{"id":"https://openalex.org/W3199101182","doi":"https://doi.org/10.3389/fimmu.2021.730404","title":"Silent SARS-CoV-2 Infections, Waning Immunity, Serology Testing, and COVID-19 Vaccination: A Perspective","display_name":"Silent SARS-CoV-2 Infections, Waning Immunity, Serology Testing, and COVID-19 Vaccination: A Perspective","publication_year":2021,"publication_date":"2021-09-21","ids":{"openalex":"https://openalex.org/W3199101182","doi":"https://doi.org/10.3389/fimmu.2021.730404","mag":"3199101182","pmid":"https://pubmed.ncbi.nlm.nih.gov/34621274"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2021.730404","doi":"https://doi.org/10.3389/fimmu.2021.730404","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.730404","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.730404/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.730404/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067235725","display_name":"Madhusudhanan Narasimhan","orcid":"https://orcid.org/0000-0001-6372-6480","observed_orcids":["https://orcid.org/0000-0001-6372-6480"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhusudhanan Narasimhan","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002346048","display_name":"Lenin Mahimainathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lenin Mahimainathan","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086975531","display_name":"Jungsik Noh","orcid":"https://orcid.org/0000-0003-1823-8589","observed_orcids":["https://orcid.org/0000-0003-1823-8589"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jungsik Noh","raw_affiliation_strings":["Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102722839","display_name":"Alagarraju Muthukumar","orcid":"https://orcid.org/0000-0002-4661-883X","observed_orcids":["https://orcid.org/0000-0002-4661-883X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alagarraju Muthukumar","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102722839"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.2218,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.56434482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"12","issue":null,"first_page":"730404","last_page":"730404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9449999928474426},{"id":"https://openalex.org/keywords/asymptomatic-infection","display_name":"asymptomatic infection","score":0.8619999885559082},{"id":"https://openalex.org/keywords/waning-immunity","display_name":"waning immunity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/serological-testing","display_name":"serological testing","score":0.9409999847412109},{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.9909999966621399},{"id":"https://openalex.org/keywords/breakthrough-infection","display_name":"breakthrough infection","score":0.9860000014305115},{"id":"https://openalex.org/keywords/unreported-infections","display_name":"unreported infections","score":0.5289999842643738},{"id":"https://openalex.org/keywords/infection-surveillance","display_name":"infection surveillance","score":0.49399998784065247},{"id":"https://openalex.org/keywords/mask-mandates","display_name":"mask mandates","score":0.48100000619888306},{"id":"https://openalex.org/keywords/disease-resurgence","display_name":"disease resurgence","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7608463764190674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6991338729858398},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6625717878341675},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.5768823027610779},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5054337978363037},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4818243086338043},{"id":"https://openalex.org/C106192422","wikidata":"https://www.wikidata.org/wiki/Q736798","display_name":"Herd immunity","level":3,"score":0.4567467272281647},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44140470027923584},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.42472442984580994},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3953717052936554},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.39040184020996094},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2336498200893402},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.19419479370117188},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18779975175857544},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14912357926368713}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000087124","descriptor_name":"COVID-19 Serological Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087124","descriptor_name":"COVID-19 Serological Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087124","descriptor_name":"COVID-19 Serological Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093742","descriptor_name":"Breakthrough Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002487","descriptor_name":"Centers for Disease Control and Prevention, U.S.","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002487","descriptor_name":"Centers for Disease Control and Prevention, U.S.","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002487","descriptor_name":"Centers for Disease Control and Prevention, U.S.","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058070","descriptor_name":"Asymptomatic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058070","descriptor_name":"Asymptomatic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058070","descriptor_name":"Asymptomatic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2021.730404","doi":"https://doi.org/10.3389/fimmu.2021.730404","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.730404","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.730404/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:34621274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34621274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7383755","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8490796","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8490796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8490796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a036990b865b499eac99e7b895d2c294","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a036990b865b499eac99e7b895d2c294","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2021.730404","doi":"https://doi.org/10.3389/fimmu.2021.730404","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.730404","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.730404/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3199101182.pdf","grobid_xml":"https://content.openalex.org/works/W3199101182.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W2129909380","https://openalex.org/W2150945177","https://openalex.org/W2157342679","https://openalex.org/W2964102418","https://openalex.org/W3008443627","https://openalex.org/W3013967887","https://openalex.org/W3017186084","https://openalex.org/W3030003181","https://openalex.org/W3031733179","https://openalex.org/W3032252754","https://openalex.org/W3064705445","https://openalex.org/W3081605726","https://openalex.org/W3087511726","https://openalex.org/W3111255098","https://openalex.org/W3112389805","https://openalex.org/W3120486632","https://openalex.org/W3126875101","https://openalex.org/W3128463352","https://openalex.org/W3130250106","https://openalex.org/W3135210768","https://openalex.org/W3143959537","https://openalex.org/W3146894320","https://openalex.org/W3152727685","https://openalex.org/W3159191704","https://openalex.org/W3159733845","https://openalex.org/W3161859061","https://openalex.org/W3163613327","https://openalex.org/W3165605711","https://openalex.org/W3168025940","https://openalex.org/W3172019474","https://openalex.org/W3179119084","https://openalex.org/W3182514649","https://openalex.org/W3184075893","https://openalex.org/W3190634807","https://openalex.org/W3193039013","https://openalex.org/W3209833474","https://openalex.org/W4246101927","https://openalex.org/W4253529377"],"related_works":["https://openalex.org/W4224320170","https://openalex.org/W4232091153","https://openalex.org/W2359024484","https://openalex.org/W3202418693","https://openalex.org/W3035425994","https://openalex.org/W2987775131","https://openalex.org/W3023442822","https://openalex.org/W4287780871","https://openalex.org/W2189668305","https://openalex.org/W3023461739"],"abstract_inverted_index":{"Severe":[0],"acute":[1],"respiratory":[2],"syndrome":[3],"coronavirus":[4],"2":[5],"(SARS-CoV-2)":[6],"virus":[7],"causes":[8],"a":[9,29,40,81,121,173,198],"spectrum":[10,77],"of":[11,44,70,78,90,159,176],"clinical":[12],"manifestations,":[13],"ranging":[14],"from":[15],"asymptomatic":[16],"to":[17,111,151,201,222,235],"mild,":[18],"moderate,":[19],"or":[20,148],"severe":[21],"illness":[22],"with":[23,167],"multi-organ":[24],"failure":[25],"and":[26,67,88,92,96,105,115,138,171,186,207,244],"death.":[27],"Using":[28],"new":[30],"machine":[31],"learning":[32],"algorithm":[33],"developed":[34],"by":[35,188],"us,":[36],"we":[37,194],"have":[38,98,120],"reported":[39],"significantly":[41],"higher":[42],"number":[43],"predicted":[45],"COVID-19":[46,65],"cases":[47,61,117],"than":[48],"the":[49,53,63,68,156,177,182,212,224,230,237],"documented":[50],"counts":[51],"across":[52],"world.":[54],"The":[55],"sole":[56],"reliance":[57],"on":[58,203],"confirmed":[59],"symptomatic":[60],"overlooking":[62],"symptomless":[64,243],"infections":[66,161],"dynamics":[69],"waning":[71,116,245],"immunity":[72],"may":[73,118],"not":[74,142],"provide":[75],"'true'":[76],"infection":[79],"proportion,":[80],"key":[82,199],"element":[83],"for":[84,113,135,232,242],"an":[85],"effective":[86],"planning":[87],"implementation":[89],"protection":[91],"prevention":[93],"strategies.":[94],"We":[95],"others":[97],"previously":[99],"shown":[100],"that":[101,211],"strategic":[102],"orthogonal":[103],"testing":[104,145],"leveraging":[106],"systematic":[107],"data-driven":[108],"modeling":[109],"approach":[110],"account":[112],"asymptomatics":[114,170,204],"situationally":[119],"compelling":[122],"role":[123],"in":[124,162,240],"informing":[125],"efficient":[126],"vaccination":[127,150],"strategies":[128],"beyond":[129],"prevalence":[130],"reporting.":[131],"However,":[132],"currently":[133],"Centers":[134],"Disease":[136],"Control":[137],"Prevention":[139],"(CDC)":[140],"does":[141],"recommend":[143],"serological":[144],"either":[146],"before":[147],"after":[149],"assess":[152],"immune":[153],"status.":[154],"Given":[155],"27%":[157],"occurrence":[158],"breakthrough":[160],"fully":[163],"vaccinated":[164],"(FV)":[165],"group":[166],"many":[168],"being":[169],"still":[172],"larger":[174],"fraction":[175],"general":[178],"mass":[179],"remaining":[180],"unvaccinated,":[181],"relaxed":[183],"mask":[184],"mandate":[185],"distancing":[187],"CDC":[189],"can":[190,218],"drive":[191],"resurgence.":[192],"Thus,":[193],"believe":[195],"it":[196],"is":[197],"time":[200],"focus":[202],"(no":[205],"symptoms)":[206],"oligosymptomatics":[208],"(so":[209],"mild":[210],"symptoms":[213],"remain":[214],"unrecognized)":[215],"as":[216],"they":[217],"be":[219],"silent":[220],"reservoirs":[221],"propagate":[223],"infection.":[225],"This":[226],"perspective":[227],"thus":[228],"highlights":[229],"need":[231],"proactive":[233],"efforts":[234],"reevaluate":[236],"current":[238],"variables/strategies":[239],"accounting":[241],"fractions.":[246]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-09-27T00:00:00"}