{"id":"https://openalex.org/W3200329255","doi":"https://doi.org/10.1016/j.cbi.2021.109663","title":"ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice","display_name":"ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice","publication_year":2021,"publication_date":"2021-09-20","ids":{"openalex":"https://openalex.org/W3200329255","doi":"https://doi.org/10.1016/j.cbi.2021.109663","mag":"3200329255","pmid":"https://pubmed.ncbi.nlm.nih.gov/34547296"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbi.2021.109663","doi":"https://doi.org/10.1016/j.cbi.2021.109663","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbi.2021.109663","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023873863","display_name":"Yilong Cui","orcid":"https://orcid.org/0000-0001-8852-7461","observed_orcids":["https://orcid.org/0000-0001-8852-7461"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilong Cui","raw_affiliation_strings":["Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031200647","display_name":"Miao Song","orcid":"https://orcid.org/0000-0001-7248-7418","observed_orcids":["https://orcid.org/0000-0001-7248-7418"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Song","raw_affiliation_strings":["Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078423869","display_name":"Bonan Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bonan Xiao","raw_affiliation_strings":["Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387495","display_name":"Menglin Liu","orcid":"https://orcid.org/0009-0004-2355-7802","observed_orcids":["https://orcid.org/0009-0004-2355-7802"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menglin Liu","raw_affiliation_strings":["Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036685392","display_name":"Pengli Liu","orcid":"https://orcid.org/0000-0001-5979-3998","observed_orcids":["https://orcid.org/0000-0001-5979-3998","https://orcid.org/0000-0002-4446-1314"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengli Liu","raw_affiliation_strings":["Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394727","display_name":"Yanfei Han","orcid":"https://orcid.org/0000-0002-2996-7552","observed_orcids":["https://orcid.org/0000-0002-2996-7552"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanfei Han","raw_affiliation_strings":["Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381370","display_name":"Bing Shao","orcid":"https://orcid.org/0000-0003-1651-2337","observed_orcids":["https://orcid.org/0000-0003-1651-2337"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Shao","raw_affiliation_strings":["Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100414592","display_name":"Yanfei Li","orcid":"https://orcid.org/0000-0002-4563-6825","observed_orcids":["https://orcid.org/0000-0002-4563-6825"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanfei Li","raw_affiliation_strings":["Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. Electronic address: liyanfei@neau.edu.cn","Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. Electronic address: liyanfei@neau.edu.cn","institution_ids":["https://openalex.org/I169572211"]},{"raw_affiliation_string":"Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100414592"],"corresponding_institution_ids":["https://openalex.org/I169572211"],"apc_list":{"value":3310,"currency":"USD","value_usd":3310},"apc_paid":null,"fwci":3.9223,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.9405046,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"349","issue":null,"first_page":"109663","last_page":"109663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aluminum-toxicity","display_name":"aluminum toxicity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.921999990940094},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5289999842643738},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.878000020980835},{"id":"https://openalex.org/keywords/aluminum-chloride","display_name":"aluminum chloride","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mitochondrial-damage","display_name":"mitochondrial damage","score":0.7450000047683716},{"id":"https://openalex.org/keywords/dietary-aluminum","display_name":"dietary aluminum","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.9841041564941406},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8183944821357727},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7775077819824219},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6775925755500793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5272960662841797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4586176872253418},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.41134849190711975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37103471159935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35831645131111145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33188819885253906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21022507548332214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20147088170051575}],"mesh":[{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cbi.2021.109663","doi":"https://doi.org/10.1016/j.cbi.2021.109663","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbi.2021.109663","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:34547296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34547296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2732541058","display_name":null,"funder_award_id":"31872530","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1529233910","https://openalex.org/W1963906069","https://openalex.org/W1966746516","https://openalex.org/W1977093725","https://openalex.org/W1982863723","https://openalex.org/W1983028298","https://openalex.org/W1995317658","https://openalex.org/W2002637963","https://openalex.org/W2017100952","https://openalex.org/W2019551875","https://openalex.org/W2036333816","https://openalex.org/W2061894544","https://openalex.org/W2062349310","https://openalex.org/W2063882755","https://openalex.org/W2072967133","https://openalex.org/W2095001576","https://openalex.org/W2108326484","https://openalex.org/W2110862168","https://openalex.org/W2116562304","https://openalex.org/W2139367650","https://openalex.org/W2158260462","https://openalex.org/W2167340008","https://openalex.org/W2293889237","https://openalex.org/W2296123019","https://openalex.org/W2516720801","https://openalex.org/W2589863619","https://openalex.org/W2605384809","https://openalex.org/W2740312086","https://openalex.org/W2763646283","https://openalex.org/W2770603454","https://openalex.org/W2791517164","https://openalex.org/W2883982153","https://openalex.org/W2884914467","https://openalex.org/W2890084120","https://openalex.org/W2896399648","https://openalex.org/W2896928442","https://openalex.org/W2914528413","https://openalex.org/W2939816388","https://openalex.org/W2949110934","https://openalex.org/W2966328786","https://openalex.org/W2985906129","https://openalex.org/W3000469971","https://openalex.org/W3012524903","https://openalex.org/W3094844018","https://openalex.org/W3135535880","https://openalex.org/W3161041025","https://openalex.org/W3166142047","https://openalex.org/W3173171792","https://openalex.org/W3182666626"],"related_works":["https://openalex.org/W3178079710","https://openalex.org/W3166142047","https://openalex.org/W3161041025","https://openalex.org/W4318064547","https://openalex.org/W137333441","https://openalex.org/W3012405424","https://openalex.org/W2380256339","https://openalex.org/W2017234501","https://openalex.org/W2083312414","https://openalex.org/W1966814522"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-09-27T00:00:00"}
