{"id":"https://openalex.org/W3196956808","doi":"https://doi.org/10.1016/j.xinn.2021.100160","title":"A dual-targeted multifunctional nanoformulation for potential prevention and therapy of Alzheimer's disease","display_name":"A dual-targeted multifunctional nanoformulation for potential prevention and therapy of Alzheimer's disease","publication_year":2021,"publication_date":"2021-08-31","ids":{"openalex":"https://openalex.org/W3196956808","doi":"https://doi.org/10.1016/j.xinn.2021.100160","mag":"3196956808","pmid":"https://pubmed.ncbi.nlm.nih.gov/34901904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8640585"},"language":"en","primary_location":{"id":"doi:10.1016/j.xinn.2021.100160","doi":"https://doi.org/10.1016/j.xinn.2021.100160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xinn.2021.100160","pdf_url":null,"source":{"id":"https://openalex.org/S4210236180","display_name":"The Innovation","issn_l":"2666-6758","issn":["2666-6758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Innovation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xinn.2021.100160","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091383657","display_name":"Dongju Zhao","orcid":"https://orcid.org/0000-0002-0589-5670","observed_orcids":["https://orcid.org/0000-0002-0589-5670"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongju Zhao","raw_affiliation_strings":["School of Life Sciences, Tianjin University, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101892780","display_name":"Yuqing Tang","orcid":"https://orcid.org/0000-0003-4483-2688","observed_orcids":["https://orcid.org/0000-0003-4483-2688"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Tang","raw_affiliation_strings":["School of Life Sciences, Tianjin University, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110657545","display_name":"Xinjun Suo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinjun Suo","raw_affiliation_strings":["Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China","institution_ids":["https://openalex.org/I2802534033","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074150254","display_name":"Chaonan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaonan Zhang","raw_affiliation_strings":["School of Life Sciences, Tianjin University, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021016615","display_name":"Yan Dou","orcid":"https://orcid.org/0000-0002-6905-2787","observed_orcids":["https://orcid.org/0000-0002-6905-2787"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Dou","raw_affiliation_strings":["Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China"],"raw_orcid":"https://orcid.org/0000-0002-6905-2787","affiliations":[{"raw_affiliation_string":"Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China","institution_ids":["https://openalex.org/I2802534033","https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042143812","display_name":"Jin Keun Chang","orcid":"https://orcid.org/0000-0002-6752-8526","observed_orcids":["https://orcid.org/0000-0002-6752-8526"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Chang","raw_affiliation_strings":["School of Life Sciences, Tianjin University, Tianjin 300072, China"],"raw_orcid":"https://orcid.org/0000-0002-6752-8526","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021016615","https://openalex.org/A5042143812"],"corresponding_institution_ids":["https://openalex.org/I162868743","https://openalex.org/I2802534033","https://openalex.org/I5740404"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":1.9029,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.86102926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"2","issue":"4","first_page":"100160","last_page":"100160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dual-targeted-drug-delivery","display_name":"dual-targeted drug delivery","score":0.6830000281333923},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.9120000004768372},{"id":"https://openalex.org/keywords/amyloid-beta-aggregates","display_name":"amyloid-beta aggregates","score":0.9110000133514404},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9440000057220459},{"id":"https://openalex.org/keywords/disease-prevention","display_name":"disease prevention","score":0.492000013589859},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hippocampal-atrophy","display_name":"hippocampal atrophy","score":0.996999979019165},{"id":"https://openalex.org/keywords/app-ps1-mice","display_name":"APP/PS1 mice","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6040210127830505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5503864884376526},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.524241030216217},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4321008324623108},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33948689699172974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15149205923080444},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.05799669027328491},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.xinn.2021.100160","doi":"https://doi.org/10.1016/j.xinn.2021.100160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xinn.2021.100160","pdf_url":null,"source":{"id":"https://openalex.org/S4210236180","display_name":"The Innovation","issn_l":"2666-6758","issn":["2666-6758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Innovation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8640585","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8640585/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8640585/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation (Camb)","raw_type":"Text"},{"id":"pmid:34901904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34901904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation (Cambridge (Mass.))","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:075fcd76bbe94a41bff1b9118de1097e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/075fcd76bbe94a41bff1b9118de1097e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Innovation, Vol 2, Iss 4, Pp 100160- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.xinn.2021.100160","doi":"https://doi.org/10.1016/j.xinn.2021.100160","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xinn.2021.100160","pdf_url":null,"source":{"id":"https://openalex.org/S4210236180","display_name":"The Innovation","issn_l":"2666-6758","issn":["2666-6758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Innovation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5447354444","display_name":"\u57fa\u4e8e\u8001\u5e74\u6027\u75f4\u5446\u590d\u6742\u53d1\u75c5\u673a\u5236\u7684\u9ad8\u534f\u540c\u6548\u5e94\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u7684\u6784\u5efa","funder_award_id":"51573128","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8476051780","display_name":"\u53cc\u6a21\u6001\u63a2\u9488\u5f15\u5bfc\u667a\u80fd\u57fa\u56e0\u7cbe\u51c6\u6cbb\u7597\u7cfb\u7edf\u7684\u7814\u7a76","funder_award_id":"51873150","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3196956808.pdf","grobid_xml":"https://content.openalex.org/works/W3196956808.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1492443634","https://openalex.org/W1977178308","https://openalex.org/W2016787780","https://openalex.org/W2018659142","https://openalex.org/W2027783468","https://openalex.org/W2071214407","https://openalex.org/W2082517369","https://openalex.org/W2085800477","https://openalex.org/W2121806371","https://openalex.org/W2159821105","https://openalex.org/W2165201727","https://openalex.org/W2215956681","https://openalex.org/W2252054300","https://openalex.org/W2263173985","https://openalex.org/W2294586018","https://openalex.org/W2296523452","https://openalex.org/W2310415701","https://openalex.org/W2324917897","https://openalex.org/W2535730691","https://openalex.org/W2755558750","https://openalex.org/W2756282825","https://openalex.org/W2759665961","https://openalex.org/W2766388141","https://openalex.org/W2768499679","https://openalex.org/W2786474781","https://openalex.org/W2788048790","https://openalex.org/W2788808587","https://openalex.org/W2793159348","https://openalex.org/W2849172012","https://openalex.org/W2884855541","https://openalex.org/W2900354882","https://openalex.org/W2900969673","https://openalex.org/W2923350517","https://openalex.org/W2940915183","https://openalex.org/W2946487204","https://openalex.org/W2970566248","https://openalex.org/W2977696708","https://openalex.org/W2995770731","https://openalex.org/W3004110416","https://openalex.org/W3006949946","https://openalex.org/W3013352992","https://openalex.org/W3016518159","https://openalex.org/W3023013291","https://openalex.org/W3099031341"],"related_works":["https://openalex.org/W2891482489","https://openalex.org/W4405808321","https://openalex.org/W4380871616","https://openalex.org/W4402385019","https://openalex.org/W4414412861","https://openalex.org/W3120590729","https://openalex.org/W7125377224","https://openalex.org/W2626258297","https://openalex.org/W4380264020","https://openalex.org/W4405416913"],"abstract_inverted_index":{"Antioxidation":[0],"and":[1,30,56,85,95,123,128,138],"adjustable":[2,40],"treatment":[3,10,125],"strategies":[4],"are":[5],"critical":[6],"for":[7,48,117,141],"the":[8,27,49,54,61,82,118,145],"effective":[9],"of":[11,63,89,106,126],"Alzheimer's":[12],"disease":[13],"(AD).":[14],"Here,":[15],"we":[16],"design":[17,53],"a":[18,103],"dual-targeted":[19],"Prussian":[20],"blue":[21],"nanoformulation":[22],"(PTCN)":[23],"that":[24,73],"can":[25],"cross":[26],"blood-brain":[28],"barrier":[29],"target":[31],"amyloid":[32],"beta":[33],"aggregates":[34],"further":[35],"exert":[36],"antioxidant":[37],"effects.":[38],"An":[39],"gradient":[41],"dosing":[42],"strategy":[43],"with":[44,110],"PTCN":[45,74,99],"is":[46,102,129],"used":[47],"first":[50],"time":[51],"to":[52,131],"preventive":[55,94],"therapeutic":[57,96,136],"trials":[58],"based":[59],"on":[60],"severity":[62],"oxidative":[64],"stress":[65],"at":[66],"different":[67],"AD":[68,143],"stages.":[69],"The":[70],"results":[71],"show":[72],"could":[75],"effectively":[76],"ameliorate":[77],"AD-related":[78],"pathological":[79],"processes,":[80],"improve":[81],"cognitive":[83],"decline,":[84],"rescue":[86],"hippocampal":[87],"atrophy":[88],"APP/PS1":[90],"mice":[91],"in":[92,144],"both":[93],"trials.":[97],"Altogether,":[98],"provided":[100],"here":[101],"successful":[104],"combination":[105],"three":[107],"traditional":[108],"biomaterials":[109],"good":[111],"biosafety,":[112],"which":[113],"has":[114],"broad":[115],"prospects":[116],"early":[119],"prevention,":[120],"mild":[121],"remission,":[122],"late":[124],"AD,":[127],"expected":[130],"be":[132],"developed":[133],"into":[134],"personalized":[135],"drugs":[137],"healthcare":[139],"products":[140],"clinical":[142],"future.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-09-13T00:00:00"}