{"id":"https://openalex.org/W3200322638","doi":null,"title":"Chondroitin sulfate produces antinociception and neuroprotection in chronic constriction injury-induced neuropathic pain in rats by increasing anti-inflammatory molecules and reducing oxidative stress.","display_name":"Chondroitin sulfate produces antinociception and neuroprotection in chronic constriction injury-induced neuropathic pain in rats by increasing anti-inflammatory molecules and reducing oxidative stress.","publication_year":2021,"publication_date":"2021-09-01","ids":{"openalex":"https://openalex.org/W3200322638","mag":"3200322638","pmid":"https://pubmed.ncbi.nlm.nih.gov/34548858","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8434845"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:7340876","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8434845","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC8434845","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075186237","display_name":"Olutayo Folajimi Olaseinde","orcid":"https://orcid.org/0000-0001-6415-5288","observed_orcids":["https://orcid.org/0000-0001-6415-5288"]},"institutions":[{"id":"https://openalex.org/I134542131","display_name":"University of Ilorin","ror":"https://ror.org/032kdwk38","country_code":"NG","type":"education","lineage":["https://openalex.org/I134542131"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Olutayo Folajimi Olaseinde","raw_affiliation_strings":["Department of Physiology, Neuroscience and Inflammation Unit, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Neuroscience and Inflammation Unit, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria","institution_ids":["https://openalex.org/I134542131"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012269300","display_name":"Bamidele Victor Owoyele","orcid":"https://orcid.org/0000-0003-3503-9338","observed_orcids":["https://orcid.org/0000-0003-3503-9338"]},"institutions":[{"id":"https://openalex.org/I134542131","display_name":"University of Ilorin","ror":"https://ror.org/032kdwk38","country_code":"NG","type":"education","lineage":["https://openalex.org/I134542131"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Bamidele Victor Owoyele","raw_affiliation_strings":["Department of Physiology, Neuroscience and Inflammation Unit, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Neuroscience and Inflammation Unit, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria","institution_ids":["https://openalex.org/I134542131"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I134542131"],"apc_list":null,"apc_paid":null,"fwci":0.6094,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58340063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"5","first_page":"3","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":1.0},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8809999823570251},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9559999704360962},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8080000281333923},{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":0.9210000038146973},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9010000228881836},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/total-antioxidant-capacity","display_name":"total antioxidant capacity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/allodynia","display_name":"allodynia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/thermal-hyperalgesia","display_name":"thermal hyperalgesia","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.7274914979934692},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.718989372253418},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.6996874213218689},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5893058180809021},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5721098184585571},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5674270987510681},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5647040605545044},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.5565730333328247},{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.5434406995773315},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5258239507675171},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.4985537528991699},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.47741782665252686},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.366191029548645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3126775622367859},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.11917528510093689},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07162362337112427}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:7340876","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8434845","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34548858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34548858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of health sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8434845","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8434845/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Health Sci (Qassim)","raw_type":"Text"},{"id":"mag:3200322638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34548858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7340876","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8434845","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W1124883296","https://openalex.org/W1534880720","https://openalex.org/W1970308606","https://openalex.org/W1970510419","https://openalex.org/W1979402025","https://openalex.org/W1983702729","https://openalex.org/W1985907962","https://openalex.org/W1988209540","https://openalex.org/W1990023261","https://openalex.org/W1995061819","https://openalex.org/W1995199032","https://openalex.org/W1997515903","https://openalex.org/W1998780354","https://openalex.org/W1999405426","https://openalex.org/W2000460436","https://openalex.org/W2003572359","https://openalex.org/W2003807844","https://openalex.org/W2004416339","https://openalex.org/W2005455038","https://openalex.org/W2009296822","https://openalex.org/W2009485594","https://openalex.org/W2014449340","https://openalex.org/W2014628413","https://openalex.org/W2015239879","https://openalex.org/W2017015410","https://openalex.org/W2019428611","https://openalex.org/W2023921010","https://openalex.org/W2028179780","https://openalex.org/W2033124959","https://openalex.org/W2033586740","https://openalex.org/W2039519643","https://openalex.org/W2041400548","https://openalex.org/W2042194401","https://openalex.org/W2043175749","https://openalex.org/W2044652794","https://openalex.org/W2046147455","https://openalex.org/W2050107524","https://openalex.org/W2054706403","https://openalex.org/W2058020736","https://openalex.org/W2060086890","https://openalex.org/W2081762124","https://openalex.org/W2084562083","https://openalex.org/W2085052527","https://openalex.org/W2087454739","https://openalex.org/W2094267095","https://openalex.org/W2094628138","https://openalex.org/W2095259741","https://openalex.org/W2100626966","https://openalex.org/W2111074957","https://openalex.org/W2116030730","https://openalex.org/W2116087648","https://openalex.org/W2116687659","https://openalex.org/W2121211908","https://openalex.org/W2122312917","https://openalex.org/W2128412489","https://openalex.org/W2131057569","https://openalex.org/W2135788850","https://openalex.org/W2140923109","https://openalex.org/W2146957464","https://openalex.org/W2148158834","https://openalex.org/W2151414644","https://openalex.org/W2157583343","https://openalex.org/W2172201406","https://openalex.org/W2192585031","https://openalex.org/W2296086052","https://openalex.org/W2302273425","https://openalex.org/W2308447553","https://openalex.org/W2408199042","https://openalex.org/W2474469421","https://openalex.org/W2476515191","https://openalex.org/W2518421805","https://openalex.org/W2545937586","https://openalex.org/W2583594489","https://openalex.org/W2611042382","https://openalex.org/W2753084136","https://openalex.org/W2755322410","https://openalex.org/W2767953625","https://openalex.org/W2783737543","https://openalex.org/W2789492962","https://openalex.org/W2790082354","https://openalex.org/W2884974412","https://openalex.org/W2891235039","https://openalex.org/W2907616259","https://openalex.org/W2917362392","https://openalex.org/W2943924499","https://openalex.org/W2993665959","https://openalex.org/W2997547904","https://openalex.org/W3002456183","https://openalex.org/W3019209625"],"related_works":["https://openalex.org/W4213455377","https://openalex.org/W2789492962","https://openalex.org/W3204997278","https://openalex.org/W2138090475","https://openalex.org/W2410408819","https://openalex.org/W2663787016","https://openalex.org/W3084209267","https://openalex.org/W2898104407","https://openalex.org/W1943378174","https://openalex.org/W2462239825"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Damage":[1],"to":[2,10,156],"the":[3,36,62,66,151,164],"peripheral":[4],"and":[5,18,31,75,77,95,122,135,139,144],"central":[6],"nervous":[7],"system":[8],"lead":[9],"Neuropathic":[11],"pain":[12,30],"(NP)":[13],"which":[14],"is":[15,48],"a":[16],"widespread":[17],"devitalizing":[19],"condition.":[20],"chondroitin":[21],"sulfate":[22],"(CS),":[23],"has":[24],"been":[25],"used":[26],"in":[27,150,169],"managing":[28],"joint":[29],"osteoarthritis.":[32],"In":[33],"this":[34],"study,":[35],"effectiveness":[37],"of":[38,53,61,65,72,167],"CS":[39,102,119,152,168],"on":[40],"NP":[41],"induced":[42,125],"by":[43,100,126,128],"chronic":[44],"constriction":[45],"injury":[46],"(CCI)":[47],"examined.":[49],"METHODS:":[50],"tructural":[51],"architecture":[52],"sciatic":[54],"nerves":[55],"was":[56],"evaluated":[57],"via":[58],"histological":[59,145],"examination":[60],"transverse":[63],"section":[64],"nerves.":[67],"RESULTS:":[68],"<":[69],"0.05)":[70],"inhibition":[71],"allodynia":[73],"(cold":[74],"mechanical)":[76],"thermal":[78,123],"hyperalgesia.":[79],"Lipid":[80],"peroxidation,":[81],"tumor":[82],"necrosis":[83],"factor-\u03b1":[84],"(TNF-\u03b1),":[85],"calcitonin":[86],"gene":[87],"related":[88],"peptide":[89],"(CGRP),":[90],"C":[91],"reactive":[92],"protein":[93],"(CRP),":[94],"oxidative":[96,133],"stress":[97],"were":[98],"attenuated":[99],"CS.":[101],"also":[103],"improved":[104],"interleukin":[105],"(IL)-6,":[106],"nitric":[107],"oxide":[108],"(NO),":[109],"total":[110],"antioxidant":[111],"capacity":[112],"(TAC).":[113],"CONCLUSION:":[114],"These":[115,159],"findings":[116,146,160],"suggest":[117],"that":[118],"attenuates":[120],"allodynia,":[121],"hyperalgesia":[124],"CCI":[127,157],"downregulating":[129],"TNF-\u03b1,":[130],"CRP,":[131],"CGRP,":[132],"enzymes,":[134],"upregulating":[136],"IL-6,":[137],"NO,":[138],"TAC.":[140],"Nociceptive":[141],"behavioral":[142],"studies":[143],"showed":[147],"significant":[148],"improvement":[149],"treated":[153],"groups":[154],"compared":[155],"rats.":[158],"are":[161],"responsible":[162],"for":[163],"beneficial":[165],"effect":[166],"NP.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-09-27T00:00:00"}
