{"id":"https://openalex.org/W3199378164","doi":null,"title":"Abstract 15582: Global, but Not Cardiac Specific, Knockout of ROMK Potassium Channels Worsens Cardiac Ischemia Reperfusion Injury","display_name":"Abstract 15582: Global, but Not Cardiac Specific, Knockout of ROMK Potassium Channels Worsens Cardiac Ischemia Reperfusion Injury","publication_year":2019,"publication_date":"2019-11-19","ids":{"openalex":"https://openalex.org/W3199378164","mag":"3199378164"},"language":"en","primary_location":{"id":"mag:3199378164","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.140.suppl_1.15582","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072223969","display_name":"Kyriakos N. Papanicolaou","orcid":"https://orcid.org/0000-0003-3088-7119","observed_orcids":["https://orcid.org/0000-0003-3088-7119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyriakos N. Papanicolaou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3088-7119","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034289221","display_name":"Deepthi Ashok","orcid":"https://orcid.org/0000-0003-0252-4716","observed_orcids":["https://orcid.org/0000-0003-0252-4716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deepthi Ashok","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0252-4716","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071555900","display_name":"Ting Liu","orcid":"https://orcid.org/0000-0002-8304-5751","observed_orcids":["https://orcid.org/0000-0002-8304-5751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8304-5751","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058665938","display_name":"Tyler M. Bauer","orcid":"https://orcid.org/0000-0002-5430-5104","observed_orcids":["https://orcid.org/0000-0002-5430-5104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tyler M. Bauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5430-5104","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332651","display_name":"Zhen Li","orcid":"https://orcid.org/0000-0003-0519-2905","observed_orcids":["https://orcid.org/0000-0003-0519-2905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhen Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0519-2905","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Eduardo Costa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Cr\u00e9py","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Cr\u00e9py","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068194077","display_name":"Sara Nathan","orcid":"https://orcid.org/0000-0002-0090-0303","observed_orcids":["https://orcid.org/0000-0002-0090-0303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Nathan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0090-0303","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014186027","display_name":"David J. Lefer","orcid":"https://orcid.org/0000-0003-2293-7278","observed_orcids":["https://orcid.org/0000-0003-2293-7278","https://orcid.org/0009-0006-1025-7004"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Lefer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2293-7278","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064257229","display_name":"Elizabeth Murphy","orcid":"https://orcid.org/0000-0001-9400-0797","observed_orcids":["https://orcid.org/0000-0001-9400-0797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Murphy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9400-0797","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010660115","display_name":"Nazareno Paolocci","orcid":"https://orcid.org/0000-0001-7011-997X","observed_orcids":["https://orcid.org/0000-0001-7011-997X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nazareno Paolocci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037628835","display_name":"Darren B Foster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darren B Foster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080198568","display_name":"Brian P O'Rourke","orcid":"https://orcid.org/0000-0002-5548-4853","observed_orcids":["https://orcid.org/0000-0002-5548-4853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian O\u2019Rourke","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5548-4853","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/romk","display_name":"ROMK","score":0.8220000267028809},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.8410000205039978},{"id":"https://openalex.org/keywords/bartter-syndrome","display_name":"Bartter syndrome","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ion-exchange","display_name":"ion exchange","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.933313250541687},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6513841152191162},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6325264573097229},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5519353151321411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5458559989929199},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5367575287818909},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.42364779114723206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08069059252738953}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3199378164","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.140.suppl_1.15582","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3003257120","https://openalex.org/W2344026390","https://openalex.org/W2015344956","https://openalex.org/W2919138980","https://openalex.org/W2091819667","https://openalex.org/W7019754191","https://openalex.org/W6907653017","https://openalex.org/W4409547005","https://openalex.org/W2769071601","https://openalex.org/W2007563402"],"abstract_inverted_index":{"The":[0],"renal-outer-medullary-potassium":[1],"(ROMK)":[2],"channel,":[3],"mutated":[4],"in":[5,12],"heritable":[6],"Bartter\u2019s":[7],"syndrome,":[8],"regulates":[9],"ion":[10],"exchange":[11],"the":[13],"nephron":[14],"but":[15],"its":[16],"extra-renal":[17],"functions":[18],"remain":[19],"poorly":[20],"understood.":[21],"ROMK":[22],"is":[23],"al...":[24]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2021-09-27T00:00:00"}