{"id":"https://openalex.org/W3200445491","doi":"https://doi.org/10.1212/wnl.0000000000012586","title":"Author Response: Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE \u03b54, and Cognitive Impairment","display_name":"Author Response: Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE \u03b54, and Cognitive Impairment","publication_year":2021,"publication_date":"2021-09-20","ids":{"openalex":"https://openalex.org/W3200445491","doi":"https://doi.org/10.1212/wnl.0000000000012586","mag":"3200445491","pmid":"https://pubmed.ncbi.nlm.nih.gov/35100130"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000012586","doi":"https://doi.org/10.1212/wnl.0000000000012586","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000012586","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"peer-review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009612708","display_name":"Joseph Therriault","orcid":"https://orcid.org/0000-0002-7826-4781","observed_orcids":["https://orcid.org/0000-0002-7826-4781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Therriault","raw_affiliation_strings":["(Montreal)"],"raw_orcid":"https://orcid.org/0000-0002-7826-4781","affiliations":[{"raw_affiliation_string":"(Montreal)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006091170","display_name":"Tharick Ali Pascoal","orcid":"https://orcid.org/0000-0001-9057-8014","observed_orcids":["https://orcid.org/0000-0001-9057-8014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tharick Pascoal","raw_affiliation_strings":["(Pittsburgh)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Pittsburgh)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004968642","display_name":"Serge G. Gauthier","orcid":"https://orcid.org/0000-0003-4272-3330","observed_orcids":["https://orcid.org/0000-0003-4272-3330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serge Gauthier","raw_affiliation_strings":["(Montreal)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Montreal)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091097481","display_name":"Pedro Rosa\u2010Neto","orcid":"https://orcid.org/0000-0001-9116-1376","observed_orcids":["https://orcid.org/0000-0001-9116-1376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro Rosa-Neto","raw_affiliation_strings":["(Montreal)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Montreal)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"97","issue":"12","first_page":"609","last_page":"609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8679999709129333},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.41499999165534973},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9259999990463257},{"id":"https://openalex.org/keywords/alzheimer-s-disease-biomarkers","display_name":"Alzheimer's disease biomarkers","score":0.8429999947547913},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.949999988079071},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.703000009059906},{"id":"https://openalex.org/keywords/brain-reserve","display_name":"brain reserve","score":0.8199999928474426},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.652999997138977},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6713708639144897},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.6521873474121094},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5959507822990417},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5938271284103394},{"id":"https://openalex.org/C67739388","wikidata":"https://www.wikidata.org/wiki/Q579471","display_name":"Cognitive reserve","level":4,"score":0.5508440136909485},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5437004566192627},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5279117226600647},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5040823221206665},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.47069811820983887},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4575544595718384},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4464800953865051},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.428431898355484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4180668592453003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17469915747642517}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.0000000000012586","doi":"https://doi.org/10.1212/wnl.0000000000012586","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000012586","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:35100130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35100130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2124681501","https://openalex.org/W2771599582","https://openalex.org/W2810507529","https://openalex.org/W2901473819","https://openalex.org/W3118160302"],"related_works":["https://openalex.org/W6892276966","https://openalex.org/W4394796441","https://openalex.org/W2092037628","https://openalex.org/W4408456450","https://openalex.org/W4206671470","https://openalex.org/W3118160302","https://openalex.org/W2936591365","https://openalex.org/W4320717426","https://openalex.org/W4214755754","https://openalex.org/W4386438065"],"abstract_inverted_index":{"We":[0,26],"agree":[1],"that":[2],"in":[3,12],"the":[4,13,16,31,51],"present":[5],"publication,":[6],"Alzheimer":[7],"disease":[8],"(AD)":[9],"biomarkers":[10,44],"ruled":[11],"presence":[14],"of":[15,33,50],"AD":[17],"pathophysiology,":[18],"rather":[19],"than":[20],"ruling":[21],"out":[22],"other":[23],"specific":[24],"processes.":[25],"are":[27],"looking":[28],"forward":[29],"to":[30,45],"development":[32],"novel":[34],"alpha-synuclein,":[35],"TDP-43,":[36],"Lewy":[37],"body,":[38],"4R-tau,":[39],"3R-tau,":[40],"and":[41,58],"brain":[42,52],"reserve":[43],"provide":[46],"a":[47],"better":[48],"appraisal":[49],"abnormalities":[53],"associated":[54],"with":[55],"cognitive":[56],"decline":[57],"dementia.":[59]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-09-27T00:00:00"}
