{"id":"https://openalex.org/W3196745166","doi":"https://doi.org/10.4314/ijbcs.v15i3.3","title":"Kinetics of CD4+ T-cell recovery amongst HIV load suppressed patients on first-line antiretroviral therapy in Yaound\u00e9, Cameroon","display_name":"Kinetics of CD4+ T-cell recovery amongst HIV load suppressed patients on first-line antiretroviral therapy in Yaound\u00e9, Cameroon","publication_year":2021,"publication_date":"2021-09-07","ids":{"openalex":"https://openalex.org/W3196745166","doi":"https://doi.org/10.4314/ijbcs.v15i3.3","mag":"3196745166"},"language":"en","primary_location":{"id":"doi:10.4314/ijbcs.v15i3.3","doi":"https://doi.org/10.4314/ijbcs.v15i3.3","is_oa":true,"landing_page_url":"https://doi.org/10.4314/ijbcs.v15i3.3","pdf_url":"https://www.ajol.info/index.php/ijbcs/article/download/214115/201935","source":{"id":"https://openalex.org/S2764438579","display_name":"International Journal of Biological and Chemical Sciences","issn_l":"1991-8631","issn":["1991-8631","1997-342X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological and Chemical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ajol.info/index.php/ijbcs/article/download/214115/201935","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065476557","display_name":"Cedric Happi Mbakam","orcid":"https://orcid.org/0000-0001-6908-4570","observed_orcids":["https://orcid.org/0000-0001-6908-4570"]},"institutions":[{"id":"https://openalex.org/I1331070479","display_name":"Universit\u00e9 de Yaound\u00e9 I","ror":"https://ror.org/022zbs961","country_code":"CM","type":"education","lineage":["https://openalex.org/I1331070479"]}],"countries":["CM"],"is_corresponding":true,"raw_author_name":"Cedric Happi Mbakam","raw_affiliation_strings":["Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon","institution_ids":["https://openalex.org/I1331070479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018109734","display_name":"Julius Mbekem Nwobegahay","orcid":"https://orcid.org/0000-0002-8032-718X","observed_orcids":["https://orcid.org/0000-0002-8032-718X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julius Mbekem Nwobegahay","raw_affiliation_strings":["Millitary Health Research Center, Yaound\u00e9, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Millitary Health Research Center, Yaound\u00e9, Cameroon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009758557","display_name":"Cybelle Fodieu Mezajou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cybelle Fodieu Mezajou","raw_affiliation_strings":["Millitary Health Research Center , Yaound\u00e9 , Cameroon","PO.BOX 8445 Melen, Yaound\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Millitary Health Research Center , Yaound\u00e9 , Cameroon","institution_ids":[]},{"raw_affiliation_string":"PO.BOX 8445 Melen, Yaound\u00e9","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004734807","display_name":"Franklin S. Azebaze Agueguia","orcid":"https://orcid.org/0000-0003-0673-5465","observed_orcids":["https://orcid.org/0000-0003-0673-5465"]},"institutions":[{"id":"https://openalex.org/I1331070479","display_name":"Universit\u00e9 de Yaound\u00e9 I","ror":"https://ror.org/022zbs961","country_code":"CM","type":"education","lineage":["https://openalex.org/I1331070479"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Franklin Agueguia Azebaze","raw_affiliation_strings":["Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon","Millitary Health Research Center, Yaound\u00e9, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon","institution_ids":["https://openalex.org/I1331070479"]},{"raw_affiliation_string":"Millitary Health Research Center, Yaound\u00e9, Cameroon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014686795","display_name":"L\u00e9opold Mbous Nguimbus","orcid":"https://orcid.org/0009-0001-6565-0018","observed_orcids":["https://orcid.org/0009-0001-6565-0018"]},"institutions":[{"id":"https://openalex.org/I1331070479","display_name":"Universit\u00e9 de Yaound\u00e9 I","ror":"https://ror.org/022zbs961","country_code":"CM","type":"education","lineage":["https://openalex.org/I1331070479"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Leopold Mbous Nguimbus","raw_affiliation_strings":["Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon","institution_ids":["https://openalex.org/I1331070479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067406731","display_name":"Audrey Pamela Ngouambe Ngaleu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Audrey Pamela Ngouambe Ngaleu","raw_affiliation_strings":["University Institute and Strategic Estuary of Douala, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute and Strategic Estuary of Douala, Cameroon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029746976","display_name":"C\u00e9dric Romuald Yapfa Djomaha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9dric Romuald Yapfa Djomaha","raw_affiliation_strings":["University Institute and Strategic Estuary of Douala, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute and Strategic Estuary of Douala, Cameroon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007342396","display_name":"Mureille Maffo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mureille Maffo","raw_affiliation_strings":["University Institute and Strategic Estuary of Douala, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute and Strategic Estuary of Douala, Cameroon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020585419","display_name":"Graeme Brendon Jacobs","orcid":"https://orcid.org/0000-0002-3259-1496","observed_orcids":["https://orcid.org/0000-0002-3259-1496"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Graeme Brendon Jacobs","raw_affiliation_strings":["Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077155502","display_name":"Marie Claire Okomo Assoumou","orcid":"https://orcid.org/0000-0002-3680-0080","observed_orcids":["https://orcid.org/0000-0002-3680-0080"]},"institutions":[{"id":"https://openalex.org/I1331070479","display_name":"Universit\u00e9 de Yaound\u00e9 I","ror":"https://ror.org/022zbs961","country_code":"CM","type":"education","lineage":["https://openalex.org/I1331070479"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Marie Claire Okomo Assoumou","raw_affiliation_strings":["Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon","institution_ids":["https://openalex.org/I1331070479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061681477","display_name":"Claude Tayou Tagny","orcid":"https://orcid.org/0000-0002-2179-3105","observed_orcids":["https://orcid.org/0000-0002-2179-3105"]},"institutions":[{"id":"https://openalex.org/I1331070479","display_name":"Universit\u00e9 de Yaound\u00e9 I","ror":"https://ror.org/022zbs961","country_code":"CM","type":"education","lineage":["https://openalex.org/I1331070479"]},{"id":"https://openalex.org/I4210143507","display_name":"University Teaching Hospital of Yaounde","ror":"https://ror.org/042acmv76","country_code":"CM","type":"healthcare","lineage":["https://openalex.org/I4210143507"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Claude Tayou Tagny","raw_affiliation_strings":["University Teaching Hospital of Yaound\u00e9, University of Yaound\u00e9 1, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Teaching Hospital of Yaound\u00e9, University of Yaound\u00e9 1, Cameroon","institution_ids":["https://openalex.org/I1331070479","https://openalex.org/I4210143507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071286043","display_name":"George Mondinde Ikomey","orcid":"https://orcid.org/0000-0002-2479-0516","observed_orcids":["https://orcid.org/0000-0002-2479-0516"]},"institutions":[{"id":"https://openalex.org/I1331070479","display_name":"Universit\u00e9 de Yaound\u00e9 I","ror":"https://ror.org/022zbs961","country_code":"CM","type":"education","lineage":["https://openalex.org/I1331070479"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"George Mondinde Ikomey","raw_affiliation_strings":["Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Studies and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences (FMBS), University of Yaound\u00e9 1, Cameroon","institution_ids":["https://openalex.org/I1331070479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5065476557"],"corresponding_institution_ids":["https://openalex.org/I1331070479"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"3","first_page":"881","last_page":"888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-cell-reconstitution","display_name":"CD4+ T cell recovery","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.5299999713897705},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.6029999852180481},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.8180000185966492},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.8479999899864197},{"id":"https://openalex.org/keywords/immune-monitoring","display_name":"immune monitoring","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.550000011920929},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6209999918937683},{"id":"https://openalex.org/keywords/age-and-sex-effects","display_name":"age and sex effects","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7498879432678223},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.6349403858184814},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6140748858451843},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5309212803840637},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47666361927986145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47330155968666077},{"id":"https://openalex.org/C2993178667","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Cd4 t cell","level":4,"score":0.4493164122104645},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4325684905052185},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.41691046953201294},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41267162561416626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4118284285068512},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3395424783229828}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4314/ijbcs.v15i3.3","doi":"https://doi.org/10.4314/ijbcs.v15i3.3","is_oa":true,"landing_page_url":"https://doi.org/10.4314/ijbcs.v15i3.3","pdf_url":"https://www.ajol.info/index.php/ijbcs/article/download/214115/201935","source":{"id":"https://openalex.org/S2764438579","display_name":"International Journal of Biological and Chemical Sciences","issn_l":"1991-8631","issn":["1991-8631","1997-342X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological and Chemical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4314/ijbcs.v15i3.3","doi":"https://doi.org/10.4314/ijbcs.v15i3.3","is_oa":true,"landing_page_url":"https://doi.org/10.4314/ijbcs.v15i3.3","pdf_url":"https://www.ajol.info/index.php/ijbcs/article/download/214115/201935","source":{"id":"https://openalex.org/S2764438579","display_name":"International Journal of Biological and Chemical Sciences","issn_l":"1991-8631","issn":["1991-8631","1997-342X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological and Chemical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3196745166.pdf","grobid_xml":"https://content.openalex.org/works/W3196745166.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1492169582","https://openalex.org/W2021311356","https://openalex.org/W2024410915","https://openalex.org/W2137064842","https://openalex.org/W2412197783","https://openalex.org/W2491572170","https://openalex.org/W2589708348","https://openalex.org/W2771626406","https://openalex.org/W2775627150","https://openalex.org/W2807438673","https://openalex.org/W2946597534","https://openalex.org/W2960083702","https://openalex.org/W2968862796"],"related_works":["https://openalex.org/W2067035083","https://openalex.org/W2579809165","https://openalex.org/W2005006791","https://openalex.org/W6959499465","https://openalex.org/W3035653126","https://openalex.org/W3091907724","https://openalex.org/W4312017187","https://openalex.org/W3094559280","https://openalex.org/W2993524146","https://openalex.org/W6901727041"],"abstract_inverted_index":{"HIV":[0,28,42,242],"infected":[1,243],"patients":[2,45,78,153,186,244],"on":[3,46,80,138,245],"Antiretroviral":[4],"Therapy":[5],"(ART)":[6],"are":[7],"exposed":[8],"to":[9,23,191],"various":[10],"immunological":[11,141,238],"disorders.":[12],"Immune":[13],"reconstitution":[14],"is":[15],"one":[16],"of":[17,37,65,175,183,201,217,240],"the":[18,35,60,66,109,139,237],"most":[19],"challenging":[20],"problem":[21],"linked":[22],"morbidity":[24],"and":[25,62,71,84,94,118,123,127,134,150,163,167,170,187,233],"mortality":[26],"in":[27,49,222,236],"patients.":[29],"This":[30,52],"study":[31,57],"aimed":[32],"at":[33,59,130],"evaluating":[34],"kinetics":[36],"CD4+":[38,143,158,193,206,210,225],"T-cell":[39,144],"recovery":[40,231],"amongst":[41],"load":[43],"suppressed":[44,77,112],"first-line":[47],"ART":[48,81],"Yaound\u00e9,":[50],"Cameroon.":[51],"was":[53,101],"a":[54,91,106,173],"retrospective":[55],"cohort":[56],"performed":[58],"care":[61],"treatment":[63,204,218],"units":[64],"Yaound\u00e9":[67],"University":[68],"Teaching":[69],"Hospital":[70,73],"Essos":[72],"Center,":[74],"with":[75,157,205],"viral":[76,111],"initiated":[79],"between":[82],"March":[83],"July":[85],"2015.":[86],"Data":[87],"were":[88,116,189],"collected":[89],"using":[90,96],"standard":[92],"form":[93],"analyzed":[95],"R.3.6.2":[97],"software.":[98],"A":[99],"p<0.05":[100],"considered":[102],"statistically":[103],"significant":[104],"for":[105,152],"95%CI.":[107],"Of":[108],"499":[110],"participants,":[113],"32%":[114],"(n=160)":[115],"male":[117],"68%":[119],"(n=339)":[120],"female;":[121],"33%":[122],"40%":[124,171],"had":[125],"severe":[126],"moderate":[128],"immunodepression":[129],"baseline,":[131],"respectively;":[132],"9%":[133],"28%":[135],"remain":[136],"respectively":[137,166],"same":[140],"state.":[142],"count":[145],"increased":[146,212],"by":[147],"73%,":[148],"49%":[149],"29%":[151,221],"that":[154],"started":[155,203],"treatment,":[156],"<150":[159],"cells/ml,":[160,165],"150<CD4+<350":[161],"cells/ml":[162,177],"350<CD4+<500":[164],"14%,":[168],"34%":[169],"reached":[172],"target":[174],"500":[176,227],"or":[178],"more":[179],"after":[180],"4":[181,215],"years":[182,216],"treatment.":[184],"Elder":[185],"males":[188],"likely":[190],"have":[192],"T-cells":[194,207,211,230],"less":[195],"than":[196],"350":[197],"Cells/ml.":[198,209],"Approximately":[199],"35%":[200],"patient":[202],"<350":[208],"significantly":[213],"during":[214],"but,":[219],"just":[220],"average":[223],"achieved":[224],"\u2265":[226],"cells/ml.":[228],"CD4":[229],"represent":[232],"important":[234],"challenge":[235],"monitoring":[239],"long-term":[241],"ART.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-09-13T00:00:00"}