{"id":"https://openalex.org/W3201216376","doi":"https://doi.org/10.21203/rs.3.rs-145148/v1","title":"Proteome Study of Cutaneous Lupus Erythematosus (CLE) and Dermatomyositis Skin Lesions Reveals IL-16 Is Differentially Upregulated in CLE","display_name":"Proteome Study of Cutaneous Lupus Erythematosus (CLE) and Dermatomyositis Skin Lesions Reveals IL-16 Is Differentially Upregulated in CLE","publication_year":2021,"publication_date":"2021-01-15","ids":{"openalex":"https://openalex.org/W3201216376","doi":"https://doi.org/10.21203/rs.3.rs-145148/v1","mag":"3201216376"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-145148/v1","doi":"https://doi.org/10.21203/rs.3.rs-145148/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-145148/v1","pdf_url":"https://www.researchsquare.com/article/rs-145148/v1.pdf?c=1631885192000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-145148/v1.pdf?c=1631885192000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081279169","display_name":"Timothy B. Niewold","orcid":"https://orcid.org/0000-0003-3532-6660","observed_orcids":["https://orcid.org/0000-0003-3532-6660"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy B. Niewold","raw_affiliation_strings":["Colton Center for Autoimmunity, New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colton Center for Autoimmunity, New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036477761","display_name":"Alexander Meves","orcid":"https://orcid.org/0000-0001-7462-8288","observed_orcids":["https://orcid.org/0000-0001-7462-8288"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Meves","raw_affiliation_strings":["Mayo Clinic Rochester Department of Dermatology: Mayo Clinic Minnesota Department of Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester Department of Dermatology: Mayo Clinic Minnesota Department of Dermatology","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040139732","display_name":"Julia Scott Lehman","orcid":"https://orcid.org/0000-0002-7389-3853","observed_orcids":["https://orcid.org/0000-0002-7389-3853"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia S. Lehman","raw_affiliation_strings":["Mayo Clinic Rochester Department of Dermatology: Mayo Clinic Minnesota Department of Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester Department of Dermatology: Mayo Clinic Minnesota Department of Dermatology","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043100841","display_name":"Karin Popovic-Silwerfeldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802208705","display_name":"Danderyds sjukhus","ror":"https://ror.org/00hm9kt34","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2802208705","https://openalex.org/I28166907"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karin Popovic-Silwerfeldt","raw_affiliation_strings":["Karolinska Institute Department of Clinical Sciences Danderyd Hospital: Karolinska Institutet Institutionen for kliniska vetenskaper Danderyds sjukhus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute Department of Clinical Sciences Danderyd Hospital: Karolinska Institutet Institutionen for kliniska vetenskaper Danderyds sjukhus","institution_ids":["https://openalex.org/I2802208705","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053567105","display_name":"Aliisa H\u00e4yry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Aliisa H\u00e4yry","raw_affiliation_strings":["Karolinska Institutet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090650496","display_name":"Therese S\u00f6derlund-Matell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Therese S\u00f6derlund-Matell","raw_affiliation_strings":["Karolinska Institute: Karolinska Institutet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute: Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069965195","display_name":"Cristine M. Charlesworth","orcid":"https://orcid.org/0000-0001-7481-817X","observed_orcids":["https://orcid.org/0000-0001-7481-817X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristine M. Charlesworth","raw_affiliation_strings":["Mayo Clinic Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Cancer Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057920575","display_name":"Benjamin J. Madden","orcid":"https://orcid.org/0000-0001-9167-8535","observed_orcids":["https://orcid.org/0000-0001-9167-8535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Madden","raw_affiliation_strings":["Mayo Clinic Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Cancer Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011002229","display_name":"Ingrid E. Lundberg","orcid":"https://orcid.org/0000-0002-6068-9212","observed_orcids":["https://orcid.org/0000-0002-6068-9212"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ingrid E. Lundberg","raw_affiliation_strings":["Karolinska Institutet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054840940","display_name":"Marie Wahren\u2010Herlenius","orcid":"https://orcid.org/0000-0002-0915-7245","observed_orcids":["https://orcid.org/0000-0002-0915-7245"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marie Wahren-Herlenius","raw_affiliation_strings":["Karolinska Institutet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053954343","display_name":"Elisabet Svenungsson","orcid":"https://orcid.org/0000-0003-3396-3244","observed_orcids":["https://orcid.org/0000-0003-3396-3244"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elisabet Svenungsson","raw_affiliation_strings":["Karolinska Universitetssjukhuset i Solna: Karolinska Universitetssjukhuset"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Universitetssjukhuset i Solna: Karolinska Universitetssjukhuset","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005888154","display_name":"Vilija Oke","orcid":"https://orcid.org/0000-0002-1834-2688","observed_orcids":["https://orcid.org/0000-0002-1834-2688"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vilija Oke","raw_affiliation_strings":["Rheumatology Unit"],"raw_orcid":"https://orcid.org/0000-0002-1834-2688","affiliations":[{"raw_affiliation_string":"Rheumatology Unit","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5005888154"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-lupus-erythematosus","display_name":"cutaneous lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/dermatomyositis","display_name":"dermatomyositis","score":1.0},{"id":"https://openalex.org/keywords/skin-lesions","display_name":"skin lesions","score":0.7390000224113464},{"id":"https://openalex.org/keywords/interleukin-16","display_name":"interleukin-16","score":0.8960000276565552},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/complement-deposition","display_name":"complement deposition","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.5419999957084656},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/inflammatory-cell-infiltration","display_name":"inflammatory cell infiltration","score":0.6660000085830688},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2778751314","wikidata":"https://www.wikidata.org/wiki/Q681160","display_name":"Dermatomyositis","level":2,"score":0.8657618761062622},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5039412379264832},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.46382251381874084},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4566246271133423},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.423052042722702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4133705496788025},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3565061688423157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3176116347312927},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.10595092177391052},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08993491530418396},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07533952593803406},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06978127360343933}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-145148/v1","doi":"https://doi.org/10.21203/rs.3.rs-145148/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-145148/v1","pdf_url":"https://www.researchsquare.com/article/rs-145148/v1.pdf?c=1631885192000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-145148/v1","doi":"https://doi.org/10.21203/rs.3.rs-145148/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-145148/v1","pdf_url":"https://www.researchsquare.com/article/rs-145148/v1.pdf?c=1631885192000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1538818033","display_name":"The Role of IL-17 Axis in Inflammatory Myositis","funder_award_id":"R01AR057781","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2200175601","display_name":"Interferon Alpha as a Tool for Gene Discovery in Human Lupus","funder_award_id":"R01AR060861","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3106498125","display_name":"Interferon Regulatory Factor 5 in Human Lupus Pathogenesis","funder_award_id":"R01AR065964","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3557529938","display_name":null,"funder_award_id":"5P30 CA15083-43C1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7081226023","display_name":null,"funder_award_id":"CA15083-43C1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G844520391","display_name":null,"funder_award_id":"CA 15083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000016378","display_name":null,"funder_award_id":"5P30 CA15083-43C1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000126810","display_name":null,"funder_award_id":"CA15083","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320313227","display_name":"Lupus Research Alliance","ror":null},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320324797","display_name":"Reumatikerf\u00f6rbundet","ror":"https://ror.org/00zps9v98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3201216376.pdf","grobid_xml":"https://content.openalex.org/works/W3201216376.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1236342233","https://openalex.org/W1532037992","https://openalex.org/W1991978773","https://openalex.org/W2032064299","https://openalex.org/W2125267886","https://openalex.org/W2137396940","https://openalex.org/W2168606677","https://openalex.org/W2416562304","https://openalex.org/W3041794603"],"related_works":["https://openalex.org/W6977064917","https://openalex.org/W6939555149","https://openalex.org/W3126108395","https://openalex.org/W3013993721","https://openalex.org/W4385639441","https://openalex.org/W4379801714","https://openalex.org/W4401281212","https://openalex.org/W4392853642","https://openalex.org/W3041794603","https://openalex.org/W1992287960"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2021-09-27T00:00:00"}
