{"id":"https://openalex.org/W3196901131","doi":"https://doi.org/10.3389/fnagi.2021.599724","title":"The Association Between Perivascular Spaces and Cerebral Blood Flow, Brain Volume, and Cardiovascular Risk","display_name":"The Association Between Perivascular Spaces and Cerebral Blood Flow, Brain Volume, and Cardiovascular Risk","publication_year":2021,"publication_date":"2021-08-31","ids":{"openalex":"https://openalex.org/W3196901131","doi":"https://doi.org/10.3389/fnagi.2021.599724","mag":"3196901131","pmid":"https://pubmed.ncbi.nlm.nih.gov/34531732","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8438293"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2021.599724","doi":"https://doi.org/10.3389/fnagi.2021.599724","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2021.599724","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2021.599724/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2021.599724/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025282041","display_name":"Sirui Liu","orcid":"https://orcid.org/0000-0003-4526-7924","observed_orcids":["https://orcid.org/0000-0003-4526-7924"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sirui Liu","raw_affiliation_strings":["Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119532711","display_name":"Bo Hou","orcid":"https://orcid.org/0000-0003-0520-3969","observed_orcids":["https://orcid.org/0000-0003-0520-3969"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Hou","raw_affiliation_strings":["Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101609759","display_name":"Hui You","orcid":"https://orcid.org/0000-0002-6545-7787","observed_orcids":["https://orcid.org/0000-0002-6545-7787"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui You","raw_affiliation_strings":["Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410226","display_name":"Yiwei Zhang","orcid":"https://orcid.org/0000-0003-2411-5219","observed_orcids":["https://orcid.org/0000-0003-2411-5219"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Zhang","raw_affiliation_strings":["Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058564307","display_name":"Yi\u2010Cheng Zhu","orcid":"https://orcid.org/0000-0002-8966-1379","observed_orcids":["https://orcid.org/0000-0002-8966-1379","https://orcid.org/0000-0003-3037-0398"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yicheng Zhu","raw_affiliation_strings":["Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062325991","display_name":"Chao Ma","orcid":"https://orcid.org/0000-0002-2016-8084","observed_orcids":["https://orcid.org/0000-0002-2016-8084"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Ma","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005277049","display_name":"Zhentao Zuo","orcid":"https://orcid.org/0000-0002-5909-3884","observed_orcids":["https://orcid.org/0000-0002-5909-3884"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767814","display_name":"State Key Laboratory of Brain and Cognitive Science","ror":"https://ror.org/048wy7h78","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540","https://openalex.org/I4391767814"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhentao Zuo","raw_affiliation_strings":["Sino-Danish College, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sino-Danish College, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540","https://openalex.org/I4391767814"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100459231","display_name":"Feng Feng","orcid":"https://orcid.org/0000-0002-3507-1154","observed_orcids":["https://orcid.org/0000-0002-3507-1154"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Feng","raw_affiliation_strings":["Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5005277049","https://openalex.org/A5100459231"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I200296433","https://openalex.org/I2801228662","https://openalex.org/I4210112540","https://openalex.org/I4210165038","https://openalex.org/I4391767814"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.268,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.768451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"599724","last_page":"599724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.16660000383853912,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9800000190734863},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.9919999837875366},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6499999761581421},{"id":"https://openalex.org/keywords/pseudo-continuous-arterial-spin-labeling","display_name":"pseudo-continuous arterial spin labeling","score":0.7400000095367432},{"id":"https://openalex.org/keywords/subcortical-gray-matter","display_name":"subcortical gray matter","score":0.7080000042915344},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.7979999780654907},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"globus pallidus","score":0.9570000171661377},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":0.9940000176429749},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.8614821434020996},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.7381088733673096},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.7319638133049011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6958562135696411},{"id":"https://openalex.org/C2781423529","wikidata":"https://www.wikidata.org/wiki/Q1132309","display_name":"Caudate nucleus","level":2,"score":0.6197142601013184},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5754645466804504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4863177239894867},{"id":"https://openalex.org/C2777799939","wikidata":"https://www.wikidata.org/wiki/Q1711381","display_name":"Perivascular space","level":2,"score":0.47658488154411316},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4750387966632843},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.441488653421402},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.4371635317802429},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32548290491104126},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.17232248187065125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11661547422409058},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09716024994850159}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fnagi.2021.599724","doi":"https://doi.org/10.3389/fnagi.2021.599724","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2021.599724","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2021.599724/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7332232","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8438293","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8438293","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8438293","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Aging Neurosci","raw_type":"Text"},{"id":"pmid:34531732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34531732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in aging neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:51e273da14ee40c2b3d58072d4e350c4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/51e273da14ee40c2b3d58072d4e350c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 13 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2021.599724","doi":"https://doi.org/10.3389/fnagi.2021.599724","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2021.599724","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2021.599724/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7799999713897705,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1350668054","display_name":null,"funder_award_id":"82071899","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2756142670","display_name":null,"funder_award_id":"2019YFA0707103","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G2821966782","display_name":null,"funder_award_id":"CIFMS #2017-I2M-3-008","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G491881654","display_name":null,"funder_award_id":"2016YFC1305901","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G5967212047","display_name":null,"funder_award_id":"XDB32010300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6738447230","display_name":null,"funder_award_id":"2017-I2M-3-008","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7032346304","display_name":null,"funder_award_id":"XDB32010300","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G7308143727","display_name":null,"funder_award_id":"2017-","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G8592986710","display_name":null,"funder_award_id":"2019YFA0707103","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320327720","display_name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3196901131.pdf","grobid_xml":"https://content.openalex.org/works/W3196901131.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1542438573","https://openalex.org/W1968691313","https://openalex.org/W1970326953","https://openalex.org/W1976038311","https://openalex.org/W1982252004","https://openalex.org/W1989704288","https://openalex.org/W1989854445","https://openalex.org/W2013859768","https://openalex.org/W2030827970","https://openalex.org/W2031170958","https://openalex.org/W2039238576","https://openalex.org/W2041195767","https://openalex.org/W2081061369","https://openalex.org/W2094077567","https://openalex.org/W2097033739","https://openalex.org/W2098819343","https://openalex.org/W2100314515","https://openalex.org/W2111564996","https://openalex.org/W2111922444","https://openalex.org/W2118438010","https://openalex.org/W2146967348","https://openalex.org/W2148092884","https://openalex.org/W2149722331","https://openalex.org/W2158742097","https://openalex.org/W2158769601","https://openalex.org/W2163900294","https://openalex.org/W2300278878","https://openalex.org/W2514190886","https://openalex.org/W2543174917","https://openalex.org/W2578967079","https://openalex.org/W2602043626","https://openalex.org/W2746293221","https://openalex.org/W2755239923","https://openalex.org/W2783838682","https://openalex.org/W2898289136","https://openalex.org/W2898398170","https://openalex.org/W2900442537","https://openalex.org/W2903015015","https://openalex.org/W2964824489","https://openalex.org/W2995875704","https://openalex.org/W3005654772","https://openalex.org/W3007523081","https://openalex.org/W3025412819","https://openalex.org/W3045167444","https://openalex.org/W3083628700","https://openalex.org/W3093001455"],"related_works":["https://openalex.org/W4400369912","https://openalex.org/W4401565315","https://openalex.org/W3163818045","https://openalex.org/W4402533183","https://openalex.org/W4390200531","https://openalex.org/W4390198520","https://openalex.org/W4406992705","https://openalex.org/W4312088118","https://openalex.org/W4386758187","https://openalex.org/W4286562714"],"abstract_inverted_index":{"Background:":[0],"Basal":[1],"ganglia":[2,27,184],"perivascular":[3,28,185],"spaces":[4,29,186],"are":[5,252],"associated":[6,188,203,253],"with":[7,34,75,173,189,204,220,236,254],"cognitive":[8],"decline":[9],"and":[10,31,39,86,94,114,143,164,193,201,214,258,263],"cardiovascular":[11,22,144,230,265],"risk":[12,23,145,169,231,266],"factors.":[13],"There":[14],"is":[15],"a":[16,56,79,87,151,228],"lack":[17],"of":[18,25,59,67,112,121,141,156],"studies":[19],"on":[20],"the":[21,46,107,110,136,139,174,209,234],"burden":[24,170,232],"basal":[26,183],"(BG-PVS)":[30],"their":[32],"relationship":[33,108,137],"gray":[35],"matter":[36],"volume":[37,207],"(GMV)":[38],"GM":[40],"cerebral":[41],"blood":[42],"flow":[43],"(CBF)":[44],"in":[45,55,195,208],"aging":[47],"brain.":[48],"Here,":[49],"we":[50],"investigated":[51],"these":[52],"two":[53],"issues":[54],"large":[57],"sample":[58],"cognitively":[60,246],"intact":[61,247],"older":[62,248],"adults.":[63],"Methods:":[64],"A":[65],"total":[66],"734":[68],"volunteers":[69],"were":[70,103,123,132,148,187,202,223],"recruited.":[71],"MRI":[72],"was":[73,158,171],"performed":[74],"3.0":[76],"T":[77],"using":[78,150],"pseudo-continuous":[80],"arterial":[81],"spin":[82],"labeling":[83],"(pCASL)":[84],"sequence":[85,91],"sagittal":[88],"isotropic":[89],"T1-weighted":[90],"for":[92],"CBF":[93,194],"GMV":[95,192,257],"analysis.":[96],"The":[97,126,154,218],"images":[98,127],"obtained":[99,128],"from":[100,129],"406":[101],"participants":[102,131,219,235],"analyzed":[104],"to":[105,134,226],"investigate":[106],"between":[109,138],"severity":[111,140,155],"BG-PVS":[113,142,147,157,222,238,251],"GMV/CBF.":[115],"False":[116],"discovery":[117],"rate-corrected":[118],"P-values":[119],"(PFDR)":[120],"<0.05":[122],"considered":[124],"significant.":[125],"254":[130],"used":[133],"study":[135],"burden.":[146,267],"rated":[149],"5-grade":[152],"score.":[153],"classified":[159],"as":[160],"mild":[161,237],"(grade":[162,166],"<3)":[163],"severe":[165,221,250],"\u22653).":[167],"Cardiovascular":[168,177],"assessed":[172],"Framingham":[175],"General":[176],"Risk":[178],"Score":[179],"(FGCRS).":[180],"Results:":[181],"Severe":[182],"significantly":[190,205],"smaller":[191,255],"multiple":[196],"cortical":[197,256],"regions":[198],"(PFDR":[199,216],"<0.05),":[200],"larger":[206,260],"bilateral":[210],"caudate":[211],"nucleus,":[212],"pallidum,":[213],"putamen":[215],"<0.05).":[217],"more":[224],"likely":[225],"have":[227],"higher":[229,264],"than":[233],"(60.71%":[239],"vs.":[240],"42.93%;":[241],"P":[242],"=0.02).":[243],"Conclusion:":[244],"In":[245],"adults,":[249],"CBF,":[259],"subcortical":[261],"GMV,":[262]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-09-13T00:00:00"}