{"id":"https://openalex.org/W3200794875","doi":"https://doi.org/10.3390/cancers13184555","title":"Novel Insights into the Antagonistic Effects of Losartan against Angiotensin II/AGTR1 Signaling in Glioblastoma Cells","display_name":"Novel Insights into the Antagonistic Effects of Losartan against Angiotensin II/AGTR1 Signaling in Glioblastoma Cells","publication_year":2021,"publication_date":"2021-09-10","ids":{"openalex":"https://openalex.org/W3200794875","doi":"https://doi.org/10.3390/cancers13184555","mag":"3200794875","pmid":"https://pubmed.ncbi.nlm.nih.gov/34572782","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8469998"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13184555","doi":"https://doi.org/10.3390/cancers13184555","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13184555","pdf_url":"https://www.mdpi.com/2072-6694/13/18/4555/pdf?version=1631960849","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/18/4555/pdf?version=1631960849","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020724674","display_name":"Salvatore Panza","orcid":"https://orcid.org/0000-0001-9600-0272","observed_orcids":["https://orcid.org/0000-0001-9600-0272"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Panza","raw_affiliation_strings":["Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]},{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053927161","display_name":"Rocco Malivindi","orcid":"https://orcid.org/0000-0002-8313-2492","observed_orcids":["https://orcid.org/0000-0002-8313-2492"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rocco Malivindi","raw_affiliation_strings":["Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8313-2492","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083387777","display_name":"Amanda Caruso","orcid":"https://orcid.org/0000-0002-3254-5764","observed_orcids":["https://orcid.org/0000-0002-3254-5764"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amanda Caruso","raw_affiliation_strings":["Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]},{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044656236","display_name":"Umberto Russo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Umberto Russo","raw_affiliation_strings":["Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047748434","display_name":"Francesca Giordano","orcid":"https://orcid.org/0000-0002-7621-1969","observed_orcids":["https://orcid.org/0000-0002-7621-1969"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Giordano","raw_affiliation_strings":["Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7621-1969","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023340072","display_name":"Bal\u00e1zs Gy\u0151rffy","orcid":"https://orcid.org/0000-0002-5772-3766","observed_orcids":["https://orcid.org/0000-0002-5772-3766"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Bal\u00e1zs Gy\u0151rffy","raw_affiliation_strings":["Cancer Biomarker Research Group, Research Centre for Natural Sciences, 1117 Budapest, Hungary","Department of Bioinformatics, Semmelweis University, 1094 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biomarker Research Group, Research Centre for Natural Sciences, 1117 Budapest, Hungary","institution_ids":["https://openalex.org/I80251312"]},{"raw_affiliation_string":"Department of Bioinformatics, Semmelweis University, 1094 Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029676025","display_name":"Luca Gelsomino","orcid":"https://orcid.org/0000-0003-3076-3482","observed_orcids":["https://orcid.org/0000-0003-3076-3482"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Gelsomino","raw_affiliation_strings":["Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074610701","display_name":"Francesca De Amicis","orcid":"https://orcid.org/0000-0001-7079-1037","observed_orcids":["https://orcid.org/0000-0001-7079-1037"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca De Amicis","raw_affiliation_strings":["Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7079-1037","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046031758","display_name":"Ines Barone","orcid":"https://orcid.org/0000-0002-9769-1615","observed_orcids":["https://orcid.org/0000-0002-9769-1615"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ines Barone","raw_affiliation_strings":["Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9769-1615","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038725564","display_name":"Francesca Luisa Conforti","orcid":"https://orcid.org/0000-0001-8364-1783","observed_orcids":["https://orcid.org/0000-0001-8364-1783"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Luisa Conforti","raw_affiliation_strings":["Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8364-1783","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048878801","display_name":"Cinzia Giordano","orcid":"https://orcid.org/0000-0003-4969-0607","observed_orcids":["https://orcid.org/0000-0003-4969-0607"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Giordano","raw_affiliation_strings":["Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]},{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054597220","display_name":"Daniela Bonofiglio","orcid":"https://orcid.org/0000-0002-4142-0496","observed_orcids":["https://orcid.org/0000-0002-4142-0496"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Bonofiglio","raw_affiliation_strings":["Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4142-0496","affiliations":[{"raw_affiliation_string":"Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]},{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013221500","display_name":"Stefania Catalano","orcid":"https://orcid.org/0000-0002-6352-9628","observed_orcids":["https://orcid.org/0000-0002-6352-9628"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Catalano","raw_affiliation_strings":["Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]},{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102010816","display_name":"Sebastiano And\u00f2","orcid":"https://orcid.org/0000-0002-5412-7045","observed_orcids":["https://orcid.org/0000-0002-5412-7045"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sebastiano And\u00f2","raw_affiliation_strings":["Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Sanitario, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]},{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, CS, Italy","institution_ids":["https://openalex.org/I45204951"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102010816"],"corresponding_institution_ids":["https://openalex.org/I45204951"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":1.0983,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78816019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"13","issue":"18","first_page":"4555","last_page":"4555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.39579999446868896,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9940000176429749},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.953000009059906},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.7459999918937683},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.718999981880188},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.9049999713897705},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.843999981880188},{"id":"https://openalex.org/keywords/u87mg","display_name":"U87MG","score":0.7879999876022339},{"id":"https://openalex.org/keywords/t98g-cells","display_name":"T98G cells","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.862112283706665},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.646175742149353},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.640582263469696},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.5838870406150818},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5615127682685852},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5299369096755981},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4986116886138916},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.4400224983692169},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.42895999550819397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4206914007663727},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.41571539640426636},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4020041525363922},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3258204758167267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32541146874427795},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3224574327468872},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3201944828033447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3034396767616272},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.22888922691345215},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21555852890014648},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19715839624404907}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers13184555","doi":"https://doi.org/10.3390/cancers13184555","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13184555","pdf_url":"https://www.mdpi.com/2072-6694/13/18/4555/pdf?version=1631960849","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7358301","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8469998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34572782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34572782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8469998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8469998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:iris.unical.it:20.500.11770/325110","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11770/325110","pdf_url":null,"source":{"id":"https://openalex.org/S4377196898","display_name":"Archive of Doctoral Theses and Digital Collections (University of Calabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45204951","host_organization_name":"University of Calabria","host_organization_lineage":["https://openalex.org/I45204951"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/cancers13184555","doi":"https://doi.org/10.3390/cancers13184555","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13184555","pdf_url":"https://www.mdpi.com/2072-6694/13/18/4555/pdf?version=1631960849","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1890583091","display_name":null,"funder_award_id":"2017WNKSLR_005","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G2643656560","display_name":null,"funder_award_id":"2020-4.1.1-TKP2020","funder_id":"https://openalex.org/F4320328991","funder_display_name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium"},{"id":"https://openalex.org/G6466489280","display_name":null,"funder_award_id":"#21414","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G655170302","display_name":null,"funder_award_id":"Italian Law232/2016","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G7953259183","display_name":null,"funder_award_id":"SI.F.I.PA.CRO.DE #ARS01_00568","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G842338273","display_name":null,"funder_award_id":"# 2017EKMFTN_001","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320328991","display_name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","ror":"https://ror.org/02ey3ab96"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3200794875.pdf","grobid_xml":"https://content.openalex.org/works/W3200794875.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1513652543","https://openalex.org/W1528128932","https://openalex.org/W1603491949","https://openalex.org/W1936956202","https://openalex.org/W1969765578","https://openalex.org/W1971233212","https://openalex.org/W1972882573","https://openalex.org/W1974071557","https://openalex.org/W1976269164","https://openalex.org/W1978857579","https://openalex.org/W1979140041","https://openalex.org/W2001932267","https://openalex.org/W2003438982","https://openalex.org/W2004279850","https://openalex.org/W2004844722","https://openalex.org/W2011540227","https://openalex.org/W2023828818","https://openalex.org/W2028465590","https://openalex.org/W2030843982","https://openalex.org/W2045672038","https://openalex.org/W2046480033","https://openalex.org/W2049926490","https://openalex.org/W2050302729","https://openalex.org/W2062315618","https://openalex.org/W2073976254","https://openalex.org/W2075629192","https://openalex.org/W2081928176","https://openalex.org/W2085934079","https://openalex.org/W2093463728","https://openalex.org/W2094825563","https://openalex.org/W2098054841","https://openalex.org/W2102857569","https://openalex.org/W2115223012","https://openalex.org/W2117692326","https://openalex.org/W2134192364","https://openalex.org/W2142080475","https://openalex.org/W2143772132","https://openalex.org/W2158348986","https://openalex.org/W2164675211","https://openalex.org/W2168782395","https://openalex.org/W2231000545","https://openalex.org/W2265426319","https://openalex.org/W2295691727","https://openalex.org/W2295953618","https://openalex.org/W2412946572","https://openalex.org/W2473604962","https://openalex.org/W2527905628","https://openalex.org/W2551403261","https://openalex.org/W2607567876","https://openalex.org/W2799898775","https://openalex.org/W2806497641","https://openalex.org/W2808979164","https://openalex.org/W2898788563","https://openalex.org/W2905077224","https://openalex.org/W2907722642","https://openalex.org/W2938119062","https://openalex.org/W3006076919","https://openalex.org/W3015189012","https://openalex.org/W3036950360","https://openalex.org/W3044680969","https://openalex.org/W3056214675","https://openalex.org/W3087966987","https://openalex.org/W3118268163","https://openalex.org/W3133584830","https://openalex.org/W3156450253","https://openalex.org/W4238190948","https://openalex.org/W6645160211","https://openalex.org/W6651243476"],"related_works":["https://openalex.org/W2094825563","https://openalex.org/W3016671966","https://openalex.org/W4243104695","https://openalex.org/W2953397621","https://openalex.org/W1974742704","https://openalex.org/W7204807571","https://openalex.org/W2145221672","https://openalex.org/W4393993083","https://openalex.org/W4200357489","https://openalex.org/W4318765043"],"abstract_inverted_index":{"New":[0],"avenues":[1],"for":[2,203],"glioblastoma":[3,38,106,124,138,188,204],"therapy":[4],"are":[5],"required":[6],"due":[7],"to":[8,115,150,199],"the":[9,14,71,110,166],"limited":[10],"mortality":[11],"benefit":[12],"of":[13,70,174],"current":[15],"treatments.":[16],"The":[17,37,98,116],"renin-angiotensin":[18],"system":[19,29],"(RAS)":[20],"exhibits":[21],"local":[22,63,184],"actions":[23],"and":[24,33,43,60,77,155,171,177],"works":[25],"as":[26],"a":[27,67,89],"paracrine":[28],"in":[30,58,61,88,103,137,153,156,163],"different":[31],"tissues":[32],"tumors,":[34],"including":[35],"glioma.":[36],"cell":[39,189],"lines":[40],"U-87":[41],"MG":[42],"T98G":[44],"overexpresses":[45],"Angiotensin":[46],"II":[47,50,135,176],"(Ang":[48],"II)/Angiotensin":[49],"type":[51],"I":[52],"receptor":[53],"(AGTR1)":[54],"signaling,":[55],"which":[56],"enhances":[57],"vitro":[59,154],"vivo":[62],"estrogen":[64,86,185],"production":[65],"through":[66,92],"direct":[68],"up-regulation":[69],"aromatase":[72,100],"gene":[73],"promoters":[74],"p":[75,78],"I.f":[76],"I.4.":[79],"In":[80],"addition,":[81,164],"Ang":[82,134,175],"II/AGTR1":[83],"signaling":[84],"transactivates":[85],"receptor-\u03b1":[87],"ligand-independent":[90],"manner":[91],"mitogen-activated":[93],"protein":[94],"kinase":[95],"(MAPK)":[96],"activation.":[97],"higher":[99],"mRNA":[101],"expression":[102,145],"patients":[104],"with":[105,109],"was":[107],"associated":[108],"worst":[111],"survival":[112],"prognostic,":[113],"according":[114],"Cancer":[117],"Genome":[118],"Atlas":[119],"(TCGA).":[120],"An":[121],"intrinsic":[122],"immunosuppressive":[123,172],"tumor":[125],"milieu":[126],"has":[127],"been":[128],"previously":[129,167],"documented.":[130],"We":[131],"demonstrate":[132],"how":[133,161],"treatment":[136],"cells":[139],"increases":[140],"programmed":[141],"death-ligand":[142],"1":[143],"(PD-L1)":[144],"reversed":[146],"by":[147],"combined":[148],"exposure":[149],"Losartan":[151,192],"(LOS)":[152],"vivo.":[157],"Our":[158],"findings":[159],"highlight":[160],"LOS,":[162],"antagonizes":[165],"documented":[168],"neoangiogenetic,":[169],"profibrotic,":[170],"effects":[173,182],"drastically":[178],"inhibits":[179],"its":[180],"stimulatory":[181],"on":[183],"production,":[186],"sustaining":[187],"growth.":[190],"Thus,":[191],"may":[193],"represent":[194],"an":[195],"adjuvant":[196],"pharmacological":[197],"tool":[198],"be":[200],"repurposed":[201],"prospectively":[202],"treatment.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-09-27T00:00:00"}