{"id":"https://openalex.org/W3196948396","doi":"https://doi.org/10.1182/blood.2021011452","title":"IgM-MM is predominantly a pre\u2013germinal center disorder and has a distinct genomic and transcriptomic signature from WM","display_name":"IgM-MM is predominantly a pre\u2013germinal center disorder and has a distinct genomic and transcriptomic signature from WM","publication_year":2021,"publication_date":"2021-11-18","ids":{"openalex":"https://openalex.org/W3196948396","doi":"https://doi.org/10.1182/blood.2021011452","mag":"3196948396","pmid":"https://pubmed.ncbi.nlm.nih.gov/34792571","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8602933"},"language":"en","primary_location":{"id":"doi:10.1182/blood.2021011452","doi":"https://doi.org/10.1182/blood.2021011452","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2021011452","pdf_url":"https://ashpublications.org/blood/article-pdf/138/20/1980/1890585/bloodbld2021011452.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/138/20/1980/1890585/bloodbld2021011452.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048162877","display_name":"Abdul Hamid Bazarbachi","orcid":"https://orcid.org/0000-0003-0243-4040","observed_orcids":["https://orcid.org/0000-0003-0243-4040"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Hamid Bazarbachi","raw_affiliation_strings":["Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY;","Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;"],"raw_orcid":"https://orcid.org/0000-0003-0243-4040","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY;","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I2800364127"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063422967","display_name":"Herv\u00e9 Avet\u2010Loiseau","orcid":"https://orcid.org/0000-0002-3050-0140","observed_orcids":["https://orcid.org/0000-0002-3050-0140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Avet-Loiseau","raw_affiliation_strings":["University Cancer Center of Toulouse, Institut National de la Sant\u00e9, Toulouse, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Cancer Center of Toulouse, Institut National de la Sant\u00e9, Toulouse, France;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055748047","display_name":"Raphael Elie Szalat","orcid":"https://orcid.org/0000-0002-6198-3405","observed_orcids":["https://orcid.org/0000-0002-6198-3405"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raphael Szalat","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Boston University Medical Center, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Boston University Medical Center, Boston, MA;","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067318207","display_name":"An\u0131l Akta\u015f Samur","orcid":"https://orcid.org/0000-0002-0183-0562","observed_orcids":["https://orcid.org/0000-0002-0183-0562"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Aktas Samur","raw_affiliation_strings":["Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA;","Department of Data Science, Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":"https://orcid.org/0000-0002-0183-0562","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Data Science, Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026121534","display_name":"Zachary R. Hunter","orcid":"https://orcid.org/0000-0002-1689-1691","observed_orcids":["https://orcid.org/0000-0002-1689-1691"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Hunter","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;"],"raw_orcid":"https://orcid.org/0000-0002-1689-1691","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masood Shammas","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;"],"raw_orcid":"https://orcid.org/0000-0002-8932-6829","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030565933","display_name":"Jill Corre","orcid":"https://orcid.org/0000-0003-1580-6106","observed_orcids":["https://orcid.org/0000-0003-1580-6106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill Corre","raw_affiliation_strings":["University Cancer Center of Toulouse, Institut National de la Sant\u00e9, Toulouse, France;"],"raw_orcid":"https://orcid.org/0000-0003-1580-6106","affiliations":[{"raw_affiliation_string":"University Cancer Center of Toulouse, Institut National de la Sant\u00e9, Toulouse, France;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062468245","display_name":"Mariateresa Fulciniti","orcid":"https://orcid.org/0000-0002-1432-9742","observed_orcids":["https://orcid.org/0000-0002-1432-9742"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariateresa Fulciniti","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth C. Anderson","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050977500","display_name":"Giovanni Parmigiani","orcid":"https://orcid.org/0000-0002-8783-5961","observed_orcids":["https://orcid.org/0000-0002-8783-5961"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giovanni Parmigiani","raw_affiliation_strings":["Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA;","Department of Data Science, Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":"https://orcid.org/0000-0002-8783-5961","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Data Science, Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081299017","display_name":"Steven Peter Treon","orcid":"https://orcid.org/0000-0001-6393-6154","observed_orcids":["https://orcid.org/0000-0001-6393-6154"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven P. Treon","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;"],"raw_orcid":"https://orcid.org/0000-0001-6393-6154","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020996390","display_name":"Mohamad Mohty","orcid":"https://orcid.org/0000-0002-7264-808X","observed_orcids":["https://orcid.org/0000-0002-7264-808X","https://orcid.org/0000-0001-8536-7781"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mohamad Mohty","raw_affiliation_strings":["Service d\u2019H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire, H\u00f4pital Saint-Antoine, INSERM UMRs 938, Universit\u00e9 Sorbonne, Paris, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire, H\u00f4pital Saint-Antoine, INSERM UMRs 938, Universit\u00e9 Sorbonne, Paris, France; and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil C. Munshi","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;","VA Boston Healthcare System, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"VA Boston Healthcare System, Boston, MA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041668980","display_name":"Mehmet Samur","orcid":"https://orcid.org/0000-0002-9978-5682","observed_orcids":["https://orcid.org/0000-0002-9978-5682"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Kemal Samur","raw_affiliation_strings":["Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA;","Department of Data Science, Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":"https://orcid.org/0000-0002-9978-5682","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Data Science, Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.6069,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.90781877,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"138","issue":"20","first_page":"1980","last_page":"1985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.6610000133514404},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.4959999918937683},{"id":"https://openalex.org/keywords/cd20","display_name":"CD20","score":0.7689999938011169},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase","display_name":"Bruton's tyrosine kinase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.7509317994117737},{"id":"https://openalex.org/C137756551","wikidata":"https://www.wikidata.org/wiki/Q2386881","display_name":"Immunoglobulin class switching","level":4,"score":0.6395993232727051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6355767846107483},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.5872046947479248},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5644206404685974},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4943277835845947},{"id":"https://openalex.org/C2781038049","wikidata":"https://www.wikidata.org/wiki/Q1778287","display_name":"Waldenstrom macroglobulinemia","level":3,"score":0.48438459634780884},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.47178930044174194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.460671067237854},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.4375636577606201},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37194788455963135},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.3332291841506958},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32462796568870544},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.28587087988853455},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27566224336624146},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2721579074859619},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24953868985176086},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.24551013112068176},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.10440459847450256}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood.2021011452","doi":"https://doi.org/10.1182/blood.2021011452","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2021011452","pdf_url":"https://ashpublications.org/blood/article-pdf/138/20/1980/1890585/bloodbld2021011452.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8602933","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8602933","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:34792571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34792571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05026456v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05026456","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood, 2021, 138 (20), pp.1980-1985. ⟨10.1182/blood.2021011452⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1182/blood.2021011452","doi":"https://doi.org/10.1182/blood.2021011452","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2021011452","pdf_url":"https://ashpublications.org/blood/article-pdf/138/20/1980/1890585/bloodbld2021011452.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3668218448","display_name":null,"funder_award_id":"I01 BX001584","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4933731489","display_name":"SPORE in Multiple Myeloma","funder_award_id":"P50CA100707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000066536","display_name":null,"funder_award_id":"CA100707","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000867162","display_name":"Integrative Oncogenomics of Multiple Myeloma","funder_award_id":"P01CA155258","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G918026202","display_name":null,"funder_award_id":"CA100707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3196948396.pdf","grobid_xml":"https://content.openalex.org/works/W3196948396.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1963495263","https://openalex.org/W1977848065","https://openalex.org/W1991678541","https://openalex.org/W1994753912","https://openalex.org/W2018830398","https://openalex.org/W2046517086","https://openalex.org/W2049526822","https://openalex.org/W2052855201","https://openalex.org/W2053491916","https://openalex.org/W2057715263","https://openalex.org/W2074784947","https://openalex.org/W2082450387","https://openalex.org/W2104195581","https://openalex.org/W2139427728","https://openalex.org/W2155165473","https://openalex.org/W2235523093","https://openalex.org/W2274360660","https://openalex.org/W2291176625","https://openalex.org/W2767256995","https://openalex.org/W2792326760","https://openalex.org/W2805293188","https://openalex.org/W2805689516","https://openalex.org/W2886837533","https://openalex.org/W2924887250","https://openalex.org/W3096867320"],"related_works":["https://openalex.org/W3095089412","https://openalex.org/W2209053940","https://openalex.org/W2062776328","https://openalex.org/W2612832290","https://openalex.org/W2145703925","https://openalex.org/W2586082830","https://openalex.org/W4310119467","https://openalex.org/W1990078109","https://openalex.org/W4414302506","https://openalex.org/W2338762004"],"abstract_inverted_index":{"Immunoglobulin":[0],"M":[1],"(IgM)":[2],"multiple":[3],"myeloma":[4],"(MM)":[5],"is":[6,28],"a":[7,127],"rare":[8],"disease":[9],"subgroup.":[10],"Its":[11],"differentiation":[12],"from":[13,57],"other":[14],"IgM-producing":[15],"gammopathies":[16],"such":[17],"as":[18,91,93,109,146,148],"Waldenstr\u00f6m":[19],"macroglobulinemia":[20],"(WM)":[21],"has":[22,79],"not":[23],"been":[24],"well":[25,92,147],"characterized":[26,104],"but":[27,78],"essential":[29],"for":[30,156],"proper":[31],"risk":[32],"assessment":[33],"and":[34,42,50,59,73,88,96,142],"treatment.":[35],"In":[36],"this":[37],"study,":[38],"we":[39,132],"investigated":[40],"genomic":[41],"transcriptomic":[43],"characteristics":[44,56],"of":[45,68,121,136],"IgM-MM":[46,65,100],"samples":[47],"using":[48],"whole-genome":[49],"transcriptome":[51],"sequencing":[52],"to":[53,111],"identify":[54],"differentiating":[55],"non-IgM-MM":[58],"WM.":[60],"Our":[61],"results":[62],"suggest":[63],"that":[64],"shares":[66],"most":[67],"its":[69,119],"defining":[70],"structural":[71],"variants":[72],"gene-expression":[74],"profiling":[75],"with":[76,118],"MM,":[77],"some":[80],"key":[81],"characteristics,":[82],"including":[83,140],"t(11;14)":[84],"translocation,":[85],"chromosome":[86],"6":[87],"13":[89],"deletion":[90],"distinct":[94],"molecular":[95],"transcription-factor":[97],"signatures.":[98],"Furthermore,":[99],"translocations":[101],"were":[102],"predominantly":[103],"by":[105],"VHDHJH":[106],"recombination-induced":[107],"breakpoints,":[108],"opposed":[110],"the":[112],"usual":[113],"class-switching":[114],"region":[115],"breakpoints;":[116],"coupled":[117],"lack":[120],"class":[122],"switching,":[123],"these":[124],"data":[125],"favor":[126],"pre-germinal":[128],"center":[129],"origin.":[130],"Finally,":[131],"found":[133],"elevated":[134],"expression":[135],"clinically":[137],"relevant":[138],"targets,":[139],"CD20":[141],"Bruton":[143],"tyrosine":[144],"kinase,":[145],"high":[149],"BCL2/BCL2L1":[150],"ratio":[151],"in":[152],"IgM-MM,":[153],"providing":[154],"potential":[155],"targeted":[157],"therapeutics.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-09-13T00:00:00"}