{"id":"https://openalex.org/W3200326344","doi":"https://doi.org/10.1038/s41467-021-25430-9","title":"Genetic and epigenetic basis of hepatoblastoma diversity","display_name":"Genetic and epigenetic basis of hepatoblastoma diversity","publication_year":2021,"publication_date":"2021-09-20","ids":{"openalex":"https://openalex.org/W3200326344","doi":"https://doi.org/10.1038/s41467-021-25430-9","mag":"3200326344","pmid":"https://pubmed.ncbi.nlm.nih.gov/34538872","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8450290"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-021-25430-9","doi":"https://doi.org/10.1038/s41467-021-25430-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-25430-9","pdf_url":"https://www.nature.com/articles/s41467-021-25430-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-021-25430-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028761902","display_name":"Genta Nagae","orcid":"https://orcid.org/0000-0002-2929-7990","observed_orcids":["https://orcid.org/0000-0002-2929-7990"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Genta Nagae","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2929-7990","affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085203051","display_name":"Shogo Yamamoto","orcid":"https://orcid.org/0000-0002-5564-2567","observed_orcids":["https://orcid.org/0000-0002-5564-2567"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Yamamoto","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5564-2567","affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006066029","display_name":"Masashi Fujita","orcid":"https://orcid.org/0000-0002-1457-6233","observed_orcids":["https://orcid.org/0000-0002-1457-6233"]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Fujita","raw_affiliation_strings":["Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1457-6233","affiliations":[{"raw_affiliation_string":"Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004592307","display_name":"Takanori Fujita","orcid":"https://orcid.org/0000-0003-4372-6090","observed_orcids":["https://orcid.org/0000-0003-4372-6090"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Fujita","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002111607","display_name":"Aya Nonaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aya Nonaka","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101593156","display_name":"Takayoshi Umeda","orcid":"https://orcid.org/0000-0002-9678-0122","observed_orcids":["https://orcid.org/0000-0002-9678-0122"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Umeda","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9678-0122","affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030045521","display_name":"Shiro Fukuda","orcid":"https://orcid.org/0000-0002-0065-662X","observed_orcids":["https://orcid.org/0000-0002-0065-662X"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiro Fukuda","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0065-662X","affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080913515","display_name":"Kenji Tatsuno","orcid":"https://orcid.org/0000-0002-3046-3941","observed_orcids":["https://orcid.org/0000-0002-3046-3941"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Tatsuno","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3046-3941","affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009428591","display_name":"Kazuhiro Maejima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Maejima","raw_affiliation_strings":["Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017068781","display_name":"Akimasa Hayashi","orcid":"https://orcid.org/0000-0002-7424-8127","observed_orcids":["https://orcid.org/0000-0002-7424-8127"]},"institutions":[{"id":"https://openalex.org/I190930483","display_name":"Kyorin University","ror":"https://ror.org/0188yz413","country_code":"JP","type":"education","lineage":["https://openalex.org/I190930483"]},{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akimasa Hayashi","raw_affiliation_strings":["Department of Pathology, Kyorin University Faculty of Medicine, Tokyo, Japan","Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7424-8127","affiliations":[{"raw_affiliation_string":"Department of Pathology, Kyorin University Faculty of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I190930483"]},{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046516579","display_name":"Sho Kurihara","orcid":"https://orcid.org/0000-0001-7021-4707","observed_orcids":["https://orcid.org/0000-0001-7021-4707"]},"institutions":[{"id":"https://openalex.org/I4210125056","display_name":"Hiroshima University Hospital","ror":"https://ror.org/038dg9e86","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Kurihara","raw_affiliation_strings":["Department of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210125056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011995301","display_name":"Masato Kojima","orcid":"https://orcid.org/0000-0001-7783-0289","observed_orcids":["https://orcid.org/0000-0001-7783-0289"]},"institutions":[{"id":"https://openalex.org/I4210125056","display_name":"Hiroshima University Hospital","ror":"https://ror.org/038dg9e86","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Kojima","raw_affiliation_strings":["Department of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210125056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015311192","display_name":"Tomoro Hishiki","orcid":"https://orcid.org/0000-0002-2515-1054","observed_orcids":["https://orcid.org/0000-0002-2515-1054"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoro Hishiki","raw_affiliation_strings":["Chiba University Graduate School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiba University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023686262","display_name":"Kenichiro Watanabe","orcid":"https://orcid.org/0000-0002-8892-3082","observed_orcids":["https://orcid.org/0000-0002-8892-3082"]},"institutions":[{"id":"https://openalex.org/I4210161002","display_name":"Shizuoka Children's Hospital","ror":"https://ror.org/05x23rx38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161002"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichiro Watanabe","raw_affiliation_strings":["Shizuoka Children's Hospital, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shizuoka Children's Hospital, Shizuoka, Japan","institution_ids":["https://openalex.org/I4210161002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036006370","display_name":"Kohmei Ida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400573282","display_name":"Teikyo University Hospital, Mizonokuchi","ror":"https://ror.org/02p6v5z38","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400573282","https://openalex.org/I87531838"]},{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohmei Ida","raw_affiliation_strings":["Department of Pediatrics, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan","institution_ids":["https://openalex.org/I4400573282","https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006530394","display_name":"Michihiro Yano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132405","display_name":"Akita University Hospital","ror":"https://ror.org/02szmmq82","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132405"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michihiro Yano","raw_affiliation_strings":["Department of Pediatrics, Akita University Hospital, Akita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Akita University Hospital, Akita, Japan","institution_ids":["https://openalex.org/I4210132405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080899105","display_name":"Yoko Hiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405285822","display_name":"Natural Science Center for Basic Research and Development, Hiroshima University","ror":"https://ror.org/00cf83k21","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113306721","https://openalex.org/I4405285822"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Hiyama","raw_affiliation_strings":["Department of Biomedical Science, Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan, 734-8551, 1-2-3, Kasumi, Minami-ku, Hiroshima"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan, 734-8551, 1-2-3, Kasumi, Minami-ku, Hiroshima","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405285822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043257369","display_name":"Yukichi Tanaka","orcid":"https://orcid.org/0000-0003-1145-5249","observed_orcids":["https://orcid.org/0000-0003-1145-5249"]},"institutions":[{"id":"https://openalex.org/I4210115195","display_name":"Kanagawa Children's Medical Center","ror":"https://ror.org/022h0tq76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115195"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukichi Tanaka","raw_affiliation_strings":["Department of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan","institution_ids":["https://openalex.org/I4210115195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026949524","display_name":"Takeshi Inoue","orcid":"https://orcid.org/0000-0002-5251-2839","observed_orcids":["https://orcid.org/0000-0002-5251-2839"]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Inoue","raw_affiliation_strings":["Department of Pathology, Osaka City General Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Osaka City General Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210099064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101621568","display_name":"Hiroki Ueda","orcid":"https://orcid.org/0000-0001-9135-7117","observed_orcids":["https://orcid.org/0000-0001-9135-7117"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Ueda","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081957766","display_name":"Hidewaki Nakagawa","orcid":"https://orcid.org/0000-0003-1807-772X","observed_orcids":["https://orcid.org/0000-0003-1807-772X"]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidewaki Nakagawa","raw_affiliation_strings":["Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001413231","display_name":"Hiroyuki Aburatani","orcid":"https://orcid.org/0000-0003-0438-1544","observed_orcids":["https://orcid.org/0000-0003-0438-1544"]},"institutions":[{"id":"https://openalex.org/I4405287038","display_name":"Research Center for Advanced Science and Technology, The University of Tokyo","ror":"https://ror.org/03xzehp18","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Aburatani","raw_affiliation_strings":["Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0438-1544","affiliations":[{"raw_affiliation_string":"Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287038","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027813941","display_name":"Eiso Hiyama","orcid":"https://orcid.org/0000-0001-9179-5037","observed_orcids":["https://orcid.org/0000-0001-9179-5037"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4210125056","display_name":"Hiroshima University Hospital","ror":"https://ror.org/038dg9e86","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125056"]},{"id":"https://openalex.org/I4405285822","display_name":"Natural Science Center for Basic Research and Development, Hiroshima University","ror":"https://ror.org/00cf83k21","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113306721","https://openalex.org/I4405285822"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Eiso Hiyama","raw_affiliation_strings":["Department of Biomedical Science, Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan, 734-8551, 1-2-3, Kasumi, Minami-ku, Hiroshima. eiso@hiroshima-u.ac.jp","Department of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan. eiso@hiroshima-u.ac.jp","Department of Biomedical Science, Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan,  734-8551,  1-2-3, Kasumi, Minami-ku, Hiroshima"],"raw_orcid":"https://orcid.org/0000-0001-9179-5037","affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan, 734-8551, 1-2-3, Kasumi, Minami-ku, Hiroshima. eiso@hiroshima-u.ac.jp","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405285822"]},{"raw_affiliation_string":"Department of Pediatric Surgery, Hiroshima University Hospital, Hiroshima, Japan. eiso@hiroshima-u.ac.jp","institution_ids":["https://openalex.org/I4210125056"]},{"raw_affiliation_string":"Department of Biomedical Science, Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan,  734-8551,  1-2-3, Kasumi, Minami-ku, Hiroshima","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405285822"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5027813941"],"corresponding_institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4210125056","https://openalex.org/I4405285822"],"apc_list":{"value":5560,"currency":"USD","value_usd":5560},"apc_paid":{"value":5560,"currency":"USD","value_usd":5560},"fwci":6.4485,"has_fulltext":true,"cited_by_count":126,"citation_normalized_percentile":{"value":0.98225462,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"5423","last_page":"5423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.375,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.375,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.1370999962091446,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.13459999859333038,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatoblastoma","display_name":"hepatoblastoma","score":1.0},{"id":"https://openalex.org/keywords/pediatric-liver-tumors","display_name":"pediatric liver tumors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tert-promoter-mutation","display_name":"TERT promoter mutation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.925000011920929},{"id":"https://openalex.org/keywords/ascl2","display_name":"ASCL2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.5690000057220459},{"id":"https://openalex.org/keywords/definitive-endoderm","display_name":"definitive endoderm","score":0.9300000071525574},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7900000214576721},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6499999761581421},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8210084438323975},{"id":"https://openalex.org/C2776304256","wikidata":"https://www.wikidata.org/wiki/Q1607658","display_name":"Hepatoblastoma","level":2,"score":0.7488197088241577},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7441829442977905},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7145103216171265},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6296316385269165},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5675628185272217},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5018429756164551},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4613085091114044},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4482366442680359},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.44084370136260986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38400623202323914},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2269371747970581},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21748113632202148},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20623084902763367},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15322840213775635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10562515258789062}],"mesh":[{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000081204","descriptor_name":"Chromatin Immunoprecipitation Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-021-25430-9","doi":"https://doi.org/10.1038/s41467-021-25430-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-25430-9","pdf_url":"https://www.nature.com/articles/s41467-021-25430-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7382547","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8450290","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8450290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8450290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:34538872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34538872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25430-9","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-021-25430-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:5f3064223f474f6c908aa9492d92dd6b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5f3064223f474f6c908aa9492d92dd6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)","raw_type":"article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006831043","doi":null,"is_oa":true,"landing_page_url":"https://pure.teikyo.jp/en/publications/390b8e69-0c2e-4654-9423-d2ecd9ba1089","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1038/s41467-021-25430-9","doi":"https://doi.org/10.1038/s41467-021-25430-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-25430-9","pdf_url":"https://www.nature.com/articles/s41467-021-25430-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1622435062","display_name":null,"funder_award_id":"Ack0106070h, Ik0201066h, ck0106332h","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G1727840405","display_name":null,"funder_award_id":"15H02567","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2099707159","display_name":null,"funder_award_id":"19H02567","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2874362884","display_name":null,"funder_award_id":"14097011","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G3368128245","display_name":"Elucidation of malignant transformation based on epigenetic plasticity","funder_award_id":"19H01031","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3923183082","display_name":null,"funder_award_id":"ck0106332h","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4052452787","display_name":"Next generation cancer liquid biopsy for childhood cancers using single cell analysis","funder_award_id":"19H01056","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4689039545","display_name":null,"funder_award_id":"Ack0106070h","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4935415346","display_name":null,"funder_award_id":"15H02567, 16H02778, 19H02567","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5115676784","display_name":null,"funder_award_id":"16H02778","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G6529851860","display_name":"Elucidation of mRNA dysregulation in hepatocellular carcinoma using a novel mRNA methylome method","funder_award_id":"23K21431","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7057470157","display_name":null,"funder_award_id":"Ik0201066h","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G7763209876","display_name":null,"funder_award_id":"19H05744","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3200326344.pdf","grobid_xml":"https://content.openalex.org/works/W3200326344.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W158083236","https://openalex.org/W848101669","https://openalex.org/W1824921945","https://openalex.org/W1941186827","https://openalex.org/W1948295794","https://openalex.org/W1951457834","https://openalex.org/W1965619419","https://openalex.org/W1974532695","https://openalex.org/W1976106807","https://openalex.org/W1979819983","https://openalex.org/W1980668823","https://openalex.org/W1984804985","https://openalex.org/W2001568293","https://openalex.org/W2002122781","https://openalex.org/W2017502278","https://openalex.org/W2030286274","https://openalex.org/W2032021543","https://openalex.org/W2034878800","https://openalex.org/W2044000119","https://openalex.org/W2048177238","https://openalex.org/W2049445218","https://openalex.org/W2068127752","https://openalex.org/W2084755885","https://openalex.org/W2089873658","https://openalex.org/W2107429180","https://openalex.org/W2107460318","https://openalex.org/W2108638605","https://openalex.org/W2115462905","https://openalex.org/W2120899273","https://openalex.org/W2127105373","https://openalex.org/W2133586252","https://openalex.org/W2133899877","https://openalex.org/W2134812217","https://openalex.org/W2153562609","https://openalex.org/W2155978263","https://openalex.org/W2160562062","https://openalex.org/W2166545908","https://openalex.org/W2166992988","https://openalex.org/W2171176924","https://openalex.org/W2173818354","https://openalex.org/W2219761119","https://openalex.org/W2276335691","https://openalex.org/W2278487942","https://openalex.org/W2290421093","https://openalex.org/W2324488473","https://openalex.org/W2405041587","https://openalex.org/W2415343213","https://openalex.org/W2415932927","https://openalex.org/W2514920248","https://openalex.org/W2549880782","https://openalex.org/W2581568937","https://openalex.org/W2598133926","https://openalex.org/W2606616407","https://openalex.org/W2618958001","https://openalex.org/W2752549227","https://openalex.org/W2785491550","https://openalex.org/W2787816121","https://openalex.org/W2789869568","https://openalex.org/W2789924919","https://openalex.org/W2793005024","https://openalex.org/W2793677295","https://openalex.org/W2896757166","https://openalex.org/W2914283681","https://openalex.org/W2919337517","https://openalex.org/W2939684447","https://openalex.org/W3011815811","https://openalex.org/W3023199272","https://openalex.org/W3025453530","https://openalex.org/W3120604884"],"related_works":["https://openalex.org/W2102003904","https://openalex.org/W2334055935","https://openalex.org/W3014801075","https://openalex.org/W6894201543","https://openalex.org/W3152923322","https://openalex.org/W2565990639","https://openalex.org/W2619739105","https://openalex.org/W3049278836","https://openalex.org/W3179482204","https://openalex.org/W3047186722"],"abstract_inverted_index":{"Hepatoblastoma":[0],"(HB)":[1],"is":[2,59,164],"the":[3,45,81,86,106,147,170],"most":[4],"common":[5],"pediatric":[6,34],"liver":[7,35,88],"malignancy;":[8],"however,":[9],"hereditary":[10],"predisposition":[11],"and":[12,39,176],"acquired":[13,47],"molecular":[14,160],"aberrations":[15],"related":[16],"to":[17,151],"HB":[18,163],"clinicopathological":[19],"diversity":[20],"are":[21,78,103,111,156],"not":[22],"well":[23,132],"understood.":[24],"Here,":[25],"we":[26],"perform":[27],"an":[28],"integrative":[29],"genomic":[30],"profiling":[31,98,161],"of":[32,56,129,137,143,162,173],"163":[33],"tumors":[36],"(154":[37],"HBs":[38,102],"nine":[40],"hepatocellular":[41],"carcinomas)":[42],"based":[43],"on":[44,63],"data":[46],"from":[48,146],"a":[49,118,165],"cohort":[50],"study":[51],"(JPLT-2).":[52],"The":[53],"total":[54],"number":[55],"somatic":[57],"mutations":[58,77],"precious":[60],"low":[61],"(0.52/Mb":[62],"exonic":[64],"regions)":[65],"but":[66],"correlated":[67],"with":[68,113],"age":[69],"at":[70],"diagnosis.":[71],"Telomerase":[72],"reverse":[73],"transcriptase":[74],"(TERT)":[75],"promoter":[76],"prevalent":[79],"in":[80,85,125],"tween":[82],"HBs,":[83],"selective":[84],"transitional":[87],"cell":[89],"tumor":[90],"(TLCT,":[91],">":[92],"8":[93],"years":[94],"old).":[95],"DNA":[96],"methylation":[97,135],"reveals":[99],"that":[100],"classical":[101],"characterized":[104],"by":[105],"specific":[107],"hypomethylated":[108],"enhancers,":[109],"which":[110,155],"enriched":[112],"binding":[114],"sites":[115],"for":[116,122,168,179],"ASCL2,":[117,130],"regulatory":[119],"transcription":[120],"factor":[121],"definitive":[123],"endoderm":[124],"Wnt-pathway.":[126],"Prolonged":[127],"upregulation":[128],"as":[131,133],"fetal-liver-like":[134],"patterns":[136],"IGF2":[138],"promoters,":[139],"suggests":[140],"their":[141],"\"cell":[142],"origin\"":[144],"derived":[145],"premature":[148],"hepatoblast,":[149],"similar":[150],"intestinal":[152],"epithelial":[153],"cells,":[154],"highly":[157],"proliferative.":[158],"Systematic":[159],"promising":[166],"approach":[167],"understanding":[169],"epigenetic":[171],"drivers":[172],"hepatoblast":[174],"carcinogenesis":[175],"deriving":[177],"clues":[178],"risk":[180],"stratification.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-09-27T00:00:00"}
