{"id":"https://openalex.org/W31993593","doi":null,"title":"[Treatment of adjustment disorder with anxiety: efficacy and tolerance of etifoxine in a double-blind controlled study].","display_name":"[Treatment of adjustment disorder with anxiety: efficacy and tolerance of etifoxine in a double-blind controlled study].","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W31993593","mag":"31993593","pmid":"https://pubmed.ncbi.nlm.nih.gov/9949940"},"language":"fr","primary_location":{"id":"pmid:9949940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9949940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"L'Encephale","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017110209","display_name":"Dominique Servant","orcid":"https://orcid.org/0000-0001-9511-4155","observed_orcids":["https://orcid.org/0000-0001-9511-4155"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D Servant","raw_affiliation_strings":["Clinique de l'Anxi\u00e9t\u00e9, CHU de Lille"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinique de l'Anxi\u00e9t\u00e9, CHU de Lille","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091200157","display_name":"Pierluigi Graziani","orcid":"https://orcid.org/0000-0002-8828-8920","observed_orcids":["https://orcid.org/0000-0002-8828-8920","https://orcid.org/0000-0003-0972-8674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Graziani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064973221","display_name":"Dominique Moyse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Moyse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111707299","display_name":"Philippe Jean Parquet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Parquet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1668,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.76833333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"24","issue":"6","first_page":"569","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13118","display_name":"Psychological Treatments and Disorders","score":0.10970000177621841,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etifoxine","display_name":"etifoxine","score":1.0},{"id":"https://openalex.org/keywords/buspirone","display_name":"buspirone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.527999997138977},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5820000171661377},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.7360000014305115},{"id":"https://openalex.org/keywords/psychological-stress","display_name":"psychological stress","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2777287423","wikidata":"https://www.wikidata.org/wiki/Q412194","display_name":"Buspirone","level":4,"score":0.8854976892471313},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6892526745796204},{"id":"https://openalex.org/C2779911313","wikidata":"https://www.wikidata.org/wiki/Q845224","display_name":"Generalized anxiety disorder","level":3,"score":0.49779486656188965},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.4918985366821289},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4743455946445465},{"id":"https://openalex.org/C2776317618","wikidata":"https://www.wikidata.org/wiki/Q544006","display_name":"Anxiety disorder","level":3,"score":0.4401493966579437},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.385570764541626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3592126965522766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2927052676677704},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2685033082962036},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000223","descriptor_name":"Adaptation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000275","descriptor_name":"Adjustment Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000275","descriptor_name":"Adjustment Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000275","descriptor_name":"Adjustment Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000275","descriptor_name":"Adjustment Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D002065","descriptor_name":"Buspirone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010078","descriptor_name":"Oxazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D014149","descriptor_name":"Tranquilizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9949940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9949940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"L'Encephale","raw_type":"Clinical Trial"},{"id":"mag:31993593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9949940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W2045751236","https://openalex.org/W2169976441","https://openalex.org/W2030936891","https://openalex.org/W2014794778","https://openalex.org/W1772350833","https://openalex.org/W1971518546","https://openalex.org/W1998898263","https://openalex.org/W2045355462","https://openalex.org/W2524725054","https://openalex.org/W2794374416","https://openalex.org/W2022698528","https://openalex.org/W2023614826","https://openalex.org/W1968635896","https://openalex.org/W1992695057","https://openalex.org/W2067120759","https://openalex.org/W2321291727","https://openalex.org/W2078655774","https://openalex.org/W2072190162","https://openalex.org/W253985425","https://openalex.org/W2048383363","https://openalex.org/W2769690261","https://openalex.org/W2321889473","https://openalex.org/W2021740517","https://openalex.org/W2318004073","https://openalex.org/W2067881779","https://openalex.org/W4233958038","https://openalex.org/W2577721553","https://openalex.org/W1973531385","https://openalex.org/W2092620903","https://openalex.org/W2105509554","https://openalex.org/W2313463284","https://openalex.org/W2108163552","https://openalex.org/W2726771194","https://openalex.org/W2765779358","https://openalex.org/W2080707098","https://openalex.org/W2007818188","https://openalex.org/W1974474738","https://openalex.org/W2239939421","https://openalex.org/W2735825074","https://openalex.org/W2100670264","https://openalex.org/W2334697071","https://openalex.org/W1263380949","https://openalex.org/W2047393685","https://openalex.org/W2162533049","https://openalex.org/W2325871288","https://openalex.org/W2033756909","https://openalex.org/W2037640789","https://openalex.org/W2806156595","https://openalex.org/W1965688526","https://openalex.org/W2148284063","https://openalex.org/W2331803880","https://openalex.org/W2901948947","https://openalex.org/W2026129544","https://openalex.org/W2039852923","https://openalex.org/W2801542270","https://openalex.org/W2317946737","https://openalex.org/W2029402150","https://openalex.org/W2024167822","https://openalex.org/W1898139470","https://openalex.org/W1983593001","https://openalex.org/W1969627716"],"related_works":["https://openalex.org/W2064484863","https://openalex.org/W1993909146","https://openalex.org/W7095262295","https://openalex.org/W2036626914","https://openalex.org/W1983670291","https://openalex.org/W2889748472","https://openalex.org/W2228931176","https://openalex.org/W7221568493","https://openalex.org/W7131428661","https://openalex.org/W1551204786"],"abstract_inverted_index":{"Adjustment":[0],"disorder":[1,29,68,139],"with":[2,49,62,69,87,140],"anxiety":[3,10,70,141],"is":[4,30],"defined":[5],"as":[6],"a":[7,63,75],"clinically":[8],"significant":[9],"that":[11,27],"occurs":[12],"within":[13],"3":[14],"months":[15],"after":[16],"the":[17,54,105,116,123,129,135],"onset":[18],"of":[19,66,131,137],"an":[20],"identifiable":[21],"psychological":[22],"stressor.":[23],"Recent":[24],"studies":[25],"indicate":[26],"this":[28,50],"not":[31,109],"uncommon":[32],"and":[33,38,98,103,115,142],"must":[34],"be":[35,144],"quickly":[36],"identified":[37],"treated.":[39],"However,":[40],"few":[41],"therapeutic":[42],"trials":[43],"have":[44,71],"been":[45,72],"done":[46],"in":[47,74,122,134],"relation":[48],"disorder.":[51],"According":[52],"to":[53],"criteria":[55],"set":[56],"by":[57,146],"DSM":[58],"IV,":[59],"170":[60],"patients":[61],"primary":[64],"diagnosis":[65],"adjustment":[67,138],"enrolled":[73],"double":[76],"blind":[77],"multicenter":[78],"controlled":[79],"trial.":[80],"Patients":[81],"were":[82],"treated":[83],"for":[84],"4":[85],"weeks":[86],"etifoxine":[88,97,124,133],"(150-200":[89],"mg/d),":[90],"or":[91],"buspirone":[92,99],"(15-20":[93],"mg/d).":[94],"Also":[95],"both":[96],"show":[100,128],"clinical":[101],"efficacy":[102,117],"safety,":[104],"two":[106],"treatments":[107],"are":[108,119],"equivalent.":[110],"The":[111],"global":[112],"improvement":[113],"score":[114],"index":[118],"significantly":[120],"improved":[121],"group.":[125],"These":[126],"results":[127],"interest":[130],"using":[132],"treatment":[136],"should":[143],"confirmed":[145],"further":[147],"studies.":[148]},"counts_by_year":[{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}