{"id":"https://openalex.org/W3197559059","doi":"https://doi.org/10.1111/jfbc.13916","title":"Creatine supplementation effect on recovery following exercise\u2010induced muscle damage: A systematic review and meta\u2010analysis of randomized controlled trials","display_name":"Creatine supplementation effect on recovery following exercise\u2010induced muscle damage: A systematic review and meta\u2010analysis of randomized controlled trials","publication_year":2021,"publication_date":"2021-09-02","ids":{"openalex":"https://openalex.org/W3197559059","doi":"https://doi.org/10.1111/jfbc.13916","mag":"3197559059","pmid":"https://pubmed.ncbi.nlm.nih.gov/34472118"},"language":"en","primary_location":{"id":"doi:10.1111/jfbc.13916","doi":"https://doi.org/10.1111/jfbc.13916","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jfbc.13916","pdf_url":null,"source":{"id":"https://openalex.org/S53703007","display_name":"Journal of Food Biochemistry","issn_l":"0145-8884","issn":["0145-8884","1745-4514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021820607","display_name":"Yue Jiaming","orcid":"https://orcid.org/0009-0002-4450-8386","observed_orcids":["https://orcid.org/0009-0002-4450-8386"]},"institutions":[{"id":"https://openalex.org/I87710204","display_name":"Beijing Sport University","ror":"https://ror.org/03w0k0x36","country_code":"CN","type":"education","lineage":["https://openalex.org/I87710204"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Jiaming","raw_affiliation_strings":["China Football College, Beijing Sport University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Football College, Beijing Sport University, Beijing, China","institution_ids":["https://openalex.org/I87710204"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mohammad Hossein Rahimi","orcid":"https://orcid.org/0000-0002-8610-346X","observed_orcids":["https://orcid.org/0000-0002-8610-346X"]},"institutions":[{"id":"https://openalex.org/I4210156833","display_name":"Saveh University of Medical Sciences","ror":"https://ror.org/04v0mdj41","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210156833"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Hossein Rahimi","raw_affiliation_strings":["School of Public Health, Saveh University of Medical Science, Saveh, Iran"],"raw_orcid":"https://orcid.org/0000-0002-8610-346X","affiliations":[{"raw_affiliation_string":"School of Public Health, Saveh University of Medical Science, Saveh, Iran","institution_ids":["https://openalex.org/I4210156833"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210156833"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.4497,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.37507788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"45","issue":"10","first_page":"e13916","last_page":"e13916"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.45019999146461487,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-supplementation","display_name":"creatine supplementation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/exercise-induced-muscle-damage","display_name":"exercise-induced muscle damage","score":0.9990000128746033},{"id":"https://openalex.org/keywords/muscle-recovery","display_name":"muscle recovery","score":0.7110000252723694},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":1.0},{"id":"https://openalex.org/keywords/muscle-soreness","display_name":"muscle soreness","score":0.7749999761581421},{"id":"https://openalex.org/keywords/muscle-function","display_name":"muscle function","score":0.6940000057220459},{"id":"https://openalex.org/keywords/post-exercise-recovery","display_name":"post-exercise recovery","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.8099654912948608},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.751384973526001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7265993356704712},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7264085412025452},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6652957201004028},{"id":"https://openalex.org/C2993817360","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Muscle damage","level":2,"score":0.6545044779777527},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6134258508682251},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.547967255115509},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5422474145889282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49400025606155396},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.46126657724380493},{"id":"https://openalex.org/C28804328","wikidata":"https://www.wikidata.org/wiki/Q7623693","display_name":"Strictly standardized mean difference","level":3,"score":0.4100695252418518},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3956179618835449},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09571874141693115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09034267067909241},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07740572094917297},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063806","descriptor_name":"Myalgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D063806","descriptor_name":"Myalgia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/jfbc.13916","doi":"https://doi.org/10.1111/jfbc.13916","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jfbc.13916","pdf_url":null,"source":{"id":"https://openalex.org/S53703007","display_name":"Journal of Food Biochemistry","issn_l":"0145-8884","issn":["0145-8884","1745-4514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Biochemistry","raw_type":"journal-article"},{"id":"pmid:34472118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34472118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of food biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W987316246","https://openalex.org/W1488181513","https://openalex.org/W1496725878","https://openalex.org/W1548887451","https://openalex.org/W1840622518","https://openalex.org/W1966770656","https://openalex.org/W1982299684","https://openalex.org/W1983682681","https://openalex.org/W1992309148","https://openalex.org/W2009017773","https://openalex.org/W2012932483","https://openalex.org/W2014606067","https://openalex.org/W2016352741","https://openalex.org/W2027623539","https://openalex.org/W2030824725","https://openalex.org/W2030906451","https://openalex.org/W2042160262","https://openalex.org/W2062079512","https://openalex.org/W2064678740","https://openalex.org/W2073655240","https://openalex.org/W2098169176","https://openalex.org/W2098923148","https://openalex.org/W2100882387","https://openalex.org/W2102203452","https://openalex.org/W2125307036","https://openalex.org/W2132918663","https://openalex.org/W2134253943","https://openalex.org/W2144699036","https://openalex.org/W2146877603","https://openalex.org/W2156734439","https://openalex.org/W2157581868","https://openalex.org/W2157797207","https://openalex.org/W2161638140","https://openalex.org/W2163900586","https://openalex.org/W2178313645","https://openalex.org/W2186260885","https://openalex.org/W2264145964","https://openalex.org/W2291295533","https://openalex.org/W2293882797","https://openalex.org/W2339045168","https://openalex.org/W2510791083","https://openalex.org/W2556860644","https://openalex.org/W2568037712","https://openalex.org/W2604176879","https://openalex.org/W2614747718","https://openalex.org/W2618498021","https://openalex.org/W2654473549","https://openalex.org/W2765246109","https://openalex.org/W2773051460","https://openalex.org/W2782602413","https://openalex.org/W2802727061","https://openalex.org/W2887350367","https://openalex.org/W2887403453","https://openalex.org/W2889569875","https://openalex.org/W2896601196","https://openalex.org/W2899058238","https://openalex.org/W2903048667","https://openalex.org/W2914099881","https://openalex.org/W2920041365","https://openalex.org/W2921968404","https://openalex.org/W2936292553","https://openalex.org/W2956906384","https://openalex.org/W2961503594","https://openalex.org/W2966873022","https://openalex.org/W2971239498","https://openalex.org/W2974809809","https://openalex.org/W3017277968","https://openalex.org/W3022903699","https://openalex.org/W6629513427"],"related_works":["https://openalex.org/W3132172497","https://openalex.org/W3183167377","https://openalex.org/W4318817254","https://openalex.org/W4393005057","https://openalex.org/W4410088942","https://openalex.org/W2125307036","https://openalex.org/W2100882387","https://openalex.org/W1966770656","https://openalex.org/W4214724967","https://openalex.org/W4384497831"],"abstract_inverted_index":{"Exercise-induced":[0],"muscle":[1,14,224,229,233,249],"damage":[2,225,250],"(EIMD)":[3],"causes":[4],"increased":[5],"soreness,":[6],"impaired":[7],"function":[8,230],"of":[9,22,36,44,73,81,193,209,232,268,287],"muscles,":[10],"and":[11,55,91,109,140,147,211,227,257,283,300],"reductions":[12],"in":[13,150,160,184,187,223,245,274],"force.":[15],"Accumulating":[16],"evidence":[17],"suggests":[18],"the":[19,42,71,79,98,107,115,247,262,265,284,301,308],"beneficial":[20],"effects":[21,156,267],"creatine":[23,45,122,125,177,200,269],"on":[24,46],"EIMD.":[25,49],"Nevertheless,":[26],"outcomes":[27],"differ":[28],"substantially":[29],"across":[30],"various":[31],"articles.":[32],"The":[33,65,195,217],"main":[34],"aim":[35],"this":[37],"meta-analysis":[38],"was":[39,75,104],"to":[40,62,180,220,280],"evaluate":[41],"effect":[43],"recovery":[47],"following":[48],"Medline,":[50],"Embase,":[51],"Cochrane":[52,66],"Library,":[53],"Scopus,":[54],"Google":[56],"Scholar":[57],"were":[58,94,157],"systematically":[59],"searched":[60],"up":[61],"March":[63],"2021.":[64],"Collaboration":[67],"tool":[68],"for":[69,77,96,289],"examining":[70],"risk":[72,286],"bias":[74,288],"applied":[76,95],"assessing":[78],"quality":[80],"studies.":[82],"Weighted":[83],"mean":[84],"difference":[85],"(WMD),":[86],"95%":[87,133,169],"confidence":[88],"interval":[89],"(CI),":[90],"random-effects":[92],"model,":[93],"estimating":[97],"overall":[99,129,165],"effect.":[100],"Between":[101],"studies,":[102],"heterogeneity":[103,282],"examined":[105],"using":[106],"chi-squared":[108],"I2":[110],"statistics.":[111],"Nine":[112],"studies":[113],"met":[114],"inclusion":[116],"criteria.":[117],"Pooled":[118],"data":[119,197],"showed":[120],"that":[121,199,251,293],"significantly":[123],"reduced":[124],"kinase":[126],"(CK)":[127],"concentration":[128,164,276],"(WMD":[130,166],"=":[131,138,167,174],"\u221230.94;":[132],"CI:":[134,170],"\u221253.19,":[135],"\u22128.69;":[136],"p":[137,173],".006)":[139],"at":[141],"three":[142],"follow-up":[143],"times":[144],"(48,":[145],"72,":[146,256],"96":[148,258],"hr)":[149],"comparison":[151],"with":[152,189,305],"placebo.":[153],"In":[154,261],"contrast,":[155],"not":[158],"significant":[159,182],"lactate":[161],"dehydrogenase":[162],"(LDH)":[163],"\u22125.99;":[168],"\u221214.49,":[171],"2.50;":[172],".167),":[175],"but":[176],"supplementation":[178,241],"leaded":[179],"a":[181,221,272],"reduction":[183],"LDH":[185],"concentrations":[186],"trials":[188],"48":[190],"hr":[191,259],"measurement":[192],"LDH.":[194],"current":[196,263],"indicate":[198],"consumption":[201],"is":[202],"better":[203],"than":[204],"rest":[205],"after":[206,236],"diverse":[207],"forms":[208],"damaging":[210],"exhaustive":[212],"exercise":[213],"or":[214],"passive":[215],"recovery.":[216],"benefits":[218],"relate":[219],"decrease":[222,273],"indices":[226],"improved":[228],"because":[231],"power":[234],"loss":[235],"exercise.":[237],"Practical":[238],"applications":[239],"Creatine":[240],"would":[242],"be":[243],"effective":[244],"reducing":[246],"immediate":[248],"happens":[252],"<24,":[253],"24,":[254],"48,":[255],"post-exercise.":[260],"meta-analysis,":[264],"positive":[266],"could":[270],"cause":[271],"CK":[275],"overall.":[277],"But,":[278],"due":[279],"high":[281],"medium":[285],"articles,":[290],"we":[291],"suggest":[292],"these":[294],"results":[295],"are":[296,303],"taken":[297],"into":[298],"account":[299],"facts":[302],"interpreted":[304],"caution":[306],"by":[307],"readers.":[309]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-09-13T00:00:00"}