","display_name":"V30M mutation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glomerular-proteinuria","display_name":"glomerular proteinuria","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.6690000295639038},{"id":"https://openalex.org/keywords/kidney-biopsy","display_name":"renal biopsy","score":0.37700000405311584},{"id":"https://openalex.org/keywords/renal-survival","display_name":"renal survival","score":0.5519999861717224},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.4569999873638153},{"id":"https://openalex.org/keywords/amyloidosis-treatment","display_name":"amyloidosis treatment","score":0.4099999964237213},{"id":"https://openalex.org/keywords/nimes","display_name":"N\u00eemes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/france","display_name":"France","score":0.5109999775886536},{"id":"https://openalex.org/keywords/vascular-amyloid-deposits","display_name":"vascular amyloid deposits","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7052363753318787},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5675888061523438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.nephro.2021.07.238","doi":"https://doi.org/10.1016/j.nephro.2021.07.238","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nephro.2021.07.238","pdf_url":null,"source":{"id":"https://openalex.org/S149374293","display_name":"N\u00e9phrologie & Th\u00e9rapeutique","issn_l":"1769-7255","issn":["1769-7255","1872-9177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"N\u00e9phrologie &amp; Th\u00e9rapeutique","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W891049731","https://openalex.org/W4319588309","https://openalex.org/W7150923165","https://openalex.org/W7214265633","https://openalex.org/W4404762518","https://openalex.org/W3084066439","https://openalex.org/W3214801615","https://openalex.org/W2327733536","https://openalex.org/W2990133847","https://openalex.org/W2520971638"],"abstract_inverted_index":{"Introduction":[0],"L\u2019amylose":[1],"\u00e0":[2,132,221,320],"transthyr\u00e9tine":[3],"mut\u00e9e":[4],"(ATTR)":[5],"est":[6,19,26,54,169,191,301],"une":[7,184,202,230,237,243,262,306],"maladie":[8],"g\u00e9n\u00e9tique":[9],"syst\u00e9mique":[10],"principalement":[11],"neurologique":[12,232],"et":[13,76,92,224,240,280,287,290,322],"cardiaque.":[14],"L\u2019atteinte":[15,297],"r\u00e9nale":[16,142,214,245,298],"de":[17,74,77,97,140,148,170,218,271,273,299,309,313],"l\u2019ATTR":[18,300],"moins":[20,272],"\u00e9tudi\u00e9e.":[21],"Une":[22,188],"\u00e9volution":[23],"vers":[24],"l\u2019IRCT":[25],"cependant":[27],"rapport\u00e9e":[28],"chez":[29,193,247,251,254,257,266],"10":[30],"%":[31,268,277,284,292],"des":[32,47,62,64,89,179,269],"patients":[33,65,90,160,270],"portugais":[34],"mut\u00e9s":[35],"V30":[36,186],"M.":[37,187],"En":[38],"France,":[39],"les":[40,51,95,333],"mutations":[41],"ATTR":[42,161],"rencontr\u00e9es":[43],"sont":[44,178],"diverses.":[45],"L\u2019\u00e9volution":[46],"param\u00e8tres":[48],"r\u00e9naux":[49],"avec":[50],"nouvelles":[52,334],"th\u00e9rapies":[53],"par":[55,111,123,152,332],"ailleurs":[56],"mal":[57],"connue.":[58],"Description":[59],"Recueil":[60],"r\u00e9trospectif":[61],"cas":[63],"porteurs":[66],"d\u2019une":[67,118,212],"mutation":[68,185],"TTR":[69],"symptomatiques":[70],"suivis":[71],"aux":[72],"CHU":[73],"Marseille":[75],"N\u00eemes,":[78],"du":[79,154],"01/06/2011":[80],"au":[81,233],"01/06/2021.":[82],"Objectifs:":[83],"1)":[84],"Caract\u00e9riser":[85],"le":[86,323],"ph\u00e9notype":[87],"r\u00e9nal":[88,325],"ATTR,":[91],"2)":[93],"identifier":[94],"facteurs":[96],"risque":[98,149],"d\u2019IRC":[99,150],"dans":[100,316,326],"cette":[101,317,327],"population":[102,328],"(mutation,":[103],"atteintes":[104],"extra-r\u00e9nales,":[105],"traitements).":[106],"M\u00e9thodes":[107],"Prot\u00e9inurie":[108],"glom\u00e9rulaire":[109,190],"d\u00e9finie":[110,122],"un":[112,124],"RPCU":[113],"\u2265":[114],"0,5":[115],"g/g":[116],"compos\u00e9":[117],"majorit\u00e9":[119],"d\u2019albumine.":[120],"IRC":[121,256,263,318],"DFG":[125],"estim\u00e9":[126],"<":[127],"60":[128,281,286],"mL/min/1,73m":[129],"2":[130,156],"confirm\u00e9":[131],"3":[133],"mois":[134],"d\u2019intervalle.":[135],"Analyse":[136,139],"transversale":[137],"descriptive.":[138],"survie":[141],"r\u00e9alis\u00e9e":[143],"selon":[144],"Kaplan":[145],"Meier.":[146],"Facteurs":[147],"identifi\u00e9s":[151],"test":[153],"Chi":[155],".":[157],"R\u00e9sultats":[158],"85":[159],"ont":[162,183,210],"\u00e9t\u00e9":[163],"identifi\u00e9s.":[164],"Leur":[165],"\u00e2ge":[166],"moyen":[167],"actuel":[168],"63":[171],"\u00b1":[172],"15ans,":[173],"58":[174,226],"ans,":[175,275,282],"(68":[176],"%)":[177,196,200,206,209,228,236,242],"hommes,":[180],"42":[181],"(49,4%)":[182],"prot\u00e9inurie":[189],"pr\u00e9sente":[192],"9/61":[194],"(14":[195],"patients,":[197],"24":[198],"(28.2":[199],"pr\u00e9sentent":[201],"IRC,":[203],"dont":[204],"2(2,3":[205,208],"IRCT,":[207],"b\u00e9n\u00e9fici\u00e9":[211],"biopsie":[213],"confirmant":[215],"la":[216,260],"pr\u00e9sence":[217],"d\u00e9p\u00f4ts":[219],"amylo\u00efdes":[220],"pr\u00e9dominance":[222],"glom\u00e9rulaires":[223],"vasculaires.":[225],"(68,2":[227],"pr\u00e9sentaient":[229],"atteinte":[231,238,244],"diagnostic,":[234],"23(27,1":[235],"cardiaque":[239],"16(27,5":[241],"(prot\u00e9inurie":[246],"10,":[248],"syndrome":[249],"n\u00e9phrotique":[250],"1,":[252],"HTA":[253],"7,":[255],"13).":[258],"Dans":[259],"cohorte,":[261],"\u00e9tait":[264],"observ\u00e9e":[265],"9":[267],"40":[274,279],"15":[276],"entre":[278,285],"34":[283],"80":[288,294],"ans":[289],"57":[291],"apr\u00e8s":[293],"ans.":[295],"Conclusion":[296],"m\u00e9connue,":[302],"pourtant":[303],"l\u2019IRC":[304],"concerne":[305],"proportion":[307],"importante":[308],"patients.":[310],"La":[311],"participation":[312],"l\u2019amylose":[314],"elle-m\u00eame":[315],"reste":[319],"\u00e9tudier,":[321],"pronostic":[324],"pourrait":[329],"\u00eatre":[330],"modifi\u00e9":[331],"th\u00e9rapeutiques":[335],"sp\u00e9cifiques.":[336]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-09-27T00:00:00"}