{"id":"https://openalex.org/W3200220739","doi":"https://doi.org/10.1093/ehjcr/ytab032","title":"Topiramate induced type 1 Brugada pattern","display_name":"Topiramate induced type 1 Brugada pattern","publication_year":2021,"publication_date":"2021-09-01","ids":{"openalex":"https://openalex.org/W3200220739","doi":"https://doi.org/10.1093/ehjcr/ytab032","mag":"3200220739","pmid":"https://pubmed.ncbi.nlm.nih.gov/34557629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8454208"},"language":"en","primary_location":{"id":"doi:10.1093/ehjcr/ytab032","doi":"https://doi.org/10.1093/ehjcr/ytab032","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjcr/ytab032","pdf_url":"https://academic.oup.com/ehjcr/article-pdf/5/9/ytab032/40422442/ytab032.pdf","source":{"id":"https://openalex.org/S2735316389","display_name":"European Heart Journal - Case Reports","issn_l":"2514-2119","issn":["2514-2119"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal - Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ehjcr/article-pdf/5/9/ytab032/40422442/ytab032.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049426151","display_name":"Procolo Marchese","orcid":"https://orcid.org/0000-0002-2677-9214","observed_orcids":["https://orcid.org/0000-0002-2677-9214"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Procolo Marchese","raw_affiliation_strings":["Mazzoni Hospital, Viale Iris 1, Ascoli Piceno, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2677-9214","affiliations":[{"raw_affiliation_string":"Mazzoni Hospital, Viale Iris 1, Ascoli Piceno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066766143","display_name":"Francesca Gennaro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Gennaro","raw_affiliation_strings":["Mazzoni Hospital, Viale Iris 1, Ascoli Piceno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazzoni Hospital, Viale Iris 1, Ascoli Piceno, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108102802","display_name":"Giovanni Mazzotta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanni Mazzotta","raw_affiliation_strings":["Mazzoni Hospital, Viale Iris 1, Ascoli Piceno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazzoni Hospital, Viale Iris 1, Ascoli Piceno, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018203682","display_name":"Pedro Brugada","orcid":"https://orcid.org/0000-0003-3172-6106","observed_orcids":["https://orcid.org/0000-0003-3172-6106"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pedro Brugada","raw_affiliation_strings":["Cardiovascular Division, Free University of Brussels (UZ Brussel) VUB, Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-3172-6106","affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Free University of Brussels (UZ Brussel) VUB, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049426151"],"corresponding_institution_ids":[],"apc_list":{"value":590,"currency":"EUR","value_usd":726},"apc_paid":{"value":590,"currency":"EUR","value_usd":726},"fwci":0.1747,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.44217204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"5","issue":"9","first_page":"ytab032","last_page":"ytab032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topiramate","display_name":"topiramate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/brugada-syndrome","display_name":"Brugada syndrome","score":0.765999972820282},{"id":"https://openalex.org/keywords/type-1-brugada-pattern","display_name":"type 1 Brugada pattern","score":0.8930000066757202},{"id":"https://openalex.org/keywords/drug-induced-ecg-changes","display_name":"drug-induced ECG changes","score":0.7379999756813049},{"id":"https://openalex.org/keywords/ajmaline-test","display_name":"ajmaline test","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sodium-channel-blockade","display_name":"sodium channel blockade","score":0.7239999771118164},{"id":"https://openalex.org/keywords/calcium-channel-blockade","display_name":"calcium channel blockade","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8109999895095825},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sudden-cardiac-death-risk","display_name":"sudden cardiac death risk","score":0.7319999933242798},{"id":"https://openalex.org/keywords/j-point-elevation","display_name":"J-point elevation","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2777683783","wikidata":"https://www.wikidata.org/wiki/Q221174","display_name":"Topiramate","level":3,"score":0.7989082932472229},{"id":"https://openalex.org/C2777382798","wikidata":"https://www.wikidata.org/wiki/Q599683","display_name":"Brugada syndrome","level":2,"score":0.6996934413909912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4236885607242584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35365599393844604},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.098642498254776},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0867929756641388}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/ehjcr/ytab032","doi":"https://doi.org/10.1093/ehjcr/ytab032","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjcr/ytab032","pdf_url":"https://academic.oup.com/ehjcr/article-pdf/5/9/ytab032/40422442/ytab032.pdf","source":{"id":"https://openalex.org/S2735316389","display_name":"European Heart Journal - Case Reports","issn_l":"2514-2119","issn":["2514-2119"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal - Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7346945","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8454208","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34557629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34557629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal. Case reports","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:8454208","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8454208/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Heart J Case Rep","raw_type":"Text"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:154081","doi":null,"is_oa":true,"landing_page_url":"https://biblio.vub.ac.be/vubir/topiramate-induced-type-1-brugada-pattern(bff5f978-2242-4e59-88db-c92d7f09fd70).html","pdf_url":"https://biblio.vub.ac.be/vubirfiles/88114948/76835021.pdf","source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/ehjcr/ytab032","doi":"https://doi.org/10.1093/ehjcr/ytab032","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjcr/ytab032","pdf_url":"https://academic.oup.com/ehjcr/article-pdf/5/9/ytab032/40422442/ytab032.pdf","source":{"id":"https://openalex.org/S2735316389","display_name":"European Heart Journal - Case Reports","issn_l":"2514-2119","issn":["2514-2119"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal - Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3200220739.pdf","grobid_xml":"https://content.openalex.org/works/W3200220739.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1981099796","https://openalex.org/W2087421035","https://openalex.org/W2888481150"],"related_works":["https://openalex.org/W2335730637","https://openalex.org/W2116953844","https://openalex.org/W4416321911","https://openalex.org/W4285405816","https://openalex.org/W1988405467","https://openalex.org/W4388776160","https://openalex.org/W4399126226","https://openalex.org/W7214484774","https://openalex.org/W7222710998","https://openalex.org/W3042023015"],"abstract_inverted_index":{"For":[0],"the":[1,12,94,140,176,183,189,261,267,276,301,310,313,344],"podcast":[2],"associated":[3,338],"with":[4,28,299,348],"this":[5,256,281,332],"article,":[6],"please":[7],"visit":[8],"https://academic.oup.com/ehjcr/pages/podcast":[9],"This":[10],"is":[11,105,164,170,271],"case":[13,333],"of":[14,58,72,91,101,112,139,149,178,185,195,239,263,275,278,292,312,331,352],"a":[15,42,165,211],"38":[16],"years":[17],"old":[18],"woman":[19],"referred":[20],"to":[21,191,210,220,229,273,315],"our":[22],"clinic":[23],"because":[24,90],"her":[25,108],"electrocardiogram":[26],"(ECG)":[27],"V1\u20132":[29],"at":[30],"2nd,":[31],"3rd,":[32],"and":[33,36,69,78,158,181,198,233,243,288,309,329,337],"4th":[34],"right":[35],"left":[37],"parasternal":[38],"intercostal":[39],"space":[40],"showed":[41,110,137],"classical":[43],"type":[44,114,141,250,268],"1":[45,115,142,251],"Brugada":[46,113,143,205,249,306],"pattern":[47,144],"(Figure":[48,128],"1A).":[49],"She":[50,82],"had":[51,285],"no":[52,55,62,64,67,70,286,289],"risk":[53],"factors,":[54],"family":[56,290],"history":[57,71,291],"sudden":[59,293],"cardiac":[60,294],"death,":[61],"syncope,":[63],"chest":[65,76],"pain,":[66],"dyspnoea,":[68],"palpitations.":[73],"Blood":[74],"tests,":[75],"X-rays,":[77],"echocardiography":[79],"were":[80],"normal.":[81],"was":[83,121,297],"on":[84,241],"daily":[85],"topiramate":[86,102,126,155,161,240,279],"50":[87,156],"mg":[88,148,157],"b.i.d.":[89],"migraine":[92],"for":[93,172,182,327],"past":[95],"3":[96],"years.":[97],"After":[98],"5":[99],"days":[100],"wash-out":[103],"(half-life":[104],"21":[106],"h),":[107],"ECG":[109,252],"disappearance":[111],"ECG.":[116],"Nevertheless,":[117],"J":[118],"point":[119],"elevation":[120],"still":[122],"present":[123],"even":[124],"after":[125,145,160],"discontinuation":[127],"1B).":[129],"The":[130,236,321],"patient":[131,345],"underwent":[132],"an":[133],"ajmaline":[134,264],"test":[135],"that":[136,169,204,260,274,324],"induction":[138],"only":[146],"10":[147],"drug":[150,168],"administration.":[151],"Electrocardiogram.":[152],"(A)":[153],"Under":[154],"(B)":[159],"washout.":[162],"Topiramate":[163],"broad-spectrum":[166],"antiepileptic":[167],"approved":[171],"preventing":[173],"or":[174,214],"reducing":[175],"frequency":[177],"epileptic":[179],"seizures,":[180],"prophylaxis":[184],"migraine.":[186],"It":[187],"possesses":[188],"ability":[190],"block":[192],"several":[193],"types":[194],"voltage-gated":[196],"Na+":[197],"Ca2+":[199],"channels.1,2":[200],"It\u2019s":[201],"well":[202],"known":[203],"syndrome":[206,307],"could":[207,227,246],"be":[208,316],"due":[209],"sodium":[212,242],"(mainly)":[213],"calcium":[215,244],"channel":[216,245],"impaired":[217],"function":[218],"leading":[219],"outward/inward":[221],"current":[222],"imbalance":[223],"which":[224],"in":[225,255,265,280,305,346],"turns":[226],"lead":[228],"phase":[230],"two":[231],"re-entry":[232],"ventricular":[234],"fibrillation.3":[235],"inhibitory":[237],"effect":[238,262,277],"explain":[247],"its":[248],"inducing":[253],"activity":[254],"particular":[257],"patient.":[258,282],"Notably":[259],"provoking":[266],"I":[269],"changes":[270],"similar":[272],"Since":[283],"she":[284,296],"symptoms":[287],"death":[295],"discharged":[298],"all":[300],"recommendation":[302],"are":[303],"needed":[304],"patients":[308],"list":[311],"drugs":[314],"avoided":[317],"including":[318,335],"topiramate.":[319],"Consent:":[320],"authors":[322],"confirm":[323],"written":[325],"consent":[326],"submission":[328],"publication":[330],"report":[334],"images":[336],"text":[339],"has":[340],"been":[341],"obtained":[342],"from":[343],"line":[347],"COPE":[349],"guidance.":[350],"Conflict":[351],"interest:":[353],"none":[354],"declared.":[355]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-09-27T00:00:00"}
