{"id":"https://openalex.org/W3196941990","doi":"https://doi.org/10.1016/j.neulet.2021.136218","title":"Blockade of GPR55 in dorsal periaqueductal gray produces anxiety-like behaviors and evocates defensive aggressive responses in alcohol-pre-exposed rats","display_name":"Blockade of GPR55 in dorsal periaqueductal gray produces anxiety-like behaviors and evocates defensive aggressive responses in alcohol-pre-exposed rats","publication_year":2021,"publication_date":"2021-09-03","ids":{"openalex":"https://openalex.org/W3196941990","doi":"https://doi.org/10.1016/j.neulet.2021.136218","mag":"3196941990","pmid":"https://pubmed.ncbi.nlm.nih.gov/34487839"},"language":"en","primary_location":{"id":"doi:10.1016/j.neulet.2021.136218","doi":"https://doi.org/10.1016/j.neulet.2021.136218","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2021.136218","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065852182","display_name":"Priscila V\u00e1zquez-Le\u00f3n","orcid":"https://orcid.org/0000-0003-4924-1238","observed_orcids":["https://orcid.org/0000-0003-4924-1238"]},"institutions":[{"id":"https://openalex.org/I190103667","display_name":"Autonomous University of Aguascalientes","ror":"https://ror.org/03ec8vy26","country_code":"MX","type":"education","lineage":["https://openalex.org/I190103667"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Priscila V\u00e1zquez-Le\u00f3n","raw_affiliation_strings":["Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas, Universidad Aut\u00f3noma de Aguascalientes, Ciudad Universitaria, 20131 Aguascalientes, Ags., Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas, Universidad Aut\u00f3noma de Aguascalientes, Ciudad Universitaria, 20131 Aguascalientes, Ags., Mexico","institution_ids":["https://openalex.org/I190103667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089312571","display_name":"Abraham Miranda-P\u00e1ez","orcid":"https://orcid.org/0000-0003-0985-1816","observed_orcids":["https://orcid.org/0000-0003-0985-1816"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Abraham Miranda-P\u00e1ez","raw_affiliation_strings":["Departamento de Fisiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Wilfrido Massieu esq. Manuel Stampa s/n Col. Nueva Industrial Vallejo CP: 07738 Alc. Gustavo A. Madero, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Wilfrido Massieu esq. Manuel Stampa s/n Col. Nueva Industrial Vallejo CP: 07738 Alc. Gustavo A. Madero, Mexico City, Mexico","institution_ids":["https://openalex.org/I59361560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046583313","display_name":"Argelia Calvillo-Robledo","orcid":"https://orcid.org/0009-0001-2934-0127","observed_orcids":["https://orcid.org/0009-0001-2934-0127"]},"institutions":[{"id":"https://openalex.org/I190103667","display_name":"Autonomous University of Aguascalientes","ror":"https://ror.org/03ec8vy26","country_code":"MX","type":"education","lineage":["https://openalex.org/I190103667"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Argelia Calvillo-Robledo","raw_affiliation_strings":["Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas, Universidad Aut\u00f3noma de Aguascalientes, Ciudad Universitaria, 20131 Aguascalientes, Ags., Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas, Universidad Aut\u00f3noma de Aguascalientes, Ciudad Universitaria, 20131 Aguascalientes, Ags., Mexico","institution_ids":["https://openalex.org/I190103667"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088515854","display_name":"Bruno A. Marichal\u2010Cancino","orcid":"https://orcid.org/0000-0003-0244-5209","observed_orcids":["https://orcid.org/0000-0003-0244-5209"]},"institutions":[{"id":"https://openalex.org/I190103667","display_name":"Autonomous University of Aguascalientes","ror":"https://ror.org/03ec8vy26","country_code":"MX","type":"education","lineage":["https://openalex.org/I190103667"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Bruno A. Marichal-Cancino","raw_affiliation_strings":["Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas, Universidad Aut\u00f3noma de Aguascalientes, Ciudad Universitaria, 20131 Aguascalientes, Ags., Mexico. Electronic address: bruno.marichal@edu.uaa.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas, Universidad Aut\u00f3noma de Aguascalientes, Ciudad Universitaria, 20131 Aguascalientes, Ags., Mexico. Electronic address: bruno.marichal@edu.uaa.mx","institution_ids":["https://openalex.org/I190103667"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088515854"],"corresponding_institution_ids":["https://openalex.org/I190103667"],"apc_list":{"value":2770,"currency":"USD","value_usd":2770},"apc_paid":null,"fwci":1.0345,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72029803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"764","issue":null,"first_page":"136218","last_page":"136218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr55","display_name":"GPR55","score":0.9980000257492065},{"id":"https://openalex.org/keywords/periaqueductal-gray","display_name":"periaqueductal gray","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dorsal-periaqueductal-gray","display_name":"dorsal periaqueductal gray","score":0.9599999785423279},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.902999997138977},{"id":"https://openalex.org/keywords/defensive-aggression","display_name":"defensive aggression","score":0.8519999980926514},{"id":"https://openalex.org/keywords/alcohol-preference","display_name":"alcohol preference","score":0.7390000224113464},{"id":"https://openalex.org/keywords/alcohol-exposure","display_name":"alcohol exposure","score":0.7580000162124634},{"id":"https://openalex.org/keywords/lpi","display_name":"LPI","score":0.8569999933242798},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.8109999895095825},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.7080142498016357},{"id":"https://openalex.org/C2781069035","wikidata":"https://www.wikidata.org/wiki/Q1243765","display_name":"Periaqueductal gray","level":4,"score":0.6983659863471985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4730103313922882},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4646470248699188},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4557861387729645},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4546409845352173},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.4139782190322876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33390486240386963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3191004693508148},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3081512153148651},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27795085310935974},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.11461141705513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11018139123916626},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10954007506370544}],"mesh":[{"descriptor_ui":"D000374","descriptor_name":"Aggression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000374","descriptor_name":"Aggression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neulet.2021.136218","doi":"https://doi.org/10.1016/j.neulet.2021.136218","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2021.136218","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:34487839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34487839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7724148291","display_name":null,"funder_award_id":"406562","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"}],"funders":[{"id":"https://openalex.org/F4320318914","display_name":"Universidad Aut\u00f3noma de Aguascalientes","ror":"https://ror.org/03ec8vy26"},{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320336053","display_name":"Sistema Nacional de Investigadores","ror":"https://ror.org/02h3fqt03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1485038464","https://openalex.org/W1568432828","https://openalex.org/W1593555249","https://openalex.org/W1819429514","https://openalex.org/W1844090762","https://openalex.org/W1887249759","https://openalex.org/W1963841728","https://openalex.org/W1964220304","https://openalex.org/W1970144655","https://openalex.org/W1976768202","https://openalex.org/W1977546136","https://openalex.org/W1994033057","https://openalex.org/W2015830587","https://openalex.org/W2020825180","https://openalex.org/W2029003083","https://openalex.org/W2051473277","https://openalex.org/W2062529972","https://openalex.org/W2075256367","https://openalex.org/W2078200263","https://openalex.org/W2079860184","https://openalex.org/W2080853395","https://openalex.org/W2082433795","https://openalex.org/W2084787756","https://openalex.org/W2086549864","https://openalex.org/W2091057846","https://openalex.org/W2091474137","https://openalex.org/W2092809554","https://openalex.org/W2095302802","https://openalex.org/W2098804683","https://openalex.org/W2102089125","https://openalex.org/W2104816213","https://openalex.org/W2126629647","https://openalex.org/W2149886328","https://openalex.org/W2163573952","https://openalex.org/W2163815564","https://openalex.org/W2313492890","https://openalex.org/W2501047946","https://openalex.org/W2517918289","https://openalex.org/W2733736690","https://openalex.org/W2744152866","https://openalex.org/W2745292704","https://openalex.org/W2761993208","https://openalex.org/W2766767705","https://openalex.org/W2803918511","https://openalex.org/W2807759151","https://openalex.org/W2808421575","https://openalex.org/W2889913859","https://openalex.org/W2910414836","https://openalex.org/W2912348787","https://openalex.org/W2913367166","https://openalex.org/W2955504961","https://openalex.org/W3005943714","https://openalex.org/W3021731833","https://openalex.org/W3041843912","https://openalex.org/W3084940043","https://openalex.org/W3096999426","https://openalex.org/W3138198874","https://openalex.org/W3184395594","https://openalex.org/W6638862950"],"related_works":["https://openalex.org/W4411163209","https://openalex.org/W2104816213","https://openalex.org/W3096999426","https://openalex.org/W4386390698","https://openalex.org/W2097587221","https://openalex.org/W2539822733","https://openalex.org/W7207567435","https://openalex.org/W2056407573","https://openalex.org/W2033469687","https://openalex.org/W3197323646"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-09-13T00:00:00"}