{"id":"https://openalex.org/W3200768869","doi":"https://doi.org/10.1016/j.mrfmmm.2021.111762","title":"Biochemical and photochemical mechanisms that produce different UV-induced mutation spectra","display_name":"Biochemical and photochemical mechanisms that produce different UV-induced mutation spectra","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W3200768869","doi":"https://doi.org/10.1016/j.mrfmmm.2021.111762","mag":"3200768869","pmid":"https://pubmed.ncbi.nlm.nih.gov/34563793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8671204"},"language":"en","primary_location":{"id":"doi:10.1016/j.mrfmmm.2021.111762","doi":"https://doi.org/10.1016/j.mrfmmm.2021.111762","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mrfmmm.2021.111762","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0027510721000257/pdf","source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0027510721000257/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061352298","display_name":"Tomohiko Sugiyama","orcid":"https://orcid.org/0000-0003-2942-3667","observed_orcids":["https://orcid.org/0000-0003-2942-3667"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tomohiko Sugiyama","raw_affiliation_strings":["Department of Biological Sciences; Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH, 45701, USA. Electronic address: sugiyama@ohio.edu","Department of Biological Sciences","Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH, 45701, USA"],"raw_orcid":"https://orcid.org/0000-0003-2942-3667","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences; Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH, 45701, USA. Electronic address: sugiyama@ohio.edu","institution_ids":["https://openalex.org/I4210106879"]},{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH, 45701, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018236111","display_name":"Brianna Keinard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brianna Keinard","raw_affiliation_strings":["Department of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059231960","display_name":"Griffin Best","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Griffin Best","raw_affiliation_strings":["Department of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072433480","display_name":"Mahima R. Sanyal","orcid":"https://orcid.org/0000-0002-9095-7388","observed_orcids":["https://orcid.org/0000-0002-9095-7388"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahima R. Sanyal","raw_affiliation_strings":["Department of Biological Sciences; Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH, 45701, USA","Department of Biological Sciences","Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH, 45701, USA"],"raw_orcid":"https://orcid.org/0000-0002-9095-7388","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences; Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH, 45701, USA","institution_ids":["https://openalex.org/I4210106879"]},{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Molecular and Cellular Biology Graduate Program, Ohio University, Athens, OH, 45701, USA","institution_ids":["https://openalex.org/I4210106879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061352298"],"corresponding_institution_ids":["https://openalex.org/I4210106879"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.7061,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.65144352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"823","issue":null,"first_page":"111762","last_page":"111762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uv-mutagenesis","display_name":"UV mutagenesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/pyrimidine-dimers","display_name":"pyrimidine dimers","score":0.8009999990463257},{"id":"https://openalex.org/keywords/translesion-synthesis","display_name":"translesion synthesis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/y-family-dna-polymerases","display_name":"Y-family DNA polymerases","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cytosine-deamination","display_name":"cytosine deamination","score":0.875},{"id":"https://openalex.org/keywords/c-t-transitions","display_name":"C>T transitions","score":0.6970000267028809},{"id":"https://openalex.org/keywords/guanine-oxidation","display_name":"guanine oxidation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mutation-spectrum","display_name":"mutation spectrum","score":0.6480000019073486},{"id":"https://openalex.org/keywords/sunlight","display_name":"sunlight","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C167975912","wikidata":"https://www.wikidata.org/wiki/Q1018722","display_name":"Pyrimidine dimer","level":4,"score":0.822872519493103},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.8030775785446167},{"id":"https://openalex.org/C145782189","wikidata":"https://www.wikidata.org/wiki/Q628025","display_name":"Deamination","level":3,"score":0.7748252153396606},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6660877466201782},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5400065183639526},{"id":"https://openalex.org/C2779554091","wikidata":"https://www.wikidata.org/wiki/Q182990","display_name":"Uracil","level":3,"score":0.5388744473457336},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5052943825721741},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.48867157101631165},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.46610674262046814},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.41669905185699463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41124963760375977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4001506268978119},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39346104860305786},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3740854859352112},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3281668424606323},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.32562482357025146},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.24747827649116516},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18990227580070496},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13426446914672852}],"mesh":[{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004277","descriptor_name":"DNA, Single-Stranded","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004277","descriptor_name":"DNA, Single-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011740","descriptor_name":"Pyrimidine Dimers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011740","descriptor_name":"Pyrimidine Dimers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013472","descriptor_name":"Sunlight","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.mrfmmm.2021.111762","doi":"https://doi.org/10.1016/j.mrfmmm.2021.111762","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mrfmmm.2021.111762","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0027510721000257/pdf","source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","raw_type":"journal-article"},{"id":"pmid:34563793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34563793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8671204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8671204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mutat Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.mrfmmm.2021.111762","doi":"https://doi.org/10.1016/j.mrfmmm.2021.111762","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mrfmmm.2021.111762","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0027510721000257/pdf","source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1272409968","display_name":"NGS-based analysis of mutation signatures during the translesion synthesis","funder_award_id":"9r15es029723-02a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G159763570","display_name":null,"funder_award_id":"R15 GM116098","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4203705315","display_name":"NGS-based analysis of mutation signatures during the translesion synthesis","funder_award_id":"1r15gm116098-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G877538270","display_name":null,"funder_award_id":"R15ES029723","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3200768869.pdf","grobid_xml":"https://content.openalex.org/works/W3200768869.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1709525116","https://openalex.org/W1786896381","https://openalex.org/W1840855988","https://openalex.org/W1966505793","https://openalex.org/W1967935080","https://openalex.org/W1968679294","https://openalex.org/W1969190950","https://openalex.org/W1970925815","https://openalex.org/W1974383197","https://openalex.org/W1981121984","https://openalex.org/W1984626661","https://openalex.org/W1984743062","https://openalex.org/W1991924773","https://openalex.org/W1992025635","https://openalex.org/W1993548347","https://openalex.org/W1995535123","https://openalex.org/W1997901827","https://openalex.org/W1998439415","https://openalex.org/W2001955887","https://openalex.org/W2006803834","https://openalex.org/W2008507595","https://openalex.org/W2039787322","https://openalex.org/W2040898244","https://openalex.org/W2041683774","https://openalex.org/W2042344660","https://openalex.org/W2042802564","https://openalex.org/W2045775784","https://openalex.org/W2048155476","https://openalex.org/W2051435128","https://openalex.org/W2052673967","https://openalex.org/W2055955746","https://openalex.org/W2063240589","https://openalex.org/W2067139494","https://openalex.org/W2067957471","https://openalex.org/W2076488752","https://openalex.org/W2077373507","https://openalex.org/W2077403011","https://openalex.org/W2079288268","https://openalex.org/W2080941285","https://openalex.org/W2085719635","https://openalex.org/W2090566390","https://openalex.org/W2091201245","https://openalex.org/W2092392558","https://openalex.org/W2094123289","https://openalex.org/W2095328031","https://openalex.org/W2103797279","https://openalex.org/W2112864654","https://openalex.org/W2113356069","https://openalex.org/W2115568198","https://openalex.org/W2117157796","https://openalex.org/W2120053712","https://openalex.org/W2128077400","https://openalex.org/W2129361946","https://openalex.org/W2142233919","https://openalex.org/W2143064529","https://openalex.org/W2152061559","https://openalex.org/W2158606857","https://openalex.org/W2160656722","https://openalex.org/W2281395179","https://openalex.org/W2470508052","https://openalex.org/W2542991120","https://openalex.org/W2611187032","https://openalex.org/W2754311144","https://openalex.org/W2784555568","https://openalex.org/W2944489970","https://openalex.org/W2995233526","https://openalex.org/W3004480399","https://openalex.org/W3091193245","https://openalex.org/W4233505281","https://openalex.org/W4238202099","https://openalex.org/W6670673774"],"related_works":["https://openalex.org/W2944489970","https://openalex.org/W2129361946","https://openalex.org/W1998439415","https://openalex.org/W4390732826","https://openalex.org/W4372336060","https://openalex.org/W2111009290","https://openalex.org/W2077373507","https://openalex.org/W1992294575","https://openalex.org/W4392593920","https://openalex.org/W2131412000"],"abstract_inverted_index":{"Although":[0],"UV-induced":[1,12,279],"mutagenesis":[2,280],"has":[3,233],"been":[4],"studied":[5],"extensively,":[6],"the":[7,55,71,121,137,141],"precise":[8],"mechanisms":[9,277],"that":[10,48,79,92,117,130,173,262],"convert":[11],"DNA":[13,23],"damage":[14],"into":[15,82],"mutations":[16,165],"remain":[17],"elusive.":[18],"One":[19],"well-studied":[20],"mechanism":[21,47],"involves":[22,49],"polymerase":[24,146],"(Pol)":[25],"\u03b7":[26],"and":[27,70,140,218],"\u03b6,":[28],"which":[29,190,239],"produces":[30],"C":[31,186],">":[32,187,236,251],"T":[33,235,250],"transitions":[34],"during":[35],"translesion":[36],"synthesis":[37],"(TLS)":[38],"across":[39],"pyrimidine":[40,68,258,270],"dimers.":[41,271],"We":[42,114],"previously":[43],"proposed":[44],"another":[45,243],"biochemical":[46],"multiple":[50,276],"UV-irradiations":[51],"with":[52,159],"incubation":[53,60,119],"in":[54,57,66,100,120,202,206,242],"dark":[56,122],"between.":[58],"The":[59,102,162,247],"facilitates":[61],"spontaneous":[62],"deamination":[63,132,175],"of":[64,169,196,268,278],"cytosine":[65,81,131,174],"a":[67,151,207,225],"dimer,":[69],"subsequent":[72],"UV":[73],"irradiation":[74],"induces":[75],"photolyase-independent":[76],"(direct)":[77],"photoreversal":[78,104],"converts":[80],"monomeric":[83],"uracil":[84],"residue.":[85],"In":[86],"this":[87,180,263],"paper,":[88],"we":[89,200],"first":[90],"demonstrate":[91,116],"natural":[93],"sunlight":[94],"can":[95],"induce":[96],"both":[97,126,136,215],"mutational":[98,127,181,264],"processes":[99],"vitro.":[101],"direct":[103],"was":[105,176],"also":[106,115,149,184],"reproduced":[107],"by":[108,194],"monochromatic":[109],"UVB":[110],"at":[111],"300":[112],"nm.":[113],"post-irradiation":[118,170],"is":[123,133,266,281],"required":[124,134],"for":[125,135,179],"processes,":[128],"suggesting":[129,261],"Pol":[138,147,160,163,216,229,248],"\u03b7/\u03b6-dependent":[139],"photoreversal-dependent":[142,219],"mechanisms.":[143],"Another":[144],"Y-family":[145],"\u03b9":[148],"mediated":[150],"mutagenic":[152],"TLS":[153],"on":[154],"UV-damaged":[155],"templates":[156],"when":[157],"combined":[158],"\u03b6.":[161],"\u03b9-dependent":[164,230,249],"were":[166,191,254],"largely":[167],"independent":[168,267],"incubation,":[171],"indicating":[172],"not":[177],"essential":[178],"process.":[182],"Sunlight-exposure":[183],"induced":[185],"A":[188],"transversions":[189],"likely":[192],"caused":[193],"oxidation":[195],"guanine":[197],"residues.":[198],"Finally,":[199],"constructed":[201],"vitro":[203],"mutation":[204,212,231],"spectra":[205,220],"comparable":[208],"format":[209],"to":[210,224,256],"cancer":[211,226,244],"signatures.":[213],"While":[214],"\u03b7-dependent":[217],"showed":[221],"high":[222],"similarities":[223],"signature":[227,245],"(SBS7a),":[228],"spectrum":[232],"distinct":[234],"A/C":[237,252],"substitutions,":[238],"are":[240],"found":[241],"(SBS7d).":[246],"substitutions":[253],"resistant":[255],"T4":[257],"dimer":[259],"glycosylase-treatment,":[260],"process":[265],"cis-syn":[269],"An":[272],"updated":[273],"model":[274],"about":[275],"discussed.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-09-27T00:00:00"}