{"id":"https://openalex.org/W3200715212","doi":"https://doi.org/10.1080/21655979.2021.1965694","title":"Overexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy","display_name":"Overexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3200715212","doi":"https://doi.org/10.1080/21655979.2021.1965694","mag":"3200715212","pmid":"https://pubmed.ncbi.nlm.nih.gov/34528498","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8806855"},"language":"en","primary_location":{"id":"doi:10.1080/21655979.2021.1965694","doi":"https://doi.org/10.1080/21655979.2021.1965694","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21655979.2021.1965694","pdf_url":null,"source":{"id":"https://openalex.org/S4210193419","display_name":"Bioengineered","issn_l":"2165-5979","issn":["2165-5979","2165-5987"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineered","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3200715212"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/21655979.2021.1965694","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028693528","display_name":"Lijin Zhu","orcid":"https://orcid.org/0000-0002-8206-0570","observed_orcids":["https://orcid.org/0000-0002-8206-0570"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijin Zhu","raw_affiliation_strings":["The Affiliated Hospital of Qingdao University","Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101624585","display_name":"Yuanyuan Zhao","orcid":"https://orcid.org/0000-0001-6002-8214","observed_orcids":["https://orcid.org/0000-0001-6002-8214"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhao","raw_affiliation_strings":["The Affiliated Hospital of Qingdao University","Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345873","display_name":"Yu Li","orcid":"https://orcid.org/0000-0002-9439-8421","observed_orcids":["https://orcid.org/0000-0002-9439-8421","https://orcid.org/0000-0002-6490-5672","https://orcid.org/0009-0002-2893-5580"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yu","raw_affiliation_strings":["The Affiliated Hospital of Qingdao University","Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101411841","display_name":"Xinjia He","orcid":"https://orcid.org/0000-0003-2263-9772","observed_orcids":["https://orcid.org/0000-0003-2263-9772"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinjia He","raw_affiliation_strings":["The Affiliated Hospital of Qingdao University","Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086881016","display_name":"Ying-Ju Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]},{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingju Wang","raw_affiliation_strings":["Qingdao Municipal Hospital Affiliated To Qingdao University","Center Of Stomatology, Qingdao Municipal Hospital Affiliated To Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Municipal Hospital Affiliated To Qingdao University","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210116869","https://openalex.org/I4210119987"]},{"raw_affiliation_string":"Center Of Stomatology, Qingdao Municipal Hospital Affiliated To Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210119987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076259951","display_name":"Peng Jiang","orcid":"https://orcid.org/0000-0003-1946-9135","observed_orcids":["https://orcid.org/0000-0003-1946-9135"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Jiang","raw_affiliation_strings":["Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University","Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101516047","display_name":"Rong Yu","orcid":"https://orcid.org/0009-0008-0816-9587","observed_orcids":["https://orcid.org/0009-0008-0816-9587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Yu","raw_affiliation_strings":["Jimo District People\u2019s Hospital","Department of Otolaryngology, Jimo District People's Hospital, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jimo District People\u2019s Hospital","institution_ids":[]},{"raw_affiliation_string":"Department of Otolaryngology, Jimo District People's Hospital, Qingdao, Shandong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318346","display_name":"Wei Li","orcid":"https://orcid.org/0000-0003-0388-1467","observed_orcids":["https://orcid.org/0000-0003-0388-1467"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University","Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010425755","display_name":"Bin Dong","orcid":"https://orcid.org/0000-0002-1033-5790","observed_orcids":["https://orcid.org/0000-0002-1033-5790"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Dong","raw_affiliation_strings":["Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University","Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388976","display_name":"Xiang Wang","orcid":"https://orcid.org/0000-0001-5538-4310","observed_orcids":["https://orcid.org/0000-0001-5538-4310"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Wang","raw_affiliation_strings":["Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University","Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100818698","display_name":"Yinying Dong","orcid":"https://orcid.org/0009-0000-3345-4170","observed_orcids":["https://orcid.org/0009-0000-3345-4170","https://orcid.org/0009-0007-0660-5093"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yinying Dong","raw_affiliation_strings":["The Affiliated Hospital of Qingdao University","Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Qingdao University","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Department Of Tumor Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100818698"],"corresponding_institution_ids":["https://openalex.org/I4210116869"],"apc_list":{"value":2335,"currency":"GBP","value_usd":2864},"apc_paid":{"value":2335,"currency":"GBP","value_usd":2864},"fwci":1.0286,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.68504935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"5516","last_page":"5528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.482699990272522,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.482699990272522,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.2152000069618225,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.07479999959468842,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adam9","display_name":"ADAM9","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.906000018119812},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":1.0},{"id":"https://openalex.org/keywords/x-ray-irradiation","display_name":"X-ray irradiation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/radiotherapy-resistance","display_name":"radiotherapy resistance","score":0.6819999814033508},{"id":"https://openalex.org/keywords/mhcc97h-cells","display_name":"MHCC97H cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.9088420867919922},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.683216392993927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6605725288391113},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6448552012443542},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6197075247764587},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5469196438789368},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5269466042518616},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4666903614997864},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.45654866099357605},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4334872364997864},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4161273241043091},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20069485902786255},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.17158249020576477},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1553584337234497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12792089581489563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10891416668891907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.03708586096763611},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/21655979.2021.1965694","doi":"https://doi.org/10.1080/21655979.2021.1965694","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21655979.2021.1965694","pdf_url":null,"source":{"id":"https://openalex.org/S4210193419","display_name":"Bioengineered","issn_l":"2165-5979","issn":["2165-5979","2165-5987"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineered","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8806855","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8806855/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8806855/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineered","raw_type":"Text"},{"id":"pmid:34528498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34528498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineered","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/21655979.2021.1965694","doi":"https://doi.org/10.1080/21655979.2021.1965694","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21655979.2021.1965694","pdf_url":null,"source":{"id":"https://openalex.org/S4210193419","display_name":"Bioengineered","issn_l":"2165-5979","issn":["2165-5979","2165-5987"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineered","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1597925545","display_name":null,"funder_award_id":"number Y-QL2019-0337","funder_id":"https://openalex.org/F4320326042","funder_display_name":"Chinese Society of Clinical Oncology"},{"id":"https://openalex.org/G4957373890","display_name":null,"funder_award_id":"number 81803058","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7973366875","display_name":null,"funder_award_id":"Y-QL2019-0337","funder_id":"https://openalex.org/F4320326042","funder_display_name":"Chinese Society of Clinical Oncology"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326042","display_name":"Chinese Society of Clinical Oncology","ror":"https://ror.org/05sfnze82"},{"id":"https://openalex.org/F4320333688","display_name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","ror":null},{"id":"https://openalex.org/F4320335465","display_name":"National Outstanding Youth Foundation of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3200715212.pdf","grobid_xml":"https://content.openalex.org/works/W3200715212.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W906615614","https://openalex.org/W1426921023","https://openalex.org/W1757407923","https://openalex.org/W1966636348","https://openalex.org/W1969753692","https://openalex.org/W1979246588","https://openalex.org/W1988249582","https://openalex.org/W1990107313","https://openalex.org/W1995018922","https://openalex.org/W1998662458","https://openalex.org/W1999630076","https://openalex.org/W2019722747","https://openalex.org/W2035508274","https://openalex.org/W2070771534","https://openalex.org/W2104766456","https://openalex.org/W2109855687","https://openalex.org/W2127313936","https://openalex.org/W2137423570","https://openalex.org/W2147920544","https://openalex.org/W2151659885","https://openalex.org/W2153661308","https://openalex.org/W2154788827","https://openalex.org/W2170366300","https://openalex.org/W2177646965","https://openalex.org/W2198248975","https://openalex.org/W2476475786","https://openalex.org/W2548531532","https://openalex.org/W2605526341","https://openalex.org/W2652256693","https://openalex.org/W2742650334","https://openalex.org/W2744713071","https://openalex.org/W2765437589","https://openalex.org/W2770432229","https://openalex.org/W2773226416","https://openalex.org/W2783271434","https://openalex.org/W2789943000","https://openalex.org/W2791449743","https://openalex.org/W2799625384","https://openalex.org/W2805718585","https://openalex.org/W2807203680","https://openalex.org/W2811022449","https://openalex.org/W2888426374","https://openalex.org/W2893172333","https://openalex.org/W2897330595","https://openalex.org/W2904224335","https://openalex.org/W2905933967","https://openalex.org/W2947237927","https://openalex.org/W2990221627","https://openalex.org/W2990261551","https://openalex.org/W2997452251","https://openalex.org/W3095954762","https://openalex.org/W3126849875","https://openalex.org/W4249598849"],"related_works":["https://openalex.org/W4213043682","https://openalex.org/W4281849464","https://openalex.org/W4205797377","https://openalex.org/W2368198401","https://openalex.org/W4406709214","https://openalex.org/W2046219038","https://openalex.org/W4404293464","https://openalex.org/W2023416053","https://openalex.org/W3160124311","https://openalex.org/W2897154459"],"abstract_inverted_index":{"A":[0],"disintegrin":[1],"and":[2,34,63,68,94,111,126,155,170,215,232],"a":[3,46,210],"metalloprotease":[4],"(ADAM)9":[5],"upregulated":[6],"within":[7,218],"human":[8],"hepatocellular":[9],"carcinoma":[10],"(HCC)":[11],"cells,":[12,231],"but":[13],"its":[14,37],"effect":[15,28],"on":[16,31,204],"HCC":[17,32,80,105,115,143,185,219,230],"radiosensitivity":[18,33,78,166,172,228],"remains":[19],"unknown.":[20],"The":[21,77,138],"present":[22],"work":[23,160],"aimed":[24],"to":[25,35],"examine":[26],"the":[27,127,130,162,171,178,198,227],"of":[29,79,132,140,173,180,200,229],"ADAM9":[30,52,65,84,168,183,202,207,225],"reveal":[36],"possible":[38],"mechanism,":[39],"which":[40],"may":[41],"be":[42],"helpful":[43],"in":[44,51,114,142],"identifying":[45],"potential":[47],"therapeutic":[48],"strategy.":[49],"Changes":[50],"expression":[53,85,203,217],"after":[54,120,146,167,177,221],"X-ray":[55,147],"irradiation":[56],"were":[57,72,118,122],"identified":[58],"using":[59,74],"western":[60],"blot,":[61],"qRT-PCR,":[62],"immunofluorescence.":[64],"stable":[66],"knockdown":[67],"overexpression":[69,179],"cell":[70,106,165,186],"lines":[71],"constructed":[73],"lentivirus":[75],"packaging.":[76],"cells":[81,144,175],"with":[82,213],"altered":[83,201],"was":[86,135],"examined":[87],"by":[88,124],"CCK-8":[89,150],"assays,":[90,151,158],"subcutaneous":[91,152],"tumorigenesis":[92,153],"experiments,":[93,154],"clone":[95,156],"formation":[96,157],"assays.":[97],"This":[98],"study":[99],"also":[100],"determined":[101],"how":[102],"autophagy":[103,187,193,233],"affected":[104],"radiosensitivity.":[107,205],"Furthermore,":[108,182],"ADAM9,":[109],"p62":[110,216],"Bax":[112,214],"expressions":[113],"tissues":[116,220],"that":[117],"removed":[119],"radiotherapy":[121],"detected":[123],"immunohistochemistry,":[125],"relationship":[128],"among":[129],"levels":[131],"these":[133],"molecules":[134],"statistically":[136],"analyzed.":[137],"level":[139,208],"ADAM9expression":[141],"increased":[145,163],"irradiation.":[148],"Through":[149],"this":[159,235],"discovered":[161],"MHCC97H":[164],"knockdown,":[169],"Huh7":[174],"decreased":[176,226],"ADAM9.":[181],"induced":[184],"via":[188],"downregulating":[189],"Nrf2":[190],"expression,":[191],"while":[192],"inhibition":[194],"or":[195],"induction":[196],"reversed":[197],"effects":[199],"Moreover,":[206],"showed":[209],"negative":[211],"correlation":[212],"radiotherapy.":[222],"Taken":[223],"together,":[224],"mediated":[234],"process.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-09-27T00:00:00"}
